Browse by UCL Department: listings for include files
- UCL (195485)
- UCL (195485)
- Provost and Vice Provost Offices (194260)
- School of Life and Medical Sciences (95391)
- Faculty of Brain Sciences (35370)
- UCL Queen Square Institute of Neurology (15184)
- UK Dementia Research Institute (272)
- UCL Queen Square Institute of Neurology (15184)
- Faculty of Brain Sciences (35370)
- School of Life and Medical Sciences (95391)
- Provost and Vice Provost Offices (194260)
- UCL (195485)
Number of items at this level: 271.
2025
Balligand, Thomas;
Carpenet, Claire;
Olivé Palau, Sergi;
Jaspers, Tom;
Suresh, Pavana;
Liu, Xin;
Medhi, Himadri;
... Dewilde, Maarten; + view all
(2025)
A pair of congenic mice for imaging of transplants by positron emission tomography using anti-transferrin receptor nanobodies.
eLife
, 14
, Article RP104302. 10.7554/eLife.104302.
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Blackburn, Emily Victoria;
(2025)
Investigating BDNF/TrkB signalling in neuronal models of Alzheimer's disease in Down syndrome.
Doctoral thesis (Ph.D), UCL(University College London).
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Boyanova, Sevda;
Banks, Gareth;
Lipina, Tatiana V;
Bains, Rasneer Sonia;
Forrest, Hamish;
Stewart, Michelle;
Carcolé, Mireia;
... Wiseman, Frances K; + view all
(2025)
Multi-modal comparative phenotyping of knock-in mouse models of frontotemporal dementia/amyotrophic lateral sclerosis.
Disease Models & Mechanisms
, 18
(8)
, Article dmm052324. 10.1242/dmm.052324.
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Cuypers, Marie-Lynn;
Jaspers, Tom;
Clerckx, Jarne;
Leekens, Simon;
Cawthorne, Christopher;
Bormans, Guy;
Cleeren, Frederik;
... Dewilde, Maarten; + view all
(2025)
Increasing brain half-life of antibodies by additional binding to myelin oligodendrocyte glycoprotein, a CNS specific protein.
Fluids and Barriers of the CNS
, 22
(1)
, Article 11. 10.1186/s12987-025-00624-1.
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De Strooper, Bart;
Haass, Christian;
Hardy, John;
Zetterberg, Henrik;
(2025)
The regulatory rollercoaster continues—EMA refuses donanemab.
The Lancet
, 405
(10492)
pp. 1810-1812.
10.1016/S0140-6736(25)00833-5.
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De Strooper, Bart;
Scheltens, Philip;
Salloway, Stephen;
(2025)
Breaking Barriers: Delivering Therapeutics to the Brain in Alzheimer’s
Disease.
The Journal of Prevention of Alzheimer's Disease
, 12
(7)
, Article 100229. 10.1016/j.tjpad.2025.100229.
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Farrell, C;
Buhidma, Y;
Mumford, P;
Heywood, WE;
Hällqvist, J;
Flores-Aguilar, L;
Andrews, EJ;
... Wiseman, FK; + view all
(2025)
Apolipoprotein E abundance is elevated in the brains of individuals with Down syndrome-Alzheimer's disease.
Acta Neuropathologica
, 149
(1)
, Article 49. 10.1007/s00401-025-02889-0.
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Fertan, Emre;
Hung, Christy;
Danial, John SH;
Lam, Jeff YL;
Preman, Pranav;
Albertini, Giulia;
English, Elizabeth A;
... Klenerman, David; + view all
(2025)
Clearance of beta-amyloid and tau aggregates is size dependent and altered by an inflammatory challenge.
Brain Communications
, 7
(1)
, Article fcae454. 10.1093/braincomms/fcae454.
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Fertan, Emre;
Lam, Jeff YL;
Albertini, Giulia;
Dewilde, Maarten;
Wu, Yunzhao;
Akingbade, Oluwatomi ES;
Böken, Dorothea;
... Klenerman, David; + view all
(2025)
Lecanemab preferentially binds to smaller aggregates present at early Alzheimer's disease.
Alzheimer's & Dementia
, 21
(4)
, Article e70086. 10.1002/alz.70086.
