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Number of items: 208.

Article

Ackland, GL; Kazymov, V; Marina, N; Singer, M; Gourine, AV; (2013) Peripheral neural detection of danger-associated and pathogen-associated molecular patterns. Crit Care Med , 41 (6) e85 - e92. 10.1097/CCM.0b013e31827c0b05.

Ackland, GL; Whittle, J; Toner, A; Machhada, A; Del Arroyo, AG; Sciuso, A; Jenkins, N; ... Gourine, AV; + view all Ackland, GL; Whittle, J; Toner, A; Machhada, A; Del Arroyo, AG; Sciuso, A; Jenkins, N; Dyson, A; Struthers, R; Sneyd, JR; Minto, G; Singer, M; Shah, AM; Gourine, AV; - view fewer (2016) Molecular Mechanisms Linking Autonomic Dysfunction and Impaired Cardiac Contractility in Critical Illness. Critical Care Medicine , 44 (8) e614-e624. 10.1097/CCM.0000000000001606.

Aissaoui, Nadia; Boissier, Florence; Chew, Michelle; Singer, Mervyn; Vignon, Philippe; (2025) Sepsis-induced cardiomyopathy. European Heart Journal , 46 (34) pp. 3339-3353. 10.1093/eurheartj/ehaf340.

Andreis, DT; Singer, M; (2016) Catecholamines for inflammatory shock: a Jekyll-and-Hyde conundrum. Intensive Care Medicine , 42 (9) pp. 1387-1397. 10.1007/s00134-016-4249-z.

Antcliffe, DB; Santhakumaran, S; Orme, RML; Ward, JK; Al-Beidh, F; O'Dea, K; Perkins, GD; ... Gordon, AC; + view all Antcliffe, DB; Santhakumaran, S; Orme, RML; Ward, JK; Al-Beidh, F; O'Dea, K; Perkins, GD; Singer, M; McAuley, DF; Mason, AJ; Cross, M; Ashby, D; Gordon, AC; - view fewer (2019) Levosimendan in septic shock in patients with biochemical evidence of cardiac dysfunction: a subgroup analysis of the LeoPARDS randomised trial. Intensive Care Medicine , 45 (10) pp. 1392-1400. 10.1007/s00134-019-05731-w.

Arina, P; Baso, B; Moro, V; Patel, H; Ambler, G; Voegele, P; Arulkumaran, N; ... Singer, M; + view all Arina, P; Baso, B; Moro, V; Patel, H; Ambler, G; Voegele, P; Arulkumaran, N; Brealey, D; Singer, M; - view fewer (2021) Discriminating between CPAP success and failure in COVID-19 patients with severe respiratory failure. Intensive Care Medicine , 47 pp. 237-239. 10.1007/s00134-020-06304-y.

Arina, P; Moro, V; Baso, B; Baxter-Derrington, C; Singer, M; (2021) Sepsis in severe COVID-19 is rarely septic shock: a retrospective single-centre cohort study. British Journal of Anaesthesia 10.1016/j.bja.2021.08.007. (In press).

Arina, Pietro; Hofmaenner, Daniel A; Singer, Mervyn; (2024) Definition and Epidemiology of Sepsis. Seminars in Respiratory and Critical Care Medicine , 45 (4) pp. 461-468. 10.1055/s-0044-1787990.

Arina, Pietro; Sorge, Matteo; Gallo, Andrea; Di Mauro, Vittoria; Vitale, Nicoletta; Cappello, Paola; Brazzi, Luca; ... Fanelli, Vito; + view all Arina, Pietro; Sorge, Matteo; Gallo, Andrea; Di Mauro, Vittoria; Vitale, Nicoletta; Cappello, Paola; Brazzi, Luca; Barandalla-Sobrados, Maria; Cimino, James; Ranieri, V Marco; Altruda, Fiorella; Singer, Mervyn; Catalucci, Daniele; Brancaccio, Mara; Fanelli, Vito; - view fewer (2022) Modulation of LTCC Pathways by a Melusin Mimetic Increases Ventricular Contractility During LPS-Induced Cardiomyopathy. Shock , 57 (6) pp. 318-325. 10.1097/SHK.0000000000001926.

Arulkumaran, N; Lanphere, C; Gaupp, C; Burns, JR; Singer, M; Howorka, S; (2021) DNA Nanodevices with Selective Immune Cell Interaction and Function. ACS Nano , 15 (3) pp. 4394-4404. 10.1021/acsnano.0c07915.

Arulkumaran, Nishkantha; Singer, Mervyn; Howorka, Stefan; Burns, Jonathan R; (2023) Creating complex protocells and prototissues using simple DNA building blocks. Nature Communications , 14 , Article 1314. 10.1038/s41467-023-36875-5.

Arulkumaran, N; Brealey, D; Howell, D; Singer, M; (2020) Use of non-invasive ventilation for patients with COVID-19: a cause for concern? The Lancet Respiratory Medicine , 8 (6) , Article e45. 10.1016/S2213-2600(20)30181-8.

Arulkumaran, N; Green, J; Khan, A; Bonnici, T; Longobardo, A; Singer, M; (2021) Influence of respiratory and inflammatory parameters preceding intubation on survival of patients with COVID-19 ARDS- A single centre retrospective analysis. Journal of Critical Care , 62 pp. 289-291. 10.1016/j.jcrc.2021.01.001.

Arulkumaran, N; Pollen, S; Greco, E; Courtneidge, H; Hall, AM; Duchen, MR; Tam, FWK; ... Singer, M; + view all Arulkumaran, N; Pollen, S; Greco, E; Courtneidge, H; Hall, AM; Duchen, MR; Tam, FWK; Unwin, RJ; Singer, M; - view fewer (2018) Renal Tubular Cell Mitochondrial Dysfunction Occurs Despite Preserved Renal Oxygen Delivery in Experimental Septic Acute Kidney Injury. Critical Care Medicine , 46 (4) e318-e325. 10.1097/CCM.0000000000002937.

Arulkumaran, N; Sixma, ML; Jentho, E; Ceravola, E; Bass, PS; Kellum, JA; Unwin, RJ; ... Singer, M; + view all Arulkumaran, N; Sixma, ML; Jentho, E; Ceravola, E; Bass, PS; Kellum, JA; Unwin, RJ; Tam, FWK; Singer, M; - view fewer (2017) Sequential analysis of a panel of biomarkers and pathologic findings in a resuscitated rat model of sepsis and recovery. Critical Care Medicine , 45 (8) e821-e830. 10.1097/CCM.0000000000002381.

Arulkumaran, N; Sixma, ML; Pollen, S; Ceravola, E; Jentho, E; Prendecki, M; Bass, PS; ... Singer, M; + view all Arulkumaran, N; Sixma, ML; Pollen, S; Ceravola, E; Jentho, E; Prendecki, M; Bass, PS; Tam, FWK; Unwin, RJ; Singer, M; - view fewer (2018) P2X7receptor antagonism ameliorates renal dysfunction in a rat model of sepsis. Physiological Reports , 6 (5) , Article e13622. 10.14814/phy2.13622.

Arulkumaran, N; Thomas, M; Brealey, D; Alwan, F; Singh, D; Lunn, M; Welch, A; ... Scully, M; + view all Arulkumaran, N; Thomas, M; Brealey, D; Alwan, F; Singh, D; Lunn, M; Welch, A; Clark, S; Raith, E; Reddy, U; Low, R; Leverett, D; Singer, M; Scully, M; - view fewer (2021) Plasma exchange for COVID-19 thrombo-inflammatory disease. EJHaem , 2 (1) pp. 26-32. 10.1002/jha2.140.

Arulkumaran, N; Turner, CM; Sixma, ML; Singer, M; Unwin, R; Tam, FW; (2013) Purinergic signaling in inflammatory renal disease. Front Physiol , 4 , Article 194. 10.3389/fphys.2013.00194.

Asehnoune, Karim; Taccone, Fabio S; Singer, Mervyn; (2022) High oxygen level in traumatic brain injury patients. Never ending story? Intensive Care Medicine , 48 (12) pp. 1772-1774. 10.1007/s00134-022-06903-x.

Atramont, Alice; Martin, Guillaume L; Singer, Mervyn; Tajahmady, Ayden; Agamaliyev, Emin; Harhay, Michael O; Leone, Marc; Atramont, Alice; Martin, Guillaume L; Singer, Mervyn; Tajahmady, Ayden; Agamaliyev, Emin; Harhay, Michael O; Leone, Marc; Legrand, Matthieu; - view fewer (2024) One-Year Survival and Hospital-free Days in Critical Illness After Viral Pneumonia. American Journal of Respiratory and Critical Care Medicine , 209 (8) pp. 1019-1022. 10.1164/rccm.202310-1771le.

Atramont, A; Lindecker-Cournil, V; Rudant, J; Tajahmady, A; Drewniak, N; Fouard, A; Singer, M; ... Legrand, M; + view all Atramont, A; Lindecker-Cournil, V; Rudant, J; Tajahmady, A; Drewniak, N; Fouard, A; Singer, M; Leone, M; Legrand, M; - view fewer (2019) Association of Age With Short-term and Long-term Mortality Among Patients Discharged From Intensive Care Units in France. JAMA Network Open , 2 (5) , Article e193215. 10.1001/jamanetworkopen.2019.3215.

Baillie, J Kenneth; Angus, Derek; Burnham, Katie; Calandra, Thierry; Calfee, Carolyn; Gutteridge, Alex; Hacohen, Nir; ... Randolph, Adrienne G; + view all Baillie, J Kenneth; Angus, Derek; Burnham, Katie; Calandra, Thierry; Calfee, Carolyn; Gutteridge, Alex; Hacohen, Nir; Khatri, Purvesh; Langley, Raymond; Ma'ayan, Avi; Marshall, John; Maslove, David; Prescott, Hallie C; Rowan, Kathy; Scicluna, Brendon P; Seymour, Christopher; Shankar-Hari, Manu; Shapiro, Nathan; Wiersinga, W Joost; Singer, Mervyn; Randolph, Adrienne G; - view fewer (2024) Causal inference can lead us to modifiable mechanisms and informative archetypes in sepsis. Intensive Care Medicine , 50 (12) pp. 2031-2042. 10.1007/s00134-024-07665-4.

Baković, J; Yu, BYK; Silva, D; Chew, SP; Kim, S; Ahn, S-H; Palmer, L; ... Gout, I; + view all Baković, J; Yu, BYK; Silva, D; Chew, SP; Kim, S; Ahn, S-H; Palmer, L; Aloum, L; Stanzani, G; Malanchuk, O; Duchen, MR; Singer, M; Filonenko, V; Lee, T-H; Skehel, M; Gout, I; - view fewer (2019) A key metabolic integrator, coenzyme A, modulates the activity of peroxiredoxin 5 via covalent modification. Molecular and Cellular Biochemistry , 461 pp. 91-102. 10.1007/s11010-019-03593-w.

Barichello, Tatiana; Generoso, Jaqueline S; Singer, Mervyn; Dal-Pizzol, Felipe; (2022) Biomarkers for sepsis: more than just fever and leukocytosis-a narrative review. Critical Care , 26 , Article 14. 10.1186/s13054-021-03862-5.

Barnes, TH; Singer, M; (2021) Low cost devices to help in COVID-19. [Editorial comment]. Trends in Anaesthesia and Critical Care , 38 pp. 21-23. 10.1016/j.tacc.2021.03.011.

Bateman, RM; Sharpe, MD; Singer, M; Ellis, CG; (2017) The Effect of Sepsis on the Erythrocyte. International Journal of Molecular Sciences , 18 (9) , Article 1932. 10.3390/ijms18091932.

Besen, Bruno AMP; Ranzani, Otavio T; Singer, Mervyn; (2023) Management of diabetic ketoacidosis. Intensive Care Medicine , 49 pp. 95-98. 10.1007/s00134-022-06894-9.

Boerma, EC; Singer, M; (2017) Beta-blockers in sepsis: time to reconsider current constraints? British Journal of Anaesthesia , 119 (4) pp. 560-561. 10.1093/bja/aex266.

Cavaillon, J-M; Singer, M; Skirecki, T; (2020) Sepsis therapies: learning from 30 years of failure of translational research to propose new leads. EMBO Molecular Medicine , 12 (4) , Article e10128. 10.15252/emmm.201810128.

Chan, XHS; O'Connor, CJ; Martyn, E; Clegg, AJ; Choy, BJK; Soares, AL; Shulman, R; ... Wilson, APR; + view all Chan, XHS; O'Connor, CJ; Martyn, E; Clegg, AJ; Choy, BJK; Soares, AL; Shulman, R; Stone, NRH; De, S; Bitmead, J; Hail, L; Brealey, D; Arulkumaran, N; Singer, M; Wilson, APR; - view fewer (2022) Reducing broad-spectrum antibiotic use in intensive care unit between first and second waves of COVID-19 did not adversely affect mortality. Journal of Hospital Infection , 124 pp. 37-46. 10.1016/j.jhin.2022.03.007.

