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Effect of Spinal Manometers on Cerebrospinal Fluid Amyloid-beta Concentration

Toombs, J; Foiani, MS; Paterson, RW; Heslegrave, A; Wray, S; Schott, JM; Fox, NC; ... Zetterberg, H; + view all (2017) Effect of Spinal Manometers on Cerebrospinal Fluid Amyloid-beta Concentration. Journal of Alzheimer's Disease , 56 (3) pp. 885-891. 10.3233/JAD-161126. Green open access

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Abstract

The effect of spinal manometers on cerebrospinal fluid (CSF) amyloid-β (Aβ) concentration was investigated. Pooled human CSF samples were divided in two, one half passed through a manometer into a collection tube, the other transferred directly to a collection tube. CSF was analyzed for Aβ38/40/42 using an electrochemiluminescence immunoassay. Relative to control, use of a manometer decreased Aβ38/40/42 concentration by 5.6% (±1.5SE), 4.4% (±1.7SE), and 4.3% (±2.4SE), respectively. The ratios of Aβ42 :40, Aβ42 :38, and Aβ40 :38 were not affected by manometer treatment. Factors which artificially lower CSF Aβ concentrations are relevant to clinical diagnosis for AD and study design.

Type: Article
Title: Effect of Spinal Manometers on Cerebrospinal Fluid Amyloid-beta Concentration
Open access status: An open access version is available from UCL Discovery
DOI: 10.3233/JAD-161126
Publisher version: http://dx.doi.org/10.3233/JAD-161126
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Alzheimer’s disease, amyloid-�, biomarkers, cerebrospinal fluid, manometer, pre-analytical factor
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > UK Dementia Research Institute
URI: https://discovery.ucl.ac.uk/id/eprint/1536051
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