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Fowler, Stephanie L;
Behr, Tiana S;
Turkes, Emir;
O'Brien, Darragh P;
Cauhy, Paula Maglio;
Rawlinson, Isadora;
Edmonds, Marisa;
... Ryskeldi-Falcon, Benjamin; + view all
(2025)
Tau filaments are tethered within brain extracellular vesicles in Alzheimer's disease.
Nature Neuroscience
, 28
(1)
pp. 40-48.
10.1038/s41593-024-01801-5.
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Heneka, Michael T;
Van der Flier, Wiesje M;
Jessen, Frank;
Hoozemanns, Jeroen;
Thal, Dietmar Rudolf;
Boche, Delphine;
Brosseron, Frederic;
... Riechers, Sean-Patrick; + view all
(2025)
Neuroinflammation in Alzheimer disease.
Nature Reviews Immunology
, 25
pp. 321-352.
10.1038/s41577-024-01104-7.
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Jakabek, D;
Isaacs, AM;
De Strooper, B;
Tuszynski, M;
Lane, R;
Uspenskaya, O;
McDade, E;
... Mummery, CJ; + view all
(2025)
CTAD taskforce: genetic therapies in Alzheimer’s disease.
The Journal of Prevention of Alzheimer's Disease
, Article 100269. 10.1016/j.tjpad.2025.100269.
(In press).
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Kedia, S;
Fertan, E;
Wu, Y;
Zhang, YP;
Meisl, G;
Lam, JYL;
K. Wiseman, F;
... Klenerman, D; + view all
(2025)
SynPull: An advanced method for studying neurodegeneration-related aggregates in synaptosomes using super-resolution microscopy.
Cell Chemical Biology
, 32
(2)
338-351.e4.
10.1016/j.chembiol.2025.01.001.
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Morito, Takahiro;
Qi, Mohan;
Kamano, Naoko;
Sasaguri, Hiroki;
Bez, Sumi;
Foiani, Martha;
Duff, Karen;
... Watamura, Naoto; + view all
(2025)
Human MAPT knockin mouse models of frontotemporal dementia for the neurodegenerative research community.
Cell Reports: Methods
, 5
(4)
, Article 101024. 10.1016/j.crmeth.2025.101024.
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Murphy, Kitty B;
Hu, Di;
Wolfs, Leen;
Rohde, Susan K;
Fauro, Gonzalo Leguia;
Geric, Ivana;
Mancuso, Renzo;
... Marzi, Sarah J; + view all
(2025)
The APOE isoforms differentially shape the transcriptomic and epigenomic landscapes of human microglia xenografted into a mouse model of Alzheimer’s disease.
Nature Communications
, 16
, Article 4883. 10.1038/s41467-025-60099-4.
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Policarpo, Rafaela;
Wolfs, Leen;
Martinez-Montero, Saul;
Vandermeulen, Lina;
Royaux, Ines;
Van Peer, Gert;
Mestdagh, Pieter;
... d'Ydewalle, Constantin; + view all
(2025)
The MIR-NAT MAPT-AS1 does not regulate Tau
expression in human neurons.
PLoS ONE
, 20
(1)
, Article e0314973. 10.1371/journal.pone.0314973.
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Serneels, Lutgarde;
Sierksma, Annerieke;
Pasciuto, Emanuela;
Geric, Ivana;
Nair, Arya;
Martinez-Muriana, Anna;
Snellinx, An;
(2025)
A versatile mouse model to advance human microglia transplantation research in neurodegenerative diseases.
Molecular Neurodegeneration volume
, 20
(1)
, Article 29. 10.1186/s13024-025-00823-2.
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Stuart, Skye;
(2025)
Modulating trans-synaptic tau transfer in vitro and in vivo.
Doctoral thesis (Ph.D), UCL (University College London).
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Taddei, Raquel N;
Duff, Karen E;
(2025)
Synapse vulnerability and resilience across the clinical spectrum of dementias.
Nature Reviews Neurology
10.1038/s41582-025-01094-7.
(In press).
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Taddei, Raquel N;
Duff, Karen E;
(2025)
Synapse vulnerability and resilience underlying Alzheimer's disease.
eBioMedicine
, 112
, Article 105557. 10.1016/j.ebiom.2025.105557.
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Wenz, Katharina;
(2025)
Investigating candidate genes for amyloid-β accumulation and toxicity in Alzheimer’s disease-Down syndrome.
