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Simultaneous representation of multiple time horizons by entorhinal grid cells and CA1 place cells

Chaudhuri-Vayalambrone, Prannoy; Rule, Michael Everett; Bauza, Marius; Krstulovic, Marino; Kerekes, Pauline; Burton, Stephen; O'Leary, Timothy; (2023) Simultaneous representation of multiple time horizons by entorhinal grid cells and CA1 place cells. Cell Reports , 42 (7) , Article 112716. 10.1016/j.celrep.2023.112716. Green open access

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Abstract

Grid cells and place cells represent the spatiotemporal continuum of an animal’s past, present, and future locations. However, their spatiotemporal relationship is unclear. Here, we co-record grid and place cells in freely foraging rats. We show that average time shifts in grid cells tend to be prospective and are proportional to their spatial scale, providing a nearly instantaneous readout of a spectrum of progressively increasing time horizons ranging hundreds of milliseconds. Average time shifts of place cells are generally larger compared to grid cells and also increase with place field sizes. Moreover, time horizons display nonlinear modulation by the animal’s trajectories in relation to the local boundaries and locomotion cues. Finally, long and short time horizons occur at different parts of the theta cycle, which may facilitate their readout. Together, these findings suggest that population activity of grid and place cells may represent local trajectories essential for goal-directed navigation and planning.

Type: Article
Title: Simultaneous representation of multiple time horizons by entorhinal grid cells and CA1 place cells
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.celrep.2023.112716
Publisher version: https://doi.org/10.1016/j.celrep.2023.112716
Language: English
Additional information: © The Author(s), 2023 This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
Keywords: grid cell, place cell, spatiotemporal, hippocampus, medial entorhinal, predictive coding, Neuroscience
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > The Sainsbury Wellcome Centre
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > UK Dementia Research Institute
URI: https://discovery.ucl.ac.uk/id/eprint/10187066
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