Browse by UCL Department: listings for include files
- UCL (198873)
- UCL (198873)
- Provost and Vice Provost Offices (197632)
- School of Life and Medical Sciences (96745)
- Faculty of Life Sciences (15536)
- UCL School of Pharmacy (4157)
- Pharmacology (515)
- UCL School of Pharmacy (4157)
- Faculty of Life Sciences (15536)
- School of Life and Medical Sciences (96745)
- Provost and Vice Provost Offices (197632)
- UCL (198873)
Number of items at this level: 515.
2025
Atkinson, Emily A;
Gregory, Holly N;
Carter, Lara N;
Evans, Rachael E;
Roberton, Victoria H;
Dickman, Rachael;
Phillips, James B;
(2025)
An immunomodulatory encapsulation system to deliver human iPSC-derived dopaminergic neuron progenitors for Parkinson's disease treatment.
Biomaterials Science
, 13
(8)
pp. 2012-2025.
10.1039/d4bm01566e.
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Chen, Chuyu;
Masotti, Meghan;
Shepard, Nathaniel;
Promes, Vanessa;
Tombesi, Giulia;
Arango, Daniel;
Manzoni, Claudia;
... Parisiadou, Loukia; + view all
(2025)
LRRK2 mediates haloperidol-induced changes in indirect pathway striatal projection neurons.
Molecular Psychiatry
10.1038/s41380-025-03030-z.
(In press).
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D'Agate, Salvatore;
Velickovic, Peter;
Garcia-Barrios, Noelia;
Ramon-Garcia, Santiago;
Della Pasqua, Oscar;
(2025)
Optimizing β-lactam-containing antibiotic combination therapy for the treatment of Buruli ulcer.
British Journal of Clinical Pharmacology
, 91
(1)
pp. 179-189.
10.1111/bcp.16209.
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Di, Chang;
Wu, Tong;
Gao, Kai;
Li, Na;
Song, Huifang;
Wang, Lili;
Sun, Haojie;
... Huang, Zhuo; + view all
(2025)
Carvedilol inhibits neuronal hyperexcitability caused by epilepsy-associated KCNT1 mutations.
British Journal of Pharmacology
, 182
(1)
pp. 162-180.
10.1111/bph.17360.
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Doman, Eleanor A;
Ovenden, Nicholas C;
Phillips, James B;
Shipley, Rebecca J;
(2025)
Biomechanical modelling infers that collagen content within peripheral nerves is a greater indicator of axial Young’s modulus than structure.
Biomechanics and Modeling in Mechanobiology
, 24
pp. 297-309.
10.1007/s10237-024-01911-w.
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Duon, Janna K;
Van Dijkman, Sven;
Ong, Gary;
Marta, Alexandra;
Ceci, Adriana;
Bonifazi, Ernesto;
Della Pasqua, Oscar;
(2025)
Characterizing local and systemic exposure to clobetasol propionate in healthy subjects and patients with atopic dermatitis.
British Journal of Clinical Pharmacology
10.1002/bcp.70102.
(In press).
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Duong, JK;
van Dijkman, SC;
Ong, GPY;
Marta, A;
Ceci, A;
Bonifazi, E;
Della Pasqua, Oscar;
(2025)
Evaluation of the effect of clobetasol propionate on circulating cortisol and growth velocity in children with atopic dermatitis: a modelling and simulation study.
Dermatology
(In press).
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Geard, AF;
Massaro, G;
Hughes, MP;
Arbuthnot, P;
Waddington, SN;
Rahim, AA;
(2025)
Generation and Treatment of a Novel Severe Model of Visceral Gaucher Disease by Genetic Therapy.
Pharmaceutics
, 17
(5)
, Article 650. 10.3390/pharmaceutics17050650.
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Gregori, Martina;
Pereira, Gustavo JS;
Allen, Robert;
West, Nicholas;
Chau, Kai-Yin;
Cai, Xinjiang;
Bostock, Matthew P;
... Patel, Sandip; + view all
(2025)
Lysosomal TPC2 channels disrupt Ca2+ entry and dopaminergic function in models of LRRK2-Parkinson's disease.
Journal of Cell Biology
, 224
(6)
, Article e202412055. 10.1083/jcb.202412055.
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Gregory, Holly N;
Johnson, Louis DV;
Phillips, James B;
(2025)
An emulsion electrospun nanofibrous scaffold loaded with glial cell line-derived neurotrophic factor for nerve regeneration.
Frontiers in Cell and Developmental Biology
, 13
, Article 1567654. 10.3389/fcell.2025.1567654.
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Habib, Abdella M;
Li, Shengnan;
Zhang, Chenjing;
Ji, Meijun;
Osorio, Nancy;
Penalba, Virginie;
Torres, Jesus M;
... Coste, Bertrand; + view all
(2025)
MDFIC2 is a PIEZO channel modulator that can alleviate mechanical allodynia associated with neuropathic pain.
Proceedings of the National Academy of Sciences
, 122
(45)
, Article e2512426122. 10.1073/pnas.2512426122.
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Karakitsios, E;
Della Pasqua, Oscar;
Dokoumetzidis, A;
(2025)
Extrapolation of lung pharmacokinetics of Bedaquiline across species using Physiologically Based Pharmacokinetic modelling.
British Journal of Clinical Pharmacology
, 91
(11)
pp. 3167-3178.
10.1002/bcp.70163.
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Kempthorne, Liam;
Vaizoglu, Deniz;
Cammack, Alexander J;
Carcolé, Mireia;
Roberts, Martha J;
Mikheenko, Alla;
Fisher, Alessia;
... Isaacs, Adrian M; + view all
(2025)
Dual-targeting CRISPR-CasRx reduces C9orf72 ALS/FTD sense and antisense repeat RNAs in vitro and in vivo.
Nature Communications
, 16
, Article 459. 10.1038/s41467-024-55550-x.
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Laranjeira, Simão;
Guillemot-Legris, Owein;
Girmahun, Gedion;
Phillips, James B;
Shipley, Rebecca J;
(2025)
Open-source software to calculate the static sciatic index automatically.
Regenerative Medicine
, 20
(2-3)
pp. 77-85.
10.1080/17460751.2025.2476390.
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Ma, Yingchang;
Colic, Ines;
Muwaffak, Maha;
Rahim, Ahad A;
Brocchini, Steve;
Williams, Gareth R;
(2025)
In-situ hyaluronic acid-tyramine hydrogels prolong the release of extracellular vesicles and enhance stability.
International Journal of Pharmaceutics
, Article 125650. 10.1016/j.ijpharm.2025.125650.
(In press).
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Maruf, Ali;
Gerasymchuk, Dmytro;
Hlushchuk, Irena;
Er, Safak;
Milewska, Małgorzata;
Chmielarz, Piotr;
Domanskyi, Andrii;
... Wandzik, Ilona; + view all
(2025)
Trehalose-releasing nanogels reduce α-synuclein-induced Lewy body-like inclusions in primary mouse hippocampal neurons.
Journal of Materials Chemistry B
10.1039/d4tb02704c.
(In press).
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Mobasheri, A;
Morlion, B;
Sood Sethi, V;
Cardosa, M;
Della Pasqua, Oscar;
Kalita, P;
(2025)
Combination Versus Single-Drug Nonprescription Analgesics for Acute Pain Management: A Narrative Review.
British Journal of Clinical Pharmacology
, 91
(10)
pp. 2796-2816.
10.1002/bcp.70180.
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Nash, A;
Lee, IN;
Fox, G;
Phillips, J;
White, LJ;
Marlow, M;
(2025)
An evaluation of spraying as a delivery method for human mesenchymal stem cells suspended in low-methyl pectin solutions.
Stem Cell Research and Therapy
, 16
(1)
, Article 246. 10.1186/s13287-025-04331-4.
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Norton, WE;
Kebodeaux, CD;
Phillips, A;
Donohoe, KL;
Caldas, LM;
(2025)
Live and learn: Utilizing MyDispense to increase student knowledge and confidence in caring for patients with diverse religious backgrounds.
Currents in Pharmacy Teaching and Learning
, 17
(2)
, Article 102232. 10.1016/j.cptl.2024.102232.
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Powell, Rebecca A;
Atkinson, Emily A;
Smith, Poppy O;
Patani, Rickie;
Jat, Parmjit S;
Guillemot-Legris, Owein;
Phillips, James B;
(2025)
Engineered Neural Tissue (EngNT) Containing Human iPSC-Derived Schwann Cell Precursors Promotes Axon Growth in a Rat Model of Peripheral Nerve Injury.
Bioengineering
, 12
(9)
, Article 904. 10.3390/bioengineering12090904.
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Rahim, Ahad A;
Kurian, Manju A;
Zhou, Haiyan;
Ferguson, Ross;
Tabrizi, Sarah J;
Lignani, Gabriele;
Aquilina, Kristian;
(2025)
Genetic therapies for neurological diseases.
Pharmacological Reviews
, Article 100093. 10.1016/j.pharmr.2025.100093.
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Rajbanshi, Abhishek;
Hilton, Eleanor;
Atkinson, Emily;
Phillips, JamesB;
Vanukuru, Shiva;
Khutoryanskiy, Vitaliy V;
Gibbons, Adam;
... Cook, Michael T; + view all
(2025)
Thermoresponsive engineered emulsions stabilised with branched copolymer surfactants for nasal drug delivery of molecular therapeutics.
International Journal of Pharmaceutics
, 676
, Article 125506. 10.1016/j.ijpharm.2025.125506.
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Rayner, MLD;
Ruiz, AJ;
Viel, C;
(2025)
The combination of neurotropic B vitamins (B1, B6, and B12) is superior to individual B vitamins in promoting neurite growth in vitro.
In Vitro Cellular and Developmental Biology - Animal
, 61
(3)
pp. 264-267.
10.1007/s11626-025-01024-3.
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Recino, Asha;
Rayner, Melissa LD;
Rohn, Jennifer L;
Pasqua, Oscar Della;
UCL Repurposing TIN, Committee;
(2025)
Therapeutic innovation in drug repurposing: Challenges and opportunities.
Drug Discovery Today
, Article 104390. 10.1016/j.drudis.2025.104390.
(In press).
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Sartorelli, J;
Ng, J;
Rahim, AA;
Waddington, SN;
Kurian, MA;
(2025)
Genetic therapies for movement disorders - current status.
Journal of Neurology
, 272
, Article 220. 10.1007/s00415-025-12940-5.
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Smith, Poppy O;
Jat, Parmjit;
Phillips, James B;
(2025)
Endothelial Cells Differentiated from Human Induced
Pluripotent Stem Cells Form Aligned Network Structures in
Engineered Neural Tissue.
Journal of Functional Biomaterials
, 16
(11)
, Article 425. 10.3390/jfb16110425.
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Sutton, Emma R;
McCallion, Eve;
Hoolachan, Joseph M;
Çetin, Özge;
Pacheco-Torres, Paloma;
Rashid, Saman;
Bouhmidi, Sihame;
... Bowerman, Melissa; + view all
(2025)
Mifepristone alone and in combination with scAAV9-SMN1 gene therapy improves disease phenotypes in Smn2B/- spinal muscular atrophy mice.
Scientific Reports
, 15
, Article 40225. 10.1038/s41598-025-24050-3.
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van Dijkman, SC;
Kamble, P;
Kowalski, JA;
Della Pasqua, Oscar;
(2025)
Cefuroxime axetil dosing regimens and probability of target attainment in adults and children.
British Journal of Clinical Pharmacology
, 19
(11)
pp. 3213-3224.
10.1002/bcp.70158.
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Wang, Jiaxin;
Gao, Shuaixin;
Fu, Su;
Li, Yawei;
Su, Li;
Li, Xiaoman;
Wu, Guanghao;
... Wan, You; + view all
(2025)
Irisin reprograms microglia through activation of STAT6 and prevents cognitive dysfunction after surgery in mice.
Brain, Behavior, and Immunity
, 125
pp. 68-91.
10.1016/j.bbi.2024.12.019.
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Wang, Shuaiyu;
(2025)
Distinct roles of somatodendritic and axonal Group I metabotropic glutamate receptors in modulating hippocampal granule cell excitability.
Doctoral thesis (Ph.D), UCL (University College London).
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Wu, Shuo;
Rajiah, Tracia;
Ali, Afia B;
(2025)
Therapeutic Potential for Cannabidiol on Alzheimer’s Disease-Related Neuroinflammation: A Systematic Review and Meta-Analysis.
International Journal of Molecular Sciences
, 26
(24)
, Article 11963. 10.3390/ijms262411963.
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Zwi-Dantsis, Limor;
Mohamed, Saira;
Massaro, Giulia;
Moeendarbary, Emad;
(2025)
Adeno-Associated Virus Vectors: Principles, Practices, and Prospects in Gene Therapy.
Viruses
, 17
(2)
, Article 239. 10.3390/v17020239.
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2024
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Cui, Kun;
Qi, Xuetao;
Liu, Zilong;
Sun, Weiqi;
Jiao, Peijie;
Liu, Chang;
Tong, Jifu;
... Yi, Ming; + view all
(2024)
Dominant activities of fear engram cells in the dorsal dentate gyrus underlie fear generalization in mice.
PLoS Biology
, 22
(7)
, Article e3002679. 10.1371/journal.pbio.3002679.
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D’Agate, S;
Ruiz Gabarre, D;
Della Pasqua, O;
(2024)
Population pharmacokinetics and dose rationale for aciclovir in term and pre-term neonates with herpes.
Pharmacology Research & Perspectives
, 12
(3)
, Article e1193. 10.1002/prp2.1193.
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Delahousse, J;
Wagner, AD;
Borchmann, S;
Adjei, AA;
Haanen, J;
Burgers, F;
Letsch, A;
... Mir, O; + view all
(2024)
Sex differences in the pharmacokinetics of anticancer drugs: a systematic review.
ESMO Open
, 9
(12)
, Article 104002. 10.1016/j.esmoop.2024.104002.
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Efthymiou, Stephanie;
Han, Wenyan;
Ilyas, Muhammad;
Li, Jun;
Yu, Yichao;
Scala, Marcello;
Malintan, Nancy T;
... Houlden, Henry; + view all
(2024)
Human mutations in SLITRK3 implicated in GABAergic synapse development in mice.
Frontiers in Molecular Neuroscience
, 17
, Article 1222935. 10.3389/fnmol.2024.1222935.
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Ekram, Basm;
Trueman, Ryan P;
Phillips, James B;
Ros, Helena;
Abd El-Hady, Bothaina M;
El-Gendy, Dalia M;
(2024)
Electrospun polyvinylidene fluoride with novel facile synthesized functionalized boron nitride quantum dots for neural applications.
Polymer Engineering and Science
, 64
(4)
pp. 1534-1547.
10.1002/pen.26632.
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Fornari, C;
Arrieta, A;
Bradley, JS;
Tout, M;
Magalhaes, P;
Auriol, FK;
Borella, E;
... Habboubi, N; + view all
(2024)
Dose rationale for the use of meropenem/vaborbactam combination in paediatric patients with Gram-negative bacterial infections.
British Journal of Clinical Pharmacology
, 90
(10)
pp. 2597-2610.
10.1111/bcp.16145.
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Fu, Su;
Sun, Haojie;
Wang, Jiaxin;
Gao, Shuaixin;
Zhu, Liu;
Cui, Kun;
Liu, Shimeng;
... Wan, You; + view all
(2024)
Impaired neuronal macroautophagy in the prelimbic cortex contributes to comorbid anxiety-like behaviors in rats with chronic neuropathic pain.
Autophagy
, 20
(7)
pp. 1559-1576.
10.1080/15548627.2024.2330038.
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Garcia, Gabriel;
Van Dijkman, Sven C;
Pavord, Ian;
Singh, Dave;
Oosterholt, Sean;
Fulmali, Sourabh;
Majumdar, Anurita;
(2024)
A Simulation Study of the Effect of Clinical Characteristics and Treatment Choice on Reliever Medication Use, Symptom Control and Exacerbation Risk in Moderate–Severe Asthma.
Advances in Therapy
, 41
(8)
pp. 3916-3216.
10.1007/s12325-024-02914-w.
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Healy, Paul;
Allegaert, Karel;
Della Pasqua, Oscar;
(2024)
Evaluation of the effect of CYP2D6 and OCT1 polymorphisms on the pharmacokinetics of tramadol: Implications for clinical safety and dose rationale in paediatric chronic pain.
British Journal of Clinical Pharmacology
10.1111/bcp.16201.
(In press).
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Hoolachan, Joseph M;
McCallion, Eve;
Sutton, Emma R;
Çetin, Özge;
Pacheco-Torres, Paloma;
Dimitriadi, Maria;
Sari, Suat;
... Bowerman, Melissa; + view all
(2024)
A transcriptomics-based drug repositioning approach to identify drugs with similar activities for the treatment of muscle pathologies in spinal muscular atrophy (SMA) models.
Human Molecular Genetics
, 33
(5)
pp. 400-425.
10.1093/hmg/ddad192.
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Howe, Geoffrey;
Bal, Mehtap;
Wasmuth, Matthew;
Massaro, G;
Rahim, Ahad;
Ali, Sadfer;
Rivera, Milena;
... Nesbeth, Darren; + view all
(2024)
An autonucleolytic suspension HEK293F host cell line for high-titre serum-free AAV5 and AAV9 production with reduced levels of DNA impurity.
Molecular Therapy - Methods and Clinical Development
, Article 101317. 10.1016/j.omtm.2024.101317.
(In press).
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Laranjeira, Simão;
Guillemot-Legris, Owen;
Girmahun, Gedion;
Roberton, Victoria;
Phillips, James B;
Shipley, Rebecca J;
(2024)
In silico model for automated calculation of functional metrics in animal models of peripheral nerve injury repair.
Computers in Biology and Medicine
, 181
, Article 109036. 10.1016/j.compbiomed.2024.109036.
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Lava, Sebastiano AG;
Laurence, Craig;
Di Deo, Alessandro;
Sekarski, Nicole;
Burch, Michael;
Della Pasqua, Oscar;
(2024)
Dapagliflozin and Empagliflozin in Paediatric Indications: A Systematic Review.
Pediatric Drugs
, 26
pp. 229-243.
10.1007/s40272-024-00623-z.
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Li, Jialin;
Haj Ebrahimi, Anita;
Ali, Afia B;
(2024)
Advances in Therapeutics to Alleviate Cognitive Decline and Neuropsychiatric Symptoms of Alzheimer’s Disease.
International Journal of Molecular Sciences
, 25
(10)
, Article 5169. 10.3390/ijms25105169.
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Manzoni, Claudia;
Kia, Demis A;
Ferrari, Raffaele;
Leonenko, Ganna;
Costa, Beatrice;
Saba, Valentina;
Jabbari, Edwin;
... Escott-Price, Valentina; + view all
(2024)
Genome-wide analyses reveal a potential role for the MAPT, MOBP, and APOE loci in sporadic frontotemporal dementia.
The American Journal of Human Genetics
10.1016/j.ajhg.2024.05.017.
(In press).
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Massaro, Giulia;
Geard, Amy F;
Nelvagal, Hemanth R;
Gore, Katrina;
Clemo, Nadine K;
Waddington, Simon N;
Rahim, Ahad A;
(2024)
Comparison of different promoters to improve AAV vector-mediated gene therapy for neuronopathic Gaucher disease.
Human Molecular Genetics
, Article ddae081. 10.1093/hmg/ddae081.
(In press).
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Mercer, Audrey;
Sancandi, Marco;
Maclatchy, Amy;
Lange, Sigrun;
(2024)
Brain-Region-Specific Differences in Protein Citrullination/Deimination in a Pre-Motor Parkinson’s Disease Rat Model.
International Journal of Molecular Sciences
, 25
(20)
, Article 11168. 10.3390/ijms252011168.
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Murphy, JF;
Lavelle, M;
Asciak, L;
Burdis, R;
Levis, HJ;
Ligorio, C;
McGuire, J;
... Huang, YYS; + view all
(2024)
Biofabrication and biomanufacturing in Ireland and the UK.
Bio-Design and Manufacturing
, 7
(6)
pp. 825-856.
10.1007/s42242-024-00316-z.
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Nardotto, Glauco Henrique Balthazar;
Svenson, Elin M;
Bollela, Valdes Roberto;
Rocha, Adriana;
Slavov, Svetoslav Nanev;
Ximenez, João Paulo Bianchi;
Della Pasqua, Oscar;
(2024)
Effect of Interindividual Variability in Metabolic Clearance and Relative Bioavailability on Rifampicin Exposure in Tuberculosis Patients with and without HIV Co-Infection: Does Formulation Quality Matter?
Pharmaceutics
, 16
(8)
, Article 970. 10.3390/pharmaceutics16080970.
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Paggiaro, Pierluigi;
Garcia, Gabriel;
Roche, Nicolas;
Verma, Manish;
Plank, Maximilian;
Oosterholt, Sean;
Duong, Janna K;
... Della Pasqua, Oscar; + view all
(2024)
Baseline Characteristics and Maintenance Therapy Choice on Symptom Control, Reliever Use, Exacerbation Risk in Moderate–Severe Asthma: A Clinical Modelling and Simulation Study.
Advances in Therapy
, 41
pp. 4065-4088.
10.1007/s12325-024-02962-2.
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Poupon-Bejuit, Laura;
Geard, Amy;
Millicheap, Nathan;
Rocha-Ferreira, Eridan;
Hagberg, Henrik;
Thornton, Claire;
Rahim, Ahad A;
(2024)
Diabetes drugs activate neuroprotective pathways in models of neonatal hypoxic-ischemic encephalopathy.
EMBO Molecular Medicine
10.1038/s44321-024-00079-1.
(In press).
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Romani, Armando;
Antonietti, Alberto;
Bella, Davide;
Budd, Julian;
Giacalone, Elisabetta;
Kurban, Kerem;
Sáray, Sára;
... Markram, Henry; + view all
(2024)
Community-based reconstruction and simulation of a full-scale model of the rat hippocampus CA1 region.
PLOS Biology
, 22
(11)
, Article e3002861. 10.1371/journal.pbio.3002861.
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Scardovi, AL;
Bartolucci, D;
Montemurro, L;
Bortolotti, S;
Angelucci, S;
Amadesi, C;
Nieddu, G;
... Tonelli, R; + view all
(2024)
Preclinical Pharmacokinetics in Tumors and Normal Tissues of the Antigene PNA Oligonucleotide MYCN-Inhibitor BGA002.
Nucleic Acid Therapeutics
10.1089/nat.2024.0005.
(In press).
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Sethi, V;
Qin, L;
Trocóniz, IF;
Van der Laan, L;
Cox, E;
Della Pasqua, O;
(2024)
Model-Based Assessment of the Liver Safety Profile of Acetaminophen to Support its Combination Use with Topical Diclofenac in Mild-to-Moderate Osteoarthritis Painb.
