Browse by UCL Department: listings for include files
- UCL (196853)
- UCL (196853)
- Provost and Vice Provost Offices (195621)
- School of Life and Medical Sciences (95959)
- Faculty of Brain Sciences (35587)
- UCL Queen Square Institute of Neurology (15276)
- UK Dementia Research Institute (276)
- UCL Queen Square Institute of Neurology (15276)
- Faculty of Brain Sciences (35587)
- School of Life and Medical Sciences (95959)
- Provost and Vice Provost Offices (195621)
- UCL (196853)
Number of items at this level: 276.
A
Ackels, T;
Erskine, A;
Dasgupta, D;
Marin, AC;
Warner, TPA;
Tootoonian, S;
Fukunaga, I;
... Schaefer, AT; + view all
(2021)
Fast odour dynamics are encoded in the olfactory system and guide behaviour.
Nature
, 593
pp. 558-563.
10.1038/s41586-021-03514-2.
|
|
Agnew, T;
Goldsworthy, M;
Aguilar, C;
Morgan, A;
Simon, M;
Hilton, H;
Esapa, C;
... Cox, RD; + view all
(2018)
A Wars2 Mutant Mouse Model Displays OXPHOS Deficiencies and Activation of Tissue-Specific Stress Response Pathways.
Cell Reports
, 25
(12)
3315-3328.e6.
10.1016/j.celrep.2018.11.080.
|
 |
|
Ahlfors, H;
Anyanwu, N;
Pakanavicius, E;
Dinischiotu, N;
Lana-Elola, E;
Watson-Scales, S;
Tosh, J;
... Tybulewicz, VLJ; + view all
(2019)
Gene expression dysregulation domains are not a specific feature of Down syndrome.
Nature Communications
, 10
(1)
, Article 2489. 10.1038/s41467-019-10129-9.
|
|
|
Ahmed, MM;
Dhanasekaran, AR;
Tong, S;
Wiseman, FK;
Fisher, EM;
Tybulewicz, VL;
Gardiner, KJ;
(2013)
Protein profiles in Tc1 mice implicate novel pathway perturbations in the Down syndrome brain.
Human Molecular Genetics
, 22
(9)
1709 -1724.
10.1093/hmg/ddt017.
|
 |
|
Alić, I;
Goh, PA;
Murray, A;
Portelius, E;
Gkanatsiou, E;
Gough, G;
Mok, KY;
... Nižetić, D; + view all
(2020)
Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain.
Molecular Psychiatry
10.1038/s41380-020-0806-5.
|
|
|
Altendahl, M;
Cotter, DL;
Staffaroni, AM;
Wolf, A;
Mumford, P;
Cobigo, Y;
Casaletto, K;
... Walsh, CM; + view all
(2020)
REM sleep is associated with white matter integrity in cognitively healthy, older adults.
PLoS One
, 15
(7)
, Article e0235395. 10.1371/journal.pone.0235395.
|
|
|
Andrews, Rebecca;
Fu, Bin;
Toomey, Christina E;
Breiter, Jonathan C;
Lachica, Joanne;
Beckwith, Joseph S;
Tian, Ru;
... Lee, Steven F; + view all
(2025)
Large-scale visualization of α-synuclein oligomers in Parkinson’s disease brain tissue.
Nature Biomedical Engineering
10.1038/s41551-025-01496-4.
(In press).
|
|
|
Arancibia-Carcamo, IL;
Attwell, D;
(2014)
The node of Ranvier in CNS pathology.
Acta Neuropathol
, 28
(8)
pp. 161-175.
10.1007/s00401-014-1305-z.
|
|
|
Arancibia-Carcamo, IL;
Ford, MC;
Cossell, L;
Ishida, K;
Tohyama, K;
Attwell, D;
(2017)
Node of Ranvier length as a potential regulator of myelinated axon conduction speed.
eLife
, 6
, Article e23329. 10.7554/eLife.23329.
|
|
Area-Gomez, E;
Larrea, D;
Pera, M;
Agrawal, RR;
Guilfoyle, DN;
Pirhaji, L;
Shannon, K;
... Nuriel, T; + view all
(2020)
APOE4 is Associated with Differential Regional Vulnerability to Bioenergetic Deficits in Aged APOE Mice.
Scientific Reports
, 10
, Article 4277. 10.1038/s41598-020-61142-8.
|
|
|
Attwell, D;
Madry, C;
Kyrargyri, V;
Arancibia-Carcamo, IL;
Jolivet, R;
Kohsaka, S;
Bryan, R;
(2018)
Microglial ramification, surveillance and interleukin-1beta release are regulated by the two-pore domain K+ channel THIK-1.
Neuron
, 97
(2)
pp. 299-312.
10.1016/j.neuron.2017.12.002.
|
|
B
|
Baligacs, Nora;
Albertini, Giulia;
Borrie, Sarah C;
Serneels, Lutgarde;
Pridans, Clare;
Balusu, Sriram;
De Strooper, Bart;
(2024)
Homeostatic microglia initially seed and
activated microglia later reshape amyloid
plaques in Alzheimer’s Disease.
Nature Communications
, 15
, Article 10634. 10.1038/s41467-024-54779-w.
|
|
|
Balligand, Thomas;
Carpenet, Claire;
Olivé Palau, Sergi;
Jaspers, Tom;
Suresh, Pavana;
Liu, Xin;
Medhi, Himadri;
... Dewilde, Maarten; + view all
(2025)
A pair of congenic mice for imaging of transplants by positron emission tomography using anti-transferrin receptor nanobodies.
eLife
, 14
, Article RP104302. 10.7554/eLife.104302.
|
|
|
Balusu, Sriram;
De Strooper, Bart;
(2024)
The necroptosis cell death pathway drives neurodegeneration in Alzheimer's disease.
Acta Neuropathologica
, 147
(1)
, Article 96. 10.1007/s00401-024-02747-5.
|
|
Balusu, Sriram;
Horré, Katrien;
Thrupp, Nicola;
Craessaerts, Katleen;
Snellinx, An;
Serneels, Lutgarde;
T'Syen, Dries;
... De Strooper, Bart; + view all
(2023)
MEG3 activates necroptosis in human neuron xenografts modeling Alzheimer’s disease.
Science
, 381
(6663)
pp. 1176-1182.
10.1126/science.abp9556.
|
|
|
Barski, JJ;
Hartmann, J;
Rose, CR;
Hoebeek, F;
Morl, K;
Noll-Hussong, M;
De Zeeuw, CI;
... Meyer, M; + view all
(2003)
Calbindin in cerebellar Purkinje cells is a critical determinant of the precision of motor coordination.
Journal of Neuroscience
, 23
(8)
3469 - 3477.
|
|
|
Bartels, T;
(2019)
A traffic jam leads to Lewy bodies.
Nature Neuroscience
, 22
pp. 1043-1045.
10.1038/s41593-019-0435-y.
|
|
Bartels, T;
De Schepper, S;
Hong, S;
(2020)
Microglia modulate neurodegeneration in Alzheimer's and Parkinson's diseases.
Science
, 370
(6512)
pp. 66-69.
10.1126/science.abb8587.
|
|
|
Bauza, Marius;
Krstulovic, Marino;
Krupic, Julija;
(2023)
Unsupervised, frequent and remote: A novel platform for personalised digital phenotyping of long-term memory in humans.
PLoS One
, 18
(4)
, Article e0284220. 10.1371/journal.pone.0284220.
|
|
|
Birkle, Tim;
Brown, GC;
(2021)
I'm Infected, Eat Me! Innate Immunity Mediated by Live, Infected Cells Signaling To Be Phagocytosed.
Infection and Immunity
, 89
(5)
, Article e00476-20. 10.1128/iai.00476-20.
|
|
Birkle, Timothy JY;
Brown, Guy C;
(2023)
Syk inhibitors protect against microglia-mediated neuronal loss in culture.
Frontiers in Aging Neuroscience
, 15
, Article 1120952. 10.3389/fnagi.2023.1120952.
|
|
Blackburn, Emily Victoria;
(2025)
Investigating BDNF/TrkB signalling in neuronal models of Alzheimer's disease in Down syndrome.
Doctoral thesis (Ph.D), UCL(University College London).
|
|
Blaudin de Thé, F-X;
Lassus, B;
Schaler, AW;
Fowler, SL;
Goulbourne, CN;
Jeggo, R;
Mannoury la Cour, C;
... Duff, KE; + view all
(2021)
P62 accumulates through neuroanatomical circuits in response to tauopathy propagation.
Acta Neuropathologica Communications
, 9
, Article 177. 10.1186/s40478-021-01280-w.
|
|
|
Boorman, Luke W;
Harris, Samuel S;
Shabir, Osman;
Lee, Llywelyn;
Eyre, Beth;
Howarth, Clare;
Berwick, Jason;
(2023)
Bidirectional alterations in brain temperature profoundly modulate spatiotemporal neurovascular responses in-vivo.
Communications Biology
, 6
(1)
, Article 185. 10.1038/s42003-023-04542-6.
|
|
Boyanova, Sevda;
Banks, Gareth;
Lipina, Tatiana V;
Bains, Rasneer Sonia;
Forrest, Hamish;
Stewart, Michelle;
Carcolé, Mireia;
... Wiseman, Frances K; + view all
(2025)
Multi-modal comparative phenotyping of knock-in mouse models of frontotemporal dementia/amyotrophic lateral sclerosis.
Disease Models & Mechanisms
, 18
(8)
, Article dmm052324. 10.1242/dmm.052324.
|
|
Busche, MA;
(2019)
Tau suppresses neuronal activity in vivo, even before tangles form.
Brain
, 142
(4)
pp. 843-846.
10.1093/brain/awz060.
|
|
Busche, MA;
Hyman, BT;
(2020)
Synergy between amyloid-β and tau in Alzheimer's disease.
Nature Neuroscience
, 23
pp. 1183-1193.
10.1038/s41593-020-0687-6.
|
|
Busche, MA;
Wegmann, S;
Dujardin, S;
Commins, C;
Schiantarelli, J;
Klickstein, N;
Kamath, T;
... Hyman, BT; + view all
(2019)
Tau impairs neural circuits, dominating amyloid-beta effects, in Alzheimer models in vivo.
Nature Neuroscience
, 22
(1)
pp. 57-64.
10.1038/s41593-018-0289-8.
|
C
|
Calafate, S;
Özturan, G;
Thrupp, N;
Vanderlinden, J;
Santa-Marinha, L;
Morais-Ribeiro, R;
Ruggiero, A;
... de Wit, J; + view all
(2023)
Early alterations in the MCH system link aberrant neuronal activity and sleep disturbances in a mouse model of Alzheimer’s disease.
Nature Neuroscience
10.1038/s41593-023-01325-4.
(In press).
|
|
|
Cannavo, C;
Cleverley, K;
Maduro, C;
Mumford, P;
Moulding, D;
Fisher, EMC;
Wiseman, FK;
(2022)
Endosomal structure and APP biology are not altered in a preclinical mouse cellular model of Down syndrome.
PLoS ONE
, 17
(5)
, Article e0262558. 10.1371/journal.pone.0262558.
|
|
Cannavo, C;
Tosh, J;
Fisher, EMC;
Wiseman, FK;
(2020)
Using mouse models to understand Alzheimer's disease mechanisms in the context of trisomy of chromosome 21.
In: Dierssen, M, (ed.)
Progress in Brain Research.
(pp. 181-208).
Elsevier: London, UK.
|
|
Capano, LS;
Sato, C;
Ficulle, E;
Yu, A;
Horie, K;
Kwon, JS;
Burbach, KF;
... Yoo, AS; + view all
(2022)
Recapitulation of endogenous 4R tau expression and formation of insoluble tau in directly reprogrammed human neurons.
Cell Stem Cell
, 29
(6)
918-932.e8.
10.1016/j.stem.2022.04.018.
|
|
Chang, P;
Bush, D;
Schorge, S;
Good, M;
Canonica, T;
Shing, N;
Noy, S;
... Fisher, EMC; + view all
(2020)
Altered Hippocampal-Prefrontal Neural Dynamics in Mouse Models of Down Syndrome.
Cell Reports
, 30
(4)
1152-1163.e4.
10.1016/j.celrep.2019.12.065.
|
|
|
Chaudhuri-Vayalambrone, Prannoy;
Rule, Michael Everett;
Bauza, Marius;
Krstulovic, Marino;
Kerekes, Pauline;
Burton, Stephen;
O'Leary, Timothy;
(2023)
Simultaneous representation of multiple time horizons by entorhinal grid cells and CA1 place cells.
Cell Reports
, 42
(7)
, Article 112716. 10.1016/j.celrep.2023.112716.
|
|
|
Chelban, V;
Wilson, MP;
Warman Chardon, J;
Vandrovcova, J;
Zanetti, MN;
Zamba-Papanicolaou, E;
Efthymiou, S;
... SYNaPS Study Group, .; + view all
(2019)
PDXK mutations cause polyneuropathy responsive to PLP supplementation.
Annals of Neurology
10.1002/ana.25524.
(In press).
|
|
|
Chen, S;
Acosta, D;
Li, L;
Liang, J;
Chang, Y;
Wang, C;
Fitzgerald, J;
... Fu, H; + view all
(2022)
Wolframin is a novel regulator of tau pathology and neurodegeneration.
