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Where have all the Orais gone? Commentary on "Orai1 channels are essential for amplification of glutamate-evoked Ca²⁺ signals in dendritic spines to regulate working and associative memory"

Hartmann, J; Chen-Engerer, H-J; Konnerth, A; (2021) Where have all the Orais gone? Commentary on "Orai1 channels are essential for amplification of glutamate-evoked Ca²⁺ signals in dendritic spines to regulate working and associative memory". Cell Calcium , 96 , Article 102372. 10.1016/j.ceca.2021.102372. Green open access

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Abstract

Orai1 channels were reported as critical contributors to the Ca2+ signal in hippocampal neurons underlying synaptic plasticity associated with learning and memory. We discuss the results in view of conflicting other reports that stressed the roles of Orai2 channels but failed to detect functions of Orai1 channels in these neurons.

Type: Article
Title: Where have all the Orais gone? Commentary on "Orai1 channels are essential for amplification of glutamate-evoked Ca²⁺ signals in dendritic spines to regulate working and associative memory"
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.ceca.2021.102372
Publisher version: https://doi.org/10.1016/j.ceca.2021.102372
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Neuronal calcium homeostasis; Orai channels; Spine calcium signaling; Synaptic plasticity
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > UK Dementia Research Institute
URI: https://discovery.ucl.ac.uk/id/eprint/10122511
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