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Neuronal HCN channel Function and Plasticity

Shah, MM; (2018) Neuronal HCN channel Function and Plasticity. Current Opinion in Physiology , 2 pp. 92-97. 10.1016/j.cophys.2018.01.001. Green open access

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Abstract

The hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channel is a voltage-gated cation channel that is activated with hyperpolarization. Four subunits, HCN1–4, have thus far been identified. All four subunits are expressed in the central nervous system (CNS), though their expression pattern varies considerably. In many CNS neurons, HCN channels are localised to somato-dendritic compartments where they regulate the resting membrane potential and membrane resistance, and thereby affect synaptic potential shapes and integration and neuronal firing patterns. Emerging evidence suggests that HCN channels are also present within certain axons and synaptic terminals. Modulation of presynaptic HCN channel activity leads to altered synaptic release in a synapsespecific manner. Given that HCN channel function can be modified by activity-dependent and neurotransmitter receptor activation, HCN channels may diversely affect neuronal and network excitability, thereby affecting physiological states such as learning and memory as well as pathophysiological conditions such as epilepsy and depression.

Type: Article
Title: Neuronal HCN channel Function and Plasticity
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.cophys.2018.01.001
Publisher version: https://doi.org/10.1016/j.cophys.2018.01.001
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmacology
URI: https://discovery.ucl.ac.uk/id/eprint/10043066
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