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A traffic jam leads to Lewy bodies

Bartels, T; (2019) A traffic jam leads to Lewy bodies. Nature Neuroscience , 22 pp. 1043-1045. 10.1038/s41593-019-0435-y. Green open access

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Abstract

Shahmoradian and colleagues report that the structure of Lewy bodies in Parkinson’s disease consists of α-synuclein and lipid vesicle clusters instead of the long-assumed amyloid fibril core. This finding has implications for our understanding of the underlying pathogenesis of synucleinopathies.

Type: Article
Title: A traffic jam leads to Lewy bodies
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s41593-019-0435-y
Publisher version: https://doi.org/10.1038/s41593-019-0435-y
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > UK Dementia Research Institute
URI: https://discovery.ucl.ac.uk/id/eprint/10079013
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