Chisholm, KI; Ida, KK; Davies, AL; Papkovsky, DB; Singer, M; Dyson, A; Tachtsidis, I; ... Smith, KJ; + view all Chisholm, KI; Ida, KK; Davies, AL; Papkovsky, DB; Singer, M; Dyson, A; Tachtsidis, I; Duchen, MR; Smith, KJ; - view fewer (2016) In Vivo Imaging of Flavoprotein Fluorescence During Hypoxia Reveals the Importance of Direct Arterial Oxygen Supply to Cerebral Cortex Tissue. Advances in Experimental Medicine and Biology , 876 pp. 233-239. 10.1007/978-1-4939-3023-4_29.

Chisholm, KI; Ida, KK; Davies, AL; Tachtsidis, I; Papkovsky, DB; Dyson, A; Singer, M; ... Smith, KJ; + view all Chisholm, KI; Ida, KK; Davies, AL; Tachtsidis, I; Papkovsky, DB; Dyson, A; Singer, M; Duchen, MR; Smith, KJ; - view fewer (2016) Hypothermia protects brain mitochondrial function from hypoxemia in a murine model of sepsis. Journal of Cerebral Blood Flow and Metabolism , 36 (11) 1955 -1964. 10.1177/0271678X15606457.

Choi, Sang Ho; Cesar, Antoni; Snow, Timothy Arthur Chandos; Saleem, Naveed; Arulkumaran, Nishkantha; Singer, Mervyn; (2023) Efficacy of Doxycycline for Mild-to-moderate Community-acquired Pneumonia in Adults: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Clinical Infectious Diseases , 76 (4) pp. 683-691. 10.1093/cid/ciac615.

Choi, Sang-Ho; Cesar, Antoni; Snow, Timothy Arthur Chandos; Saleem, Naveed; Arulkumaran, Nishkantha; Singer, Mervyn; (2023) Respiratory fluoroquinolone monotherapy versus β-lactam plus macrolide combination therapy for hospitalized adults with community-acquired pneumonia: A systematic review and meta-analysis of randomised controlled trials. International Journal of Antimicrobial Agents , 62 (3) , Article 106905. 10.1016/j.ijantimicag.2023.106905.

Cilloniz, C; Dominedo, C; Ielpo, A; Ferrer, M; Gabarrus, A; Battaglini, D; Bermejo-Martin, J; ... Torres, A; + view all Cilloniz, C; Dominedo, C; Ielpo, A; Ferrer, M; Gabarrus, A; Battaglini, D; Bermejo-Martin, J; Meli, A; Garcia-Vidal, C; Liapikou, A; Singer, M; Torres, A; - view fewer (2019) Risk and Prognostic Factors in Very Old Patients with Sepsis Secondary to Community-Acquired Pneumonia. Journal of Clinical Medicine , 8 (7) , Article 961. 10.3390/jcm8070961.

Clapp, BR; Hirschfield, GM; Storry, C; Gallimore, JR; Stidwill, RP; Singer, M; Deanfield, JE; ... Hineorani, AD; + view all Clapp, BR; Hirschfield, GM; Storry, C; Gallimore, JR; Stidwill, RP; Singer, M; Deanfield, JE; MacAllister, RJ; Pepys, MB; Vallance, P; Hineorani, AD; - view fewer (2005) Inflammation and endothelial function: Direct vascular effects of human C-reactive protein on nitric oxide bioavailability. Circulation , 111 (12) pp. 1530-1536. 10.1161/01.CIR.0000159336.31613.31.

Corona, Alberto; De Santis, Vincenzo; Vitale, Domenico; Nencini, Cecilia; Potalivo, Antonella; Prete, Anna; Barzaghi, Nicoletta; ... Singer, Mervyn; + view all Corona, Alberto; De Santis, Vincenzo; Vitale, Domenico; Nencini, Cecilia; Potalivo, Antonella; Prete, Anna; Barzaghi, Nicoletta; Tardivo, Sara; Terzitta, Marina; Malfatto, Anna; Tritapepe, Luigi; Locatelli, Alessandro; Singer, Mervyn; - view fewer (2022) Tracheostomy in critically ill patients with SARS 2 COVID-19 infection: a prospective observational multi-center study of short- and long-term outcomes. Canadian Journal of Respiratory Therapy: CJRT , 58 pp. 155-161. 10.29390/cjrt-2022-018.

Damiani, E; Adrario, E; Girardis, M; Romano, R; Pelaia, P; Singer, M; Donati, A; (2014) Arterial hyperoxia and mortality in critically ill patients: a systematic review and meta-analysis. Critical Care , 18 , Article 711. 10.1186/s13054-014-0711-x.

Damiani, E; Dyson, A; Zacchetti, L; Donati, A; Singer, M; (2016) Exploring alternative routes for oxygen administration. Intensive Care Medicine Experimental , 4 , Article 34. 10.1186/s40635-016-0108-z.

Dark, P; Perkins, GD; McMullan, R; McAuley, D; Gordon, AC; Clayton, J; Mistry, D; ... Lall, R; + view all Dark, P; Perkins, GD; McMullan, R; McAuley, D; Gordon, AC; Clayton, J; Mistry, D; Young, K; Regan, S; McGowan, N; Stevenson, M; Gates, S; Carlson, GL; Walsh, T; Lone, NI; Mouncey, PR; Singer, M; Wilson, P; Felton, T; Marshall, K; Hossain, AM; Lall, R; - view fewer (2023) biomArker-guided Duration of Antibiotic treatment in hospitalised Patients with suspecTed Sepsis (ADAPT-Sepsis): A protocol for a multicentre randomised controlled trial. Journal of the Intensive Care Society 10.1177/17511437231169193. (In press).

Dark, Paul; Hossain, Anower; Mcauley, Daniel F; Brealey, David; Carlson, Gordon; Clayton, Jonathan C; Felton, Timothy W; ... ADAPT, Sepsis Collaborators; + view all Dark, Paul; Hossain, Anower; Mcauley, Daniel F; Brealey, David; Carlson, Gordon; Clayton, Jonathan C; Felton, Timothy W; Ghuman, Belinder K; Gordon, Anthony C; Hellyer, Thomas P; Lone, Nazir I; Manazar, Uzma; Richards, Gillian; Mccullagh, Iain J; Mcmullan, Ronan; Mcnamee, James J; Mcneil, Hannah C; Mouncey, Paul R; Naisbitt, Micheal J; Parker, Robert J; Poole, Ruth L; Rostron, Anthony J; Singer, Mervyn; Stevenson, Matt D; Walsh, Tim S; Welters, Ingeborg D; Whitehouse, Tony; Whiteley, Simon; Wilson, Peter; Young, Keith K; Perkins, Gavin D; Lall, Ranjit; ADAPT, Sepsis Collaborators; - view fewer (2024) Biomarker-Guided Antibiotic Duration for Hospitalized Patients With Suspected Sepsis. Journal of the American Medical Association (JAMA) , 333 (8) pp. 682-693. 10.1001/jama.2024.26458.

De Pascale, G; Singer, M; Brealey, D; (2017) Comparison of stroke volume measurement between non-invasive bioreactance and esophageal Doppler in patients undergoing major abdominal-pelvic surgery. Journal of Anesthesia , 31 (4) pp. 545-551. 10.1007/s00540-017-2351-1.

Demiselle, J; Wepler, M; Hartmann, C; Radermacher, P; Schortgen, F; Meziani, F; Singer, M; ... Asfar, P; + view all Demiselle, J; Wepler, M; Hartmann, C; Radermacher, P; Schortgen, F; Meziani, F; Singer, M; Seegers, V; Asfar, P; - view fewer (2018) Hyperoxia toxicity in septic shock patients according to the Sepsis-3 criteria: a post hoc analysis of the HYPER2S trial. Annals of Intensive Care , 8 , Article 90. 10.1186/s13613-018-0435-1.

Desai, RA; Davies, AL; Del Rossi, N; Tachrount, M; Dyson, A; Gustavson, B; Kaynezhad, P; ... Smith, KJ; + view all Desai, RA; Davies, AL; Del Rossi, N; Tachrount, M; Dyson, A; Gustavson, B; Kaynezhad, P; Mackenzie, L; van der Putten, MA; McElroy, D; Schiza, D; Linington, C; Singer, M; Harvey, AR; Tachtsidis, I; Golay, X; Smith, KJ; - view fewer (2020) Nimodipine reduces dysfunction and demyelination in models of multiple sclerosis. Annals of Neurology , 88 (1) pp. 123-136. 10.1002/ana.25749.

Donati, A; Damiani, E; Domizi, R; Scorcella, C; Carsetti, A; Tondi, S; Monaldi, V; ... Singer, M; + view all Donati, A; Damiani, E; Domizi, R; Scorcella, C; Carsetti, A; Tondi, S; Monaldi, V; Adrario, E; Romano, R; Pelaia, P; Singer, M; - view fewer (2016) Near-infrared spectroscopy for assessing tissue oxygenation and microvascular reactivity in critically ill patients: a prospective observational study. Critical Care , 20 , Article 311. 10.1186/s13054-016-1500-5.

Donati, A; Damiani, E; Zuccari, S; Domizi, R; Scorcella, C; Girardis, M; Giulietti, A; ... Singer, M; + view all Donati, A; Damiani, E; Zuccari, S; Domizi, R; Scorcella, C; Girardis, M; Giulietti, A; Vignini, A; Adrario, E; Romano, R; Mazzanti, L; Pelaia, P; Singer, M; - view fewer (2017) Effects of short-term hyperoxia on erythropoietin levels and microcirculation in critically Ill patients: a prospective observational pilot study. BMC Anesthesiology , 17 , Article 49. 10.1186/s12871-017-0342-2.

Du, Bin; Wang, Chunting; Singer, Mervyn; (2022) Learning for the next pandemic: when high level evidence is not readily available... Journal of Thoracic Disease , 14 (5) pp. 1738-1743. 10.21037/jtd-22-201.

Du, Bin; Wang, Chunting; Singer, Mervyn; (2021) Learning for the next pandemic: the Wuhan experience of managing critically ill people. BMJ , 375 , Article e066090. 10.1136/bmj-2021-066090.

Durand, Manon; Hagimont, Eugenie; Louis, Huguette; Asfar, Pierre; Frippiat, Jean-Pol; Singer, Mervyn; Gauchotte, Guillaume; ... Kimmoun, Antoine; + view all Durand, Manon; Hagimont, Eugenie; Louis, Huguette; Asfar, Pierre; Frippiat, Jean-Pol; Singer, Mervyn; Gauchotte, Guillaume; Labat, Carlos; Lacolley, Patrick; Levy, Bruno; Chousterman, Benjamin Glenn; Kimmoun, Antoine; - view fewer (2022) The β1-Adrenergic Receptor Contributes to Sepsis-Induced Immunosuppression Through Modulation of Regulatory T-Cell Inhibitory Function*. Critical Care Medicine , 50 (9) E707-E718. 10.1097/CCM.0000000000005503.

Durham, T; Zander, D; Stomeo, N; Minnion, M; Hogarth, G; Feelisch, M; Singer, M; Durham, T; Zander, D; Stomeo, N; Minnion, M; Hogarth, G; Feelisch, M; Singer, M; Dyson, A; - view fewer (2020) Chemistry, pharmacology, and cellular uptake mechanisms of thiometallate sulfide donors. British Journal of Pharmacology , 177 (4) pp. 745-756. 10.1111/bph.14670.

Dyson, A; Dal-Pizzol, F; Sabbatini, G; Lach, AB; Galfo, F; Dos Santos Cardoso, J; Pescador Mendonça, B; ... Singer, M; + view all Dyson, A; Dal-Pizzol, F; Sabbatini, G; Lach, AB; Galfo, F; Dos Santos Cardoso, J; Pescador Mendonça, B; Hargreaves, I; Bollen Pinto, B; Bromage, DI; Martin, JF; Moore, KP; Feelisch, M; Singer, M; - view fewer (2017) Ammonium tetrathiomolybdate following ischemia/reperfusion injury: Chemistry, pharmacology, and impact of a new class of sulfide donor in preclinical injury models. PLoS Med , 14 (7) , Article e1002310. 10.1371/journal.pmed.1002310.

Ehler, J; Barrett, LK; Taylor, V; Groves, M; Scaravilli, F; Wittstock, M; Kolbaske, S; ... Petzold, A; + view all Ehler, J; Barrett, LK; Taylor, V; Groves, M; Scaravilli, F; Wittstock, M; Kolbaske, S; Grossmann, A; Henschel, J; Gloger, M; Sharshar, T; Chretien, F; Gray, F; Noeldge-Schomburg, G; Singer, M; Sauer, M; Petzold, A; - view fewer (2017) Translational evidence for two distinct patterns of neuroaxonal injury in sepsis: a longitudinal, prospective translational study. Critical Care , 21 , Article 262. 10.1186/s13054-017-1850-7.

Ekbal, NJ; Hennis, P; Dyson, A; Mythen, M; James, MFM; Singer, M; (2018) The anion study: effect of different crystalloid solutions on acid base balance, physiology, and survival in a rodent model of acute isovolaemic haemodilution. Br J Anaesth , 120 (6) pp. 1412-1419. 10.1016/j.bja.2018.01.026.

