Manzoni, C;
(2017)
The LRRK2-macroautophagy axis and its relevance to Parkinson's disease.
Biochemical Society Transactions
, 45
(1)
pp. 155-162.
10.1042/BST20160265.
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Abstract
A wide variety of different functions and an impressive array of interactors have been associated with leucine-rich repeat kinase 2 (LRRK2) over the years. Here, I discuss the hypothesis that LRRK2 may be capable of interacting with different proteins at different times and places, therefore, controlling a plethora of diverse functions based on the different complexes formed. Among these, I will then focus on macroautophagy in the general context of the endolysosomal system. First, the relevance of autophagy in Parkinson's disease will be evaluated giving a brief overview of all the relevant Parkinson's disease genes; then, the association of LRRK2 with macroautophagy and the endolysosomal pathway will be analyzed based on the supporting literature.
| Type: | Article |
|---|---|
| Title: | The LRRK2-macroautophagy axis and its relevance to Parkinson's disease |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1042/BST20160265 |
| Publisher version: | https://doi.org/10.1042/BST20160265 |
| Language: | English |
| Additional information: | © 2017 The Author(s). This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (https://creativecommons.org/licenses/by/4.0). |
| Keywords: | autophagy, leucine-rich repeat kinase, neurodegeneration, Parkinson's disease |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmacology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10094181 |
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