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Tau-targeting antibody therapies: too late, wrong epitope or wrong target?

Jabbari, E; Duff, KE; (2021) Tau-targeting antibody therapies: too late, wrong epitope or wrong target? Nature Medicine , 27 (8) pp. 1341-1342. 10.1038/s41591-021-01465-9. Green open access

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Abstract

Two phase 2 studies of N-terminal tau–targeting antibody therapy fail to show clinical efficacy in progressive supranuclear palsy, despite evidence of target engagement.

Type: Article
Title: Tau-targeting antibody therapies: too late, wrong epitope or wrong target?
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s41591-021-01465-9
Publisher version: https://doi.org/10.1038/s41591-021-01465-9
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Science & Technology, Life Sciences & Biomedicine, Biochemistry & Molecular Biology, Cell Biology, Medicine, Research & Experimental, Research & Experimental Medicine, PROGRESSIVE SUPRANUCLEAR PALSY
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > UK Dementia Research Institute
URI: https://discovery.ucl.ac.uk/id/eprint/10135167
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