Pain and Therapy
, 13
pp. 127-143.
10.1007/s40122-023-00566-2.
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Sethi, Vidhu;
Anand, Chetan;
Della Pasqua, Oscar;
(2024)
Clinical Assessment of Osteoarthritis Pain: Contemporary Scenario, Challenges, and Future Perspectives.
Pain and Therapy
, 13
pp. 391-408.
10.1007/s40122-024-00592-8.
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Sethi, Vidhu;
Qin, Li;
Cox, Eugene;
Troconiz, Inaki F;
Della Pasqua, Oscar;
(2024)
Model-Based Meta-Analysis Supporting the Combination of Acetaminophen and Topical Diclofenac in Acute Pain: A Therapy for Mild-to-Moderate Osteoarthritis Pain?
Pain and Therapy
, 13
(1)
pp. 145-159.
10.1007/s40122-023-00569-z.
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Simeoli, R;
Lava, SAG;
Di Deo, A;
Roversi, M;
Cairoli, S;
Tambucci, R;
Rea, F;
... Goffredo, BM; + view all
(2024)
Pharmacokinetic Evaluation of Oral Viscous Budesonide in Paediatric Patients with Eosinophilic Oesophagitis in Repaired Oesophageal Atresia.
Pharmaceutics
, 16
(7)
, Article 872. 10.3390/pharmaceutics16070872.
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Smith, Poppy O;
Huang, Guanbingxue;
Devries, Kate;
Nazhat, Showan N;
Phillips, James B;
(2024)
Automated production of nerve repair constructs containing endothelial cell tube-like structures.
Biofabrication
, 17
(1)
, Article 015024. 10.1088/1758-5090/ad8efd.
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Trueman, Ryan P;
Guillemot-Legris, Owein;
Lancashire, Henry T;
Mehta, Abijeet S;
Tropp, Joshua;
Daso, Rachel E;
Rivnay, Jonathan;
... Schroeder, Bob C; + view all
(2024)
Aligned Bioelectronic Polypyrrole/Collagen Constructs for Peripheral Nerve Interfacing.
Advanced Engineering Materials
, Article e2301488. 10.1002/adem.202301488.
(In press).
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Tsilova, SL;
Schreiber, BE;
Lever, R;
Parhizkar, M;
(2024)
Polymeric nanoparticles produced by electrohydrodynamic atomisation for the passive delivery of imatinib.
European Journal of Pharmaceutics and Biopharmaceutics
, 202
, Article 114412. 10.1016/j.ejpb.2024.114412.
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van Dijkman, Sven C;
Yorgancıoğlu, Arzu;
Pavord, Ian;
Brusselle, Guy;
Pitrez, Paulo M;
Oosterholt, Sean;
Fumali, Sourabh;
... Della Pasqua, Oscar; + view all
(2024)
Effect of Individual Patient Characteristics and Treatment Choices on Reliever Medication Use in Moderate-Severe Asthma: A Poisson Analysis of Randomised Clinical Trials.
Advances in Therapy
10.1007/s12325-023-02774-w.
(In press).
|
|
|
Wang, Y;
Yang, H;
Li, N;
Wang, L;
Guo, C;
Ma, W;
Liu, S;
... Huang, Z; + view all
(2024)
A Novel Ubiquitin Ligase Adaptor PTPRN Suppresses Seizure Susceptibility through Endocytosis of NaV1.2 Sodium Channels.
Advanced Science
, Article 2400560. 10.1002/advs.202400560.
(In press).
|
|
Wetzel, Andrea;
Lei, Si Hang;
Liu, Tiansheng;
Hughes, Michael P;
Peng, Yunan;
McKay, Tristan;
Waddington, Simon N;
... Harvey, Kirsten; + view all
(2024)
Dysregulated Wnt and NFAT signaling in a Parkinson's disease LRRK2 G2019S knock-in model.
Scientific Reports
, 14
(1)
, Article 12393. 10.1038/s41598-024-63130-8.
|
|
|
Zangari, Martina;
Zabucchi, Giuliano;
Conti, Martina;
Lorenzon, Paola;
Borelli, Violetta;
Constanti, Andrew;
Dellisanti, Francesco;
... Bernareggi, Annalisa; + view all
(2024)
Effect of Synthetic Vitreous Fiber Exposure on TMEM16A Channels in a Xenopus laevis Oocyte Model.
International Journal of Molecular Sciences
, 25
(16)
p. 8661.
10.3390/ijms25168661.
|
|
Zhang, Weicong;
Liu, Tiansheng;
Li, Jialin;
Singh, Jaijeet;
Chan, Andi;
Islam, Anam;
Petrache, Alexandra;
... Ali, Afia B; + view all
(2024)
Decreased extrasynaptic δ-GABA_{A} receptors in PNN-associated parvalbumin interneurons correlates with anxiety in APP and tau mouse models of Alzheimer's disease.
British Journal of Pharmacology
10.1111/bph.16441.
(In press).
|
|
Zhao, Yibo;
Bracher-Smith, Matthew;
Li, Yuelin;
Harvey, Kirsten;
Escott-Price, Valentina;
Lewis, Patrick A;
Manzoni, Claudia;
(2024)
Transcriptomics and weighted protein network analyses of the LRRK2 protein interactome reveal distinct molecular signatures for sporadic and LRRK2 Parkinson’s Disease.
npj Parkinson's Disease
, 10
, Article 144. 10.1038/s41531-024-00761-8.
|
2023
|
Alchi, MB;
Lever, R;
Flossmann, O;
Jayne, D;
(2023)
Efficacy and safety of low- versus high-dose glucocorticoid regimens for induction of remission of anti-neutrophil cytoplasm antibody-associated vasculitis: a systematic review and meta-analysis.
Scandinavian Journal of Rheumatology
, 52
(5)
pp. 564-573.
10.1080/03009742.2023.2211387.
|
|
Ali, Afia;
Islam, Anam;
Constanti, Andrew;
(2023)
The fate of interneurons, GABAA receptor sub-types and perineuronal nets in Alzheimer’s disease.
Brain Pathology
, 33
(1)
, Article e13129. 10.1111/bpa.13129.
|
|
Allahham, Nour;
Colic, Ines;
Rayner, Melissa LD;
Gurnani, Pratik;
Phillips, James B;
Rahim, Ahad A;
Williams, Gareth R;
(2023)
Advanced Formulation Approaches for Emerging Therapeutic Technologies.
In: Michel, Martin C, (ed.)
Handbook of Experimental Pharmacology.
(pp. 1-23).
Springer Verlag: Berlin, Heidelberg, Germany.
|
|
Berg, Maxime;
Eleftheriadou, Despoina;
Phillips, James B;
Shipley, Rebecca J;
(2023)
Mathematical modelling with Bayesian inference to quantitatively characterize therapeutic cell behaviour in nerve tissue engineering.
Journal of the Royal Society Interface
, 20
(206)
, Article 20230258. 10.1098/rsif.2023.0258.
|
|
Bernareggi, Annalisa;
Zangari, Martina;
Constanti, Andrew;
Zacchi, Paola;
Borelli, Violetta;
Mangogna, Alessandro;
Lorenzon, Paola;
(2023)
Asbestos Fibers Enhance the TMEM16A Channel Activity in Xenopus Oocytes.
Membranes
, 13
(2)
, Article 180. 10.3390/membranes13020180.
|
|
Della Pasqua, Oscar;
Singh, Dave;
Oosterholt, Sean;
Pavord, Ian;
Garcia, Gabriel;
PG, Abhijith;
(2023)
Understanding the Clinical Implications of Individual Patient Characteristics and Treatment Choice on the Risk of Exacerbation in Asthma Patients with Moderate–Severe Symptoms.
Advances in Therapy
, 40
pp. 4606-4625.
10.1159/000531385.
|
|
Di Deo, Alessandro;
Oosterholt, Sean;
Horrigan, Joseph P;
McMorn, Alison;
Della Pasqua, Oscar;
(2023)
Population pharmacokinetics and pharmacokinetic-pharmacodynamic correlations of tideglusib for the treatment of adolescents with autism spectrum disorders.
Presented at: Pharmacology 2022, Liverpool, UK.
|
|
Di Donfrancesco, A;
Berlingieri, C;
Giacomello, M;
Frascarelli, C;
Magalhaes Rebelo, AP;
Bindoff, LA;
Reeval, S;
... Brunetti, D; + view all
(2023)
PPAR-gamma agonist pioglitazone recovers mitochondrial quality control in fibroblasts from PITRM1-deficient patients.
Frontiers in Pharmacology
, 14
, Article 1220620. 10.3389/fphar.2023.1220620.
|
|
|
Estevez-Fraga, Carlos;
Altmann, Andre;
Parker, Christopher S;
Scahill, Rachael;
Costa, Beatrice;
Chen, Zhongbo;
Manzoni, Claudia;
... McColgan, Peter; + view all
(2023)
Genetic topography and cortical cell loss in Huntington's disease link development and neurodegeneration.
Brain
, Article awad275. 10.1093/brain/awad275.
|
|
Gong, Grace Q;
Bilanges, Benoit;
Allsop, Ben;
Masson, Glenn R;
Roberton, Victoria;
Askwith, Trevor;
Oxenford, Sally;
... Vanhaesebroeck, Bart; + view all
(2023)
A small-molecule PI3Kα activator for cardioprotection and neuroregeneration.
Nature
, 618
pp. 159-168.
10.1038/s41586-023-05972-2.
|
|
|
Gregory, Holly N;
Guillemot-Legris, Owein;
Crouch, Daisy;
Williams, Gareth;
Phillips, James B;
(2023)
Electrospun aligned tacrolimus-loaded polycaprolactone biomaterials for peripheral nerve repair.
Regenerative Medicine
10.2217/rme-2023-0151.
(In press).
|
|
|
Gregory, Holly Nicole;
(2023)
Nanofibrous biomaterials with encapsulated therapeutics and aligned architecture for peripheral nerve regeneration.
Doctoral thesis (Ph.D), UCL (University College London).
|
|
Guillemot-Legris, Owein;
Girmahun, Gedion;
Shipley, Rebecca J;
Phillips, James B;
(2023)
Local Administration of Minocycline Improves Nerve Regeneration in Two Rat Nerve Injury Models.
International Journal of Molecular Sciences
, 24
(15)
, Article 12085. 10.3390/ijms241512085.
|
|
Healy, Paul;
Verrest, Luka;
Felisi, Mariagrazia;
Ceci, Adriana;
Della Pasqua, Oscar;
GAPP Consortium;
(2023)
Dose rationale for gabapentin and tramadol in pediatric patients with chronic pain.
Pharmacol Res Perspect
, 11
(5)
, Article e01138. 10.1002/prp2.1138.
|
|
|
Hogwood, John;
Mulloy, Barbara;
Lever, Rebecca;
Gray, Elaine;
Page, Clive P;
(2023)
Pharmacology of Heparin and Related Drugs: An Update.
Pharmacological Reviews
, 75
(2)
pp. 328-379.
10.1124/pharmrev.122.000684.
|
|
Huang, Zhong;
Powell, Rebecca;
Kankowski, Svenja;
Phillips, James B;
Haastert-Talini, Kirsten;
(2023)
Culture Conditions for Human Induced Pluripotent Stem Cell-Derived Schwann Cells: A Two-Centre Study.
International Journal of Molecular Sciences
, 24
(6)
, Article 5366. 10.3390/ijms24065366.
|
|
Hughes, Michael Paul;
Nelvagal, Hemanth Ramesh;
Coombe-Tennant, Oliver;
Smith, Dave;
Smith, Claire;
Massaro, Giulia;
Poupon-Bejuit, Laura;
... Rahim, Ahad Abdul; + view all
(2023)
A Novel Small NPC1 Promoter Enhances AAV-Mediated Gene Therapy in Mouse Models of Niemann–Pick Type C1 Disease.
Cells
, 12
(12)
, Article 1619. 10.3390/cells12121619.
|
|
Kelly, Katie;
Lewis, Patrick A;
Plun-Favreau, Helene;
Manzoni, Claudia;
(2023)
Protein network analysis links the NSL complex to Parkinson's disease via mitochondrial and nuclear biology.
Molecular Omics
10.1039/d2mo00325b.
(In press).
|
|
Laranjeira, S;
Roberton, VH;
Phillips, JB;
Shipley, RJ;
(2023)
Perspectives on optimizing local delivery of drugs to peripheral nerves using mathematical models.
WIREs Mechanisms of Disease
, Article e1593. 10.1002/wsbm.1593.
(In press).
|
|
Musuamba, FT;
Cheung, AY;
Colin, P;
Davies, EH;
Barret, JS;
Pappalardo, F;
Chappell, M;
... Rusten, IS; + view all
(2023)
Moving Toward a Question-Centric Approach for Regulatory Decision Making in the Context of Drug Assessment.
Clinical Pharmacology & Therapeutics
, 114
(1)
pp. 41-50.
10.1002/cpt.2856.
|
|
Oosterholt, Sean;
Pavord, Ian D;
Brusselle, Guy;
Yorgancıoğlu, Arzu;
Pitrez, Paulo M;
Abhijith, PG;
Teli, Chirag;
(2023)
Modelling ASthma TrEatment Responses (MASTER): Effect of individual patient characteristics on the risk of exacerbation in moderate or severe asthma: A time-to-event analysis of randomized clinical trials.
British Journal of Clinical Pharmacology
10.1111/bcp.15801.
(In press).
|
|
Papassidero, P;
Wichert-Ana, L;
Lia, EN;
Alexandre-Santos, L;
Trevisan, AC;
Coelho, EB;
Della Pasqua, O;
... Dach, F; + view all
(2023)
Pharmacodynamic effect of gabapentin on central nervous system in patients with chronic low back pain: a [99mTc]Tc-ECD SPECT study.
Regional Anesthesia and Pain Medicine
10.1136/rapm-2022-104047.
(In press).
|
|
Rahmani, Rayane;
Rambarack, Naiomi;
Singh, Jaijeet;
Constanti, Andrew;
Ali, Afia B;
(2023)
Age-Dependent Sex Differences in Perineuronal Nets in an APP Mouse Model of Alzheimer’s Disease Are Brain Region-Specific.
International Journal of Molecular Sciences
, 24
(19)
, Article 14917. 10.3390/ijms241914917.
|
|
Roberton, Victoria H;
Gregory, Holly N;
Angkawinitwong, Ukrit;
Mokrane, Omar;
Boyd, Ashleigh S;
Shipley, Rebecca J;
Williams, Gareth R;
(2023)
Local delivery of tacrolimus using electrospun poly-ε-caprolactone nanofibres suppresses the T-cell response to peripheral nerve allografts.
Journal of Neural Engineering
, 20
(1)
, Article 016035. 10.1088/1741-2552/acad2a.
|
|
Sancandi, Marco;
De Caro, Carmen;
Cypaite, Neringa;
Marascio, Nadia;
Avagliano, Carmen;
De Marco, Carmela;
Russo, Emilio;
... Mercer, Audrey; + view all
(2023)
Effects of a probiotic suspension Symprove™ on a rat early-stage Parkinson’s disease model.
Frontiers in Aging Neuroscience
, 14
, Article 986127. 10.3389/fnagi.2022.986127.
|
|
Shao, Luying;
Zhao, Yibo;
Heinrich, Michael;
Prieto, Jose Maria;
Manzoni, Claudia;
(2023)
Active natural compounds perturb the melanoma risk-gene network.
G3
10.1093/g3journal/jkad274.
(In press).
|
|
Topczewska, Aleksandra;
Giacalone, Elisabetta;
Pratt, Wendy S;
Migliore, Michele;
Dolphin, Annette C;
Shah, Mala M;
(2023)
T-type Ca2+ and persistent Na+ currents synergistically elevate ventral, not dorsal, entorhinal cortical stellate cell excitability.
Cell Reports
, 42
(7)
, Article 112699. 10.1016/j.celrep.2023.112699.
|
|
Trueman, Ryan P;
Finn, Peter Gilhooly;
Westwood, Megan M;
Dey, Avishek;
Palgrave, Robert;
Tabor, Alethea;
Phillips, James B;
(2023)
Improving the biological interfacing capability of Improving the biological interfacing capability of diketopyrrolopyrrole polymers via p-type doping.
Journal of Materials Chemistry C
10.1039/d3tc01148h.
(In press).
|
|
|
Villani, Umberto;
Della Pasqua, Oscar;
(2023)
From animal to in silico to humans: Clinical trial simulations as a tool for optimization of Phase I studies with antitubercular drugs.
Presented at: Pharmacology 2022, Liverpool, UK.
|
|
Waddington, Simon N;
Peranteau, William H;
Rahim, Ahad A;
Boyle, Ashley K;
Kurian, Manju A;
Gissen, Paul;
Chan, Jerry KY;
(2023)
Fetal gene therapy.
Journal of Inherited Metabolic Disease
10.1002/jimd.12659.
(In press).
|
|
Whiteley, Zoe;
Massaro, Giulia;
Gkogkos, Georgios;
Gavriilidis, Asterios;
Waddington, Simon N;
Rahim, Ahad A;
Craig, Duncan QM;
(2023)
Microfluidic production of nanogels as alternative triple transfection reagents for the manufacture of adeno-associated virus vectors.
Nanoscale
10.1039/d2nr06401d.
(In press).
|
|
Wilcox, Matthew;
Rayner, Melissa Ld;
Guillemot-Legris, Owein;
Platt, Isobel;
Brown, Hazel;
Quick, Tom;
Phillips, James B;
(2023)
Serum neurofilament light chain measurements following nerve injury.
Journal of the Peripheral Nervous System
, 28
(3)
pp. 500-507.
10.1111/jns.12576.
|
2022
|
Aboheimed, Ghada I;
AlRasheed, Maha M;
Almudimeegh, Sultan;
Peña-Guerra, Karla A;
Cardona-Londoño, Kelly J;
Salih, Mustafa A;
Seidahmed, Mohammed Z;
... Ruiz, Arnaud J; + view all
(2022)
Clinical, genetic, and functional characterization of the glycine receptor β-subunit A455P variant in a family affected by hyperekplexia syndrome.
Journal of Biological Chemistry
, Article 102018. 10.1016/j.jbc.2022.102018.
|
|
Aldabbagh, Yousif;
Islam, Anam;
Zhang, Weicong;
Whiting, Paul;
Ali, Afia B;
(2022)
Alzheimer’s Disease Enhanced Tonic Inhibition is Correlated With Upregulated Astrocyte GABA Transporter-3/4 in a Knock-In APP Mouse Model.
Frontiers in Pharmacology
, 13
, Article 822499. 10.3389/fphar.2022.822499.
|
|
Borella, Elisa;
Oosterholt, Sean;
Magni, Paolo;
Pasqua, Oscar Della;
(2022)
Characterisation of individual ferritin response in patients receiving chelation therapy.
British Journal of Clinical Pharmacology
10.1111/bcp.15290.
(In press).
|
|
Cogo, Susanna;
Ho, Franz Y;
Tosoni, Elena;
Tomkins, James E;
Tessari, Isabella;
Iannotta, Lucia;
Montine, Thomas J;
... Greggio, Elisa; + view all
(2022)
The Roc domain of LRRK2 as a hub for protein-protein interactions: a focus on PAK6 and its impact on RAB phosphorylation.
Brain Research
, 1778
, Article 147781. 10.1016/j.brainres.2022.147781.
|
|
Cogo, Susanna;
Tomkins, James E;
Vavouraki, Nikoleta;
Giusti, Veronica;
Forcellato, Federica;
Franchin, Cinzia;
Tessari, Isabella;
... Greggio, Elisa; + view all
(2022)
Cytosolic sequestration of spatacsin by Protein Kinase A and 14-3-3 proteins.
Neurobiology of Disease
, 174
, Article 105858. 10.1016/j.nbd.2022.105858.
|
|
Devine, Michael J;
Szulc, Blanka R;
Howden, Jack H;
López-Doménech, Guillermo;
Ruiz, Arnaud;
Kittler, Josef T;
(2022)
Mitochondrial Ca²⁺ Uniporter haploinsufficiency enhances long-term potentiation at hippocampal mossy fibre synapses.
Journal of Cell Science
10.1242/jcs.259823.
(In press).
|
|
Di Donfrancesco, Alessia;
Massaro, Giulia;
Di Meo, Ivano;
Tiranti, Valeria;
Bottani, Emanuela;
Brunetti, Dario;
(2022)
Gene Therapy for Mitochondrial Diseases: Current Status and Future Perspective.
Pharmaceutics
, 14
(6)
, Article 1287. 10.3390/pharmaceutics14061287.
|
|
Duong, Janna K;
Nand, Romina A;
Patel, Aarti;
Della Pasqua, Oscar;
Gross, Annette S;
(2022)
A physiologically based pharmacokinetic model of clopidogrel in populations of European and Japanese ancestry: An evaluation of CYP2C19 activity.
Pharmacology Research & Perspectives
, 10
(2)
, Article e00946. 10.1002/prp2.946.
|
|
Eleftheriadou, D;
Berg, M;
Phillips, JB;
Shipley, RJ;
(2022)
A combined experimental and computational framework to evaluate the behavior of therapeutic cells for peripheral nerve regeneration.
Biotechnology and Bioengineering
10.1002/bit.28105.
(In press).
|
|
Gross, AS;
Harry, AC;
Clifton, CS;
Della Pasqua, O;
(2022)
Clinical Trial Diversity: An Opportunity for Improved Insight into the Determinants of Variability in Drug Response.
British Journal of Clinical Pharmacology
, 88
(6)
pp. 2700-2717.
10.1111/bcp.15242.
|
|
Ingleby-Talecki, Lindsey;
van Dijkman, Sven C;
Oosterholt, Sean P;
Della Pasqua, Oscar;
Winter, Christina;
Cunnington, Marianne;
Rebar, Linda;
... Chaudhary, Khuram W; + view all
(2022)
Cardiac sodium channel inhibition by lamotrigine: in vitro characterization and clinical implications.
Clinical and Translational Science
, 15
(8)
pp. 1978-1989.
10.1111/cts.13311.
|
|
Islam, Anam;
Saito, Takashi;
Saido, Takaomi;
Ali, Afia B;
(2022)
Presubiculum principal cells are preserved from degeneration in knock-in APP/TAU mouse models of Alzheimer’s disease.
Seminars in Cell & Developmental Biology
10.1016/j.semcdb.2022.03.001.
(In press).
|
|
Johnson, RC;
Saez-Lopez, E;
Anagonou, ES;
Kpoton, GG;
Ayelo, AG;
Gnimavo, RS;
Mignanwande, FZ;
... Ramon-Garcia, S; + view all
(2022)
Comparison of 8 weeks standard treatment (rifampicin plus clarithromycin) vs. 4 weeks standard plus amoxicillin/clavulanate treatment [RC8 vs. RCA4] to shorten Buruli ulcer disease therapy (the BLMs4BU trial): study protocol for a randomized controlled multi-centre trial in Benin.
