Harris, SS;
Schwerd-Kleine, T;
Lee, BI;
Busche, MA;
(2021)
The Reciprocal Interaction Between Sleep and Alzheimer’s Disease.
In:
Circadian Clock in Brain Health and Disease.
(pp. 169-188).
Springer, Cham
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Abstract
It is becoming increasingly recognized that patients with a variety of neurodegenerative diseases exhibit disordered sleep/wake patterns. While sleep impairments have typically been thought of as sequelae of underlying neurodegenerative processes in sleep-wake cycle regulating brain regions, including the brainstem, hypothalamus, and basal forebrain, emerging evidence now indicates that sleep deficits may also act as pathophysiological drivers of brain-wide disease progression. Specifically, recent work has indicated that impaired sleep can impact on neuronal activity, brain clearance mechanisms, pathological build-up of proteins, and inflammation. Altered sleep patterns may therefore be novel (potentially reversible) dynamic functional markers of proteinopathies and modifiable targets for early therapeutic intervention using non-invasive stimulation and behavioral techniques. Here we highlight research describing a potentially reciprocal interaction between impaired sleep and circadian patterns and the accumulation of pathological signs and features in Alzheimer's disease, the most prevalent neurodegenerative disease in the elderly.
| Type: | Book chapter |
|---|---|
| Title: | The Reciprocal Interaction Between Sleep and Alzheimer’s Disease |
| ISBN-13: | 978-3-030-81146-4 |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/978-3-030-81147-1_10 |
| Publisher version: | https://doi.org/10.1007/978-3-030-81147-1_10 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Alzheimer’s disease, Amyloid-beta, Clinical, Learning and memory, Sleep impairment, Sleep-wake cycle, Slow-wave sleep, Tau, Translational, Aged, Alzheimer Disease, Amyloid beta-Peptides, Basal Forebrain, Humans, Neurodegenerative Diseases, Sleep |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > UK Dementia Research Institute |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10138950 |
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