Doctoral thesis (Ph.D), UCL (University College London).
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Wu, Y;
Cleverley, K;
Wiseman, FK;
(2025)
Reduction of Cystatin B results in increased cathepsin B activity in disomic but not Trisomy 21 human cellular and mouse models.
PLoS ONE
, 20
(1)
, Article e0316822. 10.1371/journal.pone.0316822.
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Yang, Jie;
Yamashita-Kanemaru, Yumi;
Morris, Benjamin I;
Contursi, Annalisa;
Trajkovski, Daniel;
Xu, Jingru;
Patrascan, Ilinca;
... Roychoudhuri, Rahul; + view all
(2025)
Aspirin prevents metastasis by limiting platelet TXA2 suppression of T cell immunity.
Nature
10.1038/s41586-025-08626-7.
(In press).
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2024
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Baligacs, Nora;
Albertini, Giulia;
Borrie, Sarah C;
Serneels, Lutgarde;
Pridans, Clare;
Balusu, Sriram;
De Strooper, Bart;
(2024)
Homeostatic microglia initially seed and
activated microglia later reshape amyloid
plaques in Alzheimer’s Disease.
Nature Communications
, 15
, Article 10634. 10.1038/s41467-024-54779-w.
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Balusu, Sriram;
De Strooper, Bart;
(2024)
The necroptosis cell death pathway drives neurodegeneration in Alzheimer's disease.
Acta Neuropathologica
, 147
(1)
, Article 96. 10.1007/s00401-024-02747-5.
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Clarke-Williams, Charlie J;
Lopes-dos-Santos, Vítor;
Lefèvre, Laura;
Brizee, Demi;
Causse, Adrien A;
Rothaermel, Roman;
Hartwich, Katja;
... Dupret, David; + view all
(2024)
Coordinating brain-distributed network activities in memory resistant to extinction.
Cell
, 187
(2)
409-427.e19.
10.1016/j.cell.2023.12.018.
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Crowley, Gerard;
Attwell, David;
Phatnani, Hemali;
Sontheimer, Harald;
Hong, Soyon;
(2024)
Glia in Neurodegenerative Disease.
Cold Spring Harbor perspectives in biology
a041375.
10.1101/cshperspect.a041375.
(In press).
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de Boni, Laura;
Wallis, Amber;
Hays Watson, Aurelia;
Ruiz-Riquelme, Alejandro;
Leyland, Louise-Ann;
Bourinaris, Thomas;
Hannaway, Naomi;
... Bartels, Tim; + view all
(2024)
Aggregation-resistant alpha-synuclein tetramers are reduced in the blood of Parkinson's patients.
EMBO Molecular Medicine
10.1038/s44321-024-00083-5.
(In press).
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De Strooper, Bart;
Haass, Christian;
Hardy, John;
Zetterberg, Henrik;
(2024)
Divisions over the regulation of lecanemab.
The Lancet
, 404
(10468)
pp. 2160-2161.
10.1016/S0140-6736(24)02513-3.
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De Strooper, Bart;
Karran, Eric;
(2024)
New precision medicine avenues to the prevention of Alzheimer's disease from insights into the structure and function of γ-secretases.
The EMBO Journal
10.1038/s44318-024-00057-w.
(In press).
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Duggan, Michael R;
Gomez, Gabriela T;
Joynes, Cassandra M;
Bilgel, Murat;
Chen, Jingsha;
Fattorelli, Nicola;
Hohman, Timothy J;
... Walker, Keenan A; + view all
(2024)
Proteome-wide analysis identifies plasma immune regulators of amyloid-beta progression.
Brain, Behavior, and Immunity
, 120
pp. 604-619.
10.1016/j.bbi.2024.07.002.
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Erkert, Lena;
Gamez-Belmonte, Reyes;
Kabisch, Melanie;
Schödel, Lena;
Patankar, Jay V;
Gonzalez-Acera, Miguel;
Mahapatro, Mousumi;
... Becker, Christoph; + view all
(2024)
Alzheimer's disease-related presenilins are key to intestinal epithelial cell function and gut immune homoeostasis.
Gut
10.1136/gutjnl-2023-331622.
(In press).