Trials
, 23
, Article 559. 10.1186/s13063-022-06473-9.
|
|
Kellaway, Simon C;
Roberton, Victoria;
Jones, Joshua N;
Loczenski, Rabea;
Phillips, James B;
White, Lisa J;
(2022)
Engineered neural tissue made using hydrogels derived from decellularised tissues for the regeneration of peripheral nerves.
Acta Biomaterialia
10.1016/j.actbio.2022.12.003.
(In press).
|
|
Koçoğlu, Cemile;
Ferrari, Raffaele;
Roes, Maxime;
Vandeweyer, Geert;
Kooy, R Frank;
van Broeckhoven, Christine;
Manzoni, Claudia;
(2022)
Protein interaction network analysis reveals genetic enrichment of immune system genes in frontotemporal dementia.
Neurobiology of Aging
10.1016/j.neurobiolaging.2022.03.018.
(In press).
|
|
|
Laranjeira, S;
Pellegrino, G;
Bhangra, KS;
Phillips, JB;
Shipley, RJ;
(2022)
In silico framework to inform the design of repair constructs for peripheral nerve injury repair.
Journal of the Royal Society Interface
, 19
(188)
, Article 20210824. 10.1098/rsif.2021.0824.
|
|
Li, X;
Li, T;
Zhan, F;
Cheng, F;
Lu, L;
Zhang, B;
Li, J;
... Yao, H; + view all
(2022)
Design, Synthesis, and Biological Evaluation of Novel Chromanone Derivatives as Multifunctional Agents for the Treatment of Alzheimer's Disease.
ACS Chemical Neuroscience
, 13
(23)
pp. 3488-3501.
10.1021/acschemneuro.2c00520.
|
|
Li, X;
Li, T;
Zhang, P;
Li, X;
Lu, L;
Sun, Y;
Zhang, B;
... Xu, J; + view all
(2022)
Discovery of novel hybrids containing clioquinol−1-benzyl-1,2,3,6-tetrahydropyridine as multi-target-directed ligands (MTDLs) against Alzheimer's disease.
European Journal of Medicinal Chemistry
, 244
, Article 114841. 10.1016/j.ejmech.2022.114841.
|
|
Lia, EN;
Papassidero, PC;
Coelho, EB;
Dach, F;
Alexandre-Santos, L;
Trevisan, AC;
Santos, LELE;
... Wichert-Ana, L; + view all
(2022)
Neurobiological substrates of chronic low back pain (CLBP): a brain [⁹⁹ᵐTc]Tc-ECD SPECT study.
European Journal of Hybrid Imaging
, 6
(1)
, Article 26. 10.1186/s41824-022-00145-2.
|
|
Liu, Y;
Uras, G;
Onuwaje, I;
Li, W;
Yao, H;
Xu, S;
Li, X;
... Xu, J; + view all
(2022)
Novel inhibitors of AChE and Aβ aggregation with neuroprotective properties as lead compounds for the treatment of Alzheimer's disease.
European Journal of Medicinal Chemistry
, 235
, Article 114305. 10.1016/j.ejmech.2022.114305.
|
|
Mamais, Adamantios;
Kaganovich, Alice;
Harvey, Kirsten;
(2022)
Convergence of signalling pathways in innate immune responses and genetic forms of Parkinson's disease.
Neurobiology of Disease
, 169
, Article 105721. 10.1016/j.nbd.2022.105721.
|
|
|
Mamais, Adamantios;
Kluss, Jillian H;
Bonet-Ponce, Luis;
Landeck, Natalie;
Langston, Rebekah G;
Smith, Nathan;
Beilina, Alexandra;
... Cookson, Mark R; + view all
(2022)
Correction: Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia.
PLOS Biology
, 20
(5)
, Article e3001621. 10.1371/journal.pbio.3001621.
|
|
Mercer, Audrey;
Jaunmuktane, Zane;
Hristova, Mariya;
Lange, Sigrun;
(2022)
Differential, Stage Dependent Detection of Peptidylarginine Deiminases and Protein Deimination in Lewy Body Diseases—Findings from a Pilot Study.
International Journal of Molecular Sciences
, 23
(21)
, Article 13117. 10.3390/ijms232113117.
|
|
Muliaditan, M;
Teutonico, D;
Ortega-Mur, F;
Ferre, S;
Della Pasqua, Oscar;
(2022)
Prediction of lung exposure to anti-tubercular drugs using plasma pharmacokinetic data: implications for dose selection.
European Journal of Pharmaceutical Sciences
, 173
, Article 106163. 10.1016/j.ejps.2022.106163.
|
|
Nardotto, GHB;
Bollela, VB;
Rocha, A;
Della Pasqua, O;
Lanchot, VL;
(2022)
No implication of HIV coinfection on the plasma exposure to rifampicin, pyrazinamide, and ethambutol in tuberculosis patients.
Clinical and Translational Science
, 15
(2)
pp. 514-523.
10.1111/cts.13169.
|
|
Ostergaard, John R;
Nelvagal, Hemanth R;
Cooper, Jonathan D;
(2022)
Top-down and bottom-up propagation of disease in the neuronal ceroid lipofuscinoses.
Frontiers in Neurology
, 13
, Article 1061363. 10.3389/fneur.2022.1061363.
|
|
Poupon-Bejuit, L;
Hughes, MP;
Liu, W;
Geard, A;
Faour-Slika, N;
Whaler, S;
Massaro, G;
(2022)
A GLP1 receptor agonist diabetes drug ameliorates neurodegeneration in a mouse model of infantile neurometabolic disease.
Scientific Reports
, 12
(1)
, Article 13825. 10.1038/s41598-022-17338-1.
|
|
Rayner, Melissa LD;
Kellaway, Simon C;
Kingston, Isabel;
Guillemot-Legris, Owein;
Gregory, Holly;
Healy, Jess;
Phillips, James B;
(2022)
Exploring the Nerve Regenerative Capacity of Compounds with Differing Affinity for PPARγ In Vitro and In Vivo.
Cells
, 12
(1)
, Article 42. 10.3390/cells12010042.
|
|
Tallarico, M;
Leo, A;
Guarnieri, L;
Zito, MC;
De Caro, C;
Nicoletti, F;
Russo, E;
... Citraro, R; + view all
(2022)
N-acetylcysteine aggravates seizures while improving depressive-like and cognitive impairment comorbidities in the WAG/Rij rat model of absence epilepsy.
Molecular Neurobiology
, 59
pp. 2702-2714.
10.1007/s12035-021-02720-3.
|
|
Trueman, RP;
Ahlawat, AS;
Phillips, JB;
(2022)
A Shock to the (Nervous) System: Bioelectricity Within Peripheral Nerve Tissue Engineering.
Tissue Engineering Part B: Reviews
, 28
(5)
pp. 1137-1150.
10.1089/ten.TEB.2021.0159.
|
|
Yuan, Banghao;
Hatchett-Walker, Caroline;
Long, Philip;
Xu, Zhihan;
Stephenson, F Anne;
Haider, Shozeb;
Jovanovic, Jasmina N;
(2022)
Control of cell surface expression of GABAA receptors by a conserved region at the end of the N-terminal extracellular domain of receptor subunits.
Journal of Biological Chemistry
, 298
(12)
, Article 102590. 10.1016/j.jbc.2022.102590.
|
2021
|
Babcock, MC;
Mikulka, CR;
Wang, B;
Chandriani, S;
Chandra, S;
Xu, Y;
Webster, K;
... Crawford, BE; + view all
(2021)
Substrate reduction therapy for Krabbe disease and metachromatic leukodystrophy using a novel ceramide galactosyltransferase inhibitor.
Scientific Reports
, 11
, Article 14486. 10.1038/s41598-021-93601-1.
|
|
|
Barbier, M;
Camuzat, A;
Hachimi, KE;
Guegan, J;
Rinaldi, D;
Lattante, S;
Houot, M;
... Le Ber, I; + view all
(2021)
SLITRK2, an X-linked modifier of the age at onset in C9orf72 frontotemporal lobar degeneration.
Brain
, 144
(9)
pp. 2798-2811.
10.1093/brain/awab171.
|
|
Bashir, S;
Dziemidowicz, K;
(2021)
Critical appraisal: how to evaluate research for use inclinical practice.
The Pharmaceutical Journal
, 306
(7950)
pp. 1-15.
10.1211/PJ.2021.1.85492.
|
|
Blauwendraat, C;
Iwaki, H;
Makarious, MB;
Bandres-Ciga, S;
Leonard, H;
Grenn, FP;
Lake, J;
... Lynch, TL; + view all
(2021)
Investigation of Autosomal Genetic Sex Differences in Parkinson's disease.
Annals of Neurology
, 90
(1)
pp. 35-42.
10.1002/ana.26090.
|
|
Chen, Z;
Zhang, D;
Reynolds, RH;
Gustavsson, EK;
García-Ruiz, S;
D'Sa, K;
Fairbrother-Browne, A;
... Ryten, M; + view all
(2021)
Human-lineage-specific genomic elements are associated with neurodegenerative disease and APOE transcript usage.
Nature Communications
, 12
, Article 2076. 10.1038/s41467-021-22262-5.
|
|
|
Citraro, R;
Lembo, F;
De Caro, C;
Tallarico, M;
Coretti, L;
Iannone, LF;
Leo, A;
... De Sarro, G; + view all
(2021)
First evidence of an altered microbiota and intestinal damage and its link to absence epilepsy in a genetic animal model, the WAG/Rij rat.
Epilepsia
, 62
(2)
pp. 529-541.
10.1111/epi.16813.
|
|
Coy, R;
Berg, M;
Phillips, JB;
Shipley, RJ;
(2021)
Modelling-informed cell-seeded nerve repair construct designs for treating peripheral nerve injuries.
PLoS Computational Biology
, 17
(7)
, Article e1009142. 10.1371/journal.pcbi.1009142.
|
|
|
D'Agate, S;
Chavan, C;
Manyak, M;
Palacios-Moreno, JM;
Oelke, M;
Michel, MC;
Roehrborn, CG;
(2021)
Model-based meta-analysis of the time to first acute urinaryretention or benign prostatic hyperplasia-related surgery inpatients with moderate or severe symptoms.
British Journal of Clinical Pharmacology
10.1111/bcp.14682.
(In press).
|
|
|
D'Agate, S;
Musuamba, FT;
Jacqz-Aigrain, E;
Della Pasqua, O;
(2021)
Simplified Dosing Regimens for Gentamicin in Neonatal Sepsis.
FrFrontiers in Pharmacology
, 12
, Article 624662. 10.3389/fphar.2021.624662.
|
|
|
Fullerton, JN;
Della Pasqua, O;
Likic, R;
(2021)
Model antibiotic use to improve outcomes.
British Journal of Clinical Pharmacology
, 87
(3)
pp. 738-740.
10.1111/bcp.14559.
|
|
Gregory, H;
Phillips, JB;
(2021)
Materials for peripheral nerve repair constructs: Natural proteins or synthetic polymers?
Neurochemistry International
, 143
, Article 104953. 10.1016/j.neuint.2020.104953.
|
|
Kara, E;
Crimi, A;
Wiedmer, A;
Emmenegger, M;
Manzoni, C;
Bandres-Ciga, S;
D'Sa, K;
... Aguzzi, A; + view all
(2021)
An integrated genomic approach to dissect the genetic landscape regulating the cell-to-cell transfer of α-synuclein.
Cell Reports
, 35
(10)
, Article 109189. 10.1016/j.celrep.2021.109189.
|
|
|
Kellaway, Simon Christopher;
(2021)
Hydrogels derived from decellularised tissues for nerve repair.
Doctoral thesis (Ph.D), UCL (University College London).
|
|
Kia, DA;
Zhang, D;
Guelfi, S;
Manzoni, C;
Hubbard, L;
Reynolds, RH;
Botía, J;
... Botiá, JA; + view all
(2021)
Identification of Candidate Parkinson Disease Genes by Integrating Genome-Wide Association Study, Expression, and Epigenetic Data Sets.
JAMA Neurology
, 78
(4)
pp. 464-472.
10.1001/jamaneurol.2020.5257.
|
|
|
Klionsky, DJ;
Abdel-Aziz, AK;
Abdelfatah, S;
Abdellatif, M;
Abdoli, A;
Abel, S;
Abeliovich, H;
... Taylor, A; + view all
(2021)
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition).
Autophagy
, 17
(1)
pp. 1-382.
10.1080/15548627.2020.1797280.
|
|
Kluss, JH;
Mazza, MC;
Li, Y;
Manzoni, C;
Lewis, PA;
Cookson, MR;
Mamais, A;
(2021)
Preclinical modeling of chronic inhibition of the Parkinson's disease associated kinase LRRK2 reveals altered function of the endolysosomal system in vivo.
Molecular Neurodegeneration
, 16
(1)
, Article 17. 10.1186/s13024-021-00441-8.
|
|
|
Leo, A;
De Caro, C;
Mainardi, P;
Tallarico, M;
Nesci, V;
Marascio, N;
Striano, P;
... Citraro, R; + view all
(2021)
Increased efficacy of combining prebiotic and postbiotics approaches in mouse models relevant to autism and depression.
Neuropharmacology
, 198
, Article 108782. 10.1016/j.neuropharm.2021.108782.
|
|
Manzoni, C;
Ferrari, R;
(2021)
Mendelian and Sporadic FTD: Disease Risk and Avenues from Genetics to Disease Pathways Through In Silico Modelling.
Advances in Experimental Medicine and Biology
, 1281
pp. 283-296.
10.1007/978-3-030-51140-1_17.
|
|
Massaro, G;
Geard, AF;
Liu, W;
Coombe-Tennant, O;
Waddington, SN;
Baruteau, J;
Gissen, P;
(2021)
Gene Therapy for Lysosomal Storage Disorders: Ongoing Studies and Clinical Development.
Biomolecules
, 11
(4)
, Article 611. 10.3390/biom11040611.
|
|
|
Muangsanit, P;
Roberton, V;
Costa, E;
Phillips, JB;
(2021)
Engineered aligned endothelial cell structures in tethered collagen hydrogels promote peripheral nerve regeneration.
Acta Biomaterialia
, 126
pp. 224-237.
10.1016/j.actbio.2021.03.039.
|
|
Muliaditan, M;
Della Pasqua, O;
(2021)
Bacterial growth dynamics and PKPD relationships of rifampicin and bedaquiline in BALB/c mice.
British Journal of Pharmacology
, 179
(6)
pp. 1251-1263.
10.1111/bph.15688.
|
|
Nelvagal, HR;
Dearborn, JT;
Ostergaard, JR;
Sands, MS;
Cooper, JD;
(2021)
Spinal manifestations of CLN1 disease start during the early postnatal period.
Neuropathology and Applied Neurobiology
, 47
(2)
pp. 251-267.
10.1111/nan.12658.
|
|
|
Ng, J;
Barral, S;
Barrigon, CDLF;
Lignani, G;
Erdem, FA;
Wallings, R;
Privolizzi, R;
... Kurian, MA; + view all
(2021)
Gene therapy restores dopamine transporter expression and ameliorates pathology in iPSC and mouse models of infantile parkinsonism.
Science Translational Medicine
, 13
(594)
, Article eaaw1564. 10.1126/scitranslmed.aaw1564.
|
|
|
Oosterholt, SP;
Della Pasqua, O;
(2021)
Extrapolation and dosing recommendations for raxibacumab in children from birth to < 18 years of age.
British Journal of Clinical Pharmacology
10.1111/bcp.14893.
(In press).
|
|
Oosterholt, SP;
Della Pasqua, O;
(2021)
Population pharmacokinetics of raxibacumab in healthy adult subjects.
British Journal of Clinical Pharmacology
10.1111/bcp.14894.
(In press).
|
|
|
Phillips, JB;
(2021)
'EngNT' - Engineering live neural tissue for nerve replacemen.
Emerging Topics in Life Sciences
10.1042/ETLS20210085.
|
|
|
Powell, R;
Phillips, JB;
(2021)
Engineered Tissues Made from Human iPSC-Derived Schwann Cells for Investigating Peripheral Nerve Regeneration In Vitro.
Methods in Molecular Biology
, 2269
pp. 245-254.
10.1007/978-1-0716-1225-5_17.
|
|
Powell, R;
Eleftheriadou, D;
Kellaway, S;
Phillips, JB;
(2021)
Natural Biomaterials as Instructive Engineered Microenvironments That Direct Cellular Function in Peripheral Nerve Tissue Engineering.
Frontiers in Bioengineering and Biotechnology
, 9
, Article 674473. 10.3389/fbioe.2021.674473.
|
|
|
Rayner, MLD;
Day, AGE;
Bhangra, KS;
Sinden, J;
Phillips, JB;
(2021)
Engineered neural tissue made using clinical-grade human neural stem cells supports regeneration in a long gap peripheral nerve injury model.
Acta Biomaterialia
, 135
pp. 203-213.
10.1016/j.actbio.2021.08.030.
|
|
Rayner, MLD;
Healy, J;
Phillips, JB;
(2021)
Repurposing small molecules to target ppar-γ as new therapies for peripheral nerve injuries.
Biomolecules
, 11
(9)
, Article 1301. 10.3390/biom11091301.
|
|
|
Roberton, VH;
(2021)
The Immune Response and Implications for Nerve Repair.
In: Phillips, J and Hercher, D and Hausner, T, (eds.)
Peripheral Nerve Tissue Engineering and Regeneration.
(pp. 1-30).
Springer Nature: Cham, Switzerland.
|
|
Romano, F;
D’Agate, S;
Della Pasqua, O;
(2021)
Model-informed repurposing of medicines for SARS-CoV-2: extrapolation of antiviral activity and dose rationale for paediatric patients.
Pharmaceutics
, 13
(8)
, Article 1299. 10.3390/pharmaceutics13081299.
|
|
Sancandi, Marco;
(2021)
Exploring the aetiology of pre-motor Parkinson's disease and the efficacy of potential neuroprotective therapies.
Doctoral thesis (Ph.D), UCL (University College London).
|
|
Seixas-Moizes, J;
Boerlage, A;
Lia, EN;
Lopes e Santos, LE;
Zucoloto, ML;
Dach, F;
Papassidero, PC;
... Wichert-Ana, L; + view all
(2021)
Translation, cross-cultural adaptation, and validation of the Portuguese version of the Rotterdam Elderly Pain Observation Scale (REPOS).
Dementia and Geriatric Cognitive Disorders
(In press).
|
|
|
Shah, MM;
(2021)
A new HCN1 channelopathy: implications for epilepsy.
Brain
, 144
(7)
pp. 1939-1940.
10.1093/brain/awab220.
|
|
Simone, R;
Javad, F;
Emmett, W;
Wilkins, OG;
Almeida, FL;
Barahona-Torres, N;
Zareba-Paslawska, J;
... De Silva, R; + view all
(2021)
MIR-NATs repress MAPT translation and aid proteostasis in neurodegeneration.
Nature
, 594
pp. 117-123.
10.1038/s41586-021-03556-6.
|
|
Storm, CS;
Kia, DA;
Almramhi, MM;
Bandres-Ciga, S;
Finan, C;
Hingorani, AD;
Wood, NW;
(2021)
Finding genetically-supported drug targets for Parkinson's disease using Mendelian randomization of the druggable genome.
Nature Communications
, 12
(1)
, Article 7342. 10.1038/s41467-021-26280-1.
|
|
|
Sun, H;
Yi, M;
Wan, Y;
(2021)
Conditional Gene Editing in Presynaptic Extinction-ensemble Cells via the CRISPR-SaCas9 System.
Bio-protocol
, 11
(23)
, Article e4246. 10.21769/BioProtoc.4246.
|
|
Tawfik, EA;
Alshamsan, A;
Abul Kalam, M;
Raish, M;
Alkholief, M;
Stapleton, P;
Harvey, K;
... Barker, SA; + view all
(2021)
In vitro and in vivo biological assessment of dual drug-loaded coaxial nanofibers for the treatment of corneal abrasion.
International Journal of Pharmaceutics
, 604
, Article 120732. 10.1016/j.ijpharm.2021.120732.
|
|
Thomson, AM;
(2021)
Circuits and Synapses: Hypothesis, Observation, Controversy and Serendipity – An Opinion Piece.
Frontiers in Neural Circuits
, 15
10.3389/fncir.2021.732315.
|
|
|
Tomkins, JE;
Manzoni, C;
(2021)
Advances in protein-protein interaction network analysis for Parkinson's disease.
Neurobiology of Disease
, 155
, Article 105395. 10.1016/j.nbd.2021.105395.
(In press).
|
|
|
Vavouraki, N;
Tomkins, JE;
Kara, E;
Houlden, H;
Hardy, J;
Tindall, MJ;
Lewis, PA;
(2021)
Integrating protein networks and machine learning for disease stratification in the Hereditary Spastic Paraplegias.
iScience
, Article 102484. 10.1016/j.isci.2021.102484.
(In press).
|
|
|
Victor, S;
Rocha-Ferreira, E;
Rahim, A;
Hagberg, H;
Edwards, D;
(2021)
New possibilities for neuroprotection in neonatal hypoxic-ischemic encephalopathy.
European Journal of Pediatrics
10.1007/s00431-021-04320-8.
(In press).
|
|
|
White, KA;
Nelvagal, HR;
Poole, TA;
Lu, B;
Johnson, TB;
Davis, S;
Pratt, MA;
... Weimer, JM; + view all
(2021)
Intracranial delivery of AAV9 gene therapy partially prevents retinal degeneration and visual deficits in CLN6-Batten disease mice.
Molecular Therapy - Methods and Clinical Development
, 20
pp. 497-507.
10.1016/j.omtm.2020.12.014.
|
|
|
Wilcox, M;
Dos Santos Canas, L;
Hargunani, R;
Tidswell, T;
Brown, H;
Modat, M;
Phillips, JB;
... Quick, T; + view all
(2021)
Volumetric MRI is a promising outcome measure of muscle reinnervation.
Scientific Reports
, 11
, Article 22433. 10.1038/s41598-021-01342-y.
|
|
|
Wilcox, MB;
Jessen, KR;
Quick, TJ;
Phillips, JB;
(2021)
The molecular profile of nerve repair: humans mirror rodents.
Neural Regen Research
, 16
(7)
pp. 1440-1441.
10.4103/1673-5374.301014.
|
|
|
Yaghini, E;
Tacconi, E;
Pilling, A;
Rahman, P;
Broughton, J;
Naasani, I;
Keshtgar, MRS;
... Della Pasqua, O; + view all
(2021)
Population pharmacokinetic modelling of indium-based quantum dot nanoparticles: preclinical in vivo studies.