Fish, Matthew; Arkless, Kate; Jennings, Aislinn; Wilson, Julie; Carter, Michael J; Arbane, Gill; Campos, Sara; ... Shankar-Hari, Manu; + view all Fish, Matthew; Arkless, Kate; Jennings, Aislinn; Wilson, Julie; Carter, Michael J; Arbane, Gill; Campos, Sara; Novellas, Neus; Wester, Rianne; Petrov, Nedyalko; Niazi, Umar; Sanderson, Barney; Ellis, Richard; Saqi, Mansoor; Spencer, Jo; Singer, Mervyn; Martinez-Nunez, Rocio T; Pitchford, Simon; Swanson, Chad M; Shankar-Hari, Manu; - view fewer (2022) Cellular and molecular mechanisms of IMMunE dysfunction and Recovery from SEpsis-related critical illness in adults: An observational cohort study (IMMERSE) protocol paper. Journal of the Intensive Care Society , 23 (3) pp. 318-324. 10.1177/1751143720966286.

Fox, TA; Troy-Barnes, E; Kirkwood, AA; Chan, WY; Day, JW; Chavda, SJ; Kumar, EA; ... Ardeshna, KM; + view all Fox, TA; Troy-Barnes, E; Kirkwood, AA; Chan, WY; Day, JW; Chavda, SJ; Kumar, EA; David, K; Tomkins, O; Sanchez, E; Scully, M; Khwaja, A; Lambert, J; Singer, M; Roddie, C; Morris, EC; Yong, KL; Thomson, KJ; Ardeshna, KM; - view fewer (2020) Response to 'Impact of immunosuppression on mortality in critically ill COVID-19 patients'. British Journal of Haematology , 191 (3) pp. 505-506. 10.1111/bjh.17110.

Fox, TA; Troy-Barnes, E; Kirkwood, AA; Chan, WY; Day, J; Chavda, SJ; Kumar, EA; ... Ardeshna, KM; + view all Fox, TA; Troy-Barnes, E; Kirkwood, AA; Chan, WY; Day, J; Chavda, SJ; Kumar, EA; David, K; Tomkins, O; Sanchez, E; Scully, M; Khwaja, A; Lambert, J; Singer, M; Roddie, C; Morris, EC; Yong, KL; Thomson, KJ; Ardeshna, KM; - view fewer (2020) Clinical outcomes and risk factors for severe COVID‐19 infection in patients with haematological disorders receiving chemo‐ or immunotherapy. British Journal of Haematology , 191 (2) pp. 194-206. 10.1111/bjh.17027.

Frampton, D; Rampling, T; Cross, A; Bailey, H; Heaney, J; Byott, M; Scott, R; ... Nastouli, E; + view all Frampton, D; Rampling, T; Cross, A; Bailey, H; Heaney, J; Byott, M; Scott, R; Sconza, R; Price, J; Margaritis, M; Bergstrom, M; Spyer, MJ; Miralhes, PB; Grant, P; Kirk, S; Valerio, C; Mangera, Z; Prabhahar, T; Moreno-Cuesta, J; Arulkumaran, N; Singer, M; Shin, GY; Sanchez, E; Paraskevopoulou, SM; Pillay, D; McKendry, RA; Mirfenderesky, M; Houlihan, CF; Nastouli, E; - view fewer (2021) Genomic characteristics and clinical effect of the emergent SARS-CoV-2 B.1.1.7 lineage in London, UK: a whole-genome sequencing and hospital-based cohort study. Lancet Infectious Diseases 10.1016/S1473-3099(21)00170-5. (In press).

Friesecke, S; Träger, K; Schittek, GA; Molnar, Z; Bach, F; Kogelmann, K; Bogdanski, R; ... Brunkhorst, FM; + view all Friesecke, S; Träger, K; Schittek, GA; Molnar, Z; Bach, F; Kogelmann, K; Bogdanski, R; Weyland, A; Nierhaus, A; Nestler, F; Olboeter, D; Tomescu, D; Jacob, D; Haake, H; Grigoryev, E; Nitsch, M; Baumann, A; Quintel, M; Schott, M; Kielstein, JT; Meier-Hellmann, A; Born, F; Schumacher, U; Singer, M; Kellum, J; Brunkhorst, FM; - view fewer (2019) International registry on the use of the CytoSorb® adsorber in ICU patients. Medizinische Klinik - Intensivmedizin und Notfallmedizin , 114 pp. 699-707. 10.1007/s00063-017-0342-5.

Gant, Vanya; Singer, Mervyn; (2022) Combining pathogen and host metagenomics for a better sepsis diagnostic. Nature Microbiology , 7 (11) pp. 1713-1714. 10.1038/s41564-022-01255-0.

Gayat, E; Cariou, A; Deye, N; Vieillard-Baron, A; Jaber, S; Damoisel, C; Lu, Q; ... Mebazaa, A; + view all Gayat, E; Cariou, A; Deye, N; Vieillard-Baron, A; Jaber, S; Damoisel, C; Lu, Q; Monnet, X; Rennuit, I; Azoulay, E; Leone, M; Oueslati, H; Guidet, B; Friedman, D; Tesniere, A; Sonneville, R; Montravers, P; Pili-Floury, S; Lefrant, J-Y; Duranteau, J; Laterre, P-F; Brechot, N; Chevreul, K; Michel, M; Cholley, B; Legrand, M; Launay, J-M; Vicaut, E; Singer, M; Resche-Rigon, M; Mebazaa, A; - view fewer (2018) Determinants of long-term outcome in ICU survivors: results from the FROG-ICU study. Critical Care , 22 , Article 8. 10.1186/s13054-017-1922-8.

Girardis, M; Busani, S; Damiani, E; Donati, A; Rinaldi, L; Marudi, A; Morelli, A; ... Singer, M; + view all Girardis, M; Busani, S; Damiani, E; Donati, A; Rinaldi, L; Marudi, A; Morelli, A; Antonelli, M; Singer, M; - view fewer (2016) Effect of Conservative vs Conventional Oxygen Therapy on Mortality Among Patients in an Intensive Care Unit The Oxygen-ICU Randomized Clinical Trial. JAMA - Journal of the American Medical Association , 316 (15) pp. 1583-1589. 10.1001/jama.2016.11993.

Gordon, AC; Orme, RML; Singer, M; (2017) Levosimendan in Sepsis. [Letter]. The New England Journal of Medicine , 376 (8) p. 800. 10.1056/NEJMc1616632.

Gordon, AC; Perkins, GD; Singer, M; McAuley, DF; Orme, RML; Santhakumaran, S; Mason, AJ; ... Ashby, D; + view all Gordon, AC; Perkins, GD; Singer, M; McAuley, DF; Orme, RML; Santhakumaran, S; Mason, AJ; Cross, M; Al-Beidh, F; Best-Lane, J; Brealey, D; Nutt, CL; McNamee, JJ; Reschreiter, H; Breen, A; Liu, KD; Ashby, D; - view fewer (2016) Levosimendan for the Prevention of Acute Organ Dysfunction in Sepsis. The New England Journal of Medicine , 375 (17) pp. 1638-1648. 10.1056/NEJMoa1609409.

Gordon, AC; Santhakumaran, S; Al-Beidh, F; Orme, RML; Perkins, GD; Singer, M; McAuley, DF; ... Ashby, D; + view all Gordon, AC; Santhakumaran, S; Al-Beidh, F; Orme, RML; Perkins, GD; Singer, M; McAuley, DF; Mason, AJ; Ward, JK; O’Dea, KP; Felton, T; Cross, M; Best-Lane, J; Lexow, J; Campbell, A; Ashby, D; - view fewer (2018) Levosimendan to prevent acute organ dysfunction in sepsis: the LeoPARDS RCT. Efficacy and Mechanism Evaluation , 5 (6) pp. 1-94. 10.3310/eme05060.

Gray, ME; Marland, JRK; Dunare, C; Blair, EO; Meehan, J; Tsiamis, A; Kunkler, IH; ... Potter, MA; + view all Gray, ME; Marland, JRK; Dunare, C; Blair, EO; Meehan, J; Tsiamis, A; Kunkler, IH; Murray, AF; Argyle, D; Dyson, A; Singer, M; Potter, MA; - view fewer (2019) In vivo validation of a miniaturized electrochemical oxygen sensor for measuring intestinal oxygen tension. American Journal of Physiology - Gastrointestinal and Liver Physiology , 317 (2) G242-G252. 10.1152/ajpgi.00050.2019.

Harris, S; Singer, M; Sanderson, C; Grieve, R; Harrison, D; Rowan, K; (2018) Correction to: Impact on mortality of prompt admission to critical care for deteriorating ward patients: an instrumental variable analysis using critical care bed strain. [Corrigendum]. Intensive Care Medicine , 44 (5) p. 701. 10.1007/s00134-018-5254-1.

Harris, S; Singer, M; Sanderson, C; Grieve, R; Harrison, D; Rowan, K; (2018) Impact on mortality of prompt admission to critical care for deteriorating ward patients: an instrumental variable analysis using critical care bed strain. Intensive Care Medicine , 44 (5) pp. 606-615. 10.1007/s00134-018-5148-2.

Harrisa, S; Shi, S; Brealey, D; MacCallum, NS; Denaxas, S; Perez-Suarez, D; Ercole, A; ... Singer, M; + view all Harrisa, S; Shi, S; Brealey, D; MacCallum, NS; Denaxas, S; Perez-Suarez, D; Ercole, A; Watkinson, P; Jones, A; Ashworth, S; Beale, R; Young, D; Brett, S; Singer, M; - view fewer (2018) Critical Care Health Informatics Collaborative (CCHIC): Data, tools and methods for reproducible research: A multi-centre UK intensive care database. International Journal of Medical Informatics , 112 pp. 82-89. 10.1016/j.ijmedinf.2018.01.006.

Hellman, J; Bahrami, S; Boros, M; Chaudry, I; Fritsch, G; Gozdzik, W; Inoue, S; ... Huber-Lang, M; + view all Hellman, J; Bahrami, S; Boros, M; Chaudry, I; Fritsch, G; Gozdzik, W; Inoue, S; Radermacher, P; Singer, M; Osuchowski, MF; Huber-Lang, M; - view fewer (2019) Part III: Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS) for Fluid Resuscitation and Antimicrobial Therapy Endpoints. Shock , 51 (1) pp. 33-43. 10.1097/SHK.0000000000001209.

Hill, NE; Murphy, KG; Saeed, S; Phadke, R; Chambers, D; Wilson, DR; Brett, SJ; Hill, NE; Murphy, KG; Saeed, S; Phadke, R; Chambers, D; Wilson, DR; Brett, SJ; Singer, M; - view fewer (2017) Impact of ghrelin on body composition and muscle function in a long-term rodent model of critical illness. PLoS ONE , 12 (8) , Article e0182659. 10.1371/journal.pone.0182659.

Hofmaenner, DA; Kleyman, A; Press, A; Bauer, M; Singer, M; (2022) The Many Roles of Cholesterol in Sepsis: A Review. American Journal of Respiratory and Critical Care Medicine , 205 (4) pp. 388-396. 10.1164/rccm.202105-1197TR.

Hofmaenner, Daniel A; Kleyman, Anna; Singer, Mervyn; (2021) Cholesterol and its association with muscle weakness in critical illness. Critical Care , 25 , Article 296. 10.1186/s13054-021-03722-2.

Hofmaenner, Daniel A; Singer, Mervyn; (2024) Challenging management dogma where evidence is non-existent, weak, or outdated: part II. Intensive Care Medicine , 50 (11) pp. 1804-1813. 10.1007/s00134-024-07634-x.

Hofmaenner, Daniel A; Singer, Mervyn; (2022) The challenge of pharmacological thromboprophylaxis in ICU patients: anti-FXa activity does not constitute the simple solution. Author's reply. Intensive Care Medicine , 48 pp. 1118-1119. 10.1007/s00134-022-06768-0.

Hofmaenner, Daniel A; Singer, Mervyn; (2022) Challenging management dogma where evidence is non-existent, weak or outdated. Intensive Care Medicine , 48 pp. 548-558. 10.1007/s00134-022-06659-4.

Ida, KK; Chisholm, KI; Malbouisson, LMS; Papkovsky, DB; Dyson, A; Singer, M; Duchen, MR; Ida, KK; Chisholm, KI; Malbouisson, LMS; Papkovsky, DB; Dyson, A; Singer, M; Duchen, MR; Smith, KJ; - view fewer (2017) Protection of cerebral microcirculation, mitochondrial function and electrocortical activity by small-volume resuscitation with terlipressin in a model of haemorrhagic shock. British Journal of Anaesthesia 10.1016/j.bja.2017.11.074. (In press).

Johnson, Thomas W; Holt, James; Kleyman, Anna; Zhou, Shengyu; Sammut, Eva; Bruno, Vito Domenico; Gaupp, Charlotte; ... Dyson, Alex; + view all Johnson, Thomas W; Holt, James; Kleyman, Anna; Zhou, Shengyu; Sammut, Eva; Bruno, Vito Domenico; Gaupp, Charlotte; Stanzani, Giacomo; Martin, John; Arina, Pietro; Deutsch, Julia; Ascione, Raimondo; Singer, Mervyn; Dyson, Alex; - view fewer (2024) Development and translation of thiometallate sulfide donors using a porcine model of coronary occlusion and reperfusion. Redox Biology , 73 , Article 103167. 10.1016/j.redox.2024.103167.

