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Engineered neural tissue for peripheral nerve repair.

Georgiou, M; Bunting, SC; Davies, HA; Loughlin, AJ; Golding, JP; Phillips, JB; (2013) Engineered neural tissue for peripheral nerve repair. Biomaterials , 34 (30) 7335 - 7343. 10.1016/j.biomaterials.2013.06.025. Green open access

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Abstract

A new combination of tissue engineering techniques provides a simple and effective method for building aligned cellular biomaterials. Self-alignment of Schwann cells within a tethered type-1 collagen matrix, followed by removal of interstitial fluid produces a stable tissue-like biomaterial that recreates the aligned cellular and extracellular matrix architecture associated with nerve grafts. Sheets of this engineered neural tissue supported and directed neuronal growth in a co-culture model, and initial in vivo tests showed that a device containing rods of rolled-up sheets could support neuronal growth during rat sciatic nerve repair (5 mm gap). Further testing of this device for repair of a critical-sized 15 mm gap showed that, at 8 weeks, engineered neural tissue had supported robust neuronal regeneration across the gap. This is, therefore, a useful new approach for generating anisotropic engineered tissues, and it can be used with Schwann cells to fabricate artificial neural tissue for peripheral nerve repair.

Type: Article
Title: Engineered neural tissue for peripheral nerve repair.
Location: Netherlands
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.biomaterials.2013.06.025
Publisher version: http://dx.doi.org/10.1016/j.biomaterials.2013.06.0...
Language: English
Additional information: �© 2013 Elsevier Ltd. All rights reserved. This work is licensed under a Creative Commons Attribution 3.0 Unported License.
Keywords: Collagen, Hydrogel, Nerve guide, Nerve regeneration, Nerve tissue engineering, Schwann cell
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmacology
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
URI: https://discovery.ucl.ac.uk/id/eprint/1414809
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