European Journal of Pharmaceutical Sciences
, 157
, Article 105639. 10.1016/j.ejps.2020.105639.
|
|
2020
|
Bartlett, RD;
Burley, S;
Ip, M;
Phillips, JB;
Choi, D;
(2020)
Cell Therapies for Spinal Cord Injury: Trends and Challenges of Current Clinical Trials.
Neurosurgery
, 87
(4)
E456-E472.
10.1093/neuros/nyaa149.
|
|
Bartlett, RD;
Eleftheriadou, D;
Evans, R;
Choi, D;
Phillips, JB;
(2020)
Mechanical properties of the spinal cord and brain: Comparison with clinical-grade biomaterials for tissue engineering and regenerative medicine.
Biomaterials
, 258
, Article 120303. 10.1016/j.biomaterials.2020.120303.
|
|
Beilina, A;
Bonet-Ponce, L;
Kumaran, R;
Kordich, JJ;
Ishida, M;
Mamais, A;
Kaganovich, A;
... Cookson, MR; + view all
(2020)
The Parkinson’s disease protein LRRK2 interacts with the GARP complex to promote retrograde transport to the trans-Golgi network.
Cell Reports
, 31
(5)
, Article 107614. 10.1016/j.celrep.2020.107614.
|
|
|
Carrara, L;
Magni, P;
Teutonico, D;
Pasotti, L;
Pasqua, OD;
Kloprogge, F;
(2020)
Ethambutol disposition in humans: challenges and limitations of whole-body physiologically-based pharmacokinetic modelling in early drug development.
European Journal of Pharmaceutical Sciences
, 150
, Article 105359. 10.1016/j.ejps.2020.105359.
|
|
Choompoo, N;
Bartley, OJM;
Precious, SV;
Vinh, NN;
Schnell, C;
Garcia, A;
Roberton, VH;
... Rosser, AE; + view all
(2020)
Induced pluripotent stem cells derived from the developing striatum as a potential donor source for cell replacement therapy for Huntington disease.
Cytotherapy
10.1016/j.jcyt.2020.06.001.
(In press).
|
|
|
Costa, B;
Manzoni, C;
Bernal-Quiros, M;
Kia, D;
Aguilar, M;
Alvarez, I;
Alvarez, V;
... Hardy, J; + view all
(2020)
C9orf72, age at onset, and ancestry help discriminate behavioral from language variants in FTLD cohorts.
Neurology
, 95
(24)
e3288-e3302.
10.1212/WNL.0000000000010914.
|
|
Coy, R;
Al-Badri, G;
Kayal, C;
O'Rourke, C;
Kingham, PJ;
Phillips, JB;
Shipley, RJ;
(2020)
Combining in silico and in vitro models to inform cell seeding strategies in tissue engineering.
Journal of the Royal Society Interface
, 17
(164)
, Article 20190801. 10.1098/rsif.2019.0801.
|
|
|
D'Agate, S;
Chavan, C;
Manyak, M;
Palacios-Moreno, JM;
Oelke, M;
Michel, MC;
Roehrborn, CG;
(2020)
Impact of early vs. delayed initiation of dutasteride/tamsulosin combination therapy on the risk of acute urinary retention or BPH-related surgery in LUTS/BPH patients with moderate-to-severe symptoms at risk of disease progression.
World Journal of Urology
10.1007/s00345-020-03517-0.
(In press).
|
|
|
D'Agate, S;
Wilson, T;
Adalig, B;
Manyak, M;
Palacios-Moreno, JM;
Chavan, C;
Oelke, M;
... Della Pasqua, O; + view all
(2020)
Model-based meta-analysis of individual IPSS trajectories in patients with benign prostatic hyperplasia with moderate or severe symptoms.
British Journal of Clinical Pharmacology
, 86
(8)
pp. 1585-1599.
10.1111/bcp.14268.
|
|
|
D'Agate, S;
Wilson, T;
Adalig, B;
Manyak, M;
Palacios-Moreno, JM;
Chavan, C;
Oelke, M;
... Della Pasqua, O; + view all
(2020)
Impact of disease progression on individual IPSS trajectories and consequences of immediate versus delayed start of treatment in patients with moderate or severe LUTS associated with BPH.
World Journal of Urology
, 38
pp. 463-472.
10.1007/s00345-019-02783-x.
|
|
D’Agate, S;
Musuamba Tshinanu, F;
Della Pasqua, O;
(2020)
Dose rationale for amoxicillin in neonatal sepsis when referral is not possible.
Frontiers in Pharmacology
, 11
, Article 521933. 10.3389/fphar.2020.521933.
|
|
|
Ecker, A;
Romani, A;
Sáray, S;
Káli, S;
Migliore, M;
Falck, J;
Lange, S;
... Ramaswamy, S; + view all
(2020)
Data-driven integration of hippocampal CA1 synaptic physiology in silico.
Hippocampus
10.1002/hipo.23220.
(In press).
|
|
|
Hague, JP;
Mieczkowski, PW;
O'Rourke, C;
Loughlin, AJ;
Phillips, JB;
(2020)
Microscopic biophysical model of self-organization in tissue due to feedback between cell- and macroscopic-scale forces.
Physical Review Research
, 2
(4)
, Article 043217. 10.1103/physrevresearch.2.043217.
|
|
|
Harvey, K;
(2020)
Sequential screening nominates the Parkinson’s disease associated kinase LRRK2 as a regulator of Clathrin-mediated endocytosis.
Neurobiology of Disease
10.1016/j.nbd.2020.104948.
|
|
|
Horrigan, J;
Gomes, TB;
Snape, M;
Nikolenko, N;
McMorn, A;
Evans, S;
Yaroshinsky, A;
... Lochmüller, H; + view all
(2020)
A Phase 2 Study of AMO-02 (tideglusib) in Congenital and Childhood Onset Myotonic Dystrophy Type 1 (DM1).
Pediatric Neurology
10.1016/j.pediatrneurol.2020.08.001.
(In press).
|
|
|
Huang, Z;
Powell, R;
Phillips, JB;
Haastert-Talini, K;
(2020)
Perspective on Schwann Cells Derived from Induced Pluripotent Stem Cells in Peripheral Nerve Tissue Engineering.
Cells
, 9
(11)
, Article 2497. 10.3390/cells9112497.
|
|
|
Karda, R;
Rahim, AA;
Wong, AMS;
Suff, N;
Diaz, JA;
Perocheau, DP;
Tijani, M;
... Waddington, SN; + view all
(2020)
Generation of light-producing somatic-transgenic mice using adeno-associated virus vectors.
Scientific Reports
, 10
(1)
, Article 2121. 10.1038/s41598-020-59075-3.
|
|
|
Kayal, C;
Moeendarbary, E;
Shipley, R;
Phillips, J;
(2020)
Mechanical response of neural cells to physiologically relevant stiffness gradients.
Advanced Healthcare Materials
, 9
(8)
, Article 1901036. 10.1002/adhm.201901036.
|
|
|
Kozdon, K;
Caridi, B;
Duru, I;
Ezra, DG;
Phillips, JB;
Bailly, M;
(2020)
A Tenon's capsule/bulbar conjunctiva interface biomimetic to model fibrosis and local drug delivery.
PLoS One
, 15
(11)
, Article e0241569. 10.1371/journal.pone.0241569.
|
|
|
Krishnaswami, S;
Austin, D;
Della Pasqua, O;
Gastonguay, MR;
Gobburu, J;
Van der Graaf, PH;
Ouellet, D;
... Visser, SAG; + view all
(2020)
MID3: Mission Impossible or Model-Informed Drug Discovery and Development? Point-Counterpoint Discussions on Key Challenges.
Clinical Pharmacology & Therapeutics
10.1002/cpt.1788.
|
|
|
Leo, A;
Nesci, V;
Tallarico, M;
Amodio, N;
Gallo Cantafio, EM;
De Sarro, G;
Constanti, A;
... Citraro, R; + view all
(2020)
IL-6 Receptor Blockade by Tocilizumab Has Anti-absence and Anti-epileptogenic Effects in the WAG/Rij Rat Model of Absence Epilepsy.
Neurotherapeutics
, 17
pp. 2004-2014.
10.1007/s13311-020-00893-8.
|
|
Liu, W;
Kleine-Holthaus, S-M;
Herranz-Martin, S;
Aristorena, M;
Mole, SE;
Smith, AJ;
Ali, RR;
(2020)
Experimental gene therapies for the NCLs.
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
, 1866
(9)
, Article 165772. 10.1016/j.bbadis.2020.165772.
|
|
Liu, W;
Taso, O;
Wang, R;
Bayram, S;
Graham, AC;
Garcia-Reitboeck, P;
Mallach, A;
... Salih, DA; + view all
(2020)
Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions.
Human Molecular Genetics
10.1093/hmg/ddaa209.
(In press).
|
|
|
Maggio, A;
Kattamis, A;
Felisi, M;
Reggiardo, G;
El-Beshlawy, A;
Bejaoui, M;
Sherief, L;
... Ceci, A; + view all
(2020)
Evaluation of the effectiveness and safety of deferiprone compared to deferasirox in pediatric patients with transfusion-dependent hemoglobinopathies (DEEP-2): a multicenter, randomized, open label, non-inferiority, phase-III trial.
The Lancet Haematology
, 7
(6)
e469-e478.
10.1016/S2352-3026(20)30100-9.
|
|
Massaro, G;
Hughes, MP;
Whaler, SM;
Wallom, K-L;
Priestman, DA;
Platt, FM;
Waddington, SN;
(2020)
Systemic AAV9 gene therapy using the synapsin I promoter rescues a mouse model of neuronopathic Gaucher disease but with limited cross-correction potential to astrocytes.
Human Molecular Genetics
10.1093/hmg/ddz317.
(In press).
|
|
|
Mencacci, NE;
Reynolds, R;
Ruiz, SG;
Vandrovcova, J;
Forabosco, P;
Sánchez-Ferrer, A;
Volpato, V;
... Ryten, M; + view all
(2020)
Dystonia genes functionally converge in specific neurons and share neurobiology with psychiatric disorders.
Brain
, Article awaa217. 10.1093/brain/awaa217.
(In press).
|
|
|
Muangsanit, P;
Day, A;
Dimiou, S;
Ataç, AF;
Kayal, C;
Park, H;
Nazhat, SN;
(2020)
Rapidly formed stable and aligned dense collagen gels seeded with Schwann cells support peripheral nerve regeneration.
Journal of Neural Engineering
10.1088/1741-2552/abaa9c.
(In press).
|
|
|
Muliaditan, M;
Della Pasqua, O;
(2020)
Evaluation of pharmacokinetic‐pharmacodynamic relationships and selection of drug combinations for tuberculosis.
British Journal of Clinical Pharmacology
10.1111/bcp.14371.
(In press).
|
|
|
Nelvagal, HR;
Hurtado, ML;
Eaton, SL;
Kline, RA;
Lamont, DJ;
Sands, MS;
Wishart, TM;
(2020)
Comparative proteomic profiling reveals mechanisms for early spinal cord vulnerability in CLN1 disease.
Scientific Reports
, 10
(1)
, Article 15157. 10.1038/s41598-020-72075-7.
|
|
|
Nesci, V;
Russo, E;
Arcidiacono, B;
Citraro, R;
Tallarico, M;
Constanti, A;
Brunetti, A;
... Leo, A; + view all
(2020)
Metabolic Alterations Predispose to Seizure Development in High-Fat Diet-Treated Mice: the Role of Metformin.
Molecular Neurobiology
, 57
pp. 4778-4789.
10.1007/s12035-020-02062-6.
|
|
Petrache, AL;
Khan, AA;
Nicholson, MW;
Monaco, A;
Kuta-Siejkowska, M;
Haider, S;
Hilton, S;
... Ali, A; + view all
(2020)
Selective Modulation of α5 GABAA Receptors Exacerbates Aberrant Inhibition at Key Hippocampal Neuronal Circuits in APP Mouse Model of Alzheimer’s Disease.
Frontiers in Cellular Neuroscience
, 14
, Article 568194. 10.3389/fncel.2020.568194.
|
|
|
Plotegher, N;
Perocheau, D;
Ferrazza, R;
Massaro, G;
Bhosale, G;
Zambon, F;
Rahim, AA;
... Duchen, MR; + view all
(2020)
Impaired cellular bioenergetics caused by GBA1 depletion sensitizes neurons to calcium overload.
Cell Death & Differentiation
, 27
pp. 1588-1603.
10.1038/s41418-019-0442-2.
|
|
Poupon-Bejuit, L;
Rocha-Ferreira, E;
Thornton, C;
Hagberg, H;
Rahim, AA;
(2020)
Neuroprotective Effects of Diabetes Drugs for the Treatment of Neonatal Hypoxia-Ischemia Encephalopathy.
Frontiers in Cellular Neuroscience
, 14
, Article 112. 10.3389/fncel.2020.00112.
|
|
|
Rahim, AA;
Gissen, P;
(2020)
Gene therapy for global brain diseases: one small step for mice, one giant leap for humans.
Brain
, 143
(7)
pp. 1964-1966.
10.1093/brain/awaa189.
|
|
Rahim, AA;
Russell, C;
Mole, SE;
(2020)
Special edition: The NCLs/Batten disease.
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
, 1866
(9)
, Article 165824. 10.1016/j.bbadis.2020.165824.
|
|
Rayner, MLD;
Brown, HL;
Wilcox, M;
Phillips, JB;
Quick, TJ;
(2020)
Quantifying regeneration in patients following peripheral nerve injury.
Journal of Plastic, Reconstructive & Aesthetic Surgery
, 73
(2)
pp. 201-208.
10.1016/j.bjps.2019.10.007.
|
|
Rayner, MLD;
Grillo, A;
Williams, G;
Tawfik, E;
Zhang, T;
Volitaki, C;
Craig, DQM;
... Phillips, J; + view all
(2020)
Controlled local release of PPARγ agonists from biomaterials to treat peripheral nerve injury.
Journal of Neural Engineering
10.1088/1741-2552/aba7cc.
(In press).
|
|
|
Sabin, Antony James;
(2020)
A Quantitative Process for Enhancing End of Phase 2 Drug Development Decisions.
Doctoral thesis (Ph.D), UCL (University College London).
|
|
|
Sancandi, M;
Uysal-Onganer, P;
Kraev, I;
Mercer, A;
Lange, S;
(2020)
Protein Deimination Signatures in Plasma and Plasma-EVs and Protein Deimination in the Brain Vasculature in a Rat Model of Pre-Motor Parkinson’s Disease.
International Journal of Molecular Sciences
, 21
(8)
, Article 2743. 10.3390/ijms21082743.
|
|
|
Santoro, B;
Shah, MM;
(2020)
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels as Drug Targets for Neurological Disorders.
Annual Review of Pharmacology and Toxicology
, 60
pp. 109-131.
10.1146/annurev-pharmtox-010919-023356.
|
|
Seker Yilmaz, B;
Baruteau, J;
Rahim, AA;
Gissen, P;
(2020)
Clinical and Molecular Features of Early Infantile Niemann Pick Type C Disease.
International Journal of Molecular Sciences
, 21
(14)
, Article 5059. 10.3390/ijms21145059.
|
|
|
Shi, A;
Petrache, AL;
Shi, J;
Ali, A;
(2020)
Preserved Calretinin interneurons in an app model of Alzheimer’s Disease disrupts hippocampal inhibition via up-regulated P2Y1 purinoreceptors.
Cerebral Cortex
, 30
(3)
pp. 1272-1290.
10.1093/cercor/bhz165.
|
|
Skoura, N;
Wang-Jaira, J;
Della Pasqua, O;
Chandrasekaran, V;
Billiard, J;
Yeakey, A;
Smith, W;
... Tan, LK; + view all
(2020)
The effect of raxibacumab on the immunogenicity of anthrax vaccine adsorbed: a Phase IV, randomised, open-label, parallel-group, non-inferiority study.
The Lancet Infectious Diseases
, 20
(8)
pp. 983-991.
10.1016/S1473-3099(20)30069-4.
|
|
Tomkins, J;
Ferrari, R;
Vavouraki, N;
Hardy, J;
Lovering, R;
Lewis, P;
McGuffin, L;
(2020)
PINOT: An Intuitive Resource for Integrating Protein-Protein Interactions.
Cell Communication and Signaling
, 18
, Article 92. 10.1186/s12964-020-00554-5.
|
|
van der Spek, SJF;
Koopmans, F;
Paliukhovich, I;
Ramsden, SL;
Harvey, K;
Harvey, RJ;
Smit, AB;
(2020)
Glycine Receptor Complex Analysis Using Immunoprecipitation-Blue Native Gel Electrophoresis-Mass Spectrometry.
Proteomics
10.1002/pmic.201900403.
(In press).
|
|
|
Wilcox, M;
Gregory, H;
Powell, R;
Quick, TJ;
Phillips, JB;
(2020)
Strategies for Peripheral Nerve Repair.
Current Tissue Microenvironment Reports
, 1
(2)
pp. 49-59.
10.1007/s43152-020-00002-z.
|
|
|
Wilcox, MB;
Laranjeira, SG;
Eriksson, TM;
Jessen, KR;
Mirsky, R;
Quick, TJ;
Phillips, JB;
(2020)
Characterising cellular and molecular features of human peripheral nerve degeneration.
Acta Neuropathologica Communications
, 8
, Article 51. 10.1186/s40478-020-00921-w.
|
|
|
Zhang, D;
Guelfi, S;
Garcia-Ruiz, S;
Costa, B;
Reynolds, RH;
D’Sa, K;
Liu, W;
... Ryten, M; + view all
(2020)
Incomplete annotation has a disproportionate impact on our understanding of Mendelian and complex neurogenetic disorders.
Science Advances
, 6
(24)
, Article eaay8299. 10.1126/sciadv.aay8299.
|
|
2019
|
Bartlett, R;
Phillips, J;
Choi, D;
(2019)
Letter to the Editor, response to: ‘Intramedullary cervical spinal mass after stem cell transplantation using an olfactory mucosal cell autograft’ by Woodworth et al. July 2019.
[Letter].
Canadian Medical Association Journal
, 191
(27)
E761-E764.
10.1503/cmaj.181696.
|
|
|
Bernareggi, A;
Conte, G;
Constanti, A;
Borelli, V;
Vita, F;
Zabucchi, G;
(2019)
On the mechanism of the electrophysiological changes and membrane lesions induced by asbestos fiber exposure in Xenopus laevis oocytes.
Scientific Reports
, 9
, Article 2014. 10.1038/s41598-019-38591-x.
|
|
|
Berwick, DC;
Heaton, GR;
Azeggagh, S;
Harvey, K;
(2019)
LRRK2 Biology from structure to dysfunction: research progresses, but the themes remain the same.
Molecular Neurodegeneration
, 14
(1)
, Article 49. 10.1186/s13024-019-0344-2.
|
|
|
Bhangra, K;
Knowles, J;
Shipley, R;
Choi, D;
Phillips, J;
(2019)
Serum-free cryopreservation of engineered neural tissue.
Presented at: TCES-UKSB, Nottingham.
|
|
|
Bhangra, K;
Plotczyk, M;
Knowles, J;
Shipley, R;
Choi, D;
Phillips, J;
(2019)
The Effect of Hypoxia on the Ability of Differentiated Human Dental Pulp Stem Cells to Promote Endothelial Cell Proliferation and Neurite Outgrowth In Vitro.
Presented at: 5th International Symposium of Peripheral Nerve Regeneration (ISPNR 2019), Porto, Portugal.
|
|
Bonham, LW;
Steele, NZR;
Karch, CM;
Broce, I;
Geier, EG;
Wen, NL;
Momeni, P;
... International FTD-Genomics Consortium (IFGC), .; + view all
(2019)
Genetic variation across RNA metabolism and cell death gene networks is implicated in the semantic variant of primary progressive aphasia.
Scientific Reports
, 9
, Article 10854. 10.1038/s41598-019-46415-1.
|
|
|
Borella, E;
Oosterholt, S;
Magni, P;
Pasqua, OD;
(2019)
Use of prior knowledge and extrapolation in paediatric drug development: A case study with deferasirox.
European Journal of Pharmaceutical Sciences
, 136
, Article 104931. 10.1016/j.ejps.2019.05.009.
|
|
Chiou, T-T;
Long, P;
Schumann-Gillett, A;
Kanamarlapudi, K;
Haas, SA;
Harvey, K;
O’Mara, ML;
... Harvey, RJ; + view all
(2019)
Mutation p.R356Q in the Collybistin Phosphoinositide Binding Site Is Associated With Mild Intellectual Disability.
Frontiers in Molecular Neuroscience
, 12
, Article 60. 10.3389/fnmol.2019.00060.
|
|
|
Citraro, R;
Iannone, M;
Leo, A;
De Caro, C;
Nesci, V;
Tallarico, M;
Abdalla, K;
... Russo, E; + view all
(2019)
Evaluation of the effects of liraglutide on the development of epilepsy and behavioural alterations in two animal models of epileptogenesis.
Brain Research Bulletin
, 153
pp. 133-142.
10.1016/j.brainresbull.2019.08.001.
|
|
Clout, AE;
Della Pasqua, O;
Hanna, MG;
Orlu, M;
Pitceathly, RDS;
(2019)
Drug repurposing in neurological diseases: an integrated approach to reduce trial and error.
Journal of Neurology, Neurosurgery and Psychiatry
, 90
(11)
pp. 1270-1275.
10.1136/jnnp-2019-320879.
|
|
|
De Caro, C;
Iannone, LF;
Citraro, R;
Striano, P;
De Sarro, G;
Constanti, A;
Cryan, JF;
(2019)
Can we ‘seize’ the gut microbiota to treat epilepsy?
Neuroscience & Biobehavioral Reviews
, 107
pp. 750-764.
10.1016/j.neubiorev.2019.10.002.
|
|
De Caro, C;
Leo, A;
Nesci, V;
Ghelardini, C;
di Cesare Mannelli, L;
Striano, P;
Avagliano, C;
... Russo, E; + view all
(2019)
Intestinal inflammation increases convulsant activity and reduces antiepileptic drug efficacy in a mouse model of epilepsy.
Scientific Reports
, 9
, Article 13983. 10.1038/s41598-019-50542-0.
|
|
|
De Leeuw, TG;
Mangiarini, L;
Lundin, R;
Kaguelidou, F;
Van Der Zanden, T;
Della Pasqua, O;
Tibboel, D;
... De Wildt, SN; + view all
(2019)
Correction to: Gabapentin as add-on to morphine for severe neuropathic or mixed pain in children from age 3 months to 18 years - evaluation of the safety, pharmacokinetics, and efficacy of a new gabapentin liquid formulation: study protocol for a randomized controlled trial.
[Corrigendum].
