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Electrostatic self-assembled graphene oxide-collagen scaffolds towards a three-dimensional microenvironment for biomimetic applications

Girão, AF; Gonçalves, G; Bhangra, KS; Phillips, JB; Knowles, J; Irurueta, G; Singh, MK; ... Marques, PAAP; + view all (2016) Electrostatic self-assembled graphene oxide-collagen scaffolds towards a three-dimensional microenvironment for biomimetic applications. RSC Advances , 6 (54) pp. 49039-49051. 10.1039/c6ra10213a. Green open access

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Abstract

In light of the importance of collagen, one of the most abundant proteins in mammals, the preparation of collagen-based scaffolds is gaining interest in the field of tissue engineering. However, there is a need to develop strategies to produce collagen three dimensional structures with mechanical properties suitable for proper handling and manipulation. In this regard, we report here a self-assembled GO-collagen (GO-Col) scaffold with a porous network resulting from preferential interaction of oxygen functional groups located on the GO nanosheet edges with amine groups on the biopolymer chain. The accurate control of such conjugation, which is dependent on both the pH of the medium and the collagen/GO weight ratio used during the synthesis, allows the repulsion and bonding forces within the GO-Col nanocomposite system to be to minutely modulated and consequently also provides the opportunity to fabricate a wide range of stable GO-Col scaffolds. Results concerning the stability in physiological medium under mechanical stimulation and the cytocompatibility of the most viable GO-Col scaffold in terms of mechanical integrity and its reduced counterpart indicated that these novel scaffolds provide a useful new approach for the assembly of suitable cellular microenvironments that could be explored in tissue engineering applications.

Type: Article
Title: Electrostatic self-assembled graphene oxide-collagen scaffolds towards a three-dimensional microenvironment for biomimetic applications
Open access status: An open access version is available from UCL Discovery
DOI: 10.1039/c6ra10213a
Publisher version: http://dx.doi.org/10.1039/c6ra10213a
Language: English
Additional information: Copyright © The Royal Society of Chemistry 2016.
Keywords: graphene oxide, collagen, scaffolds, self-assembled hydrogel, Schwann cell, cytocompatibility , tissue engineering
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmacology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Biomaterials and Tissue Eng
URI: https://discovery.ucl.ac.uk/id/eprint/1498773
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