Kammann, Tobias; Hoff, Jessica; Yildirim, Ilknur; Shkodra, Blerina; Müller, Tina; Weber, Christine; Gräler, Markus H; ... Press, Adrian T; + view all Kammann, Tobias; Hoff, Jessica; Yildirim, Ilknur; Shkodra, Blerina; Müller, Tina; Weber, Christine; Gräler, Markus H; Maus, Ulrich A; Paton, James C; Singer, Mervyn; Traeger, Anja; Schubert, Ulrich S; Bauer, Michael; Press, Adrian T; - view fewer (2021) Intracellularly Released Cholesterol from Polymer-Based Delivery Systems Alters Cellular Responses to Pneumolysin and Promotes Cell Survival. Metabolites , 11 (12) , Article 821. 10.3390/metabo11120821.

Khaliq, W; Grossmann, P; Neugebauer, S; Kleyman, A; Domizi, R; Calcinaro, S; Brealey, D; ... Bauer, M; + view all Khaliq, W; Grossmann, P; Neugebauer, S; Kleyman, A; Domizi, R; Calcinaro, S; Brealey, D; Graeler, M; Kiehntopf, M; Schaeuble, S; Singer, M; Panagiotou, G; Bauer, M; - view fewer (2020) Lipid metabolic signatures deviate in sepsis survivors compared to non-survivors. Computational and Structural Biotechnology Journal , 18 pp. 3678-3691. 10.1016/j.csbj.2020.11.009.

Klompas, M; Calandra, T; Singer, M; (2018) Antibiotics for Sepsis-Finding the Equilibrium. [Editorial comment]. JAMA-Journal of the American Medical Association , 320 (14) pp. 1433-1434. 10.1001/jama.2018.12179.

Koenig, R; Kolte, A; Ahlers, O; Oswald, M; Krauss, V; Roell, D; Sommerfeld, O; ... Bauer, M; + view all Koenig, R; Kolte, A; Ahlers, O; Oswald, M; Krauss, V; Roell, D; Sommerfeld, O; Dimopoulos, G; Tsangaris, I; Antoniadou, E; Jaishankar, N; Bogatsch, H; Loeffler, M; Roedel, M; Garcia-Moreno, M; Tuchscherr, L; Sprung, CL; Singer, M; Brunkhorst, F; Oppert, M; Gerlach, H; Claus, RA; Coldewey, SM; Briegel, J; Giamarellos-Bourboulis, EJ; Keh, D; Bauer, M; - view fewer (2021) Use of IFN gamma/IL10 Ratio for Stratification of Hydrocortisone Therapy in Patients With Septic Shock. Frontiers in Immunology , 12 , Article 607217. 10.3389/fimmu.2021.607217.

Kox, Matthijs; Bauer, Michael; Bos, Lieuwe DJ; Bouma, Hjalmar; Calandra, Thierry; Calfee, Carolyn S; Chousterman, Benjamin G; ... Pickkers, Peter; + view all Kox, Matthijs; Bauer, Michael; Bos, Lieuwe DJ; Bouma, Hjalmar; Calandra, Thierry; Calfee, Carolyn S; Chousterman, Benjamin G; Derde, Lennie PG; Giamarellos-Bourboulis, Evangelos J; Gómez, Hernando; Netea, Mihai G; Ostermann, Marlies; van der Poll, Tom; Scicluna, Brendon P; Seymour, Christopher; Shankar-Hari, Manu; Shapiro, Nathan; Singer, Mervyn; Venet, Fabienne; Vlaar, Alexander PJ; van Vught, Lonneke A; Weis, Sebastian; Joost Wiersinga, W; Pickkers, Peter; - view fewer (2025) The immunology of sepsis: translating new insights into clinical practice. Nature Reviews Nephrology 10.1038/s41581-025-01004-6. (In press).

Kuganesan, M; Samra, K; Evans, E; Singer, M; Dyson, A; (2019) Selenium and hydrogen selenide: essential micronutrient and the fourth gasotransmitter? Intensive Care Medicine Experimental , 7 (1) , Article 71. 10.1186/s40635-019-0281-y.

Lall, R; Mistry, D; Skilton, E; Boota, N; Regan, S; Bion, J; Gates, S; ... Whitehouse, T; + view all Lall, R; Mistry, D; Skilton, E; Boota, N; Regan, S; Bion, J; Gates, S; Gordon, AC; Lord, J; McAuley, DF; Perkins, G; Singer, M; Young, D; Whitehouse, T; - view fewer (2021) Study into the reversal of septic shock with landiolol (beta blockade): STRESS-L Study protocol for a randomised trial. BMJ Open , 11 (2) , Article e043194. 10.1136/bmjopen-2020-043194.

Levi, M; Scully, M; Singer, M; (2018) The role of ADAMTS‐13 in the coagulopathy of sepsis. Journal of Thrombosis and Haemostasis , 16 (4) pp. 646-651. 10.1111/jth.13953.

Lipman, M; Chambers, RC; Singer, M; Brown, JS; (2020) SARS-CoV-2 pandemic: clinical picture of COVID-19 and implications for research. Thorax 10.1136/thoraxjnl-2020-215024. (In press).

Longobardo, A; Montanari, C; Shulman, R; Benhalim, S; Singer, M; Arulkumaran, N; (2021) Inhaled nitric oxide minimally improves oxygenation in COVID-19 related acute respiratory distress syndrome. British Journal of Anaesthesia , 126 (1) e44-e46. 10.1016/j.bja.2020.10.011.

Longobardo, A; Snow, TAC; Montanari, C; Shulman, R; Singer, M; Arulkumaran, N; (2021) COVID-19 and non-COVID ARDS patients demonstrate a distinct response to low dose steroids- A retrospective observational study. Journal of Critical Care , 62 pp. 46-48. 10.1016/j.jcrc.2020.11.012.

Lukaszewski, Roman A; Jones, Helen E; Gersuk, Vivian H; Russell, Paul; Simpson, Andrew; Brealey, David; Walker, Jonathan; ... Singer, Mervyn; + view all Lukaszewski, Roman A; Jones, Helen E; Gersuk, Vivian H; Russell, Paul; Simpson, Andrew; Brealey, David; Walker, Jonathan; Thomas, Matt; Whitehouse, Tony; Ostermann, Marlies; Koch, Alexander; Zacharowski, Kai; Kruhoffer, Mogens; Chaussabel, Damien; Singer, Mervyn; - view fewer (2022) Presymptomatic diagnosis of postoperative infection and sepsis using gene expression signatures. Intensive Care Medicine , 48 pp. 1133-1143. 10.1007/s00134-022-06769-z.

Madrigal-Garcia, MI; Archer, D; Singer, M; Rodrigues, M; Shenfield, A; Moreno-Cuesta, J; (2020) Do Temporal Changes in Facial Expressions Help Identify Patients at Risk of Deterioration in Hospital Wards? A Post Hoc Analysis of the Visual Early Warning Score Study. Critical Care Explorations , 2 (5) , Article e0115. 10.1097/CCE.0000000000000115.

Madrigal-Garcia, MI; Rodrigues, M; Shenfield, A; Singer, M; Moreno-Cuesta, J; (2018) What Faces Reveal: A Novel Method to Identify Patients at Risk of Deterioration Using Facial Expressions. Critical Care Medicine , 46 (7) pp. 1057-1062. 10.1097/CCM.0000000000003128.

Maláska, Jan; Stašek, Jan; Duška, František; Balík, Martin; Máca, Jan; Hruda, Jan; Vymazal, Tomáš; ... REMED Study Group; + view all Maláska, Jan; Stašek, Jan; Duška, František; Balík, Martin; Máca, Jan; Hruda, Jan; Vymazal, Tomáš; Klementová, Olga; Zatloukal, Jan; Gabrhelík, Tomáš; Novotný, Pavel; Demlová, Regina; Kubátová, Jana; Vinklerová, Jana; Svobodník, Adam; Kratochvíl, Milan; Klučka, Jozef; Gál, Roman; Singer, Mervyn; REMED Study Group; - view fewer (2022) Effect of dexamethasone in patients with ARDS and COVID-19 (REMED trial)—study protocol for a prospective, multi-centre, open-label, parallel-group, randomized controlled trial. Trials , 23 , Article 35. 10.1186/s13063-021-05963-6.

Maláska, J; Stašek, J; Duška, F; Balík, M; Máca, J; Hruda, J; Vymazal, T; ... REMED Study Group; + view all Maláska, J; Stašek, J; Duška, F; Balík, M; Máca, J; Hruda, J; Vymazal, T; Klementová, O; Zatloukal, J; Gabrhelík, T; Novotný, P; Demlová, R; Kubátová, J; Vinklerová, J; Svobodník, A; Kratochvíl, M; Klučka, J; Gál, R; Singer, M; REMED Study Group; - view fewer (2021) Effect of dexamethasone in patients with ARDS and COVID-19 - prospective, multi-centre, open-label, parallel-group, randomised controlled trial (REMED trial): A structured summary of a study protocol for a randomised controlled trial. Trials , 22 (1) , Article 172. 10.1186/s13063-021-05116-9.

Manfredini, A; Constantino, L; Pinto, MC; Michels, M; Burger, H; Kist, LW; Silva, MC; ... Dal-Pizzol, F; + view all Manfredini, A; Constantino, L; Pinto, MC; Michels, M; Burger, H; Kist, LW; Silva, MC; Gomes, LM; Dominguini, D; Steckert, A; Simioni, C; Bogo, M; Streck, E; Barichello, T; de Quevedo, J; Singer, M; Ritter, C; Dal-Pizzol, F; - view fewer (2019) Mitochondria dysfunction is associated with long-term cognitive impairment in an animal sepsis mode. Clinical Science , 133 (18) pp. 1993-2004. 10.1042/CS20190351.

Manson, JJ; Crooks, C; Naja, M; Ledlie, A; Goulden, B; Liddle, T; Khan, E; ... Tattersall, RS; + view all Manson, JJ; Crooks, C; Naja, M; Ledlie, A; Goulden, B; Liddle, T; Khan, E; Mehta, P; Martin-Gutierrez, L; Waddington, KE; Robinson, GA; Ribeiro Santos, L; McLoughlin, E; Snell, A; Adeney, C; Schim van der Loeff, I; Baker, KF; Duncan, CJA; Hanrath, AT; Lendrem, BC; De Soyza, A; Peng, J; J'Bari, H; Greenwood, M; Hawkins, E; Peckham, H; Marks, M; Rampling, T; Luintel, A; Williams, B; Brown, M; Singer, M; West, J; Jury, EC; Collin, M; Tattersall, RS; - view fewer (2020) COVID-19-associated hyperinflammation and escalation of patient care: a retrospective longitudinal cohort study. The Lancet Rheumatology , 2 (10) e594-e602. 10.1016/S2665-9913(20)30275-7.

Marini, JJ; De Backer, D; Ince, C; Singer, M; Van Haren, F; Westphal, M; Wischmeyer, P; (2017) Seven unconfirmed ideas to improve future ICU practice. Critical Care , 21 (Suppl 3) , Article 315. 10.1186/s13054-017-1904-x.

Marini, JJ; DeBacker, D; Gattinoni, L; Ince, C; Martin-Loeches, I; Singer, P; Singer, M; ... Vincent, J-L; + view all Marini, JJ; DeBacker, D; Gattinoni, L; Ince, C; Martin-Loeches, I; Singer, P; Singer, M; Westphal, M; Vincent, J-L; - view fewer (2019) Thinking forward: promising but unproven ideas for future intensive care. Critical Care , 23 (Sup 1) , Article 197. 10.1186/s13054-019-2462-1.

Marland, JRK; Gray, ME; Dunare, C; Blair, EO; Tsiamis, A; Sullivan, P; González-Fernández, E; ... Murray, AF; + view all Marland, JRK; Gray, ME; Dunare, C; Blair, EO; Tsiamis, A; Sullivan, P; González-Fernández, E; Greenhalgh, SN; Gregson, R; Clutton, RE; Parys, MM; Dyson, A; Singer, M; Kunkler, IH; Potter, MA; Mitra, S; Terry, JG; Smith, S; Mount, AR; Underwood, I; Walton, AJ; Argyle, DJ; Murray, AF; - view fewer (2020) Real-time measurement of tumour hypoxia using an implantable microfabricated oxygen sensor. Sensing and Bio-Sensing Research , 30 , Article 100375. 10.1016/j.sbsr.2020.100375.

Martin, Guillaume L; Atramont, Alice; Mazars, Marjorie; Tajahmady, Ayden; Agamaliyev, Emin; Singer, Mervyn; Leone, Marc; Martin, Guillaume L; Atramont, Alice; Mazars, Marjorie; Tajahmady, Ayden; Agamaliyev, Emin; Singer, Mervyn; Leone, Marc; Legrand, Matthieu; - view fewer (2022) Days Spent at Home and Mortality After Critical Illness: A Cluster Analysis Using Nationwide Data. Chest 10.1016/j.chest.2022.10.008. (In press).