Trials
, 20
, Article 368. 10.1186/s13063-019-3519-9.
|
|
|
De Leeuw, TG;
Mangiarini, L;
Lundin, R;
Kaguelidou, F;
Van der Zanden, T;
Della Pasqua, O;
Tibboel, D;
... GAPP consortium; + view all
(2019)
Gabapentin as add-on to morphine for severe neuropathic or mixed pain in children from age 3 months to 18 years - evaluation of the safety, pharmacokinetics, and efficacy of a new gabapentin liquid formulation: study protocol for a randomized controlled trial.
Trials
, 20
, Article 49. 10.1186/s13063-018-3169-3.
|
|
|
Gambarotta, G;
Raimondo, S;
Udina, E;
Phillips, JB;
Haastert-Talini, K;
(2019)
Editorial: Peripheral Nerve Regeneration.
Frontiers in Cellular Neuroscience
, 13
, Article 464. 10.3389/fncel.2019.00464.
|
|
|
Glaze, DG;
Neul, JL;
Kaufmann, WE;
Berry-Kravis, E;
Condon, S;
Stoms, G;
Oosterholt, S;
... Percy, AK; + view all
(2019)
Double-Blind, Randomized, Placebo-Controlled Study of Trofinetide in Pediatric Rett Syndrome.
Neurology
, 92
(16)
e1912-e1925.
10.1212/WNL.0000000000007316.
|
|
|
Granno, S;
Nixon-Abell, J;
Berwick, DC;
Tosh, J;
Heaton, G;
Almudimeegh, S;
Nagda, Z;
... Harvey, K; + view all
(2019)
Downregulated Wnt/β-catenin signalling in the Down syndrome hippocampus.
Scientific Reports
, 9
(1)
, Article 7322. 10.1038/s41598-019-43820-4.
|
|
|
Harvey, K;
Outeiro, TF;
(2019)
The role of LRRK2 in cell signalling.
Biochemical Society Transactions
, 47
(1)
pp. 197-207.
10.1042/BST20180464.
|
|
Holthaus, S-MK;
Herranz-Martin, S;
Massaro, G;
Aristorena, M;
Hoke, J;
Hughes, MP;
Maswood, R;
... Ali, RR; + view all
(2019)
Neonatal brain-directed gene therapy rescues a mouse model of neurodegenerative CLN6 Batten disease.
Human Molecular Genetics
, 28
(23)
pp. 3867-3879.
10.1093/hmg/ddz210.
|
|
Hossain, ASMMA;
Sil, BC;
Iliopoulos, F;
Lever, R;
Hadgraft, J;
Lane, ME;
(2019)
Preparation, Characterisation, and Topical Delivery of Terbinafine.
Pharmaceutics
, 11
(10)
, Article 548. 10.3390/pharmaceutics11100548.
|
|
|
Kaguelidou, F;
Le Roux, E;
Mangiarini, L;
Lundin, R;
de Leeuw, TG;
Della Pasqua, O;
Felisi, M;
... GAPP consortium, .; + view all
(2019)
Non-inferiority double-blind randomised controlled trial comparing gabapentin versus tramadol for the treatment of chronic neuropathic or mixed pain in children and adolescents: the GABA-1 trial-a study protocol.
BMJ Open
, 9
(2)
, Article e023296. 10.1136/bmjopen-2018-023296.
|
|
|
Kayal, C;
Shipley, RJ;
Phillips, JB;
(2019)
Physical and mechanical properties of RAFT-stabilised collagen gels for tissue engineering applications.
Journal of the Mechanical Behavior of Biomedical Materials
, 99
pp. 216-224.
10.1016/j.jmbbm.2019.07.011.
|
|
Kloprogge, F;
Hammond, R;
Copas, A;
Gillespie, SH;
Della Pasqua, O;
(2019)
Can phenotypic data complement our understanding of antimycobacterial effects for drug combinations?
Journal of Antimicrobial Chemotherapy
, 74
(12)
pp. 3530-3536.
10.1093/jac/dkz369.
(In press).
|
|
|
Kloprogge, F;
Hammond, R;
Kipper, K;
Gillespie, SH;
Della Pasqua, O;
(2019)
Mimicking in-vivo exposures to drug combinations in-vitro: anti-tuberculosis drugs in lung lesions and the hollow fiber model of infection.
Scientific Reports
, 9
, Article 13228. 10.1038/s41598-019-49556-5.
|
|
|
Lambert, JRA;
Howe, SJ;
Rahim, AA;
Burke, DG;
Heales, SJR;
(2019)
Inhibition of Mitochondrial Complex I Impairs Release of α-Galactosidase by Jurkat Cells.
International Journal of Molecular Sciences
, 20
(18)
, Article 4349. 10.3390/ijms20184349.
|
|
|
Lee, H;
Phillips, JB;
Hall, RM;
Tipper, JL;
(2019)
Neural cell responses to wear debris from metal-on-metal total disc replacements.
European Spine Journal
10.1007/s00586-019-06177-w.
(In press).
|
|
|
Leo, A;
De Caro, C;
Nesci, V;
Palma, E;
Tallarico, M;
Iannone, M;
Constanti, A;
... Citraro, R; + view all
(2019)
Antiepileptogenic effects of Ethosuximide and Levetiracetam in WAG/Rij rats are only temporary.
Pharmacological Reports
, 71
(5)
pp. 833-838.
10.1016/j.pharep.2019.04.017.
|
|
Medawar, E;
Benway, TA;
Liu, W;
Hanan, TA;
Haslehurst, P;
James, OT;
Yap, K;
... Edwards, FA; + view all
(2019)
Effects of rising amyloidβ levels on hippocampal synaptic transmission, microglial response and cognition in APP_{Swe}/PSEN1_{M146V} transgenic mice.
EBioMedicine
, 39
pp. 422-435.
10.1016/j.ebiom.2018.12.006.
|
|
Mole, SE;
Anderson, G;
Band, HA;
Berkovic, SF;
Cooper, JD;
Kleine Holthaus, S-M;
McKay, TR;
... Smith, AJ; + view all
(2019)
Clinical challenges and future therapeutic approaches for neuronal ceroid lipofuscinosis.
[Review].
Lancet Neurology
, 18
(1)
pp. 107-116.
10.1016/S1474-4422(18)30368-5.
|
|
Muliaditan, M;
Della Pasqua, O;
(2019)
How long will treatment guidelines for TB continue to overlook variability in drug exposure?
Journal of Antimicrobial Chemotherapy
, 74
(11)
pp. 3274-3280.
10.1093/jac/dkz319.
|
|
Outeiro, TF;
Harvey, K;
Dominguez-Meijide, A;
Gerhardt, E;
(2019)
LRRK2, alpha-synuclein, and tau: partners in crime or unfortunate bystanders?
Biochemical Society Transactions
, 47
(3)
pp. 827-838.
10.1042/BST20180466.
|
|
Petrache, AL;
Rajulawalla, A;
Shi, A;
Wetzel, A;
Saito, T;
Saido, TC;
Harvey, K;
(2019)
Aberrant Excitatory–Inhibitory Synaptic Mechanisms in Entorhinal Cortex Microcircuits During the Pathogenesis of Alzheimer’s Disease.
Cerebral Cortex
, 29
(4)
pp. 1834-1850.
10.1093/cercor/bhz016.
|
|
|
Raffaele, F;
Claudia, M;
John, H;
(2019)
Genetics and molecular mechanisms of frontotemporal lobar degeneration: an update and future avenues.
Neurobiology of Aging
, 78
pp. 98-110.
10.1016/j.neurobiolaging.2019.02.006.
|
|
Ruiz, AJ;
Rahim, AA;
(2019)
Bringing balance to the force-regulatable gene therapy for epilepsy.
[Editorial comment].
Gene Therapy
, 26
pp. 347-349.
10.1038/s41434-019-0083-6.
|
|
Santiago Toledo, Gerardo;
(2019)
Development of a xeno-free cell culture platform for novel candidate human cell therapies for neural regeneration.
Doctoral thesis (Ph.D), UCL (University College London).
|
|
Santiago-Toledo, G;
Georgiou, M;
Dos Reis, J;
Roberton, VH;
Valinhas, A;
Wood, RC;
Phillips, JB;
... Wall, IB; + view all
(2019)
Generation of c-MycERTAM-transduced human late-adherent olfactory mucosa cells for potential regenerative applications.
Scientific Reports
, 9
(1)
, Article 13190. 10.1038/s41598-019-49315-6.
|
|
|
Shah, MM;
Martinello, K;
Giacalone, E;
Migliore, M;
Brown, D;
(2019)
The subthreshold-active KV7 current regulates neurotransmission by limiting spike-induced Ca2+ influx in hippocampal mossy fiber synaptic terminals.
Communications Biology
, 2
, Article 145. 10.1038/s42003-019-0408-4.
|
|
|
Snowball, A;
Chabrol, E;
Wykes, RC;
Shekh-Ahmad, T;
Cornford, JH;
Lieb, A;
Hughes, MP;
... Schorge, S; + view all
(2019)
Epilepsy Gene Therapy Using an Engineered Potassium Channel.
Journal of Neuroscience
, 39
(16)
pp. 3159-3169.
10.1523/JNEUROSCI.1143-18.2019.
|
|
Taylor, A;
Vendramin, C;
Oosterholt, S;
Della Pasqua, O;
Scully, M;
(2019)
Pharmacokinetics of plasma infusion in congenital thrombotic thrombocytopenic purpura.
Journal of Thrombosis and Haemostasis
, 17
(1)
pp. 88-98.
10.1111/jth.14345.
|
|
Tchorek-Bentall, M;
Ruiz, YO;
Oosterholt, S;
Marks, DJ;
Pasqua, OD;
(2019)
Model-based optimisation of N-acetylcysteine for the treatment of paracetamol overdose.
Presented at: British-Pharmacology-Society Meeting (Pharmacology), London, UK.
|
|
Topczewska, A;
Evans, T;
Pratt, W;
Burgess, N;
Dolphin, A;
Shah, M;
(2019)
T-Type Ca2+ Channels and Layer II Medial Entorhinal Cortical Stellate Cell Excitability.
Presented at: American Biophysics Society Annual Meeting 2019, Baltimore, MD, USA.
|
|
van Dijkman, SC;
De Cock, PAJG;
Smets, K;
Decaluwe, W;
Smits, A;
Allegaert, K;
Vande Walle, J;
... Della Pasqua, O; + view all
(2019)
Dose rationale and pharmacokinetics of dexmedetomidine in mechanically ventilated new-borns: impact of design optimisation.
European Journal of Clinical Pharmacology
, 75
pp. 1393-1404.
10.1007/s00228-019-02708-y.
|
|
Wicox, M;
Quick, TJ;
Phillips, JB;
(2019)
The Effects of Surgical Antiseptics and Time Delays on RNA Isolated From Human and Rodent Peripheral Nerves.
Frontiers in Cellular Neuroscience
, 13
, Article 189. 10.3389/fncel.2019.00189.
|
|
2018
|
Antunes, NDJ;
Wichert-Ana, L;
Coelho, EB;
Della Pasqua, O;
Alexandre Junior, V;
Takayanagui, OM;
Marques, MP;
(2018)
Analysis of unbound plasma concentration of oxcarbazepine and the 10-hydroxycarbazepine enantiomers by liquid chromatography with tandem mass spectrometry in healthy volunteers.
Journal of Pharmaceutical and Biomedical Analysis
, 149
pp. 442-447.
10.1016/j.jpba.2017.11.041.
|
|
Baruteau, J;
Perocheau, DP;
Hanley, J;
Lorvellec, M;
Rocha-Ferreira, E;
Karda, R;
Ng, J;
... Waddington, SN; + view all
(2018)
Argininosuccinic aciduria fosters neuronal nitrosative stress reversed by Asl gene transfer.
Nature Communications
, 9
(1)
, Article 3505. 10.1038/s41467-018-05972-1.
|
|
|
Bhangra, K;
Knowles, J;
Shipley, R;
Choi, D;
Phillips, J;
(2018)
Directing and promoting neuronal outgrowth and non-neuronal cell migration using phosphate glass fibres embedded in engineered neural tissue for peripheral nerve regeneration.
Presented at: 5th Tissue Engineering and Regenerative Medicine International Society World Congress, Kyoto, Japan.
|
|
|
Bhangra, K;
Knowles, J;
Shipley, R;
Choi, D;
Phillips, J;
(2018)
Mechanical testing of nerve guidance conduit materials for peripheral nerve repair.
Presented at: Tissue and Cell Engineering Society Conference 2018 (TCES 2018), Keele, UK.
|
|
Biro, AA;
Bremaud, A;
Falck, J;
Ruiz, AJ;
(2018)
A-type K(+) channels impede supralinear summation of clustered glutamatergic inputs in layer 3 neocortical pyramidal neurons.
Neuropharmacology
, 140
pp. 86-99.
10.1016/j.neuropharm.2018.07.005.
|
|
|
Bonham, LW;
Steele, NZR;
Karch, CM;
Manzoni, C;
Geier, EG;
Wen, N;
Ofori-Kuragu, A;
... International FTD-Genomics Consortium (IFGC); + view all
(2018)
Protein network analysis reveals selectively vulnerable regions and biological processes in FTD.
Neurology Genetics
, 4
(5)
, Article e266. 10.1212/NXG.0000000000000266.
|
|
|
Boulkedid, R;
Abdou, AY;
Desselas, E;
Monégat, M;
de Leeuw, TG;
Avez-Couturier, J;
Dugue, S;
... Healy, P; + view all
(2018)
The research gap in chronic paediatric pain: A systematic review of randomised controlled trials.
European Journal of Pain
, 22
(2)
pp. 261-271.
10.1002/ejp.1137.
|
|
Counsell, JR;
Karda, R;
Diaz, JA;
Carey, L;
Wiktorowicz, T;
Buckley, SMK;
Ameri, S;
... Howe, SJ; + view all
(2018)
Foamy Virus Vectors Transduce Visceral Organs and Hippocampal Structures following In Vivo Delivery to Neonatal Mice.
Molecular Therapy - Nucleic Acids
, 12
pp. 626-634.
10.1016/j.omtn.2018.07.006.
|
|
|
Coy, RH;
Evans, OR;
Phillips, JB;
Shipley, RJ;
(2018)
An integrated theoretical-experimental approach to accelerate translational tissue engineering.
Journal of Tissue Engineering and Regenerative Medicine
, 12
(1)
e53-e59.
10.1002/term.2346.
|
|
Economides, G;
Falk, S;
Mercer, A;
(2018)
Biocytin Recovery and 3D Reconstructions of Filled Hippocampal CA2 Interneurons.
Journal of Visualized Experiments
, 141
, Article e58592. 10.3791/58592.
|
|
|
Eleftheriadou, D;
Evans, R;
Boyd, A;
Knowles, J;
Roberton, V;
Phillips, J;
(2018)
An alginate-based encapsulation system for the delivery of therapeutic cells to the CNS.
Presented at: TCES, Keele.
|
|
|
Evans, R;
Phillips, J;
Knowles, J;
Roberton, V;
Boyd, A;
(2018)
Alginate Hydrogels to Encapsulate hiPSC-derived Neurons for Parkinson’s Disease.
Presented at: 5th TERMIS World Congress 2018, Kyoto, Japan.
|
|
Ferrari, R;
Kia, DA;
Tomkins, JE;
Hardy, J;
Wood, NW;
Lovering, RC;
Lewis, PA;
(2018)
Stratification of candidate genes for Parkinson's disease using weighted protein-protein interaction network analysis.
BMC Genomics
, 19
, Article 452. 10.1186/s12864-018-4804-9.
|
|
|
Georgiou, M;
Reis, JND;
Wood, R;
Esteban, PP;
Roberton, V;
Mason, C;
Li, D;
... Wall, I; + view all
(2018)
Bioprocessing strategies to enhance the challenging isolation of neuro-regenerative cells from olfactory mucosa.
Scientific Reports
, 8
, Article 14440. 10.1038/s41598-018-32748-w.
|
|
|
Gonzalez-Perez, F;
Hernández, J;
Heimann, C;
Phillips, JB;
Udina, E;
Navarro, X;
(2018)
Schwann cells and mesenchymal stem cells in laminin- or fibronectin-aligned matrices and regeneration across a critical size defect of 15 mm in the rat sciatic nerve.
Journal of Neurosurgery: Spine
, 28
(1)
pp. 109-118.
10.3171/2017.5.SPINE161100.
|
|
Harrison, DJ;
Roberton, VH;
Vinh, N-N;
Brooks, SP;
Dunnett, SB;
Rosser, AE;
(2018)
The Effect of Tissue Preparation and Donor Age on Striatal Graft Morphology in the Mouse.
Cell Transplantation
, 27
(2)
pp. 230-244.
10.1177/0963689717744788.
|
|
|
Hughes, MP;
Smith, DA;
Morris, L;
Fletcher, C;
Colaco, A;
Huebecker, M;
Tordo, J;
... Rahim, AA; + view all
(2018)
AAV9 intracerebroventricular gene therapy improves lifespan, locomotor function and pathology in a mouse model of Niemann-Pick type C1 disease.
Human Molecular Genetics
, 27
(17)
pp. 3079-3098.
10.1093/hmg/ddy212.
|
|
Joel, Z;
Izquierdo, P;
Liu, W;
Hall, C;
Roberts, M;
Yap, K;
Nick, A;
... Edwards, F; + view all
(2018)
A TauP301L mouse model of dementia; development of pathology, synaptic transmission, microglial response and cognition throughout life.
BioRxiv: Cold Spring Harbor, NY, USA.
|
|
|
Kakkar, L;
Bennett, O;
Siow, B;
Quick, T;
Richardson, S;
Kaden, E;
Atkinson, D;
... Drobnjak, I; + view all
(2018)
Low frequency oscillating gradient spin-echo sequences improve sensitivity to axon diameter: An experimental study in viable nerve tissue.
NeuroImage
, 182
pp. 314-328.
10.1016/j.neuroimage.2017.07.060.
|
|
|
Khan, A;
Shekh-Ahmad, T;
Khalilova, A;
Walker, M;
Ali, AB;
(2018)
Cannabidiol exerts antiepileptic effects by restoring hippocampal interneuron functions in a temporal lobe epilepsy model.
British Journal of Pharmacology
, 175
pp. 2097-2115.
10.1111/bph.14202.
|
|
Leksmono, CS;
Manzoni, C;
Tomkins, JE;
Lucchesi, W;
Cottrell, G;
Lewis, PA;
(2018)
Measuring Lactase Enzymatic Activity in the Teaching Lab.
JOVE-Journal Of Visualized Experiments
(138)
, Article e54377. 10.3791/54377.
|
|
|
Liu, W;
Taso, O;
Wang, R;
Garcia-Reitboeck, P;
Andrews, WD;
Piers, TM;
Pocock, JM;
... Salih, D; + view all
(2018)
Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions.
bioRxiv
|
|
|
Mamais, A;
Manzoni, C;
Nazish, I;
Arber, C;
Sonustun, B;
Wray, S;
Warner, T;
... Bandopadhyay, R; + view all
(2018)
Analysis of macroautophagy related proteins in G2019S LRRK2 Parkinson's disease brains with Lewy Body pathology.
Brain Research
, 1701
pp. 75-84.
10.1016/j.brainres.2018.07.023.
|
|
|
Manzoni, C;
Kia, DA;
Vandrovcova, J;
Hardy, J;
Wood, NW;
Lewis, PA;
Ferrari, R;
(2018)
Genome, transcriptome and proteome: the rise of omics data and their integration in biomedical sciences.
Briefings in Bioinformatics
, 19
(2)
pp. 286-302.
10.1093/bib/bbw114.
|
|
|
Manzoni, C;
Mamais, A;
Dihanich, S;
Soutar, MPM;
Plun-Favreau, H;
Bandopadhyay, R;
Abeti, R;
... Lewis, PA; + view all
(2018)
mTOR independent alteration in ULK1 Ser758 phosphorylation following chronic LRRK2 kinase inhibition.
Bioscience Reports
, 38
(2)
, Article BSR20171669. 10.1042/BSR20171669.
|
|
Massaro, G;
Mattar, CNZ;
Wong, AMS;
Sirka, E;
Buckley, SMK;
Herbert, BR;
Karlsson, S;
... Rahim, AA; + view all
(2018)
Fetal gene therapy for neurodegenerative disease of infants.
Nature Medicine
, 24
pp. 1317-1323.
10.1038/s41591-018-0106-7.
|
|
Massaro, Giulia;
(2018)
Intravenously administered gene therapy for neuronopathic Gaucher disease.
Doctoral thesis (Ph.D), UCL (University College London).
|
|
Medawar, E;
Benway, T;
Liu, W;
Hanan, TA;
Haslehurst, P;
James, OT;
Yap, K;
... Edwards, FA; + view all
(2018)
Effects of rising amyloidβ levels on hippocampal synaptic transmission, microglial response and cognition in APPSwe/PSEN1M146V transgenic mice.
BioRxiv: Cold Spring Harbor, NY, USA.
|
|
|
Migliore, R;
Lupascu, CA;
Bologna, LL;
Romani, A;
Courcol, JD;
Antonel, S;
Van Geit, WAH;
... Migliore, M; + view all
(2018)
The physiological variability of channel density in hippocampal CA1 pyramidal cells and interneurons explored using a unified data-driven modeling workflow.
PLoS Computational Biology
, 14
(9)
, Article e1006423. 10.1371/journal.pcbi.1006423.
|
|
|
Mishra, EK;
Clive, AO;
Wills, GH;
Davies, HE;
Stanton, AE;
Al-Aloul, M;
Hart-Thomas, A;
... Rahman, NM; + view all
(2018)
Randomised Controlled Trial of Urokinase versus Placebo for Non-draining Malignant Pleural Effusion.
American Journal of Respiratory and Critical Care Medicine
, 197
(4)
pp. 502-508.
10.1164/rccm.201704-0809OC.
|
|
|
Muangsanit, P;
Shipley, RJ;
Phillips, JB;
(2018)
Vascularization Strategies for Peripheral Nerve Tissue Engineering.
The Anatomical Record
, 301
(10)
pp. 1657-1667.
10.1002/ar.23919.
|
|
Mukhey, D;
Phillips, JB;
Daniels, JT;
Kureshi, AK;
(2018)
Controlling human corneal stromal stem cell contraction to mediate rapid cell and matrix organization of real architecture for 3-dimensional tissue equivalents.
Acta Biomaterialia
, 67
pp. 229-237.
10.1016/j.actbio.2017.11.047.
|
|
Nicholson, Martin William;
(2018)
Diazepam-dependent modulation of GABAergic inhibitory synapses.
Doctoral thesis (Ph.D), UCL (University College London).
|
|
Nicholson, MW;
Sweeney, A;
Pekle, E;
Alam, S;
Ali, AB;
Duchen, M;
Jovanovic, JN;
(2018)
Diazepam-induced loss of inhibitory synapses mediated by PLCδ/ Ca²⁺/calcineurin signalling downstream of GABAA receptors.
Molecular Psychiatry
, 23
pp. 1851-1867.
