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Development of cortical GABAergic innervation.

Jovanovic, JN; Thomson, AM; (2011) Development of cortical GABAergic innervation. Front Cell Neurosci , 5 , Article 14. 10.3389/fncel.2011.00014. Green open access

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Abstract

The mature neocortex contains many different classes of GABAergic inhibitory interneurons, distributed, with some degree of selectivity, through six layers, and through many different regions. Some of the events in the early lives of these neurones that may determine their ultimate destination, their maturation and their selective innervation of targets appropriate for each subtype, are discussed. Both time and place of birth influence the class of interneuron that an early post-mitotic interneuronal precursor will become, driven by the selective expression of different combinations of transcription factors in different regions of their birth places in the ganglionic eminence and ventricular zone. The long distance migration of these precursors along tangential routes in marginal, subventricular, and intermediate zones and their final radial movement, into the developing cortex, is regulated by chemical cues, both attractant and repellent. Once they arrive at their final destination, they must integrate into the developing circuitry. As they mature within the cortex, their axons grow and branch in highly specific patterns that may be partially determined by the genetic blueprint for each interneuronal class and partly by the environment in which they find themselves. Finally, as each interneuron class begins to form synapses with only certain postsynaptic targets, cell-cell recognition, most probably via protein-protein interactions across the synaptic cleft, facilitate the formation of appropriate synapses.

Type: Article
Title: Development of cortical GABAergic innervation.
Location: Switzerland
Open access status: An open access version is available from UCL Discovery
DOI: 10.3389/fncel.2011.00014
Publisher version: http://dx.doi.org/10.3389/fncel.2011.00014
Language: English
Additional information: PMCID: PMC3139172. © 2011 Jovanovic and Thomson. This is an open-access article subject to a non-exclusive license between the authors and Frontiers Media SA. This Document is protected by copyright and was first published by Frontiers. All rights reserved. It is reproduced with permission
Keywords: synapse, GABA, inhibition, development, interneuron, cortex, synaptogenesis, ganglionic eminence
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmacology
URI: https://discovery.ucl.ac.uk/id/eprint/1352694
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