Martin-Loeches, Ignacio; Singer, Mervyn; Leone, Marc; (2024) Sepsis: key insights, future directions, and immediate goals. A review and expert opinion. Intensive Care Medicine , 50 (12) pp. 2043-2049. 10.1007/s00134-024-07694-z.

Maslove, David M; Tang, Benjamin; Shankar-Hari, Manu; Lawler, Patrick R; Angus, Derek C; Baillie, J Kenneth; Baron, Rebecca M; ... Marshall, John C; + view all Maslove, David M; Tang, Benjamin; Shankar-Hari, Manu; Lawler, Patrick R; Angus, Derek C; Baillie, J Kenneth; Baron, Rebecca M; Bauer, Michael; Buchman, Timothy G; Calfee, Carolyn S; Dos Santos, Claudia C; Giamarellos-Bourboulis, Evangelos J; Gordon, Anthony C; Kellum, John A; Knight, Julian C; Leligdowicz, Aleksandra; McAuley, Daniel F; McLean, Anthony S; Menon, David K; Meyer, Nuala J; Moldawer, Lyle L; Reddy, Kiran; Reilly, John P; Russell, James A; Sevransky, Jonathan E; Seymour, Christopher W; Shapiro, Nathan I; Singer, Mervyn; Summers, Charlotte; Sweeney, Timothy E; Thompson, B Taylor; van der Poll, Tom; Venkatesh, Balasubramanian; Walley, Keith R; Walsh, Timothy S; Ware, Lorraine B; Wong, Hector R; Zador, Zsolt E; Marshall, John C; - view fewer (2022) Redefining critical illness. Nature Medicine , 28 pp. 1141-1148. 10.1038/s41591-022-01843-x.

Mathieu, C; Desrois, M; Kober, F; Lalevée, N; Lan, C; Fourny, N; Iché-Torres, M; ... Leone, M; + view all Mathieu, C; Desrois, M; Kober, F; Lalevée, N; Lan, C; Fourny, N; Iché-Torres, M; Tran, TT; Lê, LT; Singer, M; Mège, J-L; Bernard, M; Leone, M; - view fewer (2018) Sex-Mediated Response to the Beta-Blocker Landiolol in Sepsis: An Experimental, Randomized Study. Critical Care Medicine , 46 (7) e684-e691. 10.1097/CCM.0000000000003146.

McGrath, BA; Brenner, MJ; Warrillow, SJ; Pandian, V; Arora, A; Cameron, TS; Anon, JM; ... Feller-Kopman, DJ; + view all McGrath, BA; Brenner, MJ; Warrillow, SJ; Pandian, V; Arora, A; Cameron, TS; Anon, JM; Martinez, GH; Truog, RD; Block, SD; Lui, GCY; McDonald, C; Rassekh, CH; Atkins, J; Qiang, L; Vergez, S; Dulguerov, P; Zenk, J; Antonelli, M; Pelosi, P; Walsh, BK; Ward, E; Shang, Y; Gasparini, S; Donati, A; Singer, M; Openshaw, PJM; Tolley, N; Markel, H; Feller-Kopman, DJ; - view fewer (2020) Tracheostomy in the COVID-19 era: global and multidisciplinary guidance. The Lancet Respiratory Medicine , 8 (7) pp. 717-725. 10.1016/S2213-2600(20)30230-7.

McKendry, Rachel A; Rogers, Elliott; Singer, Mervyn; Brown, Colin S; (2024) Invest in antimicrobial test-to-treat strategies. nature , 633 p. 525. 10.1038/d41586-024-03022-z.

McMillan, Tim; Jones, Conor; O'Connor, Cavan J; Nolan, Daniel; Chan, Xin Hui S; Ellis, Jayne; Thakker, Clare; ... Arulkumaran, Nishkantha; + view all McMillan, Tim; Jones, Conor; O'Connor, Cavan J; Nolan, Daniel; Chan, Xin Hui S; Ellis, Jayne; Thakker, Clare; Kranzer, Katharina; Stone, Neil RH; Singer, Mervyn; Wilson, A Peter R; Arulkumaran, Nishkantha; - view fewer (2021) Risk factors associated with bloodstream infections among critically ill patients with COVID-19. Journal of Infection , 83 (5) E1-E3. 10.1016/j.jinf.2021.09.010.

Meiring, C; Dixit, A; Harris, S; MacCallum, NS; Brealey, DA; Watkinson, PJ; Jones, A; ... Ercole, A; + view all Meiring, C; Dixit, A; Harris, S; MacCallum, NS; Brealey, DA; Watkinson, PJ; Jones, A; Ashworth, S; Beale, R; Brett, SJ; Singer, M; Ercole, A; - view fewer (2018) Optimal intensive care outcome prediction over time using machine learning. PLoS One , 13 (11) , Article e0206862. 10.1371/journal.pone.0206862.

Melis, Miranda J; Miller, Muska; Peters, Vera BM; Singer, Mervyn; (2023) The role of hormones in sepsis: an integrated overview with a focus on mitochondrial and immune cell dysfunction. Clinical Science , 137 (9) pp. 707-725. 10.1042/cs20220709.

Mendonça, BP; Cardoso, JDS; Michels, M; Vieira, AC; Wendhausen, D; Manfredini, A; Singer, M; ... Dyson, A; + view all Mendonça, BP; Cardoso, JDS; Michels, M; Vieira, AC; Wendhausen, D; Manfredini, A; Singer, M; Dal-Pizzol, F; Dyson, A; - view fewer (2020) Neuroprotective effects of ammonium tetrathiomolybdate, a slow-release sulfide donor, in a rodent model of regional stroke. Intensive Care Medicine Experimental , 8 (1) , Article 13. 10.1186/s40635-020-00300-8.

Merz, T; Denoix, N; Huber-Lang, M; Singer, M; Radermacher, P; McCook, O; (2020) Microcirculation vs. Mitochondria-What to Target? Frontiers in Medicine , 7 , Article 416. 10.3389/fmed.2020.00416.

Miller, Muska; Singer, Mervyn; (2022) Do antibiotics cause mitochondrial and immune cell dysfunction? A literature review. Journal of Antimicrobial Chemotherapy , 77 (5) pp. 1218-1227. 10.1093/jac/dkac025.

Miller, RF; Allen, E; Copas, A; Singer, M; Edwards, SG; (2006) Improved survival for HIV infected patients with severe Pneumocystis jirovecii pneumonia is independent of highly active antiretroviral therapy. THORAX , 61 (8) 716 - 721. 10.1136/thx.2005.055905.

Monnet, Xavier; Messina, Antonio; Greco, Massimiliano; Bakker, Jan; Aissaoui, Nadia; Cecconi, Maurizio; Coppalini, Giacomo; ... Chew, Michelle S; + view all Monnet, Xavier; Messina, Antonio; Greco, Massimiliano; Bakker, Jan; Aissaoui, Nadia; Cecconi, Maurizio; Coppalini, Giacomo; De Backer, Daniel; Edul, Vanina Kanoore; Evans, Laura; Hernandez, Glenn; Hunsicker, Oliver; Ince, Can; Kaufmann, Thomas; Levy, Bruno; Malbrain, Manu LNG; Mebazaa, Alexandre; Myatra, Sheila Nainan; Ostermann, Marlies; Pinsky, Michael R; Saugel, Bernd; Savi, Marzia; Singer, Mervyn; Teboul, Jean-Louis; Vieillard-Baron, Antoine; Vincent, Jean-Louis; Chew, Michelle S; - view fewer (2025) ESICM guidelines on circulatory shock and hemodynamic monitoring 2025. Intensive Care Medicine , 51 pp. 1971-2012. 10.1007/s00134-025-08137-z.

Moore, John PR; Shehabi, Yahya; Reade, Michael C; Bailey, Michael; Fraser, John F; Murray, Lauren; Anstey, Christopher; Moore, John PR; Shehabi, Yahya; Reade, Michael C; Bailey, Michael; Fraser, John F; Murray, Lauren; Anstey, Christopher; Singer, Mervyn; - view fewer (2022) Stress response during early sedation with dexmedetomidine compared with usual-care in ventilated critically ill patients. Critical Care , 26 (1) , Article 359. 10.1186/s13054-022-04237-0.

Moore, JPR; Anstey, C; Murray, L; Fraser, JF; Singer, M; (2018) Allostasis and sedation practices in intensive care evaluation: an observational pilot study. Intensive Care Medicine Experimental , 6 (1) , Article 13. 10.1186/s40635-018-0179-0.

Morel, J; Hargreaves, I; Brealey, D; Neergheen, V; Backman, JT; Lindig, S; Bläss, M; ... Singer, M; + view all Morel, J; Hargreaves, I; Brealey, D; Neergheen, V; Backman, JT; Lindig, S; Bläss, M; Bauer, M; McAuley, DF; Singer, M; - view fewer (2017) Simvastatin pre-treatment improves survival and mitochondrial function in a 3-day fluid-resuscitated rat model of sepsis. Clinical Science , 131 (8) pp. 747-758. 10.1042/CS20160802.

Morelli, A; Singer, M; Ranieri, VM; D'Egidio, A; Mascia, L; Orecchioni, A; Piscioneri, F; ... Romano, SM; + view all Morelli, A; Singer, M; Ranieri, VM; D'Egidio, A; Mascia, L; Orecchioni, A; Piscioneri, F; Guarracino, F; Greco, E; Peruzzi, M; Biondi-Zoccai, G; Frati, G; Romano, SM; - view fewer (2016) Heart rate reduction with esmolol is associated with improved arterial elastance in patients with septic shock: a prospective observational study. Intensive Care Medicine , 42 (10) pp. 1528-1534. 10.1007/s00134-016-4351-2.

Moreno, Rui; Rhodes, Andrew; Ranzani, Otavio; Salluh, Jorge IF; Berger-Estilita, Joana; Coopersmith, Craig M; Juffermans, Nicole P; ... Singer, Mervyn; + view all Moreno, Rui; Rhodes, Andrew; Ranzani, Otavio; Salluh, Jorge IF; Berger-Estilita, Joana; Coopersmith, Craig M; Juffermans, Nicole P; Laffey, John; Reinikainen, Matti; Neto, Ary Serpa; Tavares, Miguel; Timsit, Jean-Francois; Arias Lopez, Maria Del Pilar; Arulkumaran, Nish; Azoulay, Elie; Chaudhuri, Dipayan; De Lange, Dylan; De Waele, Jan; Dos Santos, Claudia C; Du, Bin; Einav, Sharon; Ferrer, Ricard; Fujii, Tomoko; Gershengorn, Hayley B; Haniffa, Rashan; Hasan, Mohd Shahnaz; Hollenberg, Steve; Ippolito, Mariachiara; Jung, Christian; Kirov, Mikhail; Lakbar, Ines; Lipman, Jeffrey; Liu, Vincent; Lobo, Suzana Margareth; Martin, Greg S; Metnitz, Philipp; Myatra, Sheila N; Oczkowski, Simon; Paiva, Jose-Artur; Paruk, Fathima; Pekkarinen, Pirkka T; Pilcher, David; Piquilloud, Lise; Polkki, Anssi; Prescott, Halle C; Blaser, Annika Reintam; Rezende, Ederlon; Robba, Chiara; Rochwerg, Bram; Schenck, Edward J; Sendagire, Cornelius; Siaw-Frimpong, Moses; Simpkin, Andrew J; Soares, Marcio; Summers, Charlotte; Szczeklik, Wojciech; Takala, Jukka; Vincent, Jean-Louis; Wendon, Julia; Zampieri, Fernando G; Shankar-Hari, Manu; Singer, Mervyn; - view fewer (2025) Rationale and Methodological Approach Underlying the Development of the Sequential Organ Failure Assessment (SOFA)–2 Score. Jama Network Open , 8 (10) , Article e2545040. 10.1001/jamanetworkopen.2025.45040.

Moreno, Rui; Singer, Mervyn; Rhodes, Andrew; (2024) Why does the Sequential Organ Failure Assessment score need to be updated? Critical Care Science , 36 10.62675/2965-2774.20240296-pt.

Moreno, Rui; Singer, Mervyn; Rhodes, Andrew; (2024) Why the Sequential Organ Failure Assessment score needs updating? Critical Care Science , 36 , Article e20240296en. 10.62675/2965-2774.20240296-en.

