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A Vessel for Change: Endothelial Dysfunction in Cerebral Small Vessel Disease

Quick, S; Moss, J; Rajani, RM; Williams, A; (2020) A Vessel for Change: Endothelial Dysfunction in Cerebral Small Vessel Disease. Trends in Neurosciences 10.1016/j.tins.2020.11.003. Green open access

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Abstract

The blood vessels of the brain are lined with endothelial cells and it has been long known that these help to regulate blood flow to the brain. However, there is increasing evidence that these cells also interact with the surrounding brain tissue. These interactions change when the endothelial cells become dysfunctional and have an impact in diseases such as cerebral small vessel disease, the leading cause of vascular dementia. In this review, we focus on what endothelial dysfunction is, what causes it, how it leads to surrounding brain pathology, how researchers can investigate it with current models, and where this might lead in the future for dementia therapies.

Type: Article
Title: A Vessel for Change: Endothelial Dysfunction in Cerebral Small Vessel Disease
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.tins.2020.11.003
Publisher version: http://dx.doi.org/10.1016/j.tins.2020.11.003
Language: English
Additional information: © 2020 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: vascular dementia, endothelium, myelin
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > UK Dementia Research Institute
URI: https://discovery.ucl.ac.uk/id/eprint/10117440
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