Acta Neuropathologica
, 143
pp. 547-569.
10.1007/s00401-022-02417-4.
|
|
Chen, S;
Chang, Y;
Li, L;
Acosta, D;
Li, Y;
Guo, Q;
Wang, C;
... Fu, H; + view all
(2022)
Spatially resolved transcriptomics reveals genes associated with the vulnerability of middle temporal gyrus in Alzheimer’s disease.
Acta Neuropathologica Communications
, 10
(1)
, Article 188. 10.1186/s40478-022-01494-6.
|
|
Chen, W-T;
Lu, A;
Craessaerts, K;
Pavie, B;
Sala Frigerio, C;
Corthout, N;
Qian, X;
... De Strooper, B; + view all
(2020)
Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer's Disease.
Cell
, 182
(4)
976-991.e19.
10.1016/j.cell.2020.06.038.
|
|
Choong, XY;
(2015)
Investigating contributions of trisomy 21 in Down syndrome to Alzheimer disease phenotypes in a novel mouse cross.
Doctoral thesis , UCL (University College London).
|
|
|
Cisneros, E;
di Marco, F;
Rueda-Carrasco, J;
Lillo, C;
Pereyra, G;
Martín-Bermejo, MJ;
Vargas, A;
... Bovolenta, P; + view all
(2020)
Sfrp1 deficiency makes retinal photoreceptors prone to degeneration.
Scientific Reports
, 10
(1)
, Article 5115. 10.1038/s41598-020-61970-8.
|
|
|
Claes, C;
Van Den Daele, J;
Boon, R;
Schouteden, S;
Colombo, A;
Monasor, LS;
Fiers, M;
... Verfaillie, CM; + view all
(2018)
Human stem cell-derived monocytes and microglia-like cells reveal impaired amyloid plaque clearance upon heterozygous or homozygous loss of TREM2.
Alzheimer's & Dementia
10.1016/j.jalz.2018.09.006.
|
|
|
Clarke-Williams, Charlie J;
Lopes-dos-Santos, Vítor;
Lefèvre, Laura;
Brizee, Demi;
Causse, Adrien A;
Rothaermel, Roman;
Hartwich, Katja;
... Dupret, David; + view all
(2024)
Coordinating brain-distributed network activities in memory resistant to extinction.
Cell
, 187
(2)
409-427.e19.
10.1016/j.cell.2023.12.018.
|
|
|
Clelland, James D;
Read, Laura L;
Drouet, Valerie;
Kaon, Angela;
Kelly, Alexandra;
Duff, Karen E;
Nadrich, Robert H;
... Clelland, Catherine L; + view all
(2014)
Vitamin D insufficiency and schizophrenia risk: Evaluation of hyperprolinemia as a mediator of association.
Schizophrenia Research
, 156
(1)
pp. 15-22.
10.1016/j.schres.2014.03.017.
|
|
|
Cleverley, K;
Lee, WC;
Mumford, P;
Collins, T;
Rickman, M;
Cunningham, TJ;
Cleak, J;
... Fisher, EMC; + view all
(2021)
A novel knockout mouse for the small EDRK-rich factor 2 (Serf2) showing developmental and other deficits.
Mammalian Genome
10.1007/s00335-021-09864-6.
(In press).
|
|
|
Couedic, TL;
Caillon, R;
Rossant, F;
Joutel, A;
Urien, H;
Rajani, RM;
(2020)
Deep-learning based segmentation of challenging myelin sheaths.
In:
2020 Tenth International Conference on Image Processing Theory, Tools and Applications (IPTA).
IEEE: Paris, France.
|
|
Croft, Cara L;
Paterno, Giavanna;
Vause, Ava R;
Rowe, Lyla A;
Ryu, Daniel H;
Goodwin, Marshall S;
Moran, Corey A;
... Golde, Todd E; + view all
(2022)
Optical pulse labeling studies reveal exogenous seeding slows α-synuclein clearance.
npj Parkinson's Disease
, 8
, Article 173. 10.1038/s41531-022-00434-4.
|
|
Crowley, Gerard;
Attwell, David;
Phatnani, Hemali;
Sontheimer, Harald;
Hong, Soyon;
(2024)
Glia in Neurodegenerative Disease.
Cold Spring Harbor perspectives in biology
a041375.
10.1101/cshperspect.a041375.
(In press).
|
|
|
Cuypers, Marie-Lynn;
Jaspers, Tom;
Clerckx, Jarne;
Leekens, Simon;
Cawthorne, Christopher;
Bormans, Guy;
Cleeren, Frederik;
... Dewilde, Maarten; + view all
(2025)
Increasing brain half-life of antibodies by additional binding to myelin oligodendrocyte glycoprotein, a CNS specific protein.
Fluids and Barriers of the CNS
, 22
(1)
, Article 11. 10.1186/s12987-025-00624-1.
|
|
D
|
Darricau, Morgane;
Dou, Changsong;
Kinet, Remi;
Zhu, Tao;
Zhou, Li;
Li, Xianglei;
Bedel, Aurelie;
... Planche, Vincent; + view all
(2023)
Tau seeds from Alzheimer's disease brains trigger tau spread in macaques while oligomeric-Aβ mediates pathology maturation.
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
10.1002/alz.13604.
(In press).
|
|
|
Dasgupta, Debanjan;
Warner, Tom PA;
Erskine, Andrew;
Schaefer, Andreas T;
(2022)
Coupling of Mouse Olfactory Bulb Projection Neurons to Fluctuating Odor Pulses.
Journal of Neuroscience
, 42
(21)
pp. 4278-4296.
10.1523/JNEUROSCI.1422-21.2022.
|
|
de Boni, Laura;
Wallis, Amber;
Hays Watson, Aurelia;
Ruiz-Riquelme, Alejandro;
Leyland, Louise-Ann;
Bourinaris, Thomas;
Hannaway, Naomi;
... Bartels, Tim; + view all
(2024)
Aggregation-resistant alpha-synuclein tetramers are reduced in the blood of Parkinson's patients.
EMBO Molecular Medicine
10.1038/s44321-024-00083-5.
(In press).
|
|
|
De Boni, Laura;
Watson, Aurelia Hays;
Zaccagnini, Ludovica;
Wallis, Amber;
Zhelcheska, Kristina;
Kim, Nora;
Sanderson, John;
... Bartels, Tim; + view all
(2022)
Brain region-specific susceptibility of Lewy body pathology in synucleinopathies is governed by α-synuclein conformations.
Acta Neuropathologica
10.1007/s00401-022-02406-7.
(In press).
|
|
|
De Schepper, Sebastiaan;
Ge, Judy Z;
Crowley, Gerard;
Ferreira, Laís SS;
Garceau, Dylan;
Toomey, Christina E;
Sokolova, Dimitra;
... Hong, Soyon; + view all
(2023)
Perivascular cells induce microglial phagocytic states and synaptic engulfment via SPP1 in mouse models of Alzheimer's disease.
Nature Neuroscience
10.1038/s41593-023-01257-z.
(In press).
|
|
De Schepper, S;
Crowley, G;
Hong, S;
(2021)
Understanding Microglial Diversity and Implications for Neuronal Function in Health and Disease.
Developmental Neurobiology
, 81
(5)
pp. 507-523.
10.1002/dneu.22777.
|
|
|
De Schepper, S;
Verheijden, S;
Aguilera-Lizarraga, J;
Viola, MF;
Boesmans, W;
Stakenborg, N;
Voytyuk, I;
... Boeckxstaens, G; + view all
(2018)
Self-Maintaining Gut Macrophages Are Essential for Intestinal Homeostasis.
Cell
, 175
(2)
, Article e13. 10.1016/j.cell.2018.07.048.
|
|
De Strooper, Bart;
Haass, Christian;
Hardy, John;
Zetterberg, Henrik;
(2025)
The regulatory rollercoaster continues—EMA refuses donanemab.
The Lancet
, 405
(10492)
pp. 1810-1812.
10.1016/S0140-6736(25)00833-5.
|
|
De Strooper, Bart;
Haass, Christian;
Hardy, John;
Zetterberg, Henrik;
(2024)
Divisions over the regulation of lecanemab.
The Lancet
, 404
(10468)
pp. 2160-2161.
10.1016/S0140-6736(24)02513-3.
|
|
De Strooper, Bart;
Karran, Eric;
(2024)
New precision medicine avenues to the prevention of Alzheimer's disease from insights into the structure and function of γ-secretases.
The EMBO Journal
10.1038/s44318-024-00057-w.
(In press).
|
|
De Strooper, Bart;
Scheltens, Philip;
Salloway, Stephen;
(2025)
Breaking Barriers: Delivering Therapeutics to the Brain in Alzheimer’s
Disease.
The Journal of Prevention of Alzheimer's Disease
, 12
(7)
, Article 100229. 10.1016/j.tjpad.2025.100229.
|
|
|
Delabar, JM;
Allinquant, B;
Bianchi, D;
Blumenthal, T;
Dekker, A;
Edgin, J;
O'Bryan, J;
... Busciglio, J; + view all
(2016)
Changing Paradigms in Down Syndrome: The First International Conference of the Trisomy 21 Research Society.
Molecular Syndromology
, 7
(5)
pp. 251-261.
10.1159/000449049.
|
|
|
Desai, Perlina;
(2025)
Using proximity labelling to investigate astrocyte secretory pathway proteome alterations in Alzheimer's disease.
Doctoral thesis (Ph.D), UCL (University College London).
|
|
Dierssen, M;
Herault, Y;
Helguera, P;
Martinez de Lagran, M;
Vazquez, A;
Christian, B;
Carmona-Iragui, M;
... Bhattacharyya, A; + view all
(2021)
Building the Future Therapies for Down Syndrome: The Third International Conference of the T21 Research Society.
Molecular Syndromology
10.1159/000514437.
(In press).
|
|
|
Dorion, Marie-France;
Yaqubi, Moein;
Senkevich, Konstantin;
Kieran, Nicholas W;
MacDonald, Adam;
Chen, Carol X-Q;
Luo, Wen;
... Healy, Luke M; + view all
(2023)
MerTK is a mediator of alpha-synuclein fibril uptake by human microglia.
Brain
, Article awad298,. 10.1093/brain/awad298.
(In press).
|
|
Duggan, Michael R;
Gomez, Gabriela T;
Joynes, Cassandra M;
Bilgel, Murat;
Chen, Jingsha;
Fattorelli, Nicola;
Hohman, Timothy J;
... Walker, Keenan A; + view all
(2024)
Proteome-wide analysis identifies plasma immune regulators of amyloid-beta progression.
Brain, Behavior, and Immunity
, 120
pp. 604-619.
10.1016/j.bbi.2024.07.002.
|
E
|
Erkert, Lena;
Gamez-Belmonte, Reyes;
Kabisch, Melanie;
Schödel, Lena;
Patankar, Jay V;
Gonzalez-Acera, Miguel;
Mahapatro, Mousumi;
... Becker, Christoph; + view all
(2024)
Alzheimer's disease-related presenilins are key to intestinal epithelial cell function and gut immune homoeostasis.
Gut
10.1136/gutjnl-2023-331622.
(In press).
|
|
|
Espuny-Camacho, I;
Arranz, AM;
Fiers, M;
Snellinx, A;
Ando, K;
Munck, S;
Bonnefont, J;
... De Strooper, B; + view all
(2017)
Hallmarks of Alzheimer's Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain.
Neutron
, 93
(5)
, Article e8. 10.1016/j.neuron.2017.02.001.
|
F
|
Fa, M;
Puzzo, D;
Piacentini, R;
Staniszewski, A;
Zhang, H;
Baltrons, MA;
Li Puma, DD;
... Arancio, O; + view all
(2016)
Extracellular Tau Oligomers Produce An Immediate Impairment of LTP and Memory.
Scientific Reports
, 6
, Article 19393. 10.1038/srep19393.
|
|
Falgàs, N;
Illán-Gala, I;
Allen, IE;
Mumford, P;
Essanaa, YM;
Le, MM;
You, M;
... Walsh, CM; + view all
(2021)
Specific cortical and subcortical grey matter regions are associated with insomnia severity.
PloS One
, 16
(5)
, Article e0252076. 10.1371/journal.pone.0252076.
|
|
|
Farrell, C;
Buhidma, Y;
Mumford, P;
Heywood, WE;
Hällqvist, J;
Flores-Aguilar, L;
Andrews, EJ;
... Wiseman, FK; + view all
(2025)
Apolipoprotein E abundance is elevated in the brains of individuals with Down syndrome-Alzheimer's disease.
Acta Neuropathologica
, 149
(1)
, Article 49. 10.1007/s00401-025-02889-0.
|
|
|
Farrell, Clíona;
(2024)
Exploring Alzheimer's disease and Down syndrome neuro-immune pathways using preclinical models and human post-mortem brain tissue.
Doctoral thesis (Ph.D), UCL (University College London).
|
|
|
Farrell, Cliona;
Mumford, Paige;
Wiseman, Frances K;
(2022)
Rodent Modeling of Alzheimer's Disease in Down Syndrome: In vivo and ex vivo Approaches.
Frontiers in Neuroscience
, 16
, Article 909669. 10.3389/fnins.2022.909669.
|
|
Fazzari, Maria;
Di Biase, Erika;
Zaccagnini, Ludovica;
Henriques, Alexandre;
Callizot, Noëlle;
Ciampa, Maria Grazia;
Mauri, Laura;
... Lunghi, Giulia; + view all
(2023)
GM1 oligosaccharide efficacy against α-synuclein aggregation and toxicity in vitro.
