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Cellular senescence at the crossroads of inflammation and Alzheimer's disease

Guerrero, A; De Strooper, B; Arancibia-Cárcamo, IL; (2021) Cellular senescence at the crossroads of inflammation and Alzheimer's disease. Trends in Neurosciences , 44 (9) pp. 714-727. 10.1016/j.tins.2021.06.007. Green open access

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Abstract

Aging is a key risk factor for Alzheimer's disease (AD), but the reasons for this association are not well understood. Senescent cells accumulate in aged tissues and have been shown to play causal roles in age-related pathologies through their proinflammatory secretome. The question arises whether senescence-induced inflammation might contribute to AD and bridge the gap between aging and AD. Here, we highlight the role of cellular senescence as a driver of the aging phenotype, and discuss the current evidence that connects senescence with AD and neurodegeneration.

Type: Article
Title: Cellular senescence at the crossroads of inflammation and Alzheimer's disease
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.tins.2021.06.007
Publisher version: https://doi.org/10.1016/j.tins.2021.06.007
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Ageing; neuroinflammation; microglia; astrocytes; neurodegeneration; SASP
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > UK Dementia Research Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UK Dementia Research Institute HQ
URI: https://discovery.ucl.ac.uk/id/eprint/10133829
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