UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Microglia modulate neurodegeneration in Alzheimer's and Parkinson's diseases

Bartels, T; De Schepper, S; Hong, S; (2020) Microglia modulate neurodegeneration in Alzheimer's and Parkinson's diseases. Science , 370 (6512) pp. 66-69. 10.1126/science.abb8587. Green open access

[thumbnail of Hong_abb8587 copy.pdf]
Preview
Text
Hong_abb8587 copy.pdf - Accepted Version

Download (13MB) | Preview

Abstract

Dementia is a rapidly rising global health crisis that silently disables families and ends lives and livelihoods around the world. To date, however, no early biomarkers or effective therapies exist. It is now clear that brain microglia are more than mere bystanders or amyloid phagocytes; they can act as governors of neuronal function and homeostasis in the adult brain. Here, we highlight the fundamental role of microglia as tissue-resident macrophages in neuronal health. Then, we suggest how chronic impairment in microglia-neuron cross-talk may secure the permanence of the failure of synaptic and neuronal function and health in Alzheimer’s and Parkinson’s diseases. Understanding how to assess and modulate microglia-neuron interactions critical for brain health will be key to developing effective therapies for dementia.

Type: Article
Title: Microglia modulate neurodegeneration in Alzheimer's and Parkinson's diseases
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1126/science.abb8587
Publisher version: https://doi.org/10.1126/science.abb8587
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > UK Dementia Research Institute
URI: https://discovery.ucl.ac.uk/id/eprint/10113826
Downloads since deposit
1,586Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item