Nasa, Prashant; Azoulay, Elie; Chakrabarti, Arunaloke; Divatia, Jigeeshu; Jain, Ravi; Rodrigues, Camilla; Rosenthal, Victor; ... Myatra, Sheila; + view all Nasa, Prashant; Azoulay, Elie; Chakrabarti, Arunaloke; Divatia, Jigeeshu; Jain, Ravi; Rodrigues, Camilla; Rosenthal, Victor; Alhazzani, Waleed; Arabi, Yaseen M; Bakker, Jan; Bassetti, Matteo; De Waele, Jan; Dimopoulos, George; Du, Bin; Einav, Sharon; Evans, Laura; Finfer, Simon; Guerin, Claude; Hammond, Naomi E; Jaber, Samir; Kleinpell, Ruth M; Koh, Younsuck; Kollef, Marin; Levy, Mitchell M; Machado, Flavia R; Mancebo, Jordi; Martin-Loeches, Ignacio; Mer, Mervyn; Niederman, Michael S; Pelosi, Paolo; Perner, Anders; Peter, John; Phua, Jason; Piquilloud, Lise; Pletz, Mathias W; Rhodes, Andrew; Schultz, Marcus J; Singer, Mervyn; Timsit, Jean-Francois; Venkatesh, Balasubramanian; Vincent, Jean-Louis; Welte, Tobias; Myatra, Sheila; - view fewer (2022) Infection control in the intensive care unit: expert consensus statements for SARS-CoV-2 using a Delphi method. Lancet Infectious Diseases , 22 (3) E74-E87. 10.1016/S1473-3099(21)00626-5.

Nauclér, P; Huttner, A; van Werkhoven, CH; Singer, M; Tattevin, P; Einav, S; Tängdén, T; (2020) Impact of time to antibiotic therapy on clinical outcome in patients with bacterial infections in the emergency department: implications for antimicrobial stewardship. Clinical Microbiology and Infection 10.1016/j.cmi.2020.02.032. (In press).

O'Driscoll, BR; Howard, LS; Earis, J; Mak, V; (2017) BTS guideline for oxygen use in adults in healthcare and emergency settings. Thorax , 72 (Supp. 01) ii1-ii90. 10.1136/thoraxjnl-2016-209729.

O'Dwyer, MJ; Starczewska, MH; Schrenzel, J; Zacharowski, K; Ecker, DJ; Sampath, R; Brealey, D; ... Vincent, JL; + view all O'Dwyer, MJ; Starczewska, MH; Schrenzel, J; Zacharowski, K; Ecker, DJ; Sampath, R; Brealey, D; Singer, M; Libert, N; Wilks, M; Vincent, JL; - view fewer (2017) The detection of microbial DNA but not cultured bacteria is associated with increased mortality in patients with suspected sepsis-a prospective multi-centre European observational study. Clinical Microbiology and Infection Volume 23, Issue 3, March 2017, Pages , 23 (3) 208.e1-208.e6. 10.1016/j.cmi.2016.11.010.

Osuchowski, MF; Ayala, A; Bahrami, S; Bauer, M; Boros, M; Cavaillon, J-M; Chaudry, IH; ... Zingarelli, B; + view all Osuchowski, MF; Ayala, A; Bahrami, S; Bauer, M; Boros, M; Cavaillon, J-M; Chaudry, IH; Coopersmith, CM; Deutschman, C; Drechsler, S; Efron, P; Frostell, C; Fritsch, G; Gozdzik, W; Hellman, J; Huber-Lang, M; Inoue, S; Knapp, S; Kozlov, AV; Libert, C; Marshall, JC; Moldawer, LL; Radermacher, P; Redl, H; Remick, DG; Singer, M; Thiemermann, C; Wang, P; Wiersinga, WJ; Xiao, X; Zingarelli, B; - view fewer (2018) Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis. Infection , 46 (5) pp. 687-691. 10.1007/s15010-018-1183-8.

Osuchowski, MF; Ayala, A; Bahrami, S; Bauer, M; Boros, M; Cavaillon, J-M; Chaudry, IH; ... Zingarelli, B; + view all Osuchowski, MF; Ayala, A; Bahrami, S; Bauer, M; Boros, M; Cavaillon, J-M; Chaudry, IH; Coopersmith, CM; Deutschman, C; Drechsler, S; Efron, P; Frostell, C; Fritsch, G; Gozdzik, W; Hellman, J; Huber-Lang, M; Inoue, S; Knapp, S; Kozlov, AV; Libert, C; Marshall, JC; Moldawer, LL; Radermacher, P; Redl, H; Remick, DG; Singer, M; Thiemermann, C; Wang, P; Wiersinga, WJ; Xiao, X; Zingarelli, B; - view fewer (2018) Correction to: Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis (vol 46, pg 745, 2018). Infection , 46 (5) pp. 745-747. 10.1007/s15010-018-1197-2.

Osuchowski, MF; Ayala, A; Bahrami, S; Bauer, M; Boros, M; Cavaillon, J-M; Chaudry, IH; ... Zingarelli, B; + view all Osuchowski, MF; Ayala, A; Bahrami, S; Bauer, M; Boros, M; Cavaillon, J-M; Chaudry, IH; Coopersmith, CM; Deutschman, C; Drechsler, S; Efron, P; Frostell, C; Fritsch, G; Gozdzik, W; Hellman, J; Huber-Lang, M; Inoue, S; Knapp, S; Kozlov, AV; Libert, C; Marshall, JC; Moldawer, LL; Radermacher, P; Redl, H; Remick, DG; Singer, M; Thiemermann, C; Wang, P; Wiersinga, WJ; Xiao, X; Zingarelli, B; - view fewer (2018) Minimum quality threshold in pre-clinical sepsis studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis. Intensive Care Medicine Experimental , 6 , Article 26. 10.1186/s40635-018-0189-y.

Osuchowski, MF; Ayala, A; Bahrami, S; Bauer, M; Boros, M; Cavaillon, J-M; Chaudry, IH; ... Zingarelli, B; + view all Osuchowski, MF; Ayala, A; Bahrami, S; Bauer, M; Boros, M; Cavaillon, J-M; Chaudry, IH; Coopersmith, CM; Deutschman, CS; Drechsler, S; Efron, P; Frostell, C; Fritsch, G; Gozdzik, W; Hellman, J; Huber-Lang, M; Inoue, S; Knapp, S; Kozlov, AV; Libert, C; Marshall, JC; Moldawer, LL; Radermacher, P; Redl, H; Remick, DG; Singer, M; Thiemermann, C; Wang, P; Wiersinga, WJ; Xiao, X; Zingarelli, B; - view fewer (2018) Minimum Quality Threshold in Pre-Clinical Sepsis Studies (Mqtipss): An International Expert Consensus Initiative for Improvement of Animal Modeling in Sepsis. Shock , 50 (4) pp. 377-380. 10.1097/SHK.0000000000001212.

Paketci, Susi; Williams, Jack; Pisciotta, Walter; Loye, Richard; Waller, Alessia V; Haque, Rahila; Brealey, David; ... Snow, Timothy Arthur Chandos; + view all Paketci, Susi; Williams, Jack; Pisciotta, Walter; Loye, Richard; Waller, Alessia V; Haque, Rahila; Brealey, David; Singer, Mervyn; Whittle, John; Moonesinghe, Ramani; Arulkumaran, Nishkantha; Snow, Timothy Arthur Chandos; - view fewer (2025) Peri-Operative Antimicrobial Prophylaxis Modulates CD4+ Lymphocyte Immunophenotype Ex Vivo in High-Risk Patients Undergoing Major Elective Surgery—A Preliminary Observational Study. Antibiotics , 14 (10) , Article 1026. 10.3390/antibiotics14101026.

Palmer, E; Klapaukh, R; Harris, S; Singer, M; Bonnici, T; Al-Hindawi, A; Keen, T; (2019) Intelligently learning from data. Critical Care , 23 , Article 136. 10.1186/s13054-019-2424-7.

Palmer, E; Martin, D; Singer, M; Harris, S; (2019) Reply to Tasker, and to Lellouche and L'Her. [Letter]. American Journal of Respiratory and Critical Care Medicine , 201 (4) 10.1164/rccm.201910-2045LE.

Palmer, E; Post, B; Klapaukh, R; Marra, G; MacCallum, NS; Brealey, D; Ercole, A; ... Harris, S; + view all Palmer, E; Post, B; Klapaukh, R; Marra, G; MacCallum, NS; Brealey, D; Ercole, A; Jones, A; Ashworth, S; Watkinson, P; Beale, R; Brett, SJ; Young, JD; Black, C; Rashan, A; Martin, D; Singer, M; Harris, S; - view fewer (2019) The Association Between Supra-Physiologic Arterial Oxygen Levels and Mortality in Critically Ill Patients: A Multi-Centre Observational Cohort Study. American Journal of Respiratory and Critical Care Medicine , 200 (11) pp. 1373-1380. 10.1164/rccm.201904-0849OC.

Parker, T; Brealey, D; Dyson, A; Singer, M; (2019) Optimising organ perfusion in the high-risk surgical and critical care patient: a narrative review. British Journal of Anaesthesia , 123 (2) pp. 170-176. 10.1016/j.bja.2019.03.027.

Perner, A; Gordon, AC; Angus, DC; Lamontagne, F; Machado, F; Russell, JA; Timsit, J-F; ... Singer, M; + view all Perner, A; Gordon, AC; Angus, DC; Lamontagne, F; Machado, F; Russell, JA; Timsit, J-F; Marshall, JC; Myburgh, J; Shankar-Hari, M; Singer, M; - view fewer (2017) The intensive care medicine research agenda on septic shock. Intensive Care Medicine , 43 (9) pp. 1294-1305. 10.1007/s00134-017-4821-1.

Perner, A; Gordon, AC; De Backer, D; Dimopoulos, G; Russell, JA; Lipman, J; Jensen, J-U; ... Walsh, T; + view all Perner, A; Gordon, AC; De Backer, D; Dimopoulos, G; Russell, JA; Lipman, J; Jensen, J-U; Myburgh, J; Singer, M; Bellomo, R; Walsh, T; - view fewer (2016) Sepsis: frontiers in diagnosis, resuscitation and antibiotic therapy. Intensive Care Medicine , 42 (12) pp. 1958-1969. 10.1007/s00134-016-4577-z.

Perner, A; Singer, M; (2017) Fixed minimum fluid volume for resuscitation: Con. Intensive Care Medicine , 43 (11) pp. 1681-1682. 10.1007/s00134-016-4581-3.

Peters, VBM; Arulkumaran, N; Melis, MJ; Gaupp, C; Roger, T; Shankar-Hari, M; Singer, M; (2022) Butyrate Supplementation Exacerbates Myocardial and Immune Cell Mitochondrial Dysfunction in a Rat Model of Faecal Peritonitis. Life , 12 (12) , Article 2034. 10.3390/life12122034.

Pinto, BB; Dyson, A; Umbrello, M; Carre, JE; Ritter, C; Clatworthy, I; Duchen, MR; Pinto, BB; Dyson, A; Umbrello, M; Carre, JE; Ritter, C; Clatworthy, I; Duchen, MR; Singer, M; - view fewer (2017) Improved Survival in a Long-Term Rat Model of Sepsis Is Associated With Reduced Mitochondrial Calcium Uptake Despite Increased Energetic Demand. Critical Care Medicine , 45 (8) e840-e848. 10.1097/CCM.0000000000002448.

Pinto, BB; Ritter, C; Michels, M; Gambarotta, N; Ferrario, M; Dal-Pizzol, F; Singer, M; (2017) Characterization of brain-heart interactions in a rodent model of sepsis. Molecular Neurobiology , 54 (5) pp. 3745-3752. 10.1007/s12035-016-9941-z.

Pisciotta, W; Arina, P; Hofmaenner, D; Singer, M; (2023) Difficult diagnosis in the ICU: making the right call but beware uncertainty and bias. Anaesthesia , 78 (4) pp. 501-509. 10.1111/anae.15897.

Polito, A; Sonneville, R; Guidoux, C; Barrett, L; Viltart, O; Mattot, V; Siami, S; ... Sharshar, T; + view all Polito, A; Sonneville, R; Guidoux, C; Barrett, L; Viltart, O; Mattot, V; Siami, S; de la Grandmaison, GL; Chretien, F; Singer, M; Gray, F; Annane, D; Brouland, J-P; Sharshar, T; - view fewer (2011) Changes in CRH and ACTH Synthesis during Experimental and Human Septic Shock. PLOS ONE , 6 (11) , Article e25905. 10.1371/journal.pone.0025905.

Polkki, Anssi; Reinikainen, Matti; Rochwerg, Bram; Jung, Christian; Sendagire, Cornelius; Chaudhuri, Dipayan; Martin, Greg S; ... Pekkarinen, Pirkka T; + view all Polkki, Anssi; Reinikainen, Matti; Rochwerg, Bram; Jung, Christian; Sendagire, Cornelius; Chaudhuri, Dipayan; Martin, Greg S; Selander, Tuomas; Rhodes, Andrew; Moreno, Rui; Singer, Mervyn; Laffey, John G; Pekkarinen, Pirkka T; - view fewer (2026) Optimal Cutoffs for the Ratio of Arterial Oxygen Partial Pressure to Inspired Oxygen Fraction in Categorizing Respiratory Impairment Severity in Organ Failure Scores. Acta Anaesthesiologica Scandinavica , 70 (1) , Article e70137. 10.1111/aas.70137.

Pottecher, J; Adamopoulos, C; Lejay, A; Bouitbir, J; Charles, A-L; Meyer, A; Singer, M; ... Geny, B; + view all Pottecher, J; Adamopoulos, C; Lejay, A; Bouitbir, J; Charles, A-L; Meyer, A; Singer, M; Wolff, V; Diemunsch, P; Laverny, G; Metzger, D; Geny, B; - view fewer (2018) Diabetes Worsens Skeletal Muscle Mitochondrial Function, Oxidative Stress, and Apoptosis After Lower-Limb Ischemia-Reperfusion: Implication of the RISK and SAFE Pathways? Frontiers in Physiology , 9 , Article 579. 10.3389/fphys.2018.00579.

