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Assessing the effect of photodynamic therapy on peripheral nerve and cancer cells using a thin tissue engineered collagen culture model

Wright, KE; MacRobert, AJ; Phillips, JB; (2008) Assessing the effect of photodynamic therapy on peripheral nerve and cancer cells using a thin tissue engineered collagen culture model. In: Abstracts of the Tissue and Cell Engineering Society (TCES) meeting 2-4 July 2008, University of Nottingham. (pp. 13 - 13). Green open access

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Abstract

This study used an innovative thin 3D collagen culture system, to evaluate the response of primary rat peripheral nerve cells to photodynamic therapy (PDT). PDT is a cancer therapy that involves the administration of a photosensitive drug which becomes activated following the focal application of light to tumour sites. The subsequent production of toxic singlet oxygen results in cell death. Clinically, nerve sparing has been observed after meta tetra hydroxyl phenyl chlorine (mTHPC) mediated PDT. This study aims to simulate nerve PDT in culture with a thin tissue engineered collagen scaffold model in order to assess the cellular basis for the phenomenon of peripheral nerve sparing after PDT.

Type: Proceedings paper
Title: Assessing the effect of photodynamic therapy on peripheral nerve and cancer cells using a thin tissue engineered collagen culture model
Event: Tissue and Cell Engineering Society (TCES) meeting
Location: University of Nottingham
Dates: 02 July 2008- 04 July 2008
Open access status: An open access version is available from UCL Discovery
Publisher version: http://www.ecmjournal.org/journal/supplements/vol0...
Language: English
Additional information: Reproduced with kind permission from eCM journal (www.ecmjournal.org)
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmacology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Surgical Biotechnology
URI: https://discovery.ucl.ac.uk/id/eprint/1360159
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