10.1038/s41380-018-0100-y.
|
|
O'Rourke, C;
Day, AGE;
Murray-Dunning, C;
Thanabalasundaram, L;
Cowan, J;
Stevanato, L;
Grace, N;
... Phillips, JB; + view all
(2018)
An allogeneic 'off the shelf' therapeutic strategy for peripheral nerve tissue engineering using clinical grade human neural stem cells.
Scientific Reports
, 8
(1)
, Article 2951. 10.1038/s41598-018-20927-8.
|
|
|
Osborn, DP;
Petersen, I;
Beckley, N;
Walters, K;
Nazareth, I;
Hayes, J;
(2018)
Weight change over two years in people prescribed olanzapine, quetiapine and risperidone in UK primary care: Cohort study in THIN, a UK primary care database.
Journal of Psychopharmacology
, 32
(10)
pp. 1098-1103.
10.1177/0269881118780011.
|
|
Pellegrini, L;
Hauser, DN;
Li, Y;
Mamais, A;
Beilina, A;
Kumaran, R;
Wetzel, A;
... Harvey, K; + view all
(2018)
Proteomic analysis reveals co-ordinated alterations in protein synthesis and degradation pathways in LRRK2 knockout mice.
Human Molecular Genetics
, 27
(18)
pp. 3257-3271.
10.1093/hmg/ddy232.
|
|
|
Poupon, L;
Lamoine, S;
Pereira, V;
Barriere, DA;
Lolignier, S;
Giraudet, F;
Aissouni, Y;
... Busserolles, J; + view all
(2018)
Targeting the TREK-1 potassium channel via riluzole to eliminate the neuropathic and depressive-like effects of oxaliplatin.
Neuropharmacology
, 140
pp. 43-61.
10.1016/j.neuropharm.2018.07.026.
|
|
Price, A;
Manzoni, C;
Cookson, MR;
Lewis, PA;
(2018)
The LRRK2 signalling system.
Cell and Tissue Research
10.1007/s00441-017-2759-9.
|
|
|
Rayner, MLD;
Laranjeira, S;
Evans, RE;
Shipley, RJ;
Healy, J;
Phillips, JB;
(2018)
Developing an In Vitro Model to Screen Drugs for Nerve Regeneration.
Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
, 301
(10)
pp. 1628-1637.
10.1002/ar.23918.
|
|
|
Rocha-Ferreira, E;
Poupon, L;
Zelco, A;
Leverin, A-L;
Nair, S;
Jonsdotter, A;
Carlsson, Y;
... Rahim, AA; + view all
(2018)
Neuroprotective exendin-4 enhances hypothermia therapy in a model of hypoxic-ischaemic encephalopathy.
Brain
, 141
(10)
pp. 2925-2942.
10.1093/brain/awy220.
|
|
Rossi, G;
Redaelli, V;
Contiero, P;
Fabiano, S;
Tagliabue, G;
Perego, P;
Benussi, L;
... Tagliavini, F; + view all
(2018)
Tau Mutations Serve as a Novel Risk Factor for Cancer.
Cancer Research
, 78
(13)
pp. 3731-3739.
10.1158/0008-5472.CAN-17-3175.
|
|
Sancandi, M;
Schul, EV;
Economides, G;
Constanti, A;
Mercer, A;
(2018)
Structural Changes Observed in the Piriform Cortex in a Rat Model of Pre-motor Parkinson’s Disease.
Frontiers in Cellular Neuroscience
, 12
, Article 479. 10.3389/fncel.2018.00479.
|
|
|
Schuh, CMAP;
Day, AGE;
Redl, H;
Phillips, J;
(2018)
An Optimized Collagen-Fibrin Blend Engineered Neural Tissue Promotes Peripheral Nerve Repair.
Tissue Engineering Part A
, 24
(17-18)
pp. 1332-1340.
10.1089/ten.tea.2017.0457.
|
|
|
Shah, MM;
(2018)
Neuronal HCN channel Function and Plasticity.
Current Opinion in Physiology
, 2
pp. 92-97.
10.1016/j.cophys.2018.01.001.
|
|
Strobbe, D;
Robinson, AA;
Rossi, L;
Ferraina, C;
De Biase, V;
Rodolfo, C;
Harvey, K;
... Campanella, M; + view all
(2018)
Distinct mechanisms of pathogenic DJ-1 mutations in mitochondrial quality control.
Frontiers in Molecular Neuroscience
(68)
10.3389/fnmol.2018.00068.
|
|
|
Szulc, BR;
Hilton, ST;
Ruiz, AJ;
(2018)
Physiological signature of a novel potentiator of AMPA receptor signalling.
Mol Cell Neurosci
, 92
pp. 82-92.
10.1016/j.mcn.2018.07.003.
|
|
|
Thompson, Lindsay;
(2018)
Response to Antiretroviral Therapy in Adults and Children in Resource-limited Settings.
Masters thesis (M.Phil), UCL (University College London).
|
|
Tomkins, JE;
Dihanich, S;
Beilina, A;
Ferrari, R;
Ilacqua, N;
Cookson, MR;
Lewis, PA;
(2018)
Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins.
Proteomics
, 18
(10)
, Article 1700444. 10.1002/pmic.201700444.
|
|
|
Tordo, J;
O'Leary, C;
Antunes, ASLM;
Palomar, N;
Aldrin-Kirk, P;
Basche, M;
Bennett, A;
... Henckaerts, E; + view all
(2018)
A novel adeno-associated virus capsid with enhanced neurotropism corrects a lysosomal transmembrane enzyme deficiency.
Brain
10.1093/brain/awy126.
(In press).
|
|
|
Van Dijkman, SC;
De Jager, NCB;
Rauwé, WM;
Danhof, M;
Della Pasqua, O;
(2018)
Authors' Reply to Standing et al.: "Effect of Age-Related Factors on the Pharmacokinetics of Lamotrigine and Potential Implications for Maintenance Dose Optimisation in Future Clinical Trials".
[Letter].
Clinical Pharmacokinetics
, 57
(11)
pp. 1473-1475.
10.1007/s40262-018-0698-6.
|
 |
|
Van Dijkman, SC;
De Jager, NCB;
Rauwé, WM;
Danhof, M;
Della Pasqua, O;
(2018)
Effect of Age-Related Factors on the Pharmacokinetics of Lamotrigine and Potential Implications for Maintenance Dose Optimisation in Future Clinical Trials.
Clinical Pharmacokinetics
, 57
(8)
pp. 1039-1053.
10.1007/s40262-017-0614-5.
|
|
van Dijkman, SC;
Rauwé, WM;
Danhof, M;
Della Pasqua, O;
(2018)
Pharmacokinetic interactions and dosing rationale for antiepileptic drugs in adults and children.
British Journal of Clinical Pharmacology
, 84
(1)
pp. 97-111.
10.1111/bcp.13400.
|
|
van Dijkman, SC;
Wicha, SG;
Danhof, M;
Della Pasqua, OE;
(2018)
Individualised dosing algorithms and therapeutic monitoring for antiepileptic drugs.
Clinical Pharmacology & Therapeutics
, 103
(4)
pp. 663-673.
10.1002/cpt.777.
|
|
|
Zhang, M;
Ferrari, R;
Tartaglia, MC;
Keith, J;
Surace, EI;
Wolf, U;
Sato, C;
... International FTD-Genomics Consortium (IFGC), .; + view all
(2018)
A C6orf10/LOC101929163 locus is associated with age of onset in C9orf72 carriers.
Brain
, 141
(10)
pp. 2895-2907.
10.1093/brain/awy238.
|
|
2017
|
Bellanti, F;
Del Vecchio, GC;
Putti, MC;
Maggio, A;
Filosa, A;
Cosmi, C;
Mangiarini, L;
... Della Pasqua, O; + view all
(2017)
Population pharmacokinetics and dosing recommendations for the use of deferiprone in children younger than 6 years.
British Journal of Clinical Pharmacology
, 83
(3)
pp. 593-602.
10.1111/bcp.13134.
|
|
Berwick, DC;
Javaheri, B;
Wetzel, A;
Hopkinson, M;
Nixon-Abell, J;
Grannò, S;
Pitsillides, AA;
(2017)
Pathogenic LRRK2 variants are gain-of-function mutations that enhance LRRK2-mediated repression of β-catenin signaling.
Molecular Neurodegeneration
, 12
, Article 9. 10.1186/s13024-017-0153-4.
|
|
Bhangra, K;
Knowles, J;
Shipley, R;
Choi, D;
Phillips, J;
(2017)
Bridging the interface between damaged peripheral nerve and engineered neural tissue using phosphate glass fibres.
Presented at: 4th International Symposium on Peripheral Nerve Regeneration: ISPNR 2017, Barcelona, Spain.
|
|
Bhangra, K;
Knowles, J;
Shipley, R;
Choi, D;
Phillips, J;
(2017)
Using phosphate glass fibres to improve the interface between damaged peripheral nerve and engineered neural tissue.
In:
Proceedings of the 17th annual conferance of the Tissue and Cell Engineering Society ( TCES).
(pp. p. 113).
European Cell and Material
|
|
|
Busuttil, F;
Rahim, AA;
Phillips, JB;
(2017)
Combining gene and stem cell therapy for peripheral nerve tissue engineering.
Stem Cells and Development
, 26
(4)
pp. 231-238.
10.1089/scd.2016.0188.
|
|
Cafferty, F;
Coyle, C;
Rowley, S;
Berkman, L;
MacKensie, M;
Langley, RE;
(2017)
Co-enrolment of participants into multiple cancer trials: benefits and challenges.
Clinical Oncology
, 29
(7)
e126-e133.
10.1016/j.clon.2017.02.014.
|
|
|
Citraro, R;
Leo, A;
Constanti, A;
Russo, E;
(2017)
Role of Histone Deacetylases (HDACs) in Epilepsy and Epileptogenesis.
Current Pharmaceutical Design
, 23
(37)
pp. 5546-5562.
10.2174/1381612823666171024130001.
|
|
Day, AGE;
Bhangra, KS;
Murray-Dunning, C;
Stevanato, L;
Phillips, J;
(2017)
The Effect of Hypothermic and Cryogenic Preservation on Engineered Neural Tissue.
Tissue Engineering Part C: Methods
, 23
(10)
pp. 575-582.
10.1089/ten.TEC.2017.0244.
|
|
De Cock, P;
Van Dijkman, S;
De Jaeger, A;
Willems, J;
Carlier, M;
Verstraete, A;
Delanghe, J;
... De Paepe, P; + view all
(2017)
Dose optimization of piperacillin/tazobactam in critically ill children.
Journal of Antimicrobial Chemotherapy
, 72
(7)
pp. 2002-2011.
10.1093/jac/dkx093.
|
|
De Jesus Antunes, N;
Van Dijkman, SC;
Lanchote, VL;
Wichert-Ana, L;
Coelho, EB;
Alexandre Junior, V;
Takayanagui, OM;
... Della Pasqua, O; + view all
(2017)
Population pharmacokinetics of oxcarbazepine and its metabolite 10-hydroxycarbazepine in healthy subjects.
European Journal of Pharmaceutical Sciences
, 109
(Supp)
S116-S123.
10.1016/j.ejps.2017.05.034.
|
|
Dolling, DI;
(2017)
HIV-1 viral load outcomes and the evolution of drug-resistance in low-income settings without virological monitoring.
Doctoral thesis , UCL (University College London).
|
|
Dolling, DI;
Goodall, RL;
Chirara, M;
Hakim, J;
Nkurunziza, P;
Munderi, P;
Eram, D;
... DART Virology Group, .; + view all
(2017)
The virological durability of first-line ART among HIV-positive adult patients in resource limited settings without virological monitoring: a retrospective analysis of DART trial data.
BMC Infectious Diseases
, 17
(1)
, Article 160. 10.1186/s12879-017-2266-3.
|
|
Dubois, VFS;
Danhof, M;
Della Pasqua, O;
(2017)
Characterising QT interval prolongation in early clinical development: a case study with methadone.
Pharmacology Research & Perspectives
, 5
(1)
, Article e00284. 10.1002/prp2.284.
|
|
Ferrari, R;
Lovering, RC;
Hardy, J;
Lewis, PA;
Manzoni, C;
(2017)
Weighted Protein Interaction Network Analysis of Frontotemporal Dementia.
Journal of Proteome Research
, 16
(2)
pp. 999-1013.
10.1021/acs.jproteome.6b00934.
|
|
|
Fisher, DJ;
Carpenter, JR;
Morris, TP;
Freeman, SC;
Tierney, JF;
(2017)
Meta-analytical methods to identify who benefits most from treatments: daft, deluded, or deft approach?
BMJ
, 356
, Article j573. 10.1136/bmj.j573.
|
|
Freeman, SC;
(2017)
One-step individual participant data network meta-analysis of time-to-event data.
Doctoral thesis , UCL (University College London).
|
|
Gonzalez-Perez, F;
Cobianchi, S;
Heimann, C;
Phillips, JB;
Udina, E;
Navarro, X;
(2017)
Stabilization, Rolling, and Addition of Other Extracellular Matrix Proteins to Collagen Hydrogels Improve Regeneration in Chitosan Guides for Long Peripheral Nerve Gaps in Rats.
Neurosurgery
, 80
(3)
pp. 465-474.
10.1093/neuros/nyw068.
|
|
Gullo, F;
Ceriani, M;
D'Aloia, A;
Wanke, E;
Constanti, A;
Costa, B;
Lecchi, M;
(2017)
Plant Polyphenols and Exendin-4 Prevent Hyperactivity and TNF-alpha Release in LPS-Treated In vitro Neuron/Astrocyte/Microglial Networks.
Frontiers in Neuroscience
, 11
, Article 500. 10.3389/fnins.2017.00500.
|
|
|
Harvey, RJ;
Harvey, K;
(2017)
Editorial: Molecular, Cellularand Model Organism Approaches for Understanding the Basis of Neurological Disease.
Front. Mol. Neurosci.
, 10
, Article 14. 10.3389/fnmol.2017.00074.
|
|
|
Huang, Z;
Li, G;
Aguado, C;
Lujan, R;
Shah, MM;
(2017)
HCN1 channels reduce the rate of exocytosis from a subset of cortical synaptic terminals.
Scientific Reports
, 7
, Article 40257. 10.1038/srep40257.
|
|
|
Hughes, Michael;
(2017)
The development of gene therapy for Niemann-Pick Type C disease.
Doctoral thesis (Ph.D), UCL (University College London).
|
|
Kalbassi, S;
Bachmann, SO;
Cross, E;
Roberton, VH;
Baudouin, SJ;
(2017)
Male and Female Mice Lacking Neuroligin-3 Modify the Behavior of Their Wild-Type Littermates.
eNeuro
, 4
(4)
, Article e0145-17.2017. 10.1523/ENEURO.0145-17.2017.
|
|
|
Lanchoti Fiori, GM;
D’Agate, S;
Rocha, A;
Soares Pereira, AM;
Della Pasqua, O;
Peporine Lopes, N;
(2017)
Development and validation of a quantification method for cucurbitacins E and I in rat plasma: Application to population pharmacokinetic studies.
Journal of Pharmaceutical and Biomedical Analysis
, 144
pp. 99-105.
10.1016/j.jpba.2017.02.021.
|
|
Leo, A;
Citraro, R;
Amodio, N;
De Sarro, C;
Gallo Cantafio, ME;
Constanti, A;
De Sarro, G;
(2017)
Fingolimod Exerts only Temporary Antiepileptogenic Effects but Longer-Lasting Positive Effects on Behavior in the WAG/Rij Rat Absence Epilepsy Model.
Neurotherapeutics
, 14
(4)
pp. 1134-1147.
10.1007/s13311-017-0550-y.
|
|
Leo, A;
Citraro, R;
Marra, R;
Palma, E;
Di Paola, ED;
Constanti, A;
De Sarro, G;
(2017)
The Sphingosine 1-Phosphate Signaling Pathway in Epilepsy: A Possible Role for the Immunomodulator Drug Fingolimod in Epilepsy Treatment.
CNS & Neurological Disorders - Drug Targets
, 16
(3)
pp. 311-325.
10.2174/1871527315666161104163031.
|
|
Liu, Wenfei;
(2017)
The cellular functions of TREM2 in microglia in relation to Alzheimer's disease.
Doctoral thesis (Ph.D), UCL (University College London).
|
|
|
Manzoni, C;
(2017)
The LRRK2-macroautophagy axis and its relevance to Parkinson's disease.
Biochemical Society Transactions
, 45
(1)
pp. 155-162.
10.1042/BST20160265.
|
|
|
Mercer, A;
Thomson, AM;
(2017)
Cornu Ammonis Regions–Antecedents of Cortical Layers?
Frontiers in Neuroanatomy
, 11
, Article 83. 10.3389/fnana.2017.00083.
|
|
|
Murphy, PB;
Rehal, S;
Arbane, G;
Bourke, S;
Calverley, PMA;
Crook, AM;
Dowson, L;
... Hart, N; + view all
(2017)
Effect of Home Noninvasive Ventilation With Oxygen Therapy vs Oxygen Therapy Alone on Hospital Readmission or Death After an Acute COPD Exacerbation: A Randomized Clinical Trial.
JAMA: Journal of the American Medical Association
, 317
(21)
pp. 2177-2186.
10.1001/jama.2017.4451.
|
|
Nardotto, GHB;
Lanchote, VL;
Coelho, EB;
Della Pasqua, O;
(2017)
Population pharmacokinetics of carvedilol enantiomers and their metabolites in type-2 diabetes and healthy subjects.
European Journal of Pharmaceutical Sciences
, 109
(Supp)
S108-S115.
10.1016/j.ejps.2017.05.033.
|
|
O'Rourke, C;
Hopper, C;
MacRobert, AJ;
Phillips, JB;
Woodhams, JH;
(2017)
Could clinical photochemical internalisation be optimised to avoid neuronal toxicity?
International Journal of Pharmaceutics
, 528
(1-2)
pp. 133-143.
10.1016/j.ijpharm.2017.05.071.
|
|
|
O'Rourke, C;
Lee-Reeves, C;
Drake, RA;
Cameron, GW;
Loughlin, AJ;
Phillips, JB;
(2017)
Adapting tissue-engineered in vitro CNS models for high-throughput study of neurodegeneration.
Journal of Tissue Engineering
, 8
pp. 1-9.
10.1177/2041731417697920.
|
|
|
Oosterholt, SP;
Horrigan, J;
Jones, N;
Glass, L;
Pasqua, OD;
(2017)
Population pharmacokinetics of NNZ-2566 in healthy subjects.
European Journal of Pharmaceutical Sciences
, 109
(Suppl)
S98-S107.
10.1016/j.ejps.2017.05.032.
|
|
Palleria, C;
Leo, A;
Andreozzi, F;
Citraro, R;
Iannone, M;
Spiga, R;
Sesti, G;
... Russo, E; + view all
(2017)
Liraglutide prevents cognitive decline in a rat model of streptozotocin-induced diabetes independently from its peripheral metabolic effects.
Behavioural Brain Research
, 321
pp. 157-169.
10.1016/j.bbr.2017.01.004.
|
|
Parisi, N;
Matts, PJ;
Lever, R;
Hadgraft, J;
Lane, ME;
(2017)
Hexamidine salts - applications in skin health and personal care products.
International Journal of Cosmetic Science
, 39
(4)
pp. 361-365.
10.1111/ics.12392.
|
|
Pellegrini, L;
Wetzel, A;
Grannó, S;
Heaton, G;
Harvey, K;
(2017)
Back to the tubule: microtubule dynamics in Parkinson's disease.
Cellular and Molecular Life Sciences
, 74
(3)
pp. 409-434.
10.1007/s00018-016-2351-6.
|
|
Piana, C;
Danhof, M;
Della Pasqua, O;
(2017)
Impact of disease, drug and patient adherence on the effectiveness of antiviral therapy in pediatric HIV.
Expert Opinion on Drug Metabolism and Toxicology
, 13
(5)
pp. 497-511.
10.1080/17425255.2017.1277203.
|
|
Rayner, M;
Healy, J;
Phillips, J;
(2017)
Investigating the effects of ibuprofen on axonal regeneration and functional recovery following peripheral nerve injury.
Presented at: 6th Vienna Symposium on Surgery of Peripheral Nerves, Vienna, Austria.
|
|
Sanen, K;
Martens, W;
Georgiou, M;
Ameloot, M;
Lambrichts, M;
Phillips, JB;
(2017)
Engineered neural tissue with Schwann cell differentiated human dental pulp stem cells: potential for peripheral nerve repair?
Journal of Tissue Engineering and Regenerative Medicine
, 11
(12)
pp. 3362-3372.
10.1002/term.2249.
|
|
Shallcross, L;
Beckley, N;
Rait, G;
Hayward, A;
Petersen, I;
(2017)
Antibiotic prescribing frequency amongst patients in primary care: a cohort study using electronic health records.
Journal of Antimicrobial Chemotherapy
, 72
(6)
pp. 1818-1824.
10.1093/jac/dkx048.
|
|
|
Sharma, M;
Beckley, N;
Nazareth, I;
Petersen, I;
(2017)
Effectiveness of sitagliptin compared to sulfonylureas for type 2 diabetes mellitus inadequately controlled on metformin: a systematic review and meta-analysis.
BMJ Open
, 7
(10)
, Article e017260. 10.1136/bmjopen-2017-017260.
|
|
|
Suannun, T;
Knowles, J;
Phillips, J;
(2017)
Development of engineered neural tissue containing elongated neurons supported by aligned glia for peripheral nerve regeneration.
Presented at: ISPNR, Barcelona, Spain.
|
|
|
Suannun, T;
Knowles, J;
Phillips, J;
(2017)
Investigating the use of engineered neural tissue to generate peripheral nerve repair constructs populated with neurons.
Presented at: TERMIS-EU 2017, Davos, Switzerland.
|
|
Taneja, A;
Della Pasqua, OE;
Danhof, M;
(2017)
Challenges in translational drug research in neuropathic
and inflammatory pain: the prerequisites for a new paradigm.
European Journal of Clinical Pharmacology
, 73
pp. 1219-1236.
10.1007/s00228-017-2301-8.
|
|
van den Brink, W;
Emerenciana, A;
Bellanti, F;
Della Pasqua, O;
van der Laan, JW;
(2017)
Prediction of thyroid C-cell carcinogenicity after chronic administration of GLP1-R agonists in rodents Toxicology and Applied Pharmacology.
Toxicology and Applied Pharmacology
, 320
pp. 51-69.
10.1016/j.taap.2017.02.010.
|
|
Vermeulen, E;
van den Anker, JN;
Della Pasqua, O;
Hoppu, K;
van der Lee, JH;
Global Research in Paediatrics (GRiP), .;
(2017)
How to optimise drug study design: pharmacokinetics and pharmacodynamics studies introduced to paediatricians.