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Farrell, Clíona;
(2024)
Exploring Alzheimer's disease and Down syndrome neuro-immune pathways using preclinical models and human post-mortem brain tissue.
Doctoral thesis (Ph.D), UCL (University College London).
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Germeys, Christine;
Vandoorne, Tijs;
Davie, Kristofer;
Poovathingal, Suresh;
Heeren, Kara;
Vermeire, Wendy;
Nami, FatemehArefeh;
... Van Den Bosch, Ludo; + view all
(2024)
Targeting EGLN2/PHD1 protects motor neurons and normalizes the astrocytic interferon response.
Cell Reports
, 43
(9)
, Article 114719. 10.1016/j.celrep.2024.114719.
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Giamogante, Flavia;
Barazzuol, Lucia;
Maiorca, Francesca;
Poggio, Elena;
Esposito, Alessandra;
Masato, Anna;
Napolitano, Gennaro;
... Brini, Marisa; + view all
(2024)
A SPLICS reporter reveals
-synuclein regulation of lysosome-mitochondria contacts which affects TFEB nuclear translocation.
Nature Communications
, 15
, Article 1516. 10.1038/s41467-024-46007-2.
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Hays Watson, Aurelia;
(2024)
The impact of lipid droplets on α-synuclein protein folding and aggregation propensities in Parkinson’s disease.
Doctoral thesis (Ph.D), UCL (University College London).
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Ibanez, Kristina;
Jadhav, Bharati;
Zanovello, Matteo;
Gagliardi, Delia;
Clarkson, Christopher;
Facchini, Stefano;
Garg, Paras;
... Tucci, Arianna; + view all
(2024)
Increased frequency of repeat expansion mutations across different populations.
Nature Medicine
10.1038/s41591-024-03190-5.
(In press).
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Kloske, CM;
Mahinrad, S;
Barnum, CJ;
Batista, AF;
Bradshaw, EM;
Butts, B;
Carrillo, MC;
... Wilcock, DM; + view all
(2024)
Advancements in Immunity and Dementia Research: Highlights from the 2023 AAIC Advancements: Immunity Conference.
Alzheimer's & Dementia
10.1002/alz.14291.
(In press).
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Koper, MJ;
Moonen, S;
Ronisz, A;
Ospitalieri, S;
Callaerts-Vegh, Z;
T'Syen, D;
Rabe, S;
... Thal, DR; + view all
(2024)
Inhibition of an Alzheimer’s disease–associated form of necroptosis rescues neuronal death in mouse models.
Science Translational Medicine
, 16
(771)
, Article eadf5128. 10.1126/scitranslmed.adf5128.
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Lam, Isabel;
Ndayisaba, Alain;
Lewis, Amanda J;
Fu, YuHong;
Sagredo, Giselle T;
Kuzkina, Anastasia;
Zaccagnini, Ludovica;
... Khurana, Vikram; + view all
(2024)
Rapid iPSC inclusionopathy models shed light on formation, consequence, and molecular subtype of α-synuclein inclusions.
Neuron
10.1016/j.neuron.2024.06.002.
(In press).
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Lloyd, AF;
Martinez-Muriana, A;
Davis, E;
Daniels, MJD;
Hou, P;
Mancuso, R;
Brenes, AJ;
... Howden, AJM; + view all
(2024)
Deep proteomic analysis of microglia reveals fundamental biological differences between model systems.
Cell Reports
, 43
(11)
, Article 114908. 10.1016/j.celrep.2024.114908.
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Mallach, A;
Zielonka, M;
van Lieshout, V;
An, Y;
Khoo, JH;
Vanheusden, M;
Chen, WT;
... De Strooper, B; + view all
(2024)
Microglia-astrocyte crosstalk in the amyloid plaque niche of an Alzheimer's disease mouse model, as revealed by spatial transcriptomics.
Cell Reports
, 43
(6)
, Article 114216. 10.1016/j.celrep.2024.114216.
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Mancuso, R;
Fattorelli, N;
Martinez-Muriana, A;
Davis, E;
Wolfs, L;
Van Den Daele, J;
Geric, I;
... De Strooper, B; + view all
(2024)
Xenografted human microglia display diverse transcriptomic states in response to Alzheimer’s disease-related amyloid-β pathology.
Nature Neuroscience
10.1038/s41593-024-01600-y.
(In press).
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Masato, Anna;
Andolfo, Annapaola;
Favetta, Giulia;
Bellini, Edoardo Niccolo;
Cogo, Susanna;
Dalla Valle, Luisa;
Boassa, Daniela;
... Bubacco, Luigi; + view all
(2024)
Sequestosome-1 (SQSTM1/p62) as a target in dopamine catabolite-mediated cellular dyshomeostasis.
Cell Death & Disease
, 15
, Article 424. 10.1038/s41419-024-06763-x.
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Masato, Anna;
Bubacco, Luigi;
(2024)
The αSynuclein half-life conundrum.
Neurobiology of Disease
, 196
, Article 106524. 10.1016/j.nbd.2024.106524.
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Masato, Anna;
Panzi, Chiara;
Butnaru, Ioana;
Restani, Laura;
Mazzo, Francesca;
Sher, Emanuele;
Bose, Suchira;
(2024)
Synaptic Release of Pathological Tau Is Calcium- and SNAP25-Dependent, and Blocked by BoNT-A Activity.
Toxicon
, 237
(Supp 1)
, Article 107450. 10.1016/j.toxicon.2024.107450.
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Milioto, Carmelo;
Carcolé, Mireia;
Giblin, Ashling;
Coneys, Rachel;
Attrebi, Olivia;
Ahmed, Mhoriam;
Harris, Samuel S;
... Isaacs, Adrian M; + view all
(2024)
PolyGR and polyPR knock-in mice reveal a conserved neuroprotective extracellular matrix signature in C9orf72 ALS/FTD neurons.
Nature Neuroscience
10.1038/s41593-024-01589-4.
(In press).
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Moonen, Sebastiaan;
Koper, Marta J;
Van Schoor, Evelien;
Schaeverbeke, Jolien M;
Vandenberghe, Rik;
von Arnim, Christine AF;
Tousseyn, Thomas;
... Thal, Dietmar Rudolf; + view all
(2024)
Pyroptosis in Alzheimer's disease: cell type-specific activation in microglia, astrocytes and neurons (Vol 145, pg 175, 2023).
[Corrigendum].
Acta Neuropathol
, 149
, Article 3. 10.1007/s00401-024-02841-8.
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Mumford, Paige Soleil;
(2024)
Preclinical modelling of altered
neuroinflammation and interferon hyper-sensitivity in Alzheimer’s disease-Down syndrome.
Doctoral thesis (Ph.D), UCL (University College London).
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Nazish, Iqra;
Mamais, Adamantios;
Mallach, Anna;
Bettencourt, Conceisao;
Kaganovich, Alice;
Warner, Thomas;
Hardy, John;
... Bandopadhyay, Rina; + view all
(2024)
Differential LRRK2 signalling and gene expression in WT-LRRK2 and G2019S-LRRK2 mouse microglia treated with zymosan and MLi2.
Cells
, 13
(1)
, Article 53. 10.3390/cells13010053.
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Obensa Bertroli, Clara;
(2024)
Glucocerebrosidase dysfunction results in increased membrane binding and aggregation propensity of α-synuclein in Parkinson's disease.
Doctoral thesis (Ph.D), UCL (University College London).
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Pappolla, Miguel A;
Refolo, Lorenzo;
Sambamurti, Kumar;
Zambon, Daniel;
Duff, Karen;
(2024)
Hypercholesterolemia and Alzheimer’s Disease: Unraveling the Connection and Assessing the Efficacy of Lipid-Lowering Therapies.
Journal of Alzheimer's Disease
, 101
(s1)
S371-S393.
10.3233/JAD-240388.
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Preman, Pranav;
Moechars, Daan;
Fertan, Emre;
Wolfs, Leen;
Serneels, Lutgarde;
Shah, Disha;
Lamote, Jochen;
... De Strooper, Bart; + view all
(2024)
APOE from astrocytes restores Alzheimer's Aβ-pathology and DAM-like responses in APOE deficient microglia.
EMBO Molecular Medicine
10.1038/s44321-024-00162-7.
(In press).
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Prosser, Lloyd;
(2024)
Investigating Imaging Biomarkers in Normal Ageing and Cognitive Impairment.
Doctoral thesis (Ph.D), UCL (University College London).
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Rajani, Rikesh M;
Ellingford, Robert;
Hellmuth, Mariam;
Harris, Samuel S;
Taso, Orjona S;
Graykowski, David;
Lam, Francesca Kar Wey;
... Busche, Marc Aurel; + view all
(2024)
Selective suppression of oligodendrocyte-derived amyloid beta rescues neuronal dysfunction in Alzheimer's disease.
PLoS Biology
, 22
(7)
, Article ARTN e3002727. 10.1371/journal.pbio.3002727.
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Schmidt, Andree;
Hrupka, Brian;
van Bebber, Frauke;
Sunil Kumar, Sanjay;
Feng, Xiao;
Tschirner, Sarah K;
Aßfalg, Marlene;
... Lichtenthaler, Stefan F; + view all
(2024)
The Alzheimer's disease-linked protease BACE2 cleaves VEGFR3 and modulates its signaling.
The Journal of Clinical Investigation
, Article e170550. 10.1172/JCI170550.
(In press).
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Scott-Solache, James;
(2024)
TREM2 signaling regulates microglial homeostatic
functions.
Doctoral thesis (Ph.D), UCL (University College London.
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Serneels, L;
Bammens, L;
Zwijsen, A;
Tolia, A;
Chávez-Gutiérrez, L;
De Strooper, B;
(2024)
Functional and topological analysis of PSENEN, the fourth subunit of the γ-secretase complex.
Journal of Biological Chemistry
, 300
(1)
, Article 105533. 10.1016/j.jbc.2023.105533.
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Simmonds, Emily;
Leonenko, Ganna;
Yaman, Umran;
Bellou, Eftychia;
Myers, Amanda;
Morgan, Kevin;
Brookes, Keeley;
... Escott-Price, Valentina; + view all
(2024)
Chromosome X-wide association study in case control studies of pathologically confirmed Alzheimer's disease in a European population.
Translational Psychiatry
, 14
, Article 358. 10.1038/s41398-024-03058-9.
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Sokolova, Dimitra;
Ghansah, Shari Addington;
Puletti, Francesca;
Georgiades, Tatiana;
De Schepper, Sebastiaan;
Zheng, Yongjing;
Crowley, Gerard;
... Hong, Soyon; + view all
(2024)
Astrocyte-derived MFG-E8 facilitates microglial synapse elimination in Alzheimer's disease mouse models.
BioRXiv: Cold Spring Harbor, NY, USA.
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Taddei, Raquel N;
(2024)
Understanding the role of glia and oligomeric tau in the
early synapse loss of Alzheimer disease dementia.
Doctoral thesis (Ph.D), UCL (University College London).
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Thal, Dietmar Rudolf;
De Strooper, Bart;
(2024)
Regulated cell death in neurodegeneration: pathways and therapeutic horizons.
Acta Neuropathologica
, 148
, Article 47. 10.1007/s00401-024-02808-9.
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Vandermeulen, Lina;
Geric, Ivana;
Fumagalli, Laura;
Kreir, Mohamed;
Lu, Ashley;
Nonneman, Annelies;
Premereur, Jessie;
... Mancuso, Renzo; + view all
(2024)
Regulation of human microglial gene expression and function via RNAase-H active antisense oligonucleotides in vivo in Alzheimer's disease.
, Article 37. 10.1186/s13024-024-00725-9.
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Watamura, Naoto;
Foiani, Martha S;
Bez, Sumi;
Bourdenx, Mathieu;
Santambrogio, Alessia;
Frodsham, Claire;
Camporesi, Elena;
... Saido, Takaomi C; + view all
(2024)
In vivo hyperphosphorylation of tau is associated with synaptic loss and behavioral abnormalities in the absence of tau seeds.
Nature Neuroscience
, 28
pp. 293-307.
10.1038/s41593-024-01829-7.
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Zelek, Wioleta M;
Bevan, Ryan J;
Nimmo, Jacqui;
Dewilde, Maarten;
De Strooper, Bart;
Morgan, B Paul;
(2024)
Brain-penetrant complement inhibition mitigates neurodegeneration in an Alzheimer's disease mouse model.
Brain
10.1093/brain/awae278.
(In press).
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Zilio, Gianluca;
Masato, Anna;
Sandre, Michelle;
Caregnato, Alberto;
Moret, Francesca;
Maciola, Agnieszka Katarzyna;
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