Recino, Asha;
Rayner, Melissa LD;
Rohn, Jennifer L;
Pasqua, Oscar Della;
UCL Repurposing TIN, Committee;
(2025)
Therapeutic innovation in drug repurposing: Challenges and opportunities.
Drug Discovery Today
, Article 104390. 10.1016/j.drudis.2025.104390.
(In press).
Preview |
Text
Della Pasqua_Therapeutic innovation in drug repurposing_Pre-proof.pdf Download (1MB) | Preview |
Abstract
Drug repurposing leverages existing drugs for new therapeutic uses, offering significant opportunities but facing challenges such as financial and regulatory barriers and the need for robust evidence for an efficient clinical development plan. This paper examines the critical steps in drug repurposing and their role in improving study success rates. It also highlights the support infrastructure provided by the University College London (UCL) Repurposing Therapeutic Innovation Network (TIN), as a partnership model to address these challenges through diverse expertise, enterprise insight, and tailored guidance. By fostering collaborations and offering structured support, the Repurposing TIN aims to accelerate repurposing efforts and deliver patient benefits. We invite potential collaborators to join us in advancing drug repurposing through innovative and strategic approaches.
| Type: | Article |
|---|---|
| Title: | Therapeutic innovation in drug repurposing: Challenges and opportunities |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.drudis.2025.104390 |
| Publisher version: | https://doi.org/10.1016/j.drudis.2025.104390 |
| Language: | English |
| Additional information: | © 2025 The Authors. Published by Elsevier Ltd. under a Creative Commons license (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | drug repurposing, translational pharmacology, proof of concept, clinical development plan, regulatory approval, therapeutic innovation, private-public partnerships, attrition |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmacology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10209401 |
Archive Staff Only
 |
View Item |
