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The Reciprocal Interaction Between Sleep and Alzheimer’s Disease

Harris, SS; Schwerd-Kleine, T; Lee, BI; Busche, MA; (2021) The Reciprocal Interaction Between Sleep and Alzheimer’s Disease. In: Circadian Clock in Brain Health and Disease. (pp. 169-188). Springer, Cham Green open access

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Abstract

It is becoming increasingly recognized that patients with a variety of neurodegenerative diseases exhibit disordered sleep/wake patterns. While sleep impairments have typically been thought of as sequelae of underlying neurodegenerative processes in sleep-wake cycle regulating brain regions, including the brainstem, hypothalamus, and basal forebrain, emerging evidence now indicates that sleep deficits may also act as pathophysiological drivers of brain-wide disease progression. Specifically, recent work has indicated that impaired sleep can impact on neuronal activity, brain clearance mechanisms, pathological build-up of proteins, and inflammation. Altered sleep patterns may therefore be novel (potentially reversible) dynamic functional markers of proteinopathies and modifiable targets for early therapeutic intervention using non-invasive stimulation and behavioral techniques. Here we highlight research describing a potentially reciprocal interaction between impaired sleep and circadian patterns and the accumulation of pathological signs and features in Alzheimer's disease, the most prevalent neurodegenerative disease in the elderly.

Type: Book chapter
Title: The Reciprocal Interaction Between Sleep and Alzheimer’s Disease
ISBN-13: 978-3-030-81146-4
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/978-3-030-81147-1_10
Publisher version: https://doi.org/10.1007/978-3-030-81147-1_10
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Alzheimer’s disease, Amyloid-beta, Clinical, Learning and memory, Sleep impairment, Sleep-wake cycle, Slow-wave sleep, Tau, Translational, Aged, Alzheimer Disease, Amyloid beta-Peptides, Basal Forebrain, Humans, Neurodegenerative Diseases, Sleep
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > UK Dementia Research Institute
URI: https://discovery.ucl.ac.uk/id/eprint/10138950
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