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Reducing bias in open-label trials where blinded outcome assessment is not feasible: strategies from two randomised trials.

Kahan, BC; Cro, S; Doré, CJ; Bratton, DJ; Rehal, S; Maskell, NA; Rahman, N; (2014) Reducing bias in open-label trials where blinded outcome assessment is not feasible: strategies from two randomised trials. Trials , 15 , Article 456. 10.1186/1745-6215-15-456. Green open access

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Abstract

Blinded outcome assessment is recommended in open-label trials to reduce bias, however it is not always feasible. It is therefore important to find other means of reducing bias in these scenarios.

Type: Article
Title: Reducing bias in open-label trials where blinded outcome assessment is not feasible: strategies from two randomised trials.
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1186/1745-6215-15-456
Publisher version: http://dx.doi.org/10.1186/1745-6215-15-456
Language: English
Additional information: © 2014 Kahan et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmacology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > Comprehensive CTU at UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL
URI: https://discovery.ucl.ac.uk/id/eprint/1457990
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