Póvoa, Pedro; Coelho, Luís; Dal-Pizzol, Felipe; Ferrer, Ricard; Huttner, Angela; Conway Morris, Andrew; Nobre, Vandack; ... Kalil, Andre C; + view all Póvoa, Pedro; Coelho, Luís; Dal-Pizzol, Felipe; Ferrer, Ricard; Huttner, Angela; Conway Morris, Andrew; Nobre, Vandack; Ramirez, Paula; Rouze, Anahita; Salluh, Jorge; Singer, Mervyn; Sweeney, Daniel A; Torres, Antoni; Waterer, Grant; Kalil, Andre C; - view fewer (2023) How to use biomarkers of infection or sepsis at the bedside: guide to clinicians. Intensive Care Medicine , 49 pp. 142-153. 10.1007/s00134-022-06956-y.

Puthucheary, ZA; Astin, R; Mcphail, MJW; Saeed, S; Pasha, Y; Bear, DE; Constantin, D; ... Montgomery, HE; + view all Puthucheary, ZA; Astin, R; Mcphail, MJW; Saeed, S; Pasha, Y; Bear, DE; Constantin, D; Velloso, C; Manning, S; Calvert, L; Singer, M; Batterham, RL; Gomez-Romero, M; Holmes, E; Steiner, MC; Atherton, PJ; Greenhaff, P; Edwards, LM; Smith, K; Harridge, SD; Hart, N; Montgomery, HE; - view fewer (2018) Metabolic phenotype of skeletal muscle in early critical illness. Thorax 10.1136/thoraxjnl-2017-211073. (In press).

Rahmel, T; Marko, B; Nowak, H; Bergmann, L; Thon, P; Rump, K; Kreimendahl, S; ... Koos, B; + view all Rahmel, T; Marko, B; Nowak, H; Bergmann, L; Thon, P; Rump, K; Kreimendahl, S; Rassow, J; Peters, J; Singer, M; Adamzik, M; Koos, B; - view fewer (2020) Mitochondrial dysfunction in sepsis is associated with diminished intramitochondrial TFAM despite its increased cellular expression. Scientific Reports , 10 , Article 21029. 10.1038/s41598-020-78195-4.

Ranzani, Otavio; Annane, Djillali; Singer, Mervyn; (2024) Fludrocortisone with hydrocortisone in sepsis: new evidence in an ongoing debate. Intensive Care Medicine , 50 (12) pp. 2138-2140. 10.1007/s00134-024-07699-8.

Ranzani, Otavio T; Singer, Mervyn; Salluh, Jorge IF; Shankar-Hari, Manu; Pilcher, David; Berger-Estilita, Joana; Coopersmith, Craig M; ... Moreno, Rui; + view all Ranzani, Otavio T; Singer, Mervyn; Salluh, Jorge IF; Shankar-Hari, Manu; Pilcher, David; Berger-Estilita, Joana; Coopersmith, Craig M; Juffermans, Nicole P; Laffey, John; Reinikainen, Matti; Neto, Ary Serpa; Tavares, Miguel; Timsit, Jean-Francois; Arias Lopez, Maria Del Pilar; Arulkumaran, Nish; Aryal, Diptesh; Azoulay, Elie; Celi, Leo Anthony; Chaudhuri, Dipayan; De Lange, Dylan; De Waele, Jan; Dos Santos, Claudia C; Du, Bin; Einav, Sharon; Engelbrecht, Teresa; Fazla, Fathima; Ferrer, Ricard; Finazzi, Stefano; Fujii, Tomoko; Gershengorn, Hayley B; Greene, John D; Haniffa, Rashan; Hao, Sicheng; Hasan, Mohd Shahnaz; Hollenberg, Steve; Ippolito, Mariachiara; Jung, Christian; Kirov, Mikhail; Kobari, Shigetaka; Lakbar, Ines; Lipman, Jeffrey; Liu, Vincent; Liu, Xiaoli; Lobo, Suzana M; Magatti, Demetrio; Martin, Greg S; Metnitz, Barbara; Metnitz, Philipp; Myatra, Sheila N; Oczkowski, Simon; Paiva, Jose-Artur; Paruk, Fathima; Pekkarinen, Pirkka T; Piquilloud, Lise; Polkki, Anssi; Prescott, Hallie C; Blaser, Annika Reintam; Rezende, Ederlon; Robba, Chiara; Rochwerg, Bram; Ruckly, Stephane; Samei, Rasoul; Schenck, Edward J; Secombe, Paul; Sendagire, Cornelius; Siaw-Frimpong, Moses; Simpkin, Andrew J; Soares, Marcio; Summers, Charlotte; Szczeklik, Wojciech; Takala, Jukka; Tanaka, Shiro; Tricella, Giovanni; Vincent, Jean-Louis; Wendon, Julia; Zampieri, Fernando G; Rhodes, Andrew; Moreno, Rui; - view fewer (2025) Development and Validation of the Sequential Organ Failure Assessment (SOFA)-2 Score. Journal of the American Medical Association 10.1001/jama.2025.20516. (In press).

Recknagel, P; Gonnert, FA; Westermann, M; Lambeck, S; Lupp, A; Rudiger, A; Dyson, A; ... Bauer, M; + view all Recknagel, P; Gonnert, FA; Westermann, M; Lambeck, S; Lupp, A; Rudiger, A; Dyson, A; Carré, JE; Kortgen, A; Krafft, C; Popp, J; Sponholz, C; Fuhrmann, V; Hilger, I; Claus, RA; Riedemann, NC; Wetzker, R; Singer, M; Trauner, M; Bauer, M; - view fewer (2012) Liver dysfunction and phosphatidylinositol-3-kinase signalling in early sepsis: experimental studies in rodent models of peritonitis. PLoS Med , 9 (11) , Article e1001338. 10.1371/journal.pmed.1001338.

Reinikainen, Matti; Delamarre, Louis; Blaser, Annika Reintam; Hollenberg, Steven M; Lobo, Suzana M; Rezende, Ederlon; Moreno, Rui; ... Lakbar, Inès; + view all Reinikainen, Matti; Delamarre, Louis; Blaser, Annika Reintam; Hollenberg, Steven M; Lobo, Suzana M; Rezende, Ederlon; Moreno, Rui; Rhodes, Andrew; Ranzani, Otavio T; Singer, Mervyn; Lakbar, Inès; - view fewer (2025) Association of noradrenaline dose with mortality in critically ill patients: a systematic review and dose-response meta-analysis. Critical Care , 29 (1) , Article 498. 10.1186/s13054-025-05717-9.

Rhodes, A; Evans, LE; Alhazzani, W; Levy, MM; Antonelli, M; Ferrer, R; Kumar, A; ... Dellinger, RP; + view all Rhodes, A; Evans, LE; Alhazzani, W; Levy, MM; Antonelli, M; Ferrer, R; Kumar, A; Sevransky, JE; Sprung, CL; Nunnally, ME; Rochwerg, B; Rubenfeld, GD; Angus, DC; Annane, D; Beale, RJ; Bellinghan, GJ; Bernard, GR; Chiche, J-D; Coopersmith, C; De Backer, DP; French, CJ; Fujishima, S; Gerlach, H; Hidalgo, JL; Hollenberg, SM; Jones, AE; Karnad, DR; Kleinpell, RM; Koh, Y; Lisboa, TC; Machado, FR; Marini, JJ; Marshall, JC; Mazuski, JE; McIntyre, LA; McLean, AS; Mehta, S; Moreno, RP; Myburgh, J; Navalesi, P; Nishida, O; Osborn, TM; Perner, A; Plunkett, CM; Ranieri, M; Schorr, CA; Seckel, MA; Seymour, CW; Shieh, L; Shukri, KA; Simpson, SQ; Singer, M; Thompson, BT; Townsend, SR; Van der Poll, T; Vincent, J-L; Wiersinga, WJ; Zimmerman, JL; Dellinger, RP; - view fewer (2017) Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016. Critical Care Medicine , 45 (3) pp. 486-552. 10.1097/CCM.0000000000002255.

Rhodes, A; Evans, LE; Alhazzani, W; Levy, MM; Antonelli, M; Ferrer, R; Kumar, A; ... Dellinger, RP; + view all Rhodes, A; Evans, LE; Alhazzani, W; Levy, MM; Antonelli, M; Ferrer, R; Kumar, A; Sevransky, JE; Sprung, CL; Nunnally, ME; Rochwerg, B; Rubenfeld, GD; Angus, DC; Annane, D; Beale, RJ; Bellinghan, GJ; Bernard, GR; Chiche, J-D; Coopersmith, C; De Backer, DP; French, CJ; Fujishima, S; Gerlach, H; Hidalgo, JL; Hollenberg, SM; Jones, AE; Karnad, DR; Kleinpell, RM; Koh, Y; Lisboa, TC; Machado, FR; Marini, JJ; Marshall, JC; Mazuski, JE; McIntyre, LA; McLean, AS; Mehta, S; Moreno, RP; Myburgh, J; Navalesi, P; Nishida, O; Osborn, TM; Perner, A; Plunkett, CM; Ranieri, M; Schorr, CA; Seckel, MA; Seymour, CW; Shieh, L; Shukri, KA; Simpson, SQ; Singer, M; Thompson, BT; Townsend, SR; Van der Poll, T; Vincent, J-L; Wiersinga, WJ; Zimmerman, JL; Dellinger, RP; - view fewer (2017) Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016. Intensive Care Medicine , 43 (3) pp. 304-377. 10.1007/s00134-017-4683-6.

Rowan, KM; Angus, DC; Bailey, M; Barnato, AE; Bellomo, R; Canter, RR; Coats, TJ; ... Yealy, DM; + view all Rowan, KM; Angus, DC; Bailey, M; Barnato, AE; Bellomo, R; Canter, RR; Coats, TJ; Delaney, A; Gimbel, E; Grieve, RD; Harrison, DA; Higgins, AM; Howe, B; Huang, DT; Kellum, JA; Mouncey, PR; Music, E; Peake, SL; Pike, F; Reade, MC; Sadique, MZ; Singer, M; Yealy, DM; - view fewer (2017) Early, Goal-Directed Therapy for Septic Shock - A Patient-Level Meta-Analysis. New England Journal of Medicine , 376 (23) pp. 2223-2234. 10.1056/NEJMoa1701380.

Rudiger, A; Jeger, V; Arrigo, M; Schaer, CA; Hildenbrand, FF; Arras, M; Seifert, B; ... Bettex, D; + view all Rudiger, A; Jeger, V; Arrigo, M; Schaer, CA; Hildenbrand, FF; Arras, M; Seifert, B; Singer, M; Schoedon, G; Spahn, DR; Bettex, D; - view fewer (2018) Heart rate elevations during early sepsis predict death in fluid-resuscitated rats with fecal peritonitis. Intensive Care Medicine Experimental , 6 , Article 28. 10.1186/s40635-018-0190-5.

Rudiger, A; Singer, M; (2016) Decatecholaminisation during sepsis. CRITICAL CARE , 20 (ARTN 309) 10.1186/s13054-016-1488-x.

Saleem, Naveed; Kulkarni, Adarsh; Chandos Snow, Timothy Arthur; Ambler, Gareth; Singer, Mervyn; Arulkumaran, Nishkantha; (2023) Effect of Corticosteroids on Mortality and Clinical Cure in Community-Acquired Pneumonia: A Systematic Review, Meta-analysis, and Meta-regression of Randomized Control Trials. Chest , 163 (3) pp. 484-497. 10.1016/j.chest.2022.08.2229.

Saleem, Naveed; Ryckaert, Francis; Snow, Timothy Arthur Chandos; Satta, Giovanni; Singer, Mervyn; Arulkumaran, Nishkantha; (2022) Mortality and clinical cure rates for pneumonia: a systematic review, meta-analysis, and trial sequential analysis of randomized control trials comparing bactericidal and bacteriostatic antibiotic treatments. Clinical Microbiology and Infection , 28 (7) pp. 936-945. 10.1016/j.cmi.2021.12.021.

Salluh, JIF; Soares, M; Singer, M; (2017) Spreading the knowledge on the epidemiology of sepsis. The Lancet Infectious Diseases , 17 (11) pp. 1104-1106. 10.1016/S1473-3099(17)30480-2.

Samra, K; Kuganesan, M; Smith, W; Kleyman, A; Tidswell, R; Arulkumaran, N; Singer, M; Samra, K; Kuganesan, M; Smith, W; Kleyman, A; Tidswell, R; Arulkumaran, N; Singer, M; Dyson, A; - view fewer (2021) The Pharmacology and Therapeutic Utility of Sodium Hydroselenide. International Journal of Molecular Sciences , 22 (6) , Article 3258. 10.3390/ijms22063258.