Journal of Pharmacy and Pharmacology
, 69
(4)
pp. 439-447.
10.1111/jphp.12637.
|
2016
|
Bartlett, RD;
Choi, D;
Phillips, JB;
(2016)
Biomechanical properties of the spinal cord: implications for tissue engineering and clinical translation.
Regenrative Medicine
, 11
(7)
pp. 659-673.
10.2217/rme-2016-0065.
|
|
Bhangra, KS;
Busuttil, F;
Phillips, JB;
Rahim, AA;
(2016)
Using Stem Cells to Grow Artificial Tissue for Peripheral Nerve Repair.
Stem Cells International
, 2016
, Article 7502178. 10.1155/2016/7502178.
|
|
Boeree, MJ;
Heinrich, H;
Rehal, S;
Phillips, PPJ;
(2016)
High-dose rifampicin, moxifloxacin, and SQ109 for treating tuberculosis: a multi-arm, multi-stage randomised controlled trial.
Lancet Infectious Diseases
, 17
(1)
pp. 39-49.
10.1016/S1473-3099(16)30274-2.
|
|
Brown, LE;
Nicholson, MW;
Arama, JE;
Mercer, A;
Thomson, AM;
Jovanovic, JN;
(2016)
γ-aminobutyric acid type A (GABAA) receptor subunits play a direct structural role in synaptic contact formation via their N-terminal extracellular domains.
The Journal of Biological Chemistry
, 291
(27)
pp. 13926-13942.
10.1074/jbc.M116.714790.
|
|
Citraro, R;
Leo, A;
Constanti, A;
Russo, E;
Sarro, G;
(2016)
mTOR pathway inhibition as a new therapeutic strategy in epilepsy and epileptogenesis.
Pharmacological Research
, 107
10.1016/j.phrs.2016.03.039.
|
|
Coy, R;
Kennedy, G;
Kayal, C;
O'Rourke, C;
Kingham, P;
Phillips, J;
Shipley, RJ;
(2016)
A mathematical model informed by in vitro experiments to advance engineered nerve repair construct design.
In:
(Proceedings) Tissue and Cell Engineering Society.
(pp. p. 36).
European Cells & Materials Ltd
|
|
|
Coy, RH;
Kennedy, G;
Kayal, C;
O'Rourke, C;
Kingham, PJ;
Phillips, JB;
Shipley, RJ;
(2016)
A joint theoretical-experimental approach to investigate the effects of low oxygen environments upon therapeutic cell viability and VEGF production.
European Cells and Materials
, 31
(S1)
p. 174.
|
|
|
Coyle, C;
Cafferty, FH;
Langley, RE;
(2016)
Aspirin and Colorectal Cancer Prevention and Treatment: Is It for Everyone?
Current Colorectal Cancer Reports
, 12
(1)
pp. 27-34.
10.1007/s11888-016-0306-9.
|
|
|
Coyle, C;
Cafferty, FH;
Rowley, S;
MacKenzie, M;
Berkman, L;
Gupta, S;
Pramesh, CS;
... Langley, RE; + view all
(2016)
ADD-ASPIRIN: A phase III, double-blind, placebo controlled, randomised trial assessing the effects of aspirin on disease recurrence and survival after primary therapy in common non-metastatic solid tumours.
Contemporary Clinical Trials
, 51
pp. 56-64.
10.1016/j.cct.2016.10.004.
|
|
Coyle, C;
Cafferty, FH;
Vale, C;
Langley, RE;
(2016)
Metformin as an adjuvant treatment for cancer: a systematic review and meta-analysis.
Annals of Oncology
, 27
(12)
pp. 2184-2195.
10.1093/annonc/mdw410.
|
|
Cummings, D;
Benway, T;
Foster, E;
Liu, W;
Yasvoina, M;
Lashley, T;
Murray, CE;
... Salih, D; + view all
(2016)
The pentraxin family regulates neuronal and microglial function in the CNS and is disrupted in phenotypes associated with Alzheimer’s disease.
Presented at: Alzheimer's Research UK's (ARUK) Conference 2016, Manchester, UK.
|
|
|
Dubois, VF;
Casarotto, E;
Danhof, M;
Della Pasqua, O;
(2016)
Pharmacokinetic-pharmacodynamic modelling of drug-induced QTc interval prolongation in man: prediction from in vitro human ether-à-go-go-related gene binding and functional inhibition assays and conscious dog studies.
British Journal of Pharmacology
, 173
(19)
pp. 2819-2832.
10.1111/bph.13558.
|
|
Dubois, VF;
Smania, G;
Yu, H;
Graf, R;
Chain, A;
Danhof, M;
Pasqua, OD;
(2016)
Translating QT interval prolongation from conscious dogs to humans.
British Journal of Clinical Pharmacology
, 83
(2)
pp. 349-362.
10.1111/bcp.13123.
|
|
Girão, AF;
Gonçalves, G;
Bhangra, KS;
Phillips, JB;
Knowles, J;
Irurueta, G;
Singh, MK;
... Marques, PAAP; + view all
(2016)
Electrostatic self-assembled graphene oxide-collagen scaffolds towards a three-dimensional microenvironment for biomimetic applications.
RSC Advances
, 6
(54)
pp. 49039-49051.
10.1039/c6ra10213a.
|
|
Kalscheuer, VM;
James, VM;
Himelright, ML;
Long, P;
Oegema, R;
Jensen, C;
Bienek, M;
... Harvey, RJ; + view all
(2016)
Novel Missense Mutation A789V in IQSEC2 Underlies X-Linked Intellectual Disability in the MRX78 Family.
Frontiers in Molecular Neuroscience
, 8
, Article 85. 10.3389/fnmol.2015.00085.
|
|
|
Kara, E;
Tucci, A;
Manzoni, C;
Lynch, DS;
Elpidorou, M;
Bettencourt, C;
Chelban, V;
... Houlden, H; + view all
(2016)
Genetic and phenotypic characterization of complex hereditary spastic paraplegia.
Brain
, 139
(7)
pp. 1904-1918.
10.1093/brain/aww111.
|
|
Karda, R;
Perocheau, DP;
Suff, N;
Ng, J;
Hughes, M;
Rahim, AA;
Buckley, SMK;
... Waddington, SN; + view all
(2016)
Generation of light-producing somatic-transgenic mice using adeno-associated virus vectors.
In:
Human Gene Therapy. November 2016, 27(11).
(pp. A107-A108).
Mary Ann Liebert, Inc
|
|
Kayal, C;
Shipley, RJ;
Phillips, J;
(2016)
Effect of collagen gel concentration gradients on neurite elongation.
In:
European Cells and Materials - Volume No 32 - Supplement 4.
(pp. p. 83).
European Cells & Materials Ltd
|
|
|
Kennedy, G;
Coy, R;
Kayal, C;
O'Rourke, C;
Kingham, P;
Shipley, RJ;
Phillips, J;
(2016)
In vitro experiments to inform cell seeding strategies and parameterize a mathematical model for peripheral nerve repair.
In:
European Cells and Materials - Volume No 32 - Supplement 4.
(pp. p. 21).
European Cells & Materials Ltd
|
|
|
Lane, M;
Hadgraft, J;
Parisi, N;
Paz-Alvarez, M;
Lever, R;
Matts, P;
(2016)
Topical delivery of hexamidine.
International Journal of Pharmaceutics
, 506
(1 - 2)
pp. 332-339.
10.1016/j.ijpharm.2016.04.069.
|
|
Lever, R;
Smailbegovic, A;
Riffo-Vasquez, Y;
Gray, E;
Hogwood, J;
Francis, SM;
Richardson, NV;
... Mulloy, B; + view all
(2016)
Biochemical and functional characterization of glycosaminoglycans released from degranulating rat peritoneal mast cells: Insights into the physiological role of endogenous heparin.
Pulm Pharmacol Ther
, 41
pp. 96-102.
10.1016/j.pupt.2016.11.002.
|
|
Long, P;
May, MM;
James, VM;
Grannò, S;
Johnson, JP;
Tarpey, P;
Stevenson, RE;
... Harvey, RJ; + view all
(2016)
Missense Mutation R338W in ARHGEF9 in a Family with X-linked Intellectual Disability with Variable Macrocephaly and Macro-Orchidism.
Frontiers in Molecular Neuroscience
, 8
, Article 83. 10.3389/fnmol.2015.00083.
|
|
|
Manzoni, C;
Mamais, A;
Roosen, DA;
Dihanich, S;
Soutar, MPM;
Plun-Favreau, H;
Bandopadhyay, R;
... Lewis, PA; + view all
(2016)
mTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1.
Scientific Reports
, 6
, Article 35106. 10.1038/srep35106.
|
|
|
Muliaditan, M;
Davies, GR;
Simonsson, USH;
Gillespie, SH;
Della Pasqua, O;
(2016)
The implications of model-informed drug discovery and development for tuberculosis.
Drug Discovery Today
, 22
(3)
pp. 481-486.
10.1016/j.drudis.2016.09.004.
|
|
Mulloy, B;
Lever, R;
Page, CP;
(2016)
Mast cell glycosaminoglycans.
Glycoconjugate Journal
10.1007/s10719-016-9749-0.
|
|
|
Nixon-Abell, J;
Berwick, DC;
Grannó, S;
Spain, VA;
Blackstone, C;
Harvey, K;
(2016)
Protective LRRK2 R1398H Variant Enhances GTPase and Wnt Signaling Activity.
Frontiers in Molecular Neuroscience
, 9
(18)
pp. 1-13.
10.3389/fnmol.2016.00018.
|
|
|
Nixon-Abell, J;
Berwick, DC;
Harvey, K;
(2016)
L'RRK de Triomphe: a solution for LRRK2 GTPase activity?
Biochem Soc Trans
, 44
(6)
pp. 1625-1634.
10.1042/BST20160240.
|
|
Nixon-Abell, J;
Obara, CJ;
Weigel, AV;
Li, D;
Legant, WR;
Xu, CS;
Pasolli, HA;
... Lippincott-Schwartz, J; + view all
(2016)
Increased spatiotemporal resolution reveals highly dynamic dense tubular matrices in the peripheral ER.
Science
, 354
(6311)
, Article 433. 10.1126/science.aaf3928.
|
|
|
Paulin, JJW;
Haslehurst, P;
Fellows, AD;
Liu, W;
Jackson, JD;
Joel, Z;
Cummings, DM;
(2016)
Large and small dendritic spines serve different functions in hippocampal synaptic plasticity.
Neural Plasticity
, 2016
, Article 617050. 10.1155/2016/6170509.
|
|
|
Rehal, S;
Morris, TP;
Fielding, K;
Carpenter, JR;
Phillips, PPJ;
(2016)
Non-inferiority trials: are they inferior? A systematic review of reporting in major medical journals.
BMJ Open
, 6
(10)
, Article e012594. 10.1136/bmjopen-2016-012594.
|
|
|
Rocha-Ferreira, E;
Rudge, B;
Hughes, MP;
Rahim, AA;
Hristova, M;
Robertson, NJ;
(2016)
Immediate Remote Ischemic Postconditioning Reduces Brain Nitrotyrosine Formation in a Piglet Asphyxia Model.
Oxidative Medicine and Cellular Longevity
, 2016
, Article 5763743. 10.1155/2016/5763743.
|
|
|
Rodrigues, S;
Desroches, M;
Krupa, M;
Cortes, JM;
Sejnowski, TJ;
Ali, AB;
(2016)
Time-coded neurotransmitter release at excitatory and inhibitory synapses.
Proceedings of the National Academy of Sciences
, 113
(8)
E1108-E1115.
10.1073/pnas.1525591113.
|
|
Ruiz, Arnaud;
Hilton, Steve;
(2016)
Action Potential.
[Group exhibition].
London, UK.
18 January - 06 March 2016.
|
|
|
Russo, E;
Citraro, R;
Constanti, A;
Leo, A;
Lüttjohann, A;
van Luijtelaar, G;
De Sarro, G;
(2016)
Upholding WAG/Rij rats as a model of absence epileptogenesis: Hidden mechanisms and a new theory on seizure development.
Neuroscience & Biobehavioral Reviews
, 71
pp. 388-408.
10.1016/j.neubiorev.2016.09.017.
|
|
Russo, E;
Leo, A;
Crupi, R;
Aiello, R;
Lippiello, P;
Spiga, R;
Chimirri, S;
... De Sarro, G; + view all
(2016)
Everolimus improves memory and learning while worsening depressive- and anxiety-like behavior in an animal model of depression.
Journal of Psychiatric Research
, 78
pp. 1-10.
10.1016/j.jpsychires.2016.03.008.
|
|
Sanen, K;
Paesen, R;
Luyck, S;
Phillips, J;
Lambrichts, I;
Martens, W;
Ameloot, M;
(2016)
Label-free mapping of microstructural organisation in self-aligning cellular collagen hydrogels using image correlation spectroscopy.
Acta Biomaterialia
, 30
pp. 258-264.
10.1016/j.actbio.2015.10.047.
|
|
Shah, MM;
(2016)
Recording Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel Currents (Ih) in Neurons.
Cold Spring Harbor Protocols
, 2016
(7)
pp. 661-666.
10.1101/pdb.prot091462.
|
|
Shah, MM;
(2016)
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel Currents in Neurons.
Cold Spring Harbor Protocols
, 2016
(7)
pp. 612-614.
10.1101/pdb.top087346.
|
|
Sreekanthreddy, P;
Gromnicova, R;
Davies, H;
Phillips, J;
Romero, IA;
Male, D;
(2016)
A three-dimensional model of the human blood-brain barrier to analyse the transport of nanoparticles and astrocyte/endothelial interactions.
F1000Research
, 4
, Article 1279. 10.12688/f1000research.7142.2.
|
|
|
van Dijkman, SC;
Alvarez-Jimenez, R;
Danhof, M;
Della Pasqua, O;
(2016)
Pharmacotherapy in paediatric epilepsy: from trial and error to rational drug and dose selection – a long way to go.
Expert Opinion in Drug Metabolism and Toxicology
, 12
(10)
pp. 1143-1156.
10.1080/17425255.2016.1203900.
|
|
Vardi, A;
Zigdon, H;
Meshcheriakova, A;
Klein, AD;
Yaacobi, C;
Eilam, R;
Kenwood, BM;
... Futerman, AH; + view all
(2016)
Delineating pathological pathways in a chemically-induced mouse model of Gaucher disease.
The Journal of Pathology
, 239
(4)
pp. 496-509.
10.1002/path.4751.
|
2015
|
Arama, J;
Abitbol, K;
Goffin, D;
Fuchs, C;
Sihra, TS;
Thomson, AM;
Jovanovic, JN;
(2015)
GABAA receptor activity shapes the formation of inhibitory synapses between developing medium spiny neurons.
Frontiers in Cellulor Neuroscience
, 9
, Article 290. 10.3389/fncel.2015.00290.
|
|
|
Bosaily, AE-S;
Parker, C;
Brown, LC;
Gabe, R;
Hindley, RG;
Kaplan, R;
Emberton, M;
(2015)
PROMIS - Prostate MR imaging study: A paired validating cohort study evaluating the role of multi-parametric MRI in men with clinical suspicion of prostate cancer.
CONTEMPORARY CLINICAL TRIALS
, 42
pp. 26-40.
10.1016/j.cct.2015.02.008.
|
|
|
Buckley, SM;
Delhove, JM;
Perocheau, DP;
Karda, R;
Rahim, AA;
Howe, SJ;
Ward, NJ;
... McKay, TR; + view all
(2015)
In vivo bioimaging with tissue-specific transcription factor activated luciferase reporters.
Scientific Reports
, 5
, Article 11842. 10.1038/srep11842.
|
|
|
Coyle, C;
Mangar, S;
Abel, P;
Langley, RE;
(2015)
Erythema nodosum as a result of estrogen patch therapy for prostate cancer: a case report.
Journal of Medical Case Reports
, 9
, Article 285. 10.1186/s13256-015-0776-4.
|
|
|
Cummings, DM;
Liu, W;
Portelius, E;
Bayram, S;
Yasvoina, M;
Ho, SH;
Smits, H;
... Edwards, FA; + view all
(2015)
First effects of rising amyloid-β in transgenic mouse brain: synaptic transmission and gene expression.
Brain
, 138
(7)
1992 - 2004.
10.1093/brain/awv127.
|
|
|
Hashemian, S;
O'Rourke, C;
Phillips, JB;
Strömberg, I;
Af Bjerkén, S;
(2015)
Embryonic and mature astrocytes exert different effects on neuronal growth in rat ventral mesencephalic slice cultures.
Springerplus
, 4
, Article 558. 10.1186/s40064-015-1362-3.
|
|
|
Kahan, BC;
Rehal, S;
Cro, S;
(2015)
Risk of selection bias in randomised trials.
Trials
, 16
(1)
, Article 405. 10.1186/s13063-015-0920-x.
|
|
|
Kahan, BC;
Rehal, S;
Cro, S;
(2015)
Blinded Outcome Assessment Was Infrequently Used and Poorly Reported in Open Trials.
PLoS ONE
, 10
(6)
, Article e0131926. 10.1371/journal.pone.0131926.
|
|
Leo, A;
Citraro, R;
Constanti, A;
De Sarro, G;
Russo, E;
(2015)
Are big potassium-type Ca(2+)-activated potassium channels a viable target for the treatment of epilepsy?
Expert Opinion on Therapeutic Targets
, 19
(7)
pp. 911-926.
10.1517/14728222.2015.1026258.
|
|
Manzoni, C;
Denny, P;
Lovering, RC;
Lewis, PA;
(2015)
Computational analysis of the LRRK2 interactome.
PeerJ
, 3
, Article e778. 10.7717/peerj.778.
|
|
|
Martinello, K;
Huang, Z;
Lujan, R;
Tran, B;
Watanabe, M;
Cooper, EC;
Brown, DA;
(2015)
Cholinergic afferent stimulation induces axonal function plasticity in adult hippocampal granule cells.
Neuron
, 85
(2)
346 - 363.
10.1016/j.neuron.2014.12.030.
|
|
|
Matarin, M;
Perona, M;
Salih, DA;
Yasvoina, M;
Cummings, DM;
Liu, W;
NahabooSolim, MA;
... Smith, KJ; + view all
(2015)
A Genome-wide gene-expression analysis and database in transgenic mice during development of amyloid or tau pathology.
Cell Reports
, 10
(4)
633 - 645.
10.1016/j.celrep.2014.12.041.
|
|
|
Mattar, CN;
Wong, AM;
Hoefer, K;
Alonso-Ferrero, ME;
Buckley, SM;
Howe, SJ;
Cooper, JD;
... Rahim, AA; + view all
(2015)
Systemic gene delivery following intravenous administration of AAV9 to fetal and neonatal mice and late-gestation nonhuman primates.
The FASEB Journal
, 29
(9)
3876- 3888.
10.1096/fj.14-269092.
|
|
Musuamba, FT;
Teutonico, D;
Maas, HJ;
Facius, A;
Yang, S;
Danhof, M;
Della Pasqua, O;
(2015)
Prediction of disease progression, treatment response and dropout in chronic obstructive pulmonary disease (COPD).
Pharm Res
, 32
(2)
617 - 627.
10.1007/s11095-014-1490-4.
|
|
|
Nivsarkar, MS;
Buckley, SM;
Parker, AL;
Perocheau, D;
McKay, TR;
Rahim, AA;
Howe, SJ;
(2015)
Evidence for Contribution of CD4+CD25+ Regulatory T Cells in Maintaining Immune Tolerance to Human Factor IX following Perinatal Adenovirus Vector Delivery.
Journal of Immunology Research
, 2015
, Article 397879. 10.1155/2015/397879.
|
|
O'Rourke, C;
Drake, RA;
Cameron, GW;
Jane Loughlin, A;
Phillips, JB;
(2015)
Optimising contraction and alignment of cellular collagen hydrogels to achieve reliable and consistent engineered anisotropic tissue.
Journal of Biomaterials Applications
, 30
(5)
pp. 599-607.
10.1177/0885328215597818.
|
|
Parisi, N;
Matts, PJ;
Lever, R;
Hadgraft, J;
Lane, ME;
(2015)
Preparation and characterisation of hexamidine salts.
International Journal of Pharmaceutics
, 493
(1-2)
pp. 404-411.
10.1016/j.ijpharm.2015.07.071.
|
|
Rahman, NM;
Pepperell, J;
Rehal, S;
Saba, T;
Tang, A;
Ali, N;
West, A;
... Miller, RF; + view all
(2015)
Effect of Opioids vs NSAIDs and Larger vs Smaller Chest Tube Size on Pain Control and Pleurodesis Efficacy Among Patients With Malignant Pleural Effusion: The TIME1 Randomized Clinical Trial.
JAMA: Journal of the American Medical Association
, 314
(24)
pp. 2641-2653.
10.1001/jama.2015.16840.
|
|
Sreekanthreddy, P;
Gromnicova, R;
Davies, H;
Phillips, J;
Romero, IA;
Male, D;
(2015)
A three-dimensional model of the human blood-brain barrier to analyse the transport of nanoparticles and astrocyte/endothelial interactions [version 1; referees: 2 approved with reservations].
F1000Research
, 4
, Article 1279. 10.12688/f1000research.7142.1.
|
|
|
Stödberg, T;
McTague, A;
Ruiz, AJ;
Hirata, H;
Zhen, J;
Long, P;
Farabella, I;
... Kurian, MA; + view all
(2015)
Mutations in SLC12A5 in epilepsy of infancy with migrating focal seizures.
Nature Communications
, 6
p. 8038.
10.1038/ncomms9038.
|
|
|
Szulc, BR;
Sil, BC;
Ruiz, A;
Hilton, ST;
(2015)
A Common Precursor Approach to Structurally Diverse Natural Products: The Synthesis of the Core Structure of (±)-Clausenamide and the Total Synthesis of (±)-Hyalodendrin.
European Journal of Organic Chemistry
, 2015
(34)
pp. 7438-7442.
10.1002/ejoc.201501256.
|
|
|
Wallings, R;
Manzoni, C;
Bandopadhyay, R;
(2015)
Cellular processes associated with LRRK2 function and dysfunction.
FEBS J
, 282
(15)
pp. 2806-2826.
10.1111/febs.13305.
|
2014
|
Berwick, DC;
Harvey, K;
(2014)
The regulation and deregulation of Wnt signalling by PARK genes in health and disease.
J Mol Cell Biol
, 6
(1)
pp. 3-12.
10.1093/jmcb/mjt037.
|
|
|
Botcher, NA;
Falck, JE;
Thomson, AM;
Mercer, A;
(2014)
Distribution of interneurons in the CA2 region of the rat hippocampus.
