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Structural Changes Observed in the Piriform Cortex in a Rat Model of Pre-motor Parkinson’s Disease

Sancandi, M; Schul, EV; Economides, G; Constanti, A; Mercer, A; (2018) Structural Changes Observed in the Piriform Cortex in a Rat Model of Pre-motor Parkinson’s Disease. Frontiers in Cellular Neuroscience , 12 , Article 479. 10.3389/fncel.2018.00479. Green open access

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Abstract

Early diagnosis of Parkinson’s disease (PD) offers perhaps, the most promising route to a successful clinical intervention, and the use of an animal model exhibiting symptoms comparable to those observed in PD patients in the early stage of the disease, may facilitate screening of novel therapies for delaying the onset of more debilitating motor and behavioral abnormalities. In this study, a rat model of pre-motor PD was used to study the etiology of hyposmia, a non-motor symptom linked to the early stage of the disease when the motor symptoms have yet to be experienced. The study focussed on determining the effect of a partial reduction of both dopamine and noradrenaline levels on the olfactory cortex. Neuroinflammation and striking structural changes were observed in the model. These changes were prevented by treatment with a neuroprotective drug, a glucagon-like peptide-1 (GLP1) receptor agonist, exendin-4 (EX-4).

Type: Article
Title: Structural Changes Observed in the Piriform Cortex in a Rat Model of Pre-motor Parkinson’s Disease
Open access status: An open access version is available from UCL Discovery
DOI: 10.3389/fncel.2018.00479
Publisher version: http://doi.org/10.3389/fncel.2018.00479
Language: English
Additional information: Copyright © 2018 Sancandi, Schul, Economides, Constanti and Mercer. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) - https://creativecommons.org/licenses/by/4.0/. The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Keywords: olfaction, interneurons, extracellular matrix, perineuronal nets, early stage Parkinson’s disease, GLP-1 agonist, exendin-4
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmacology
URI: https://discovery.ucl.ac.uk/id/eprint/10064032
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