Schaarschmidt, B; Vlaic, S; Medyukhina, A; Neugebauer, S; Nietzsche, S; Gonnert, FA; Roedel, J; ... Press, AT; + view all Schaarschmidt, B; Vlaic, S; Medyukhina, A; Neugebauer, S; Nietzsche, S; Gonnert, FA; Roedel, J; Singer, M; Kiehntopf, M; Figge, MT; Jacobsen, ID; Bauer, M; Press, AT; - view fewer (2018) Molecular signatures of liver dysfunction are distinct in fungal and bacterial infections in mice. Theranostics , 8 (14) pp. 3766-3780. 10.7150/thno.24333.

Scheeren, TWL; Bakker, J; De Backer, D; Annane, D; Asfar, P; Boerma, EC; Cecconi, M; ... Teboul, J-L; + view all Scheeren, TWL; Bakker, J; De Backer, D; Annane, D; Asfar, P; Boerma, EC; Cecconi, M; Duebin, A; Dunser, MW; Duranteau, J; Gordon, AC; Hamzaoui, O; Hernandez, G; Leone, M; Levy, B; Martin, C; Mebazaa, A; Monnet, X; Morelli, A; Payen, D; Pearse, R; Pinsky, MR; Radermacher, P; Reuter, D; Saugel, B; Sakr, Y; Singer, M; Squara, P; Vieillard-Baron, A; Vignon, P; Vistisen, ST; van der Horst, ICC; Vincent, J-L; Teboul, J-L; - view fewer (2019) Current use of vasopressors in septic shock. Annals of Intensive Care , 9 (1) , Article 20. 10.1186/s13613-019-0498-7.

Scheeren, TWL; Bakker, J; Kaufmann, T; Annane, D; Asfar, P; Boerma, EC; Cecconi, M; ... Teboul, J-L; + view all Scheeren, TWL; Bakker, J; Kaufmann, T; Annane, D; Asfar, P; Boerma, EC; Cecconi, M; Chew, MS; Cholley, B; Cronhjort, M; De Backer, D; Dubin, A; Duenser, MW; Duranteau, J; Gordon, AC; Hajjar, LA; Hamzaoui, O; Hernandez, G; Kanoore Edul, V; Koster, G; Landoni, G; Leone, M; Levy, B; Martin, C; Mebazaa, A; Monnet, X; Morelli, A; Payen, D; Pearse, RM; Pinsky, MR; Radermacher, P; Reuter, DA; Sakr, Y; Sander, M; Saugel, B; Singer, M; Squara, P; Vieillard-Baron, A; Vignon, P; Vincent, J-L; Van der Horst, ICC; Vistisen, ST; Teboul, J-L; - view fewer (2021) Current use of inotropes in circulatory shock. Annals of Intensive Care , 11 , Article 21. 10.1186/s13613-021-00806-8.

Semler, MW; Singer, M; (2019) Deconstructing Hyperlactatemia in Sepsis Using ScvO₂ and Base Deficit. American Journal of Respiratory and Critical Care Medicine 10.1164/rccm.201904-0899ED. (In press).

Seymour, CW; Liu, VX; Iwashyna, TJ; Brunkhorst, FM; Rea, TD; Scherag, A; Rubenfeld, G; ... Angus, DC; + view all Seymour, CW; Liu, VX; Iwashyna, TJ; Brunkhorst, FM; Rea, TD; Scherag, A; Rubenfeld, G; Kahn, JM; Shankar-Hari, M; Singer, M; Deutschman, CS; Escobar, GJ; Angus, DC; - view fewer (2016) Assessment of Clinical Criteria for Sepsis For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA - Journal of the American Medical Association , 315 (8) pp. 762-774. 10.1001/jama.2016.0288.

Shankar-Hari, M; Fear, D; Lavender, P; Mare, T; Beale, R; Swanson, C; Singer, M; Shankar-Hari, M; Fear, D; Lavender, P; Mare, T; Beale, R; Swanson, C; Singer, M; Spencer, J; - view fewer (2017) Activation-Associated Accelerated Apoptosis of Memory B Cells in Critically Ill Patients With Sepsis. Critical Care Medicine , 45 (5) pp. 875-882. 10.1097/CCM.0000000000002380.

Shankar-Hari, M; Phillips, GS; Levy, ML; Seymour, CW; Liu, VX; Deutschman, CS; Angus, DC; ... Singer, M; + view all Shankar-Hari, M; Phillips, GS; Levy, ML; Seymour, CW; Liu, VX; Deutschman, CS; Angus, DC; Rubenfeld, GD; Singer, M; - view fewer (2016) Developing a New Definition and Assessing New Clinical Criteria for Septic Shock For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA - Journal of the American Medical Association , 315 (8) pp. 775-787. 10.1001/jama.2016.0289.

Shankar-Hari, M; Singer, M; Spencer, J; (2017) Can Concurrent Abnormalities in Free Light Chains and Immunoglobulin Concentrations Identify a Target Population for Immunoglobulin Trials in Sepsis? Critical Care Medicine , 45 (11) pp. 1829-1836. 10.1097/CCM.0000000000002627.

Shi, S; Pérez-Suárez, D; Harris, S; MacCallum, N; Brealey, D; Singer, M; Hetherington, J; (2017) Critical care data processing tools. The Journal of Open Source Software , 2 (20) , Article 513. 10.21105/joss.00513.

Shipley, RJ; Brealey, D; Haniffa, R; Elwell, C; Baker, T; Lomas, DA; Singer, M; (2021) Lessons and risks of medical device deployment in a global pandemic. The Lancet Global Health 10.1016/S2214-109X(21)00028-0. (In press).

Singer, Mervyn; (2022) Less Haste, More Speed, More Science: Lessons to be Learned from COVID-19 Studies. American Journal of Respiratory and Critical Care Medicine , 205 (11) pp. 1258-1260. 10.1164/rccm.202203-0617ED.

Singer, Mervyn; Young, Paul J; Laffey, John G; Asfar, Pierre; Taccone, Fabio Silvio; Skrifvars, Markus B; Meyhoff, Christian S; Singer, Mervyn; Young, Paul J; Laffey, John G; Asfar, Pierre; Taccone, Fabio Silvio; Skrifvars, Markus B; Meyhoff, Christian S; Radermacher, Peter; - view fewer (2021) Dangers of hyperoxia. Critical Care , 25 , Article 440. 10.1186/s13054-021-03815-y.

Singer, M; (2019) Sepsis: personalization v protocolization? Critical Care , 23 (1) , Article 127. 10.1186/s13054-019-2398-5.

Singer, M; (2017) Critical illness and flat batteries. Critical Care , 21 (Suppl 3) , Article 309. 10.1186/s13054-017-1913-9.

Singer, M; (2017) Personalizing Sepsis Care. Critical Care Clinics , 34 (1) pp. 153-160. 10.1016/j.ccc.2017.08.011.

Singer, M; (2017) Antibiotics for Sepsis: Does Each Hour Really Count, or Is It Incestuous Amplification? American Journal of Respiratory and Critical Care Medicine , 196 (7) pp. 800-802. 10.1164/rccm.201703-0621ED.

Singer, M; (2017) The new definitions of SEPSIS and SEPTIC SHOCK: What do they give us? An answer. Medicina Intensiva , 41 (1) pp. 41-43. 10.1016/j.medin.2016.10.015.

Singer, M; (2016) The new sepsis consensus definitions (Sepsis-3): the good, the not-so-bad, and the actually-quite-pretty. Intensive Care Medicine , 42 (12) pp. 2027-2029. 10.1007/s00134-016-4600-4.

Singer, M; (2013) Biomarkers in sepsis. Curr Opin Pulm Med , 19 (3) 305 - 309. 10.1097/MCP.0b013e32835f1b49.

Singer, M; Deutschman, CS; Seymour, CW; Shankar-Hari, M; Annane, D; Bauer, M; Bellomo, R; ... Angus, DC; + view all Singer, M; Deutschman, CS; Seymour, CW; Shankar-Hari, M; Annane, D; Bauer, M; Bellomo, R; Bernard, GR; Chiche, J-D; Coopersmith, CM; Hotchkiss, RS; Levy, MM; Marshall, JC; Martin, GS; Opal, SM; Rubenfeld, GD; van der Poll, T; Vincent, J-L; Angus, DC; - view fewer (2016) The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA - Journal of the American Medical Association , 315 (8) pp. 801-810. 10.1001/jama.2016.0287.

Singer, M; Glynne, P; (2005) Treating critical illness: The importance of first doing no harm. PLoS Medicine , 2 (6) , Article e167. 10.1371/journal.pmed.0020167.

Singer, M; Inada-Kim, M; Shankar-Hari, M; (2019) Sepsis hysteria: excess hype and unrealistic expectations. [Letter]. The Lancet , 394 (10208) pp. 1513-1514. 10.1016/S0140-6736(19)32483-3.

Singer, M; Shankar-Hari, M; (2018) qSOFA, Cue Confusion. Annals of Internal Medicine , 168 (4) pp. 293-295. 10.7326/M17-3415.

Singer, M; Shipley, R; Baker, T; Cowell, A; Brealey, D; Lomas, D; (2020) The UCL Ventura CPAP device for COVID-19. The Lancet Respiratory Medicine , 8 (11) pp. 1076-1078. 10.1016/S2213-2600(20)30422-7.

Slob, EMA; Shulman, R; Singer, M; (2017) Experience using high-dose glucose-insulin-potassium (GIK) in critically ill patients. Journal of Critical Care , 41 pp. 72-77. 10.1016/j.jcrc.2017.04.039.

Snow, TAC; Saleem, N; Ambler, G; Nastouli, E; McCoy, LE; Singer, M; Arulkumaran, N; (2021) Convalescent plasma for COVID-19: a meta-analysis, trial sequential analysis, and meta-regression. British Journal of Anaesthesia , 127 (6) pp. 834-844. 10.1016/j.bja.2021.07.033.

Snow, TAC; Saleem, N; Ambler, G; Nastouli, E; Singer, M; Arulkumaran, N; (2021) Tocilizumab in COVID-19: a meta-analysis, trial sequential analysis, and meta-regression of randomized-controlled trials. Intensive Care Medicine , 47 (6) pp. 641-652. 10.1007/s00134-021-06416-z.

Snow, TAC; Singer, M; Arulkumaran, N; (2020) Immunomodulators in COVID-19: Two Sides to Every Coin. American Journal of Respiratory and Critical Care Medicine , 202 (10) pp. 1460-1461. 10.1164/rccm.202008-3148le.

Snow, Timothy Arthur Chandos; Cesar, Antonio; Singer, Mervyn; Arulkumaran, Nishkantha; (2022) Clarithromycin as an immunomodulator in sepsis: still a (IN)CLASS act. Critical Care , 26 , Article 238. 10.1186/s13054-022-04104-y.

Snow, Timothy Arthur Chandos; Longobardo, Alessia; Brealey, David; Down, Jim; Satta, Giovanni; Singer, Mervyn; Arulkumaran, Nishkantha; (2022) Beneficial ex vivo immunomodulatory and clinical effects of clarithromycin in COVID-19. Journal of Infection and Chemotherapy , 28 (7) pp. 948-954. 10.1016/j.jiac.2022.04.001.

Stanzani, G; Duchen, MR; Singer, M; (2019) The role of mitochondria in sepsis-induced cardiomyopathy. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease , 1865 (4) pp. 759-773. 10.1016/j.bbadis.2018.10.011.

Stanzani, G; Tidswell, R; Singer, M; (2020) Do critical care patients hibernate? Theoretical support for less is more. Intensive Care Medicine , 46 pp. 495-497. 10.1007/s00134-019-05813-9.

Terrett, Alice; Van Loo, Magalie; Sundararajan, Krishnaswamy; Brealey, David; Singer, Mervyn; Manson, Jessica; Raith, Eamon Patrick; (2025) Immune biomarkers and secondary hemophagocytic lymphohistiocytosis: a scoping review protocol. JBI Evidence Synthesis , 23 (1) pp. 158-164. 10.11124/JBIES-24-00133.

Tidswell, R; Singer, M; (2018) Sepsis - thoughtful management for the non-expert. Clinical Medicine , 18 (1) pp. 62-68. 10.7861/clinmedicine.18-1-62.

Toner, A; Jenkins, N; Ackland, GL; (2017) Baroreflex impairment and morbidity after major surgery. British Journal of Anaesthesia , 117 (3) pp. 324-331. 10.1093/bja/aew257.

Townsend, WM; Holroyd, A; Pearce, R; Mackinnon, S; Naik, P; Goldstone, AH; Linch, DC; ... Morris, EC; + view all Townsend, WM; Holroyd, A; Pearce, R; Mackinnon, S; Naik, P; Goldstone, AH; Linch, DC; Peggs, KS; Thomson, KJ; Singer, M; Howell, DC; Morris, EC; - view fewer (2013) Improved intensive care unit survival for critically ill allogeneic haematopoietic stem cell transplant recipients following reduced intensity conditioning. Br J Haematol , 161 (4) 578 - 586. 10.1111/bjh.12294.

Unger, M; Morelli, A; Singer, M; Radermacher, P; Rehberg, S; Trimmel, H; Joannidis, M; ... Krumpl, G; + view all Unger, M; Morelli, A; Singer, M; Radