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Stem-cell-derived human microglia transplanted in mouse brain to study human disease

Mancuso, R; Van Den Daele, J; Fattorelli, N; Wolfs, L; Balusu, S; Burton, O; Liston, A; ... De Strooper, B; + view all (2019) Stem-cell-derived human microglia transplanted in mouse brain to study human disease. Nature Neuroscience , 22 pp. 2111-2116. 10.1038/s41593-019-0525-x. Green open access

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Abstract

Although genetics highlights the role of microglia in Alzheimer’s disease, one-third of putative Alzheimer’s disease risk genes lack adequate mouse orthologs. Here we successfully engraft human microglia derived from embryonic stem cells in the mouse brain. The cells recapitulate transcriptionally human primary microglia ex vivo and show expression of human-specific Alzheimer’s disease risk genes. Oligomeric amyloid-β induces a divergent response in human versus mouse microglia. This model can be used to study the role of microglia in neurological diseases.

Type: Article
Title: Stem-cell-derived human microglia transplanted in mouse brain to study human disease
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s41593-019-0525-x
Publisher version: https://doi.org/10.1038/s41593-019-0525-x
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Alzheimer's disease, Neurodegeneration, Neuroimmunology
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > UK Dementia Research Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UK Dementia Research Institute HQ
URI: https://discovery.ucl.ac.uk/id/eprint/10085953
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