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Endothelial cell–oligodendrocyte interactions in small vessel disease and aging

Rajani, RM; Williams, A; (2017) Endothelial cell–oligodendrocyte interactions in small vessel disease and aging. Clinical Science , 131 (5) pp. 369-379. 10.1042/CS20160618. Green open access

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Abstract

Cerebral small vessel disease (SVD) is a prevalent, neurological disease that significantly increases the risk of stroke and dementia. The main pathological changes are vascular, in the form of lipohyalinosis and arteriosclerosis, and in the white matter (WM), in the form of WM lesions. Despite this, it is unclear to what extent the key cell types involved – the endothelial cells (ECs) of the vasculature and the oligodendrocytes of the WM – interact. Here, we describe the work that has so far been carried out suggesting an interaction between ECs and oligodendrocytes in SVD. As these interactions have been studied in more detail in other disease states and in development, we explore these systems and discuss the role these mechanisms may play in SVD.

Type: Article
Title: Endothelial cell–oligodendrocyte interactions in small vessel disease and aging
Open access status: An open access version is available from UCL Discovery
DOI: 10.1042/CS20160618
Publisher version: http://dx.doi.org/10.1042/CS20160618
Language: English
Additional information: © 2017 The Author(s) This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution Licence 4.0 (CC BY). https://creativecommons.org/licenses/by/4.0/
Keywords: dementia, endothelial cells, myelin, oligodendrocytes, small vessel disease
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > UK Dementia Research Institute
URI: https://discovery.ucl.ac.uk/id/eprint/10090170
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