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Aligned Bioelectronic Polypyrrole/Collagen Constructs for Peripheral Nerve Interfacing

Trueman, Ryan P; Guillemot-Legris, Owein; Lancashire, Henry T; Mehta, Abijeet S; Tropp, Joshua; Daso, Rachel E; Rivnay, Jonathan; ... Schroeder, Bob C; + view all (2024) Aligned Bioelectronic Polypyrrole/Collagen Constructs for Peripheral Nerve Interfacing. Advanced Engineering Materials , Article e2301488. 10.1002/adem.202301488. (In press). Green open access

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Abstract

Electrical stimulation has shown promise in clinical studies to treat nerve injuries. This work is aimed to create an aligned bioelectronic construct that can be used to bridge a nerve gap, directly interfacing with the damaged nerve tissue to provide growth support. The conductive three-dimensional bioelectronic scaffolds described herein are composite materials, comprised of conductive polypyrrole (PPy) nanoparticles embedded in an aligned collagen hydrogel. The bioelectronic constructs are seeded with dorsal root ganglion derived primary rat neurons and electrically stimulated in vitro. The PPy loaded constructs support a 1.7-fold increase in neurite length in comparison to control collagen constructs. Furthermore, upon electrical stimulation of the PPy-collagen construct, a 1.8-fold increase in neurite length is shown. This work illustrates the potential of bioelectronic constructs in neural tissue engineering and lays the groundwork for the development of novel bioelectronic materials for neural interfacing applications.

Type: Article
Title: Aligned Bioelectronic Polypyrrole/Collagen Constructs for Peripheral Nerve Interfacing
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/adem.202301488
Publisher version: http://dx.doi.org/10.1002/adem.202301488
Language: English
Additional information: © 2024 The Authors. Advanced Engineering Materials published by Wiley-VCH GmbH This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: bioelectronics, nerve repair, neural engineering, polypyrrole, tissue engineering
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmacology
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry
URI: https://discovery.ucl.ac.uk/id/eprint/10187714
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