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
, 1868
(9)
, Article 159350. 10.1016/j.bbalip.2023.159350.
|
|
Fazzari, P;
Horre, K;
Arranz, AM;
Frigerio, CS;
Saito, T;
Saido, TC;
De Strooper, B;
(2017)
PLD3 gene and processing of APP.
Nature
, 541
(7638)
10.1038/nature21030.
|
|
Fertan, Emre;
Hung, Christy;
Danial, John SH;
Lam, Jeff YL;
Preman, Pranav;
Albertini, Giulia;
English, Elizabeth A;
... Klenerman, David; + view all
(2025)
Clearance of beta-amyloid and tau aggregates is size dependent and altered by an inflammatory challenge.
Brain Communications
, 7
(1)
, Article fcae454. 10.1093/braincomms/fcae454.
|
|
Fertan, Emre;
Lam, Jeff YL;
Albertini, Giulia;
Dewilde, Maarten;
Wu, Yunzhao;
Akingbade, Oluwatomi ES;
Böken, Dorothea;
... Klenerman, David; + view all
(2025)
Lecanemab preferentially binds to smaller aggregates present at early Alzheimer's disease.
Alzheimer's & Dementia
, 21
(4)
, Article e70086. 10.1002/alz.70086.
|
|
Ficulle, E;
Kananathan, S;
Airey, D;
Gharbi, SI;
Humphryes-Kirilov, N;
Scherschel, J;
Dunbar, C;
... Bose, S; + view all
(2022)
A human tau seeded neuronal cell model recapitulates molecular responses associated with Alzheimer's disease.
Scientific Reports
, 12
, Article 2673. 10.1038/s41598-022-06411-4.
|
|
|
Firth, NC;
Startin, CM;
Hithersay, R;
Hamburg, S;
Wijeratne, PA;
Mok, KY;
Hardy, J;
... Strydom, A; + view all
(2018)
Aging related cognitive changes associated with Alzheimer's disease in Down syndrome.
Annals of Clinical and Translational Neurology
, 5
(6)
pp. 741-751.
10.1002/acn3.571.
|
|
|
Foiani, Martha;
(2020)
Investigating novel tau biomarkers for frontotemporal dementia.
Doctoral thesis (Ph.D), UCL (University College London).
|
|
Foiani, MS;
Cicognola, C;
Ermann, N;
Woollacott, IOC;
Heller, C;
Heslegrave, AJ;
Keshavan, A;
... Rohrer, JD; + view all
(2019)
Searching for novel cerebrospinal fluid biomarkers of tau pathology in frontotemporal dementia: an elusive quest.
Journal of Neurology, Neurosurgery and Psychiatry
10.1136/jnnp-2018-319266.
(In press).
|
|
|
Foiani, MS;
Woollacott, IO;
Heller, C;
Bocchetta, M;
Heslegrave, A;
Dick, KM;
Russell, LL;
... Rohrer, JD; + view all
(2018)
Plasma tau is increased in frontotemporal dementia.
Journal of Neurology, Neurosurgery and Psychiatry
, 89
(8)
pp. 804-807.
10.1136/jnnp-2017-317260.
|
|
|
Fowler, Stephanie L;
Behr, Tiana S;
Turkes, Emir;
O'Brien, Darragh P;
Cauhy, Paula Maglio;
Rawlinson, Isadora;
Edmonds, Marisa;
... Ryskeldi-Falcon, Benjamin; + view all
(2025)
Tau filaments are tethered within brain extracellular vesicles in Alzheimer's disease.
Nature Neuroscience
, 28
(1)
pp. 40-48.
10.1038/s41593-024-01801-5.
|
|
|
Frigerio, CS;
De Strooper, B;
(2016)
Alzheimer's Disease Mechanisms and Emerging Roads to Novel Therapeutics.
Annual Review of Neuroscience
, 39
pp. 57-79.
10.1146/annurev-neuro-070815-014015.
|
|
Frigerio, CS;
Fiers, M;
Voet, T;
De Strooper, B;
(2017)
Identification of Low Allele Frequency Mosaic Mutations in Alzheimer Disease.
In: Frade, JM and Gage, FH, (eds.)
Genomic Mosaicism in Neurons and Other Cell Types.
(pp. 361-378).
Humana Press: New York, NY, USA.
|
|
|
Fu, Hongjun;
Possenti, Andrea;
Freer, Rosie;
Nakano, Yoshikazu;
Hernandez Villegas, Nancy C;
Tang, Maoping;
Cauhy, Paula VM;
... Duff, Karen E; + view all
(2019)
A tau homeostasis signature is linked with the cellular and regional vulnerability of excitatory neurons to tau pathology.
Nature Neuroscience
, 22
pp. 47-56.
10.1038/s41593-018-0298-7.
|
|
|
Fu, Hongjun;
Rodriguez, Gustavo A;
Herman, Mathieu;
Emrani, Sheina;
Nahmani, Eden;
Barrett, Geoffrey;
Figueroa, Helen Y;
... Duff, Karen E; + view all
(2017)
Tau Pathology Induces Excitatory Neuron Loss, Grid Cell Dysfunction, and Spatial Memory Deficits Reminiscent of Early Alzheimer’s Disease.
Neuron
, 93
(3)
533-541.e5.
10.1016/j.neuron.2016.12.023.
|
|
|
Fu, H;
Hardy, J;
Duff, KE;
(2018)
Selective vulnerability in neurodegenerative diseases.
Nature Neuroscience
, 21
(10)
pp. 1350-1358.
10.1038/s41593-018-0221-2.
|
 |
|
Fung, CW;
Guo, J;
Fu, H;
Figueroa, HY;
Konofagou, EE;
Duff, KE;
(2020)
Atrophy associated with tau pathology precedes overt cell death in a mouse model of progressive tauopathy.
Science Advances
, 6
(42)
, Article eabc8098. 10.1126/sciadv.abc8098.
|
|
G
|
Gavriouchkina, Daria;
Tan, Yongkai;
Ziadi-Künzli, Fabienne;
Hasegawa, Yuko;
Piovani, Laura;
Zhang, Lin;
Sugimoto, Chikatoshi;
... Rokhsar, Daniel; + view all
(2022)
A single-cell atlas of bobtail squid visual and nervous system highlights molecular principles of convergent evolution.
BioRxiv: Cold Spring Harbor, NY, USA.
|
|
|
Germeys, Christine;
Vandoorne, Tijs;
Davie, Kristofer;
Poovathingal, Suresh;
Heeren, Kara;
Vermeire, Wendy;
Nami, FatemehArefeh;
... Van Den Bosch, Ludo; + view all
(2024)
Targeting EGLN2/PHD1 protects motor neurons and normalizes the astrocytic interferon response.
Cell Reports
, 43
(9)
, Article 114719. 10.1016/j.celrep.2024.114719.
|
|
|
Giamogante, Flavia;
Barazzuol, Lucia;
Maiorca, Francesca;
Poggio, Elena;
Esposito, Alessandra;
Masato, Anna;
Napolitano, Gennaro;
... Brini, Marisa; + view all
(2024)
A SPLICS reporter reveals
-synuclein regulation of lysosome-mitochondria contacts which affects TFEB nuclear translocation.
Nature Communications
, 15
, Article 1516. 10.1038/s41467-024-46007-2.
|
|
Glennon, EB;
Lau, DHW;
Gabriele, RMC;
Taylor, MF;
Troakes, C;
Opie-Martin, S;
Elliott, C;
... Noble, W; + view all
(2020)
Bridging integrator 1 protein loss in Alzheimer’s disease promotes synaptic tau accumulation and disrupts tau release.
Brain Communications
, 2
(1)
, Article fcaa011. 10.1093/braincomms/fcaa011.
|
|
|
Gomez-Suaga, P;
Perez-Nievas, BG;
Glennon, EB;
Lau, DHW;
Paillusson, S;
Morotz, GM;
Cali, T;
... Miller, CCJ; + view all
(2019)
The VAPB-PTPIP51 endoplasmic reticulum-mitochondria tethering proteins are present in neuronal synapses and regulate synaptic activity.
Acta Neuropathologica Communications
, 7
, Article 35. 10.1186/s40478-019-0688-4.
|
|
|
Gonzalez-Meljem, JM;
Haston, S;
Carreno, G;
Apps, J;
Pozzi, S;
Stache, C;
Kaushal, G;
... Martinez-Barbera, JP; + view all
(2017)
Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma.
Nature Communications
, 8
, Article 1819. 10.1038/s41467-017-01992-5.
|
|
Granno, S;
Nixon-Abell, J;
Berwick, DC;
Tosh, J;
Heaton, G;
Almudimeegh, S;
Nagda, Z;
... Harvey, K; + view all
(2019)
Downregulated Wnt/β-catenin signalling in the Down syndrome hippocampus.
Scientific Reports
, 9
(1)
, Article 7322. 10.1038/s41598-019-43820-4.
|
|
|
Gribble, SM;
Wiseman, FK;
Clayton, S;
Prigmore, E;
Langley, E;
Yang, F;
Maguire, S;
... Carter, NP; + view all
(2013)
Massively Parallel Sequencing Reveals the Complex Structure of an Irradiated Human Chromosome on a Mouse Background in the Tc1 Model of Down Syndrome.
PLOS ONE
, 8
(4)
, Article e60482. 10.1371/journal.pone.0060482.
|
|
|
Guerrero, A;
De Strooper, B;
Arancibia-Cárcamo, IL;
(2021)
Cellular senescence at the crossroads of inflammation and Alzheimer's disease.
Trends in Neurosciences
, 44
(9)
pp. 714-727.
10.1016/j.tins.2021.06.007.
|
|
Guerrero, A;
Innes, AJ;
Roux, PF;
Buisman, SC;
Jung, J;
Ortet, L;
Moiseeva, V;
... Gil, J; + view all
(2022)
3-Deazaadenosine alleviates senescence to promote cellular fitness and cell therapy efficiency in mice.
Nature Aging
, 2
(9)
pp. 851-866.
10.1038/s43587-022-00279-9.
|
|
Guerrero, Ana;
(2023)
Nucleosome disruption by 5-bromodeoxyuridine leads to senescence.
The FEBS Journal
, 290
(3)
pp. 684-687.
10.1111/febs.16630.
|
|
Guerrero, A;
Guiho, R;
Herranz, N;
Uren, A;
Withers, DJ;
Martínez-Barbera, JP;
Tietze, LF;
(2020)
Galactose-modified duocarmycin prodrugs as senolytics.
Aging Cell
, Article e13133. 10.1111/acel.13133.
(In press).
|
|
|
Guerrero, A;
Herranz, N;
Sun, B;
Wagner, V;
Gallage, S;
Guiho, R;
Wolter, K;
... Gil, J; + view all
(2019)
Cardiac glycosides are broad-spectrum senolytics.
Nature Metabolism
, 1
pp. 1074-1088.
10.1038/s42255-019-0122-z.
|
|
Guo, T;
Dakkak, D;
Rodriguez-Martin, T;
Noble, W;
Hanger, DP;
(2019)
A pathogenic tau fragment compromises microtubules, disrupts insulin signaling and induces the unfolded protein response.
Acta Neuropathologica Communications
, 7
, Article 2. 10.1186/s40478-018-0651-9.
|
|
H
|
Hall, JH;
Wiseman, FK;
Fisher, EM;
Tybulewicz, VL;
Harwood, JL;
Good, MA;
(2016)
Tc1 mouse model of trisomy-21 dissociates properties of short- and long-term recognition memory.
Neurobiology of Learning and Memory
, 130
pp. 118-128.
10.1016/j.nlm.2016.02.002.
|
|
|
Hamilton, NB;
Clarke, LE;
Arancibia-Carcamo, IL;
Kougioumtzidou, E;
Matthey, M;
Káradóttir, R;
Whiteley, L;
... Attwell, D; + view all
(2017)
Endogenous GABA controls oligodendrocyte lineage cell number, myelination, and CNS internode length.
Glia
, 65
(2)
pp. 309-321.
10.1002/glia.23093.
|
|
Harris, SS;
Schwerd-Kleine, T;
Lee, BI;
Busche, MA;
(2021)
The Reciprocal Interaction Between Sleep and Alzheimer’s Disease.
In:
Circadian Clock in Brain Health and Disease.
(pp. 169-188).
Springer, Cham
|
|
Harris, SS;
Wolf, F;
De Strooper, B;
Busche, MA;
(2020)
Tipping the Scales: Peptide-Dependent Dysregulation of Neural Circuit Dynamics in Alzheimer's Disease.
Neuron
, 107
(3)
pp. 417-435.
10.1016/j.neuron.2020.06.005.
|
|
Hartmann, J;
Chen-Engerer, H-J;
Konnerth, A;
(2021)
Where have all the Orais gone? Commentary on "Orai1 channels are essential for amplification of glutamate-evoked Ca²⁺ signals in dendritic spines to regulate working and associative memory".
Cell Calcium
, 96
, Article 102372. 10.1016/j.ceca.2021.102372.
|
|
Hays Watson, Aurelia;
(2024)
The impact of lipid droplets on α-synuclein protein folding and aggregation propensities in Parkinson’s disease.
