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Functional maps of neocortical local circuitry.

Thomson, AM; Lamy, C; (2007) Functional maps of neocortical local circuitry. Front Neurosci , 1 (1) 19 - 42. 10.3389/neuro.01.1.1.002.2007. Green open access

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Abstract

This review aims to summarize data obtained with different techniques to provide a functional map of the local circuit connections made by neocortical neurones, a reference for those interested in cortical circuitry and the numerical information required by those wishing to model the circuit. A brief description of the main techniques used to study circuitry is followed by outline descriptions of the major classes of neocortical excitatory and inhibitory neurones and the connections that each layer makes with other cortical and subcortical regions. Maps summarizing the projection patterns of each class of neurone within the local circuit and tables of the properties of these local circuit connections are provided.This review relies primarily on anatomical studies that have identified the classes of neurones and their local and long distance connections and on paired intracellular and whole-cell recordings which have documented the properties of the connections between them. A large number of different types of synaptic connections have been described, but for some there are only a few published examples and for others the details that can only be obtained with paired recordings and dye-filling are lacking. A further complication is provided by the range of species, technical approaches and age groups used in these studies. Wherever possible the range of available data are summarised and compared. To fill some of the more obvious gaps for the less well-documented cases, data obtained with other methods are also summarized.

Type: Article
Title: Functional maps of neocortical local circuitry.
Location: Switzerland
Identifier: PMCID: PMC2518047
Open access status: An open access version is available from UCL Discovery
DOI: 10.3389/neuro.01.1.1.002.2007
Publisher version: http://www.frontiersin.org//neuroscience/10.3389/n...
Language: English
Additional information: © 2007 Thomson and Lamy. This is an open-access article subject to an exclusive license agreement between the authors and the Frontiers Research Foundation. This document is protected by copyright and was first published by Frontiers. All rights reserved. It is reproduced with permission.
Keywords: cortex, pyramidal cell, interneuron(e), synapse, EPSP/C (excitatory postsynaptic potential/current), IPSP/C (inhibitory postsynaptic potential/current)
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmacology
URI: https://discovery.ucl.ac.uk/id/eprint/1351038
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