Front Neuroanat
, 8
, Article 104. 10.3389/fnana.2014.00104.
|
|
|
Brown, LE;
Fuchs, C;
Nicholson, MW;
Stephenson, FA;
Thomson, AM;
Jovanovic, JN;
(2014)
Inhibitory synapse formation in a co-culture model incorporating GABAergic medium spiny neurons and HEK293 cells stably expressing GABAA receptors.
J Vis Exp
(93)
, Article e52115. 10.3791/52115.
|
|
|
Dihanich, S;
Civiero, L;
Manzoni, C;
Mamais, A;
Bandopadhyay, R;
Greggio, E;
Lewis, PA;
(2014)
GTP binding controls complex formation by the human ROCO protein MASL1.
FEBS J
, 281
(1)
pp. 261-274.
10.1111/febs.12593.
|
|
|
Georgiou, M;
Golding, JP;
Loughlin, AJ;
Kingham, PJ;
Phillips, JB;
(2014)
Engineered neural tissue with aligned, differentiated adipose-derived stem cells promotes peripheral nerve regeneration across a critical sized defect in rat sciatic nerve.
Biomaterials
, 37C
242 - 251.
10.1016/j.biomaterials.2014.10.009.
|
|
|
Grauert, A;
Engel, D;
Ruiz, AJ;
(2014)
Endogenous zinc depresses GABAergic transmission via T-type Ca2+ channels and broadens the time window for integration of glutamatergic inputs in dentate granule cells.
JOURNAL OF PHYSIOLOGY-LONDON
, 592
(1)
67 - 86.
10.1113/jphysiol.2013.261420.
|
|
|
Haw, RTY;
Tong, CK;
Yew, A;
Lee, HC;
Phillips, JB;
Vidyadaran, S;
(2014)
A three-dimensional collagen construct to model lipopolysaccharide-induced activation of BV2 microglia.
Journal of Neuroinflammation
, 11
(1)
, Article 134. 10.1186/1742-2094-11-134.
|
|
|
Kahan, BC;
Cro, S;
Doré, CJ;
Bratton, DJ;
Rehal, S;
Maskell, NA;
Rahman, N;
(2014)
Reducing bias in open-label trials where blinded outcome assessment is not feasible: strategies from two randomised trials.
Trials
, 15
, Article 456. 10.1186/1745-6215-15-456.
|
|
|
Karda, R;
Buckley, SM;
Mattar, CN;
Ng, J;
Massaro, G;
Hughes, MP;
Kurian, MA;
... Rahim, AA; + view all
(2014)
Perinatal systemic gene delivery using adeno-associated viral vectors.
Front Mol Neurosci
, 7
, Article 89. 10.3389/fnmol.2014.00089.
|
|
|
Phillips, JB;
(2014)
Building stable anisotropic tissues using cellular collagen gels.
Organogenesis
, 10
(1)
pp. 6-8.
10.4161/org.27487.
|
|
|
Taymans, JM;
Baekelandt, V;
Harvey, K;
(2014)
Regulation and targeting of enzymes mediating Parkinson's disease pathogenesis: focus on Parkinson's disease kinases, GTPases, and ATPases.
Frontiers in Molecular Neuroscience
, 7
, Article 71. 10.3389/fnmol.2014.00071.
|
2013
|
Fuchs, C;
Abitbol, K;
Burden, JJ;
Mercer, A;
Brown, L;
Iball, J;
Anne Stephenson, F;
... Jovanovic, JN; + view all
(2013)
GABAA receptors can initiate the formation of functional inhibitory GABAergic synapses.
Eur J Neurosci
, 38
(8)
pp. 3146-3158.
10.1111/ejn.12331.
|
|
|
Georgiou, M;
Bunting, SC;
Davies, HA;
Loughlin, AJ;
Golding, JP;
Phillips, JB;
(2013)
Engineered neural tissue for peripheral nerve repair.
Biomaterials
, 34
(30)
7335 - 7343.
10.1016/j.biomaterials.2013.06.025.
|
|
|
Harvey, K;
(2013)
LRRK2: an éminence grise of Wnt-mediated neurogenesis?
Frontiers in cellular neuroscience
, 7
(82)
10.3389/fncel.2013.00082.
|
|
|
Law, BM;
Spain, VA;
Leinster, VH;
Chia, R;
Beilina, A;
Cho, HJ;
Taymans, JM;
... Harvey, K; + view all
(2013)
A direct interaction between Leucine-rich Repeat Kinase 2 and specific β-tubulin isoforms regulates tubulin acetylation.
Journal of Biological Chemistry
, 289
(2)
pp. 895-908.
10.1074/jbc.M113.507913.
|
|
|
Mamais, A;
Raja, M;
Manzoni, C;
Dihanich, S;
Lees, A;
Moore, D;
Lewis, PA;
(2013)
Divergent α-synuclein solubility and aggregation properties in G2019S LRRK2 Parkinson's disease brains with Lewy Body pathology compared to idiopathic cases.
Neurobiol Dis
, 58
pp. 183-190.
10.1016/j.nbd.2013.05.017.
|
|
|
Manzoni, C;
(2013)
Parkinson's Disease: The Catabolic Theory.
Journal of Neurology & Translational Neuroscience
, 1
, Article 1009.
|
|
|
Manzoni, C;
Lewis, PA;
(2013)
Dysfunction of the autophagy/lysosomal degradation pathway is a shared feature of the genetic synucleinopathies.
The FASEB Journal
, 27
(9)
3424 - 3429.
10.1096/fj.12-223842.
|
|
|
Manzoni, C;
Mamais, A;
Dihanich, S;
Abeti, R;
Soutar, MP;
Plun-Favreau, H;
Giunti, P;
... Lewis, PA; + view all
(2013)
Inhibition of LRRK2 kinase activity stimulates macroautophagy.
Biochim Biophys Acta
, 1833
(12)
pp. 2900-2910.
10.1016/j.bbamcr.2013.07.020.
|
|
|
Manzoni, C;
Mamais, A;
Dihanich, S;
McGoldrick, P;
Devine, MJ;
Zerle, J;
Kara, E;
... Lewis, PA; + view all
(2013)
Pathogenic Parkinson's disease mutations across the functional domains of LRRK2 alter the autophagic/lysosomal response to starvation.
Biochemical and Biophysical Research Communications
, 441
(4)
pp. 862-866.
10.1016/j.bbrc.2013.10.159.
|
|
|
Martens, W;
Sanen, K;
Georgiou, M;
Struys, T;
Bronckaers, A;
Ameloot, M;
Phillips, J;
(2013)
Human dental pulp stem cells can differentiate into Schwann cells and promote and guide neurite outgrowth in an aligned tissue-engineered collagen construct in vitro.
The FASEB Journal
, 28
(4)
pp. 1634-1643.
10.1096/fj.13-243980.
|
|
|
Osellame, LD;
Rahim, AA;
Hargreaves, IP;
Gegg, ME;
Richard-Londt, A;
Brandner, S;
Waddington, SN;
... Duchen, MR; + view all
(2013)
Mitochondria and quality control defects in a mouse model of Gaucher Disease-links to Parkinson's Disease.
Cell Metabolism
, 17
(6)
pp. 941-953.
10.1016/j.cmet.2013.04.014.
|
|
2012
|
Berwick, DC;
Harvey, K;
(2012)
LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6.
Human Molecular Genetics
, 21
(22)
4966 -4979.
10.1093/hmg/dds342.
|
|
|
Devine, MJ;
Kaganovich, A;
Ryten, M;
Mamais, A;
Trabzuni, D;
Manzoni, C;
McGoldrick, P;
... Lewis, PA; + view all
(2012)
Correction: Pathogenic LRRK2 Mutations Do Not Alter Gene Expression in Cell Model Systems or Human Brain Tissue.
PLOS ONE
, 7
(1)
, Article e22489. 10.1371/annotation/c12e4f9e-5aae-424b-a69f-fddf16976dc5.
|
|
|
James, VM;
(2012)
Molecular insights into the disease mechanisms of startle disease.
Doctoral thesis , UCL (University College London).
|
|
|
Pigott, BM;
(2012)
Nitric oxide signalling in hippocampal synaptic plasticity.
Doctoral thesis , UCL (University College London).
|
|
|
Vale, CL;
Thompson, LC;
Murphy, C;
Forcat, S;
Hanley, B;
(2012)
Involvement of consumers in studies run by the Medical Research Council Clinical Trials Unit: results of a survey.
Trials
, 13
, Article 9. 10.1186/1745-6215-13-9.
|
 |
2011
|
Devine, MJ;
Kaganovich, A;
Ryten, M;
Mamais, A;
Trabzuni, D;
Manzoni, C;
McGoldrick, P;
... Lewis, PA; + view all
(2011)
Pathogenic LRRK2 Mutations Do Not Alter Gene Expression in Cell Model Systems or Human Brain Tissue.
PLOS ONE
, 6
(7)
, Article e22489. 10.1371/journal.pone.0022489.
|
|
|
Iball, J;
Ali, AB;
(2011)
Endocannabinoid Release Modulates Electrical Coupling between CCK Cells Connected via Chemical and Electrical Synapses in CA1.
Front Neural Circuits
, 5
, Article 17. 10.3389/fncir.2011.00017.
|
|
|
Jovanovic, JN;
Thomson, AM;
(2011)
Development of cortical GABAergic innervation.
Front Cell Neurosci
, 5
, Article 14. 10.3389/fncel.2011.00014.
|
|
|
Manzoni, C;
Colombo, L;
Bigini, P;
Diana, V;
Cagnotto, A;
Messa, M;
Lupi, M;
... Salmona, M; + view all
(2011)
The Molecular Assembly of Amyloid A beta Controls Its Neurotoxicity and Binding to Cellular Proteins.
PLOS ONE
, 6
(9)
, Article e24909. 10.1371/journal.pone.0024909.
|
|
2010
|
Chung, SK;
Vanbellinghen, JF;
Mullins, JGL;
Robinson, A;
Hantke, J;
Hammond, CL;
Gilbert, DF;
... Rees, MI; + view all
(2010)
Pathophysiological Mechanisms of Dominant and Recessive GLRA1 Mutations in Hyperekplexia.
J NEUROSCI
, 30
(28)
9612 - 9620.
10.1523/JNEUROSCI.1763-10.2010.
|
|
|
Davies, JS;
Chung, S-K;
Thomas, RH;
Robinson, A;
Hammond, CL;
Mullins, JG;
Carta, E;
... Rees, MI; + view all
(2010)
The glycinergic system in human startle disease: a genetic screening approach.
Frontiers in Molecular Neuroscience
, 3
, Article 8. 10.3389/fnmol.2010.00008.
|
|
|
Goffin, D;
Ali, AB;
Rampersaud, N;
Harkavyi, A;
Fuchs, C;
Whitton, PS;
Nairn, AC;
(2010)
Dopamine-dependent tuning of striatal inhibitory synaptogenesis.
J Neurosci
, 30
(8)
2935 - 2950.
10.1523/JNEUROSCI.4411-09.2010.
|
|
|
Shah, MM;
Hammond, RS;
Hoffman, DA;
(2010)
Dendritic ion channel trafficking and plasticity.
Trends Neurosci
, 33
(7)
307 - 316.
10.1016/j.tins.2010.03.002.
|
|
|
Thomson, AM;
(2010)
Neocortical layer 6, a review.
Front Neuroanat
, 4
, Article 13. 10.3389/fnana.2010.00013.
|
|
2009
|
Huang, Z;
Walker, MC;
Shah, MM;
(2009)
Loss of Dendritic HCN1 Subunits Enhances Cortical Excitability and Epileptogenesis.
J NEUROSCI
, 29
(35)
10979 - 10988.
10.1523/JNEUROSCI.1531-09.2009.
|
|
|
Long, P;
Mercer, A;
Begum, R;
Stephens, GJ;
Sihra, TS;
Jovanovic, JN;
(2009)
Nerve Terminal GABA(A) Receptors Activate Ca2+/Calmodulin-dependent Signaling to Inhibit Voltage-gated Ca2+ Influx and Glutamate Release.
Journal of Biological Chemistry
, 284
(13)
8717 - 8728.
10.1074/jbc.M805322200.
|
|
Long, P;
Mercer, A;
Begum, R;
Stephens, GJ;
Sihra, TS;
Jovanovic, JN;
(2009)
Nerve Terminal GABA(A) Receptors Activate Ca2+/Calmodulin-dependent Signaling to Inhibit Voltage-gated Ca2+ Influx and Glutamate Release.
J BIOL CHEM
, 284
(13)
8717 - 8728.
10.1074/jbc.M805322200.
|
|
2008
|
Bee, Lucy Ann;
(2008)
Brainstem control of spinal sensory processing in the rat.
Doctoral thesis , UCL (University College London).
|
|
Harvey, RJ;
Carta, E;
Pearce, BR;
Chung, SK;
Supplisson, S;
Rees, MI;
Harvey, K;
(2008)
A critical role for glycine transporters in hyperexcitability disorders.
Front Mol Neurosci
, 1
, Article 1. 10.3389/neuro.02.001.2008.
|
|
|
Hendrich, J.K.;
(2008)
Alpha-2-delta subunits of voltage-gated calcium channels.
Doctoral thesis , University of London.
|
|
|
Huang, Z.;
(2008)
Properties of NMDA receptors in the rat basal ganglia.
Doctoral thesis , University of London.
|
|
|
Kracun, S.;
(2008)
Molecular and functional characterisation of nicotinic acetylcholine receptor chimaeras.
Doctoral thesis , University of London.
|
|
|
Scott, R;
Ruiz, A;
Henneberger, C;
Kullmann, DM;
Rusakov, DA;
(2008)
Analog modulation of mossy fiber transmission is uncoupled from changes in presynaptic Ca2+.
J NEUROSCI
, 28
(31)
7765 - 7773.
10.1523/JNEUROSCI.1296-08.2008.
|
|
|
Wright, KE;
MacRobert, AJ;
Phillips, JB;
(2008)
Assessing the effect of photodynamic therapy on peripheral nerve and cancer cells using a thin tissue engineered collagen culture model.
In:
Abstracts of the Tissue and Cell Engineering Society (TCES) meeting 2-4 July 2008, University of Nottingham.
(pp. 13 - 13).
|
|
2007
|
Ali, AB;
(2007)
Target Dependent Short-Term Synaptic Plasticity Among Hippocampal Interneurones.
Presented at: Society for Neuroscience Annual Meeting 2007, San Diego, CA, USA.
|
|
|
Ash, E.S.;
(2007)
An investigation of the neurochemical mechanisms underlying the contrasting effects of d-amphetamine in two subregions of the rat anterior cingulate cortex.
Doctoral thesis , University of London.
|
|
|
Karam, S.M.;
(2007)
Morphine modulation of excitatory transmission in the rat spinal cord.
Doctoral thesis , University of London.
|
|
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Kelly, L.;
(2007)
Regulation of calcium-permeable AMPA receptors at cerebellar interneuron synapses.
Doctoral thesis , University of London.
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Maie, I.A.S.;
(2007)
Nociceptin and the ORL-1 receptor: analgesic mechanisms and interactions with dorsal horn neurones in rat spinal cord.
Doctoral thesis , University of London.
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Mercer, A;
Trigg, HL;
Thomson, AM;
(2007)
Characterization of neurons in the CA2 subfield of the adult rat hippocampus.
J Neurosci
, 27
(27)
7329 - 7338.
10.1523/JNEUROSCI.1829-07.2007.
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Moore, C.;
(2007)
The role of neuronal nicotinic acetylcholine receptors in central cardiovascular regulation.
Doctoral thesis , University of London.
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Tabasum, F.;
(2007)
The mechanisms of metabolic regulation of the cloned equivalent of the vascular Katp/Kndp channel.
Doctoral thesis , University of London.
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Thomson, AM;
Lamy, C;
(2007)
Functional maps of neocortical local circuitry.
Front Neurosci
, 1
(1)
19 - 42.
10.3389/neuro.01.1.1.002.2007.
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2006
|
Ali, AB;
(2006)
Presynaptic inhibition of GABAA mediated unitary IPSPs by Cannabinoid receptors at synapses innervated by CCK positive interneurones in rat CA1.
Presented at: FENS Forum Neuroscience, Vienna, Austria.
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D'Arcy, K.;
(2006)
A study of the inter-bouton exchange of synaptic vesicles at central synapses.
Doctoral thesis , University of London.
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Langmead, C.J.;
(2006)
Structural and functional characterisation of neuronal Gq protein coupled receptors.
Doctoral thesis , University of London.
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Lee, Vivian Wing Yan;
(2006)
Regulation of extracellular signal-regulated protein kinases (ERK) 1 and 2 in synaptic nerve terminals.
Doctoral thesis , UCL (University College London).
|
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Rees, MI;
Harvey, K;
Pearce, BR;
Chung, S-K;
Duguid, IC;
Thomas, P;
Beatty, S;
... Harvey, RJ; + view all
(2006)
Mutations in the gene encoding GlyT2 (SLC6A5) define a presynaptic component of human startle disease.
Nature Genetics
, 38
(7)
pp. 801-806.
10.1038/ng1814.
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Wright, KE;
Liniker, E;
MacRobert, AJ;
Brown, RA;
Saffrey, MJ;
Phillips, JB;
(2006)
Investigating the effect of photodynamic therapy on nerves using tissue engineered culture models.
In:
Abstracts of the Tissue and Cell Engineering Society (TCES) meeting 3-4 July 2006, University of Sheffield.
(pp. 51 - 51).
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2005
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Ali, AB;
Kirchhecker, S;
Thomson, A;
(2005)
Properties of unitary IPSPs elicited in lacunosum moleculare interneurones in the CA1 region of the rat hippocampus.
Presented at: Inhibition in the CNS: Gordon Research Conference, New London, NH, USA.
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Doward, A.I.;
(2005)
Assembly and trafficking of nicotinic and 5HT3 receptors.
Doctoral thesis , University of London.
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Ekonomou, A;
Kazanis, I;
Malas, S;
Wood, H;
Alifragis, P;
Denaxa, M;
Karagogeos, D;
... Episkopou, V; + view all
(2005)
Neuronal migration and ventral subtype identity in the telencephalon depend on SOX1.
PLoS Biology
, 3
(6)
, Article e186. 10.1371/journal.pbio.0030186.
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Gee, V.J.;
(2005)
Molecular and functional characterization of neuronal nicotinic and 5-HT/subscript3 receptors.
Doctoral thesis , University of London.
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Ruiz, A;
Sachidhanandam, S;
Utvik, JK;
Coussen, F;
Mulle, C;
(2005)
Distinct subunits in heteromeric kainate receptors mediate ionotropic and metabotropic function at hippocampal mossy fiber synapses.
Journal of Neuroscience
, 25
(50)
11710 - 11718.
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Stewart, R.J.;
(2005)
Investigation of a role for noradrenaline in the neurochemical and behavioural effects of an established and putative target for antianxiety/antidepressant drugs: a microdialysis and behavioural study in rats and NK1 receptor knockout mice.
Doctoral thesis , University of London.
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2004
|
Ali, AB;
(2004)
Involvement of presynaptic mGluR receptors in regulating depolarisationinduced suppression of inhibition.
Presented at: FENS Forum Neuroscience, Lisbon, Portugal.
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Harvey, K;
Duguid, IC;
Alldred, MJ;
Beatty, SE;
Ward, H;
Keep, NH;
Lingenfelter, SE;
... Harvey, RJ; + view all
(2004)
The GDP-GTP exchange factor collybistin: An essential determinant of neuronal gephyrin clustering.
J NEUROSCI
, 24
(25)
5816 - 5826.
10.1523/JNEUROSCI.1184-04.2004.
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Jovanovic, JN;
Thomas, P;
Kittler, JT;
Smart, TG;
Moss, SJ;
(2004)
Brain-derived neurotrophic factor modulates fast synaptic inhibition by regulating GABA(A) receptor phosphorylation, activity, and cell-surface stability.
J NEUROSCI
, 24
(2)
522 - 530.
10.1523/JNEUROSCI.3606-03.2004.
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Taylor-Clark, TE;
(2004)
An investigation into the roles of histamine receptors in the control of human nasal blockage.
Doctoral thesis , University of London.
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Terunuma, M;
Jang, IS;
Ha, SH;
Kittler, JT;
Kanematsu, T;
Jovanovic, JN;
Nakayama, KI;
... Hirata, M; + view all
(2004)
GABA(A) receptor phospho-dependent modulation is regulated by phospholipase C-related inactive protein type 1, a novel protein phosphatase 1 anchoring protein.
J NEUROSCI
, 24
(32)
7074 - 7084.
10.1523/JNEUROSCI.1323-04.2004.
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2002
|
Brandon, NJ;
Jovanovic, JN;
Smart, TG;
Moss, SJ;
(2002)
Receptor for activated C kinase-1 facilitates protein kinase C-dependent phosphorylation and functional modulation of GABA(A) receptors with the activation of G-protein-coupled receptors.
J NEUROSCI
, 22
(15)
6353 - 6361.
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Thomson, AM;
Bannister, AP;
Mercer, A;
Morris, OT;
(2002)
Target and temporal pattern selection at neocortical synapses.
Philos Trans R Soc Lond B Biol Sci
, 357
(1428)
1781 - 1791.
10.1098/rstb.2002.1163.
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2001
|
Jovanovic, JN;
Sihra, TS;
Nairn, AC;
Hemmings, HC;
Greengard, P;
Czernik, AJ;
(2001)
Opposing changes in phosphorylation of specific sites in synapsin I during Ca2+-dependent glutamate release in isolated nerve terminals.
J NEUROSCI
, 21
(20)
7944 - 7953.
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2000
|
Kittler, JT;
Delmas, P;
Jovanovic, JN;
Brown, DA;
Smart, TG;
Moss, SJ;
(2000)
Constitutive endocytosis of GABA(A) receptors by an association with the adaptin AP2 complex modulates inhibitory synaptic currents in hippocampal neurons.
J NEUROSCI
, 20
(21)
7972 - 7977.
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Shah, M;
Haylett, DG;
(2000)
The pharmacology of hSK1 Ca2+-activated K+ channels expressed in mammalian cell lines.
Br J Pharmacol
, 129
(4)
627 - 630.
10.1038/sj.bjp.0703111.
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1999
|
Azam, R;
(1999)
The pharmacology of three inwardly rectifying potassium
Channels in neonatal rat cardiac myocytes.
Doctoral thesis , University of London.
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Turner, PJ;
(1999)
Mechanisms of hyperresponsiveness in the human nasal airway: role of kinins and nitrous oxide.
Doctoral thesis , University of London.
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Wibulswas, A;
(1999)
Functional implications of CD44 splice variant expression in rheumatoid arthritis.
Doctoral thesis , University of London.
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1996
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Dear, JW;
(1996)
Characterisation of the kynin receptor in the human nasal airway and its role in allergic rhinitis.
Doctoral thesis , University of London.
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Tatla, S;
(1996)
The role of reactive oxygen species in lymphocyte activation.
Doctoral thesis , University of London.
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