Hartmann, J;
Chen-Engerer, H-J;
Konnerth, A;
(2021)
Where have all the Orais gone? Commentary on "Orai1 channels are essential for amplification of glutamate-evoked Ca²⁺ signals in dendritic spines to regulate working and associative memory".
Cell Calcium
, 96
, Article 102372. 10.1016/j.ceca.2021.102372.
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Abstract
Orai1 channels were reported as critical contributors to the Ca2+ signal in hippocampal neurons underlying synaptic plasticity associated with learning and memory. We discuss the results in view of conflicting other reports that stressed the roles of Orai2 channels but failed to detect functions of Orai1 channels in these neurons.
| Type: | Article |
|---|---|
| Title: | Where have all the Orais gone? Commentary on "Orai1 channels are essential for amplification of glutamate-evoked Ca²⁺ signals in dendritic spines to regulate working and associative memory" |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.ceca.2021.102372 |
| Publisher version: | https://doi.org/10.1016/j.ceca.2021.102372 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Neuronal calcium homeostasis; Orai channels; Spine calcium signaling; Synaptic plasticity |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > UK Dementia Research Institute |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10122511 |
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