Doctoral thesis (Ph.D), UCL (University College London).
|
|
Heller, C;
Chan, E;
Foiani, MS;
Todd, E;
Russell, LL;
Greaves, CV;
Heslegrave, AJ;
... Rohrer, JD; + view all
(2020)
Plasma glial fibrillary acidic protein and neurofilament light chain are measures of disease severity in semantic variant primary progressive aphasia.
Journal of Neurology, Neurosurgery & Psychiatry
10.1136/jnnp-2020-325085.
(In press).
|
|
Heller, C;
Foiani, MS;
Moore, K;
Convery, R;
Bocchetta, M;
Neason, M;
Cash, DM;
... GENFI; + view all
(2020)
Plasma glial fibrillary acidic protein is raised in progranulin-associated frontotemporal dementia.
Journal of Neurology, Neurosurgery and Psychiatry
10.1136/jnnp-2019-321954.
(In press).
|
|
|
Heneka, Michael T;
Van der Flier, Wiesje M;
Jessen, Frank;
Hoozemanns, Jeroen;
Thal, Dietmar Rudolf;
Boche, Delphine;
Brosseron, Frederic;
... Riechers, Sean-Patrick; + view all
(2025)
Neuroinflammation in Alzheimer disease.
Nature Reviews Immunology
, 25
pp. 321-352.
10.1038/s41577-024-01104-7.
|
|
Hithersay, R;
Baksh, RA;
Startin, CM;
Wijeratne, P;
Hamburg, S;
Carter, B;
LonDownS Consortium;
(2020)
Optimal age and outcome measures for Alzheimer's disease prevention trials in people with Down syndrome.
Alzheimer's & Dementia
10.1002/alz.12222.
(In press).
|
|
|
Hithersay, R;
Hamburg, S;
Knight, B;
Strydom, A;
(2017)
Cognitive decline and dementia in Down syndrome.
Current Opinion in Psychiatry
, 30
(2)
pp. 102-107.
10.1097/YCO.0000000000000307.
|
|
Horsburgh, K;
Wardlaw, JM;
van Agtmael, T;
Allan, SM;
Ashford, MLJ;
Bath, PM;
Brown, R;
... Work, LM; + view all
(2018)
Small vessels, dementia and chronic diseases – molecular mechanisms and pathophysiology.
Clinical Science
, 132
(8)
pp. 851-868.
10.1042/CS20171620.
|
|
Hou, P;
Zielonka, M;
Serneels, L;
Martinez-Muriana, A;
Fattorelli, N;
Wolfs, L;
Poovathingal, S;
... De Strooper, B; + view all
(2023)
The γ-secretase substrate proteome and its role in cell signaling regulation.
Molecular Cell
, 83
(22)
4106-4122.e10.
10.1016/j.molcel.2023.10.029.
|
I
|
Ibanez, Kristina;
Jadhav, Bharati;
Zanovello, Matteo;
Gagliardi, Delia;
Clarkson, Christopher;
Facchini, Stefano;
Garg, Paras;
... Tucci, Arianna; + view all
(2024)
Increased frequency of repeat expansion mutations across different populations.
Nature Medicine
10.1038/s41591-024-03190-5.
(In press).
|
|
J
|
Jabbari, E;
Duff, KE;
(2021)
Tau-targeting antibody therapies: too late, wrong epitope or wrong target?
Nature Medicine
, 27
(8)
pp. 1341-1342.
10.1038/s41591-021-01465-9.
|
|
Jabbari, E;
Holland, N;
Chelban, V;
Jones, PS;
Lamb, R;
Rawlinson, C;
Guo, T;
... Morris, HR; + view all
(2019)
Diagnosis Across the Spectrum of Progressive Supranuclear Palsy and Corticobasal Syndrome.
JAMA Neurology
, 77
(3)
pp. 377-387.
10.1001/jamaneurol.2019.4347.
|
|
|
Jabbari, E;
Woodside, J;
Guo, T;
Magdalinou, NK;
Chelban, V;
Athauda, D;
Lees, AJ;
... Morris, HR; + view all
(2019)
Proximity extension assay testing reveals novel diagnostic biomarkers of atypical parkinsonian syndromes.
Journal of Neurology, Neurosurgery and Psychiatry
10.1136/jnnp-2018-320151.
|
|
|
Jakabek, D;
Isaacs, AM;
De Strooper, B;
Tuszynski, M;
Lane, R;
Uspenskaya, O;
McDade, E;
... Mummery, CJ; + view all
(2025)
CTAD taskforce: genetic therapies in Alzheimer’s disease.
The Journal of Prevention of Alzheimer's Disease
, Article 100269. 10.1016/j.tjpad.2025.100269.
(In press).
|
|
|
Jolly, S;
Lang, V;
Koelzer, VH;
Sala Frigerio, C;
Magno, L;
Salinas, PC;
Whiting, P;
(2019)
Single-Cell Quantification of mRNA Expression in The Human Brain.
Scientific Reports
, 9
, Article 12353. 10.1038/s41598-019-48787-w.
|
|
K
|
Karakatsani, Maria Eleni;
Ji, Robin;
Murillo, Maria F;
Kugelman, Tara;
Kwon, Nancy;
Lao, Yeh-Hsing;
Liu, Keyu;
... Konofagou, Elisa E; + view all
(2023)
Focused ultrasound mitigates pathology and improves spatial memory in Alzheimer's mice and patients.
Theranostics
, 13
(12)
pp. 4102-4120.
10.7150/thno.79898.
|
|
Kedia, S;
Fertan, E;
Wu, Y;
Zhang, YP;
Meisl, G;
Lam, JYL;
K. Wiseman, F;
... Klenerman, D; + view all
(2025)
SynPull: An advanced method for studying neurodegeneration-related aggregates in synaptosomes using super-resolution microscopy.
Cell Chemical Biology
, 32
(2)
338-351.e4.
10.1016/j.chembiol.2025.01.001.
|
|
Khalil, Bilal;
Chhangani, Deepak;
Wren, Melissa C;
Smith, Courtney L;
Lee, Jannifer H;
Li, Xingli;
Puttinger, Christian;
... Rossoll, Wilfried; + view all
(2022)
Nuclear import receptors are recruited by FG-nucleoporins to rescue hallmarks of TDP-43 proteinopathy.
Molecular Neurodegeneration
, 17
, Article 80. 10.1186/s13024-022-00585-1.
|
|
Khan, Usman A;
Liu, Li;
Provenzano, Frank A;
Berman, Diego E;
Profaci, Caterina P;
Sloan, Richard;
Mayeux, Richard;
... Small, Scott A; + view all
(2014)
Molecular drivers and cortical spread of lateral entorhinal cortex dysfunction in preclinical Alzheimer's disease.
nature neuroscience
, 17
pp. 304-311.
10.1038/nn.3606.
|
|
|
Klionsky, DJ;
Abdel-Aziz, AK;
Abdelfatah, S;
Abdellatif, M;
Abdoli, A;
Abel, S;
Abeliovich, H;
... Taylor, A; + view all
(2021)
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition).
Autophagy
, 17
(1)
pp. 1-382.
10.1080/15548627.2020.1797280.
|
|
Kloske, CM;
Mahinrad, S;
Barnum, CJ;
Batista, AF;
Bradshaw, EM;
Butts, B;
Carrillo, MC;
... Wilcock, DM; + view all
(2024)
Advancements in Immunity and Dementia Research: Highlights from the 2023 AAIC Advancements: Immunity Conference.
Alzheimer's & Dementia
10.1002/alz.14291.
(In press).
|
|
|
Kontou, G;
Antonoudiou, P;
Podpolny, M;
Szulc, BR;
Arancibia-Carcamo, IL;
Higgs, NF;
Lopez-Domenech, G;
... Kittler, JT; + view all
(2021)
Miro1-dependent mitochondrial dynamics in parvalbumin Interneurons.
eLife
10.7554/eLife.65215.
(In press).
|
|
|
Koper, MJ;
Moonen, S;
Ronisz, A;
Ospitalieri, S;
Callaerts-Vegh, Z;
T'Syen, D;
Rabe, S;
... Thal, DR; + view all
(2024)
Inhibition of an Alzheimer’s disease–associated form of necroptosis rescues neuronal death in mouse models.
Science Translational Medicine
, 16
(771)
, Article eadf5128. 10.1126/scitranslmed.adf5128.
|
|
|
Kruse, N;
Heslegrave, A;
Gupta, V;
Foiani, M;
Villar-Piqué, A;
Schmitz, M;
Lehmann, S;
... Llorens, F; + view all
(2018)
Interlaboratory Validation of Cerebrospinal Fluid Α-synuclein Quantification in the Diagnosis of Sporadic Creutzfeldt-jakob Disease.
Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
, 10
pp. 461-470.
10.1016/j.dadm.2018.06.005.
|
|
|
Kumar, JS Dileep;
Molotkov, Andrei;
Kim, Jongho;
Carberry, Patrick;
Idumonyi, Sidney;
Castrillon, John;
Duff, Karen;
... Mintz, Akiva; + view all
(2022)
Preclinical evaluation of a microtubule PET ligand [C-11]MPC-6827 in tau and amyotrophic lateral sclerosis animal models.
Pharmacological Reports
, 74
pp. 539-544.
10.1007/s43440-022-00359-y.
|
|
Kyrargyri, V;
Madry, C;
Rifat, A;
Arancibia-Carcamo, IL;
Jones, SP;
Chan, VTT;
Xu, Y;
... Attwell, D; + view all
(2020)
P2Y13 receptors regulate microglial morphology, surveillance, and resting levels of interleukin 1β release.
Glia
, 68
(2)
pp. 328-344.
10.1002/glia.23719.
|
|
L
|
Lam, Isabel;
Ndayisaba, Alain;
Lewis, Amanda J;
Fu, YuHong;
Sagredo, Giselle T;
Kuzkina, Anastasia;
Zaccagnini, Ludovica;
... Khurana, Vikram; + view all
(2024)
Rapid iPSC inclusionopathy models shed light on formation, consequence, and molecular subtype of α-synuclein inclusions.
Neuron
10.1016/j.neuron.2024.06.002.
(In press).
|
|
Langworth-Green, C;
Patel, S;
Jaunmuktane, Z;
Jabbari, E;
Morris, H;
Thom, M;
Lees, A;
... Duff, K; + view all
(2023)
Chronic effects of inflammation on tauopathies.
The Lancet Neurology
, 22
(5)
pp. 430-442.
10.1016/S1474-4422(23)00038-8.
|
|
Lashley, T;
Schott, JM;
Weston, P;
Murray, CE;
Wellington, H;
Keshavan, A;
Foti, SC;
... Zetterberg, H; + view all
(2018)
Molecular biomarkers of Alzheimer's disease: progress and prospects.
Disease Models & Mechanisms
, 11
(5)
, Article dmm031781. 10.1242/dmm.031781.
|
|
|
Lau, DHW;
Hartopp, N;
Welsh, NJ;
Mueller, S;
Glennon, EB;
Morotz, GM;
Annibali, A;
... Miller, CCJ; + view all
(2018)
Disruption of ER-mitochondria signalling in fronto-temporal dementia and related amyotrophic lateral sclerosis.
Cell Death & Disease
, 9
, Article 327. 10.1038/s41419-017-0022-7.
|
|
|
Leija Salazar, Melissa Ivonne;
(2020)
Investigation of somatic mutations in synucleinopathies.
Doctoral thesis (Ph.D), UCL (University College London).
|
|
Leija-Salazar, M;
Piette, CL;
Proukakis, C;
(2018)
Somatic mutations in neurodegeneration.
Neuropathology and Applied Neurobiology
, 44
(3)
pp. 267-285.
10.1111/nan.12465.
|
|
Leonenko, G;
Baker, E;
Stevenson-Hoare, J;
Sierksma, A;
Fiers, M;
Williams, J;
de Strooper, B;
(2021)
Identifying individuals with high risk of Alzheimer’s disease using polygenic risk scores.
Nature Communications
, 12
(1)
, Article 4506. 10.1038/s41467-021-24082-z.
|
|
|
Lezmy, J;
Arancibia-Cárcamo, IL;
Quintela-López, T;
Sherman, DL;
Brophy, PJ;
Attwell, D;
(2021)
Astrocyte Ca2+-evoked ATP release regulates myelinated axon excitability and conduction speed.
Science
, 374
(6565)
, Article eabh2858. 10.1126/science.abh2858.
|
|
|
Lipina, TV;
O'Tuathaigh, C;
Li, S;
(2021)
Editorial: Antipsychotics of New Generation: Where Are We now?
Frontiers in Pharmacology
, 12
, Article 646286. 10.3389/fphar.2021.646286.
|
|
|
Liu, Li;
Drouet, Valerie;
Wu, Jessica W;
Witter, Menno P;
Small, Scott A;
Clelland, Catherine;
Duff, Karen;
(2012)
Trans-Synaptic Spread of Tau Pathology In Vivo.
PLOS ONE
, 7
(2)
, Article e31302. 10.1371/journal.pone.0031302.
|
|
|
Ljubenkov, PA;
Miller, Z;
Mumford, P;
Zhang, J;
Allen, IE;
Mitic, L;
Staffaroni, A;
... Boxer, AL; + view all
(2019)
Peripheral Innate Immune Activation Correlates With Disease Severity in GRN Haploinsufficiency.
Frontiers in Neurology
, 10
, Article 1004. 10.3389/fneur.2019.01004.
|
|
|
Lloyd, AF;
Martinez-Muriana, A;
Davis, E;
Daniels, MJD;
Hou, P;
Mancuso, R;
Brenes, AJ;
... Howden, AJM; + view all
(2024)
Deep proteomic analysis of microglia reveals fundamental biological differences between model systems.
Cell Reports
, 43
(11)
, Article 114908. 10.1016/j.celrep.2024.114908.
|
|
|
Lombardi, V;
Querin, G;
Ziff, OJ;
Zampedri, L;
Martinelli, I;
Heller, C;
Foiani, M;
... Fratta, P; + view all
(2019)
Muscle and not neuronal biomarkers correlate with severity in spinal and bulbar muscular atrophy.
Neurology
, 92
(11)
10.1212/WNL.0000000000007097.
(In press).
|
|
|
Lopez-Domenech, G;
Higgs, NF;
Vaccaro, V;
Ros, H;
Arancibia-Carcamo, IL;
MacAskill, AF;
Kittler, JT;
(2016)
Loss of Dendritic Complexity Precedes Neurodegeneration in a Mouse Model with Disrupted Mitochondrial Distribution in Mature Dendrites.
Cell Reports
, 17
(2)
pp. 317-327.
10.1016/j.celrep.2016.09.004.
|
M
|
Ma, D;
Cardoso, MJ;
Modat, M;
Powell, N;
Wells, J;
Holmes, H;
Wiseman, F;
... Ourselin, S; + view all
(2014)
Automatic structural parcellation of mouse brain MRI using multi-atlas label fusion.
PLoS One
, 9
(1)
, Article e86576. 10.1371/journal.pone.0086576.
|
|
|
Ma, D;
Cardoso, MJ;
Zuluaga, MA;
Modat, M;
Powell, N;
Wiseman, F;
Tybulewicz, V;
... Ourselin, S; + view all
(2015)
Grey matter sublayer thickness estimation in the mouse cerebellum.
In: Navab, N and Hornegger, J and Wells, WM and Frangi, AF, (eds.)
Proceedings of 18th International Conference in Medical Image Computing and Computer-Assisted Intervention – MICCAI 2015.
(pp. pp. 644-651).
Springer International Publishing Switzerland: Munich, Germany.
|
|
|
Ma, D;
Cardoso, MJ;
Zuluaga, MA;
Modat, M;
Powell, NM;
Wiseman, FK;
Cleary, JO;
... Ourselin, SE; + view all
(2020)
Substantially thinner internal granular layer and reduced molecular layer surface in the cerebellar cortex of the Tc1 mouse model of down syndrome – a comprehensive morphometric analysis with active staining contrast-enhanced MRI.
NeuroImage
, 223
, Article 117271. 10.1016/j.neuroimage.2020.117271.
|
|
MacKenzie, G;
Subramaniam, S;
Caldwell, LJ;
Fitzgerald, D;
Harrison, NA;
Hong, S;
Irani, SR;
... Upthegrove, R; + view all
Research priorities for neuroimmunology: identifying the key research questions to be addressed by 2030.
Wellcome Open Research
, 6
, Article 194. 10.12688/wellcomeopenres.16997.1.
|
|
|
Madrigal-Matute, J;
de Bruijn, J;
van Kuijk, K;
Riascos-Bernal, DF;
Diaz, A;
Tasset, I;
Martín-Segura, A;
... Cuervo, AM; + view all
(2022)
Protective role of chaperone-mediated autophagy against atherosclerosis.
Proceedings of the National Academy of Sciences of the United States of America (PNAS)
, 119
(14)
, Article e2121133119. 10.1073/pnas.2121133119.
|
|
Madry, C;
Arancibia-Carcamo, IL;
Kyrargyri, V;
Chan, VTT;
Hamilton, NB;
Attwell, D;
(2018)
Effects of the ecto-ATPase apyrase on microglial ramification and surveillance reflect cell depolarization, not ATP depletion.
Proceedings of the National Academy of Sciences of the United States of America (PNAS)
, 115
(7)
E1608-E1617.
10.1073/pnas.1715354115.
|
|
|
Maestú, F;
de Haan, W;
Busche, MA;
DeFelipe, J;
(2021)
Neuronal excitation/inhibition imbalance: core element of a translational perspective on Alzheimer pathophysiology.
Ageing Research Reviews
, 69
, Article 101372. 10.1016/j.arr.2021.101372.
|
|
|
Magusali, N;
Graham, AC;
Piers, TM;
Panichnantakul, P;
Yaman, U;
Shoai, M;
Reynolds, RH;
... Salih, DA; + view all
(2021)
A genetic link between risk for Alzheimer's disease and severe COVID-19 outcomes via the OAS1 gene.
Brain
10.1093/brain/awab337.
(In press).
|
|
|
Mallach, A;
Zielonka, M;
van Lieshout, V;
An, Y;
Khoo, JH;
Vanheusden, M;
Chen, WT;
... De Strooper, B; + view all
(2024)
Microglia-astrocyte crosstalk in the amyloid plaque niche of an Alzheimer's disease mouse model, as revealed by spatial transcriptomics.
Cell Reports
, 43
(6)
, Article 114216. 10.1016/j.celrep.2024.114216.
|
|
Mallach, Anna Katherina;
(2021)
Microglial exosome secretion coupled to TREM2: implications on neuron-like cells.
Doctoral thesis (Ph.D), UCL (University College London).
|
|
Mancuso, R;
Fattorelli, N;
Martinez-Muriana, A;
Davis, E;
Wolfs, L;
Van Den Daele, J;
Geric, I;
... De Strooper, B; + view all
(2024)
Xenografted human microglia display diverse transcriptomic states in response to Alzheimer’s disease-related amyloid-β pathology.
Nature Neuroscience
10.1038/s41593-024-01600-y.
(In press).
|
|
Mancuso, R;
Van Den Daele, J;
Fattorelli, N;
Wolfs, L;
Balusu, S;
Burton, O;
Liston, A;
... De Strooper, B; + view all
(2019)
Stem-cell-derived human microglia transplanted in mouse brain to study human disease.
Nature Neuroscience
, 22
pp. 2111-2116.
10.1038/s41593-019-0525-x.
|
|
Marcelli, Serena;
Iannuzzi, Filomena;
Ficulle, Elena;
Mango, Dalila;
Pieraccini, Stefano;
Pellegrino, Sara;
Corbo, Massimo;
... Feligioni, Marco; + view all
(2019)
The selective disruption of presynaptic JNK2/STX1a interaction reduces NMDA receptor-dependent glutamate release.
Scientific Reports
, 9
, Article 7146. 10.1038/s41598-019-43709-2.
|
|
|
Marsh, Samuel E;
Walker, Alec J;
Kamath, Tushar;
Dissing-Olesen, Lasse;
Hammond, Timothy R;
de Soysa, T Yvanka;
Young, Adam MH;
... Stevens, Beth; + view all
(2022)
Dissection of artifactual and confounding glial signatures by single-cell sequencing of mouse and human brain.
Nature Neuroscience
, 25
(3)
pp. 306-316.
10.1038/s41593-022-01022-8.
|
|
Martinez-Lopez, Nuria;
Mattar, Pamela;
Toledo, Miriam;
Bains, Henrietta;
Kalyani, Manu;
Aoun, Marie Louise;
Sharma, Mridul;
... Singh, Rajat; + view all
(2023)
mTORC2-NDRG1-CDC42 axis couples fasting to mitochondrial fission.
Nature Cell Biology
, 25
(7)
pp. 989-1003.
10.1038/s41556-023-01163-3.
|
|
|
Masato, Anna;
Andolfo, Annapaola;
Favetta, Giulia;
Bellini, Edoardo Niccolo;
Cogo, Susanna;
Dalla Valle, Luisa;
Boassa, Daniela;
... Bubacco, Luigi; + view all
(2024)
Sequestosome-1 (SQSTM1/p62) as a target in dopamine catabolite-mediated cellular dyshomeostasis.
Cell Death & Disease
, 15
, Article 424. 10.1038/s41419-024-06763-x.
|
|
|
Masato, Anna;
Bubacco, Luigi;
(2024)
The αSynuclein half-life conundrum.
Neurobiology of Disease
, 196
, Article 106524. 10.1016/j.nbd.2024.106524.
|
|
|
Masato, Anna;
Panzi, Chiara;
Butnaru, Ioana;
Restani, Laura;
Mazzo, Francesca;
Sher, Emanuele;
Bose, Suchira;
(2024)
Synaptic Release of Pathological Tau Is Calcium- and SNAP25-Dependent, and Blocked by BoNT-A Activity.
Toxicon
, 237
(Supp 1)
, Article 107450. 10.1016/j.toxicon.2024.107450.
|
|
McGirr, A;
Lipina, TV;
Mun, H-S;
Georgiou, J;
Al-Amri, AH;
Ng, E;
Zhai, D;
... Roder, JC; + view all
(2017)
Erratum: Specific Inhibition of Phosphodiesterase-4B Results in Anxiolysis and Facilitates Memory Acquisition.
Neuropsychopharmacology
, 42
(5)
, Article 1178. 10.1038/npp.2016.263.
|
|
|
Meisl, G;
Hidari, E;
Allinson, K;
Rittman, T;
DeVos, SL;
Sanchez, JS;
Xu, CK;
... Klenerman, D; + view all
(2021)
In vivo rate-determining steps of tau seed accumulation in Alzheimer's disease.
Science Advances
, 7
(44)
, Article eabh1448. 10.1126/sciadv.abh1448.
|
|
|
Mensch, M;
Dunot, J;
Yishan, SM;
Harris, SS;
Blistein, A;
Avdiu, A;
Pousinha, PA;
... Marie, H; + view all
(2021)
A eta-alpha and A eta-beta peptides impair LTP ex vivo within the low nanomolar range and impact neuronal activity in vivo.
Alzheimer's Research & Therapy
, 13
(1)
, Article 125. 10.1186/s13195-021-00860-1.
|
|
|
Milioto, Carmelo;
Carcolé, Mireia;
Giblin, Ashling;
Coneys, Rachel;
Attrebi, Olivia;
Ahmed, Mhoriam;
Harris, Samuel S;
... Isaacs, Adrian M; + view all
(2024)
PolyGR and polyPR knock-in mice reveal a conserved neuroprotective extracellular matrix signature in C9orf72 ALS/FTD neurons.
Nature Neuroscience
10.1038/s41593-024-01589-4.
(In press).
|
|
Miranda, AM;
Ashok, A;
Chan, RB;
Zhou, B;
Xu, Y;
McIntire, LB;
Area-Gomez, E;
... Nuriel, T; + view all
(2022)
Effects of APOE4 allelic dosage on lipidomic signatures in the entorhinal cortex of aged mice.
Translational psychiatry
, 12
(1)
, Article 129. 10.1038/s41398-022-01881-6.
|
|
|
Modi, S;
López-Doménech, G;
Halff, EF;
Covill-Cooke, C;
Ivankovic, D;
Melandri, D;
Arancibia-Cárcamo, IL;
... Kittler, JT; + view all
(2019)
Miro clusters regulate ER-mitochondria contact sites and link cristae organization to the mitochondrial transport machinery.
Nature Communications
, 10
, Article 4399. 10.1038/s41467-019-12382-4.
|
|
|
Moonen, Sebastiaan;
Koper, Marta J;
Van Schoor, Evelien;
Schaeverbeke, Jolien M;
Vandenberghe, Rik;
von Arnim, Christine AF;
Tousseyn, Thomas;
... Thal, Dietmar Rudolf; + view all
(2024)
Pyroptosis in Alzheimer's disease: cell type-specific activation in microglia, astrocytes and neurons (Vol 145, pg 175, 2023).
[Corrigendum].
Acta Neuropathol
, 149
, Article 3. 10.1007/s00401-024-02841-8.
|
|
|
Moore, Brenda;
Croft, Cara;
Levites, Yona;
Xu, Guilian;
Hampton, Hailey;
Adamo, Munie;
Futch, Hunter;
... Borchelt, David; + view all
(2022)
Soluble brain homogenates from diverse human and mouse sources preferentially seed diffuse Aβ plaque pathology when injected into newborn mouse hosts.
Free Neuropathology
, 3
, Article 9. 10.17879/freeneuropathology-2022-3766.
|
|
|
Moran, Marta;
Nieto-Lopez, Francisco;
Rueda-Carrasco, Javier;
(2022)
Lipoteichoic acid and molecular weight of hyaluronic acid could explain the late inflammatory response trigger by hyaluronic acid fillers.
Journal of Cosmetic Dermatology
, 21
(11)
pp. 5610-5613.
10.1111/jocd.15243.
|
|
|
Morito, Takahiro;
Qi, Mohan;
Kamano, Naoko;
Sasaguri, Hiroki;
Bez, Sumi;
Foiani, Martha;
Duff, Karen;
... Watamura, Naoto; + view all
(2025)
Human MAPT knockin mouse models of frontotemporal dementia for the neurodegenerative research community.
Cell Reports: Methods
, 5
(4)
, Article 101024. 10.1016/j.crmeth.2025.101024.
|
|
Morotz, GM;
Glennon, EB;
Gomez-Suaga, P;
Lau, DHW;
Robinson, ED;
Sedlak, E;
Vagnoni, A;
... Miller, CCJ; + view all
(2019)
LMTK2 binds to kinesin light chains to mediate anterograde axonal transport of cdk5/p35 and LMTK2 levels are reduced in Alzheimer's disease brains.
Acta Neuropathologica Communications
, 7
(1)
, Article 73. 10.1186/s40478-019-0715-5.
|
|
|
Mórotz, GM;
Glennon, EB;
Greig, J;
Lau, DHW;
Bhembre, N;
Mattedi, F;
Muschalik, N;
... Miller, CCJ; + view all
(2019)
Kinesin light chain-1 serine-460 phosphorylation is altered in Alzheimer's disease and regulates axonal transport and processing of the amyloid precursor protein.
Acta Neuropathologica Communications
, 7
(1)
, Article 200. 10.1186/s40478-019-0857-5.
|
|
|
Mumford, Paige;
Tosh, Justin;
Anderle, Silvia;
Wikberg, Eleni Gkanatsiou;
Lau, Gloria;
Noy, Sue;
Cleverley, Karen;
... Wiseman, Frances K; + view all
(2022)
Genetic mapping of APP and amyloid-β biology modulation by trisomy 21.
Journal of Neuroscience
, 42
(33)
pp. 6453-6468.
10.1523/JNEUROSCI.0521-22.2022.
|
|
Mumford, Paige Soleil;
(2024)
Preclinical modelling of altered
neuroinflammation and interferon hyper-sensitivity in Alzheimer’s disease-Down syndrome.
Doctoral thesis (Ph.D), UCL (University College London).
|
|
|
Murphy, Kitty B;
Hu, Di;
Wolfs, Leen;
Rohde, Susan K;
Fauro, Gonzalo Leguia;
Geric, Ivana;
Mancuso, Renzo;
... Marzi, Sarah J; + view all
(2025)
The APOE isoforms differentially shape the transcriptomic and epigenomic landscapes of human microglia xenografted into a mouse model of Alzheimer’s disease.
Nature Communications
, 16
, Article 4883. 10.1038/s41467-025-60099-4.
|
|
|
Myeku, Natura;
Clelland, Catherine L;
Emrani, Sheina;
Kukushkin, Nikolay V;
Yu, Wai Haung;
Goldberg, Alfred L;
Duff, Karen E;
(2016)
Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling.
nature medicine
, 22
pp. 46-53.
10.1038/nm.4011.
|
|
N
|
Narlawar, Rajeshwar;
Serneels, Lutgarde;
Gaffric, Celia;
Gijsen, Harrie JM;
De Strooper, Bart;
Bischoff, François;
(2023)
Discovery of brain permeable 2-Azabicyclo[2.2.2]octane sulfonamides as a novel class of presenilin-1 selective γ-secretase inhibitors.
European Journal of Medicinal Chemistry
, 260
, Article 115725. 10.1016/j.ejmech.2023.115725.
|
|
Nazish, Iqra;
Mamais, Adamantios;
Mallach, Anna;
Bettencourt, Conceisao;
Kaganovich, Alice;
Warner, Thomas;
Hardy, John;
... Bandopadhyay, Rina; + view all
(2024)
Differential LRRK2 signalling and gene expression in WT-LRRK2 and G2019S-LRRK2 mouse microglia treated with zymosan and MLi2.
Cells
, 13
(1)
, Article 53. 10.3390/cells13010053.
|
|
|
Nigro, Ilaria;
Miglionico, Rocchina;
Carmosino, Monica;
Gerbino, Andrea;
Masato, Anna;
Sandre, Michele;
Bubacco, Luigi;
... Armentano, Maria Francesca; + view all
(2023)
Neuroprotective Effect of Antiapoptotic URG7 Protein on Human Neuroblastoma Cell Line SH-SY5Y.
International Journal of Molecular Sciences
, 25
(1)
, Article 481. 10.3390/ijms25010481.
|
|
Nuriel, T;
Angulo, SL;
Khan, U;
Ashok, A;
Chen, Q;
Figueroa, HY;
Emrani, S;
... Duff, KE; + view all
(2017)
Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer's disease-like pathology.
Nature Communications
, 8
, Article 1464. 10.1038/s41467-017-01444-0.
|
|
O
|
Obensa Bertroli, Clara;
(2024)
Glucocerebrosidase dysfunction results in increased membrane binding and aggregation propensity of α-synuclein in Parkinson's disease.
Doctoral thesis (Ph.D), UCL (University College London).
|
|
Ong-Palsson, E;
Njavro, JR;
Wilson, Y;
Pigoni, M;
Schmidt, A;
Mueller, SA;
Meyer, M;
... Lichtenthaler, SF; + view all
(2021)
The beta-Secretase Substrate Seizure 6-Like Protein (SEZ6L) Controls Motor Functions in Mice.
Molecular Neurobiology
10.1007/s12035-021-02660-y.
|
|
P
|
Paolicelli, RC;
Sierra, A;
Stevens, B;
Tremblay, ME;
Aguzzi, A;
Ajami, B;
Amit, I;
... Wyss-Coray, T; + view all
(2022)
Microglia states and nomenclature: A field at its crossroads.
Neuron
, 110
(21)
pp. 3458-3483.
10.1016/j.neuron.2022.10.020.
|
|
Pappolla, Miguel A;
Refolo, Lorenzo;
Sambamurti, Kumar;
Zambon, Daniel;
Duff, Karen;
(2024)
Hypercholesterolemia and Alzheimer’s Disease: Unraveling the Connection and Assessing the Efficacy of Lipid-Lowering Therapies.
Journal of Alzheimer's Disease
, 101
(s1)
S371-S393.
10.3233/JAD-240388.
|
|
|
Paterson, RW;
Slattery, CF;
Poole, T;
Nicholas, JM;
Magdalinou, NK;
Toombs, J;
Chapman, MD;
... Schott, JM; + view all
(2018)
Cerebrospinal fluid in the differential diagnosis of Alzheimer's disease: clinical utility of an extended panel of biomarkers in a specialist cognitive clinic.
Alzheimer's Research & Therapy
, 10
, Article 32. 10.1186/s13195-018-0361-3.
|
|
Pérez-González, Marta;
Solas, Maite;
Wu, Yixing;
Mela, Virginia;
(2023)
Editorial: New insights into the role of neuroinflammation and glial cells in the development of neurological disorders.
Frontiers in Cellular Neuroscience
, 17
, Article 1170013. 10.3389/fncel.2023.1170013.
|
|
Pigoni, M;
Hsia, H-E;
Hartmann, J;
Rudan Njavro, J;
Shmueli, MD;
Müller, SA;
Güner, G;
... Lichtenthaler, SF; + view all
(2020)
Seizure protein 6 controls glycosylation and trafficking of kainate receptor subunits GluK2 and GluK3.
The EMBO Journal
, 2020
, Article e103457. 10.15252/embj.2019103457.
|
|
|
Policarpo, Rafaela;
Wolfs, Leen;
Martinez-Montero, Saul;
Vandermeulen, Lina;
Royaux, Ines;
Van Peer, Gert;
Mestdagh, Pieter;
... d'Ydewalle, Constantin; + view all
(2025)
The MIR-NAT MAPT-AS1 does not regulate Tau
expression in human neurons.
PLoS ONE
, 20
(1)
, Article e0314973. 10.1371/journal.pone.0314973.
|
|
|
Powell, NM;
Modat, M;
Cardoso, MJ;
Ma, D;
Holmes, HE;
Yu, Y;
O'Callaghan, J;
... Ourselin, S; + view all
(2016)
Fully-Automated mu MRI Morphometric Phenotyping of the Tc1 Mouse Model of Down Syndrome.
PLoS ONE
, 11
(9)
, Article e0162974. 10.1371/journal.pone.0162974.
|
|
Preman, Pranav;
Moechars, Daan;
Fertan, Emre;
Wolfs, Leen;
Serneels, Lutgarde;
Shah, Disha;
Lamote, Jochen;
... De Strooper, Bart; + view all
(2024)
APOE from astrocytes restores Alzheimer's Aβ-pathology and DAM-like responses in APOE deficient microglia.
EMBO Molecular Medicine
10.1038/s44321-024-00162-7.
(In press).
|
|
|
Prosser, Lloyd;
(2024)
Investigating Imaging Biomarkers in Normal Ageing and Cognitive Impairment.
Doctoral thesis (Ph.D), UCL (University College London).
|
|
Q
|
Quick, S;
Moss, J;
Rajani, RM;
Williams, A;
(2020)
A Vessel for Change: Endothelial Dysfunction in Cerebral Small Vessel Disease.
Trends in Neurosciences
10.1016/j.tins.2020.11.003.
|
|
R
|
Rajani, Rikesh M;
Ellingford, Robert;
Hellmuth, Mariam;
Harris, Samuel S;
Taso, Orjona S;
Graykowski, David;
Lam, Francesca Kar Wey;
... Busche, Marc Aurel; + view all
(2024)
Selective suppression of oligodendrocyte-derived amyloid beta rescues neuronal dysfunction in Alzheimer's disease.
PLoS Biology
, 22
(7)
, Article ARTN e3002727. 10.1371/journal.pbio.3002727.
|
|
|
Rajani, RM;
Dupré, N;
Domenga-Denier, V;
Van Niel, G;
Heiligenstein, X;
Joutel, A;
(2021)
Characterization of early ultrastructural changes in the cerebral white matter of CADASIL small vessel disease using high pressure freezing/freeze-substitution.
Neuropathology and Applied Neurobiology
, 47
(5)
pp. 694-704.
10.1111/nan.12697.
|
|
Rajani, RM;
Quick, S;
Ruigrok, SR;
Graham, D;
Harris, SE;
Verhaaren, BFJ;
Fornage, M;
... Williams, A; + view all
(2018)
Reversal of endothelial dysfunction reduces white matter vulnerability in cerebral small vessel disease in rats.
Science Translational Medicine
, 10
(448)
, Article eaam9507. 10.1126/scitranslmed.aam9507.
|
|
|
Rajani, RM;
Ratelade, J;
Domenga-Denier, V;
Hase, Y;
Kalimo, H;
Kalaria, RN;
Joutel, A;
(2019)
Blood brain barrier leakage is not a consistent feature of white matter lesions in CADASIL.
Acta Neuropathologica Communications
, 7
(1)
, Article 187. 10.1186/s40478-019-0844-x.
|
|
|
Rajani, RM;
Williams, A;
(2017)
Endothelial cell–oligodendrocyte interactions in small vessel disease and aging.
Clinical Science
, 131
(5)
pp. 369-379.
10.1042/CS20160618.
|
|
|
Ramalingam, Nagendran;
Jin, Shan-Xue;
Moors, Tim E;
Fonseca-Ornelas, Luis;
Shimanaka, Kazuma;
Lei, Shi;
Cam, Hugh P;
... Dettmer, Ulf; + view all
(2023)
Dynamic physiological alpha-synuclein S129 phosphorylation is driven by neuronal activity.
npj Parkinson's Disease
, 9
(1)
10.1038/s41531-023-00444-w.
|
|
Requena-Komuro, Maï-Carmen;
(2022)
Subjective time perception in healthy ageing and dementia.
Doctoral thesis (Ph.D), UCL (University College London).
|
 |
|
Rifat, Ali;
Bickel, Tom;
Kreis, Patricia;
Trimbuch, Thorsten;
Onken, Julia;
Ivanov, Andranik;
Albertini, Giulia;
... Madry, Christian; + view all
(2025)
The chloride intracellular channel 1 (CLIC1) is essential for microglial morphodynamics and neuroinflammation.
Science Advances
, 11
(43)
, Article eads9181. 10.1126/sciadv.ads9181.
|
|
Rodriguez, GA;
Barrett, GM;
Duff, KE;
Hussaini, SA;
(2020)
Chemogenetic attenuation of neuronal activity in the entorhinal cortex reduces Aβ and tau pathology in the hippocampus.
PLoS Biology
, 18
(8)
, Article e3000851. 10.1371/journal.pbio.3000851.
|
|
|
Román-Vendrell, C;
Medeiros, AT;
Sanderson, JB;
Jiang, H;
Bartels, T;
Morgan, JR;
(2021)
Effects of Excess Brain-Derived Human α-Synuclein on Synaptic Vesicle Trafficking.
Frontiers in Neuroscience
, 15
10.3389/fnins.2021.639414.
|
|
|
Rovere, M;
Powers, AE;
Jiang, H;
Pitino, JC;
Fonseca-Ornelas, L;
Patel, DS;
Achille, A;
... Bartels, T; + view all
(2019)
E46K-like α-synuclein mutants increase lipid interactions and disrupt membrane selectivity.
Journal of Biological Chemistry
10.1074/jbc.RA118.006551.
(In press).
|
|
|
Rowland, JM;
van der Plas, TL;
Loidolt, M;
Lees, RM;
Keeling, J;
Dehning, J;
Akam, T;
... Packer, AM; + view all
(2023)
Propagation of activity through the cortical hierarchy and perception are determined by neural variability.
Nature Neuroscience
, 26
(9)
pp. 1584-1594.
10.1038/s41593-023-01413-5.
|
|
|
Rueda-Carrasco, Javier;
Sokolova, Dimitra;
Lee, Sang-Eun;
Childs, Thomas;
Jurčáková, Natália;
Crowley, Gerard;
De Schepper, Sebastiaan;
... Hong, Soyon; + view all
(2023)
Microglia-synapse engulfment via PtdSer-TREM2 ameliorates neuronal hyperactivity in Alzheimer's disease models.
The EMBO Journal
, Article e113246. 10.15252/embj.2022113246.
|
|
Rueda-Carrasco, J;
Hong, S;
(2020)
The Jekyll and Hyde of TREM2.
Trends Neurosciences
, 43
(10)
pp. 739-740.
10.1016/j.tins.2020.08.002.
|
|
Ruiz-Riquelme, A;
Mao, A;
Barghash, MM;
Lau, HHC;
Stuart, E;
Kovacs, GG;
Nilsson, KPR;
... Watts, JC; + view all
(2021)
Aβ43 aggregates exhibit enhanced prion-like seeding activity in mice.
Acta Neuropathologica Communications
, 9
(1)
, Article 83. 10.1186/s40478-021-01187-6.
|
|
S
|
Sala Frigerio, C;
Wolfs, L;
Fattorelli, N;
Thrupp, N;
Voytyuk, I;
Schmidt, I;
Mancuso, R;
... De Strooper, B; + view all
(2019)
The Major Risk Factors for Alzheimer's Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques.
Cell Reports
, 27
(4)
pp. 1293-1306.
10.1016/j.celrep.2019.03.099.
|
|
|
Sánchez-Valle, R;
Heslegrave, A;
Foiani, MS;
Bosch, B;
Antonell, A;
Balasa, M;
Lladó, A;
... Fox, NC; + view all
(2018)
Serum neurofilament light levels correlate with severity measures and neurodegeneration markers in autosomal dominant Alzheimer's disease.
Alzheimer's Research & Therapy
, 10
, Article 113. 10.1186/s13195-018-0439-y.
|
|
Sanderson, JB;
De, S;
Jiang, H;
Rovere, M;
Jin, M;
Zaccagnini, L;
Hays Watson, A;
... Bartels, T; + view all
(2020)
Analysis of α-synuclein species enriched from cerebral cortex of humans with sporadic dementia with Lewy bodies.
Brain Communications
, 2
(1)
, Article fcaa010. 10.1093/braincomms/fcaa010.
|
|
|
Sanjuan-Ruiz, Inmaculada;
Serneels, Lutgarde;
Craessaerts, Katleen;
Goate, Alison;
Annaert, Wim;
Chávez-Gutiérrez, Lucía;
Shi, Yonggang;
... De Strooper, Bart; + view all
(2025)
The curious case of a heterozygous loss-of-function PSEN1 variant associated with early-onset Alzheimer’s disease.
Molecular Neurodegeneration Advances
, 1
, Article 4. 10.1186/s44477-025-00004-x.
|
|
|
Schaler, AW;
Runyan, AM;
Clelland, CL;
Sydney, EJ;
Fowler, SL;
Figueroa, HY;
Shioda, S;
... Myeku, N; + view all
(2021)
PAC1 receptor-mediated clearance of tau in postsynaptic compartments attenuates tau pathology in mouse brain.
Science Translational Medicine
, 13
(595)
, Article eaba7394. 10.1126/scitranslmed.aba7394.
|
|
|
Schlepckow, K;
Morenas-Rodríguez, E;
Hong, S;
Haass, C;
(2023)
Stimulation of TREM2 with agonistic antibodies—an emerging therapeutic option for Alzheimer's disease.
The Lancet Neurology
, 22
(11)
pp. 1048-1060.
10.1016/S1474-4422(23)00247-8.
|
|
Schmidt, Andree;
Hrupka, Brian;
van Bebber, Frauke;
Sunil Kumar, Sanjay;
Feng, Xiao;
Tschirner, Sarah K;
Aßfalg, Marlene;
... Lichtenthaler, Stefan F; + view all
(2024)
The Alzheimer's disease-linked protease BACE2 cleaves VEGFR3 and modulates its signaling.
The Journal of Clinical Investigation
, Article e170550. 10.1172/JCI170550.
(In press).
|
|
Scott-Solache, James;
(2024)
TREM2 signaling regulates microglial homeostatic
functions.
Doctoral thesis (Ph.D), UCL (University College London.
|
|
Serneels, L;
Bammens, L;
Zwijsen, A;
Tolia, A;
Chávez-Gutiérrez, L;
De Strooper, B;
(2024)
Functional and topological analysis of PSENEN, the fourth subunit of the γ-secretase complex.
Journal of Biological Chemistry
, 300
(1)
, Article 105533. 10.1016/j.jbc.2023.105533.
|
|
Serneels, Lutgarde;
Sierksma, Annerieke;
Pasciuto, Emanuela;
Geric, Ivana;
Nair, Arya;
Martinez-Muriana, Anna;
Snellinx, An;
(2025)
A versatile mouse model to advance human microglia transplantation research in neurodegenerative diseases.
Molecular Neurodegeneration volume
, 20
(1)
, Article 29. 10.1186/s13024-025-00823-2.
|
|
|
Shah, D;
Gsell, W;
Wahis, J;
Luckett, ES;
Jamoulle, T;
Vermaercke, B;
Preman, P;
... De Strooper, B; + view all
(2022)
Astrocyte calcium dysfunction causes early network hyperactivity in Alzheimer's disease.
Cell Reports
, 40
(8)
, Article 111280. 10.1016/j.celrep.2022.111280.
|
|
Sierksma, A;
Lu, A;
Mancuso, R;
Fattorelli, N;
Thrupp, N;
Salta, E;
Zoco, J;
... Fiers, M; + view all
(2020)
Novel Alzheimer risk genes determine the microglia response to amyloid‐β but not to TAU pathology.
EMBO Molecular Medicine
, Article e10606. 10.15252/emmm.201910606.
(In press).
|
|
|
Sierksma, A;
Lu, A;
Salta, E;
Vanden Eynden, E;
Callaerts-Vegh, Z;
D'Hooge, R;
Blum, D;
... De Strooper, B; + view all
(2018)
Deregulation of neuronal miRNAs induced by amyloid-β or TAU pathology.
Molecular Neurodegeneration
, 13
(54)
10.1186/s13024-018-0285-1.
|
|
|
Simmonds, Emily;
Leonenko, Ganna;
Yaman, Umran;
Bellou, Eftychia;
Myers, Amanda;
Morgan, Kevin;
Brookes, Keeley;
... Escott-Price, Valentina; + view all
(2024)
Chromosome X-wide association study in case control studies of pathologically confirmed Alzheimer's disease in a European population.
Translational Psychiatry
, 14
, Article 358. 10.1038/s41398-024-03058-9.
|
|
|
Sokolova, Dimitra;
Ghansah, Shari Addington;
Puletti, Francesca;
Georgiades, Tatiana;
De Schepper, Sebastiaan;
Zheng, Yongjing;
Crowley, Gerard;
... Hong, Soyon; + view all
(2024)
Astrocyte-derived MFG-E8 facilitates microglial synapse elimination in Alzheimer's disease mouse models.
BioRXiv: Cold Spring Harbor, NY, USA.
|
|
|
Sokolova, D;
Childs, T;
Hong, S;
(2021)
Insight into the role of phosphatidylserine in complement-mediated synapse loss in Alzheimer's disease.
Faculty Opinions
, 10
, Article 19. 10.12703/r.
|
|
|
Song, S;
Ashok, A;
Williams, D;
Kaufman, M;
Duff, K;
Sproul, A;
(2021)
Efficient Derivation of Excitatory and Inhibitory Neurons from Human Pluripotent Stem Cells Stably Expressing Direct Reprogramming Factors.
Current Protocols
, 1
(6)
, Article e141. 10.1002/cpz1.141.
|
|
Sri, Sarmi;
Greenstein, Adam;
Granata, Alessandra;
Collcutt, Alex;
Jochems, Angela CC;
McColl, Barry W;
Castro, Blanca Díaz;
... Wardlaw, Joanna M; + view all
(2023)
A multi-disciplinary commentary on preclinical research to investigate vascular contributions to dementia.
Cerebral Circulation - Cognition and Behavior
, 5
, Article 100189. 10.1016/j.cccb.2023.100189.
(In press).
|
|
|
Startin, CM;
Hamburg, S;
Hithersay, R;
Al-Janabi, T;
Mok, KY;
Hardy, J;
LonDownS Consortium, .;
(2019)
Cognitive markers of preclinical and prodromal Alzheimer's disease in Down syndrome.
Alzheimer's & Dementia
, 15
(2)
pp. 245-257.
10.1016/j.jalz.2018.08.009.
|
|
Startin, CM;
Ashton, NJ;
Hamburg, S;
Hithersay, R;
Wiseman, FK;
Mok, KY;
Hardy, J;
... Strydom, A; + view all
(2019)
Plasma biomarkers for amyloid, tau, and cytokines in Down syndrome and sporadic Alzheimer's disease.
Alzheimer's Research & Therapy
, 11
, Article 26. 10.1186/s13195-019-0477-0.
|
|
|
Startin, CM;
D'Souza, H;
Ball, G;
Hamburg, S;
Hithersay, R;
Hughes, KMO;
Massand, E;
... Strydom, A; + view all
(2020)
Health comorbidities and cognitive abilities across the lifespan in Down syndrome.
Journal of Neurodevelopmental Disorders
, 12
, Article 4. 10.1186/s11689-019-9306-9.
|
|
|
Startin, CM;
Hamburg, S;
Strydom, A;
Strydom, A;
Fisher, E;
Nizetic, D;
Hardy, J;
... Karmiloff-Smith, A; + view all
(2019)
Comparison of Receptive Verbal Abilities Assessed Using the KBIT-2 and BPVS3 in Adults With Down Syndrome.
Frontiers in Psychology
, 9
, Article 2730. 10.3389/fpsyg.2018.02730.
|
|
|
Startin, CM;
Lowe, B;
Hamburg, S;
Hithersay, R;
Strydom, A;
Fisher, E;
Nizetic, D;
... Karmiloff-Smith, A; + view all
(2019)
Validating the Cognitive Scale for Down Syndrome (CS-DS) to Detect Longitudinal Cognitive Decline in Adults With Down Syndrome.
Frontiers in Psychiatry
, 10
, Article 158. 10.3389/fpsyt.2019.00158.
|
|
|
Stephen, TL;
Higgs, NF;
Sheehan, DF;
Al Awabdh, S;
López-Doménech, G;
Arancibia-Carcamo, IL;
Kittler, JT;
(2015)
Miro1 Regulates Activity-Driven Positioning of Mitochondria within Astrocytic Processes Apposed to Synapses to Regulate Intracellular Calcium Signaling.
Journal of Neuroscience
, 35
(48)
pp. 15996-16011.
10.1523/JNEUROSCI.2068-15.2015.
|
|
|
Strydom, A;
Heslegrave, A;
Startin, CM;
Mok, KY;
Hardy, J;
Groet, J;
Nizetic, D;
... LonDownS Consortium; + view all
(2018)
Neurofilament light as a blood biomarker for neurodegeneration in Down syndrome.
Alzheimer's Research & Therapy
, 10
(1)
, Article 39. 10.1186/s13195-018-0367-x.
|
|
|
Stuart, Skye;
(2025)
Modulating trans-synaptic tau transfer in vitro and in vivo.
Doctoral thesis (Ph.D), UCL (University College London).
|
T
|
Taddei, Raquel N;
(2024)
Understanding the role of glia and oligomeric tau in the
early synapse loss of Alzheimer disease dementia.
Doctoral thesis (Ph.D), UCL (University College London).
|
|
|
Taddei, Raquel N;
Duff, Karen E;
(2025)
Synapse vulnerability and resilience across the clinical spectrum of dementias.
Nature Reviews Neurology
10.1038/s41582-025-01094-7.
(In press).
|
|
Taddei, Raquel N;
Duff, Karen E;
(2025)
Synapse vulnerability and resilience underlying Alzheimer's disease.
eBioMedicine
, 112
, Article 105557. 10.1016/j.ebiom.2025.105557.
|
|
Taddei, Raquel N;
Perbet, Romain;
Mate de Gerando, Anastasie;
Wiedmer, Anne E;
Sanchez-Mico, Maria;
Connors Stewart, Theresa;
Gaona, Angelica;
... Gómez-Isla, Teresa; + view all
(2023)
Tau Oligomer–Containing Synapse Elimination by Microglia and Astrocytes in Alzheimer Disease.
JAMA Neurology
10.1001/jamaneurol.2023.3530.
(In press).
|
|
Thal, Dietmar Rudolf;
De Strooper, Bart;
(2024)
Regulated cell death in neurodegeneration: pathways and therapeutic horizons.
Acta Neuropathologica
, 148
, Article 47. 10.1007/s00401-024-02808-9.
|
|
Thomas, MSC;
Ojinaga Alfageme, O;
D'Souza, H;
Patkee, PA;
Rutherford, MA;
Mok, KY;
Hardy, J;
... LonDownS Consortium; + view all
(2020)
A multi-level developmental approach to exploring individual differences in Down syndrome: genes, brain, behaviour, and environment.
Research in Developmental Disabilities
, 104
, Article 103638. 10.1016/j.ridd.2020.103638.
|
|
|
Thrupp, N;
Sala Frigerio, C;
Wolfs, L;
Skene, NG;
Fattorelli, N;
Poovathingal, S;
Fourne, Y;
... Fiers, M; + view all
(2020)
Single-Nucleus RNA-Seq Is Not Suitable for Detection of Microglial Activation Genes in Humans.
Cell Reports
, 32
(13)
, Article 108189. 10.1016/j.celrep.2020.108189.
|
|
|
Toombs, J;
Foiani, MS;
Paterson, RW;
Heslegrave, A;
Wray, S;
Schott, JM;
Fox, NC;
... Zetterberg, H; + view all
(2017)
Effect of Spinal Manometers on Cerebrospinal Fluid Amyloid-beta Concentration.
Journal of Alzheimer's Disease
, 56
(3)
pp. 885-891.
10.3233/JAD-161126.
|
|
Toombs, J;
Foiani, MS;
Wellington, H;
Paterson, RW;
Arber, C;
Heslegrave, A;
Lunn, MP;
... Zetterberg, H; + view all
(2018)
Amyloid β peptides are differentially vulnerable to preanalytical surface exposure, an effect incompletely mitigated by the use of ratios.
Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
, 10
pp. 311-321.
10.1016/j.dadm.2018.02.005.
|
|
|
Tosh, J;
Rickman, M;
Rhymes, E;
Norona, F;
Clayton, E;
Mucke, L;
Isaacs, A;
... Wiseman, F; + view all
(2018)
The integration site of the APP transgene in the J20 mouse model of Alzheimer’s disease.
Wellcome Open Research
, 2
, Article 84. 10.12688/wellcomeopenres.12237.2.
|
|
|
Tosh, JL;
Rhymes, ER;
Mumford, P;
Whittaker, HT;
Pulford, LJ;
Noy, SJ;
Cleverley, K;
... Wiseman, FK; + view all
(2021)
Genetic dissection of down syndrome-associated alterations in APP/amyloid-β biology using mouse models.
Scientific Reports
, 11
(1)
, Article 5736. 10.1038/s41598-021-85062-3.
|
|
|
Tosh, JL;
Rickman, M;
Rhymes, E;
Norona, FE;
Clayton, E;
Mucke, L;
Isaacs, AM;
... Wiseman, FK; + view all
(2017)
The integration site of the APP transgene in the J20 mouse model of Alzheimer’s disease.
Wellcome Open Research
, 2
, Article 84. 10.12688/wellcomeopenres.12237.1.
|
|
V
|
Vandermeulen, Lina;
Geric, Ivana;
Fumagalli, Laura;
Kreir, Mohamed;
Lu, Ashley;
Nonneman, Annelies;
Premereur, Jessie;
... Mancuso, Renzo; + view all
(2024)
Regulation of human microglial gene expression and function via RNAase-H active antisense oligonucleotides in vivo in Alzheimer's disease.
, Article 37. 10.1186/s13024-024-00725-9.
|
|
|
Vijiaratnam, Nirosen;
Lawton, Michael;
Heslegrave, Amanda J;
Guo, Tong;
Tan, Manuela;
Jabbari, Edwin;
Real, Raquel;
... PRoBaND clinical consortium; + view all
(2022)
Combining biomarkers for prognostic modelling of Parkinson's disease.
Journal of Neurology, Neurosurgery and Psychiatry (JNNP)
10.1136/jnnp-2021-328365.
(In press).
|
|
Viola, MF;
Chavero-Pieres, M;
Modave, E;
Delfini, M;
Stakenborg, N;
Estévez, MC;
Fabre, N;
... Boeckxstaens, G; + view all
(2023)
Dedicated macrophages organize and maintain the enteric nervous system.
Nature
, 618
(7966)
pp. 818-826.
10.1038/s41586-023-06200-7.
|
W
|
Walgrave, H;
Penning, A;
Tosoni, G;
Snoeck, S;
Davie, K;
Davis, E;
Wolfs, L;
... Salta, E; + view all
(2023)
microRNA-132 regulates gene expression programs involved in microglial homeostasis.
iScience
, 26
(6)
, Article 106829. 10.1016/j.isci.2023.106829.
|
|
|
Walgrave, H;
Balusu, S;
Snoeck, S;
Vanden Eynden, E;
Craessaerts, K;
Thrupp, N;
Wolfs, L;
... Salta, E; + view all
(2021)
Restoring miR-132 expression rescues adult hippocampal neurogenesis and memory deficits in Alzheimer's disease.
Cell Stem Cell
10.1016/j.stem.2021.05.001.
(In press).
|
|
|
Walker, Lary C;
Diamond, Marc I;
Duff, Karen E;
Hyman, Bradley T;
(2013)
Mechanisms of Protein Seeding in Neurodegenerative Diseases.
JAMA Neurology
, 70
(3)
pp. 304-310.
10.1001/jamaneurol.2013.1453.
|
|
|
Watamura, Naoto;
Foiani, Martha S;
Bez, Sumi;
Bourdenx, Mathieu;
Santambrogio, Alessia;
Frodsham, Claire;
Camporesi, Elena;
... Saido, Takaomi C; + view all
(2024)
In vivo hyperphosphorylation of tau is associated with synaptic loss and behavioral abnormalities in the absence of tau seeds.
Nature Neuroscience
, 28
pp. 293-307.
10.1038/s41593-024-01829-7.
|
|
Watson-Scales, S;
Kalmar, B;
Lana-Elola, E;
Gibbins, D;
La Russa, F;
Wiseman, F;
Williamson, M;
... Tybulewicz, VLJ; + view all
(2018)
Analysis of motor dysfunction in Down Syndrome reveals motor neuron degeneration.
PLoS Genetics
, 14
(5)
, Article e1007383. 10.1371/journal.pgen.1007383.
|
|
|
Wenz, Katharina;
(2025)
Investigating candidate genes for amyloid-β accumulation and toxicity in Alzheimer’s disease-Down syndrome.
Doctoral thesis (Ph.D), UCL (University College London).
|
|
|
Whittaker, HT;
Zhu, S;
Di Curzio, DL;
Buist, R;
Li, X-M;
Noy, S;
Wiseman, FK;
... Martin, M; + view all
(2018)
T1, diffusion tensor, and quantitative magnetization transfer imaging of the hippocampus in an Alzheimer's disease mouse model.
Magnetic Resonance Imaging
, 50
pp. 26-37.
10.1016/j.mri.2018.03.010.
|
|
Wiseman, FK;
Al-Janabi, T;
Hardy, J;
Karmiloff-Smith, A;
Nizetic, D;
Tybulewicz, VLJ;
Fisher, EMC;
(2015)
A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome.
Nature Reviews Neuroscience
, 16
(9)
pp. 564-574.
10.1038/nrn3983.
|
|
Wiseman, FK;
Alford, KA;
Tybulewicz, VLJ;
Fisher, EMC;
(2009)
Down syndrome-recent progress and future prospects.
HUM MOL GENET
, 18
R75 - R83.
10.1093/hmg/ddp010.
|
|
|
Wiseman, FK;
Pulford, LJ;
Barkus, C;
Liao, F;
Portelius, E;
Webb, R;
Chávez-Gutiérrez, L;
... Fisher, EMC; + view all
(2018)
Trisomy of human chromosome 21 enhances amyloid-β deposition independently of an extra copy of APP.
Brain
, 141
(8)
pp. 2457-2474.
10.1093/brain/awy159.
|
|
|
Woollacott, IOC;
Nicholas, JM;
Heslegrave, A;
Heller, C;
Foiani, MS;
Dick, KM;
Russell, LL;
... Rohrer, JD; + view all
(2018)
Cerebrospinal fluid soluble TREM2 levels in frontotemporal dementia differ by genetic and pathological subgroup.
Alzheimer's Research & Therapy
, 10
, Article 79. 10.1186/s13195-018-0405-8.
|
|
|
Wu, Jessica W;
Herman, Mathieu;
Liu, Li;
Simoes, Sabrina;
Acker, Christopher M;
Figueroa, Helen;
Steinberg, Joshua I;
... Duff, Karen E; + view all
(2013)
Small Misfolded Tau Species Are Internalized via Bulk
Endocytosis and Anterogradely and Retrogradely
Transported in Neurons.
Journal of Biological Chemistry (JBC)
, 288
(3)
pp. 1856-1870.
10.1074/jbc.M112.394528.
|
|
|
Wu, Y;
Bai, Y;
McEwan, DG;
Bentley, L;
Aravani, D;
Cox, RD;
(2021)
Palmitoylated small GTPase ARL15 is translocated within Golgi network during adipogenesis.
Biology Open
10.1242/bio.058420.
(In press).
|
|
|
Wu, Y;
Cleverley, K;
Wiseman, FK;
(2025)
Reduction of Cystatin B results in increased cathepsin B activity in disomic but not Trisomy 21 human cellular and mouse models.
PLoS ONE
, 20
(1)
, Article e0316822. 10.1371/journal.pone.0316822.
|
|
|
Wu, Yixing;
Mumford, Paige;
Noy, Suzanna;
Cleverley, Karen;
Mrzyglod, Alicja;
Luo, Dinghao;
van Dalen, Floris;
... Wiseman, Frances K; + view all
(2023)
Cathepsin B abundance, activity and microglial localisation in Alzheimer's disease-Down syndrome and early onset Alzheimer's disease; the role of elevated cystatin B.
Acta Neuropathologica Communications
, 11
, Article 132. 10.1186/s40478-023-01632-8.
|
|
Wu, Yixing;
West, Nicole;
Bhattacharyya, Anita;
Wiseman, Frances K;
(2022)
Cell models for Down syndrome-Alzheimer’s disease research.
Neuronal Signaling
, 6
(1)
, Article NS20210054. 10.1042/ns20210054.
|
|
Wu, JW;
Hussaini, SA;
Bastille, IM;
Rodriguez, GA;
Mrejeru, A;
Rilett, K;
Sanders, DW;
... Duff, KE; + view all
(2016)
Neuronal activity enhances tau propagation and tau pathology in vivo.
Nature Neuroscience
, 19
(8)
pp. 1085-1092.
10.1038/nn.4328.
|
|
|
Wu, Y;
Davies, KE;
Oliver, PL;
(2016)
The antioxidant protein Oxr1 influences aspects of mitochondrial morphology.
Free Radical Biology and Medicine
, 95
pp. 255-267.
10.1016/j.freeradbiomed.2016.03.029.
|
|
|
Wu, Y;
Whittaker, HT;
Noy, S;
Cleverley, K;
Brault, V;
Herault, Y;
Fisher, EMC;
(2021)
The effects of Cstb duplication on APP/amyloid-β pathology and cathepsin B activity in a mouse model.
PLoS One
, 16
(7)
, Article e0242236. 10.1371/journal.pone.0242236.
|
|
X
|
Xiang, X;
Langlois, S;
St-Pierre, M-E;
Blinder, A;
Charron, P;
Graber, TE;
Fowler, SL;
... Cowan, KN; + view all
(2021)
Identification of pannexin 1-regulated genes, interactome, and pathways in rhabdomyosarcoma and its tumor inhibitory interaction with AHNAK.
Oncogene
, 40
(10)
pp. 1868-1883.
10.1038/s41388-020-01623-2.
|
|
Y
|
Yang, Jie;
Yamashita-Kanemaru, Yumi;
Morris, Benjamin I;
Contursi, Annalisa;
Trajkovski, Daniel;
Xu, Jingru;
Patrascan, Ilinca;
... Roychoudhuri, Rahul; + view all
(2025)
Aspirin prevents metastasis by limiting platelet TXA2 suppression of T cell immunity.
Nature
10.1038/s41586-025-08626-7.
(In press).
|
|
Z
|
Zeitlberger, AM;
Thomas-Black, G;
Garcia-Moreno, H;
Foiani, M;
Heslegrave, AJ;
Zetterberg, H;
Giunti, P;
(2018)
Plasma Markers of Neurodegeneration Are Raised in Friedreich's Ataxia.
Frontiers in Cellular Neuroscience
, 12
, Article 366. 10.3389/fncel.2018.00366.
|
|
|
Zelek, Wioleta M;
Bevan, Ryan J;
Nimmo, Jacqui;
Dewilde, Maarten;
De Strooper, Bart;
Morgan, B Paul;
(2024)
Brain-penetrant complement inhibition mitigates neurodegeneration in an Alzheimer's disease mouse model.
Brain
10.1093/brain/awae278.
(In press).
|
|
|
Zhao, J;
Rostgaard, K;
Lauwers, E;
Dahlén, T;
Ostrowski, SR;
Erikstrup, C;
Pedersen, OB;
... Edgren, G; + view all
(2023)
Intracerebral Hemorrhage among Blood Donors and Their Transfusion Recipients.
JAMA: Journal of the American Medical Association
, 330
(10)
pp. 941-950.
10.1001/jama.2023.14445.
|
|
|
Zilio, Gianluca;
Masato, Anna;
Sandre, Michelle;
Caregnato, Alberto;
Moret, Francesca;
Maciola, Agnieszka Katarzyna;
Antonini, Angelo;
... Bubacco, Luigi; + view all
(2024)
SARS-CoV-2-Mimicking Pseudoviral Particles Accelerate α-Synuclein Aggregation In Vitro.
ACS Chemical Neuroscience
, 15
(2)
pp. 215-221.
10.1021/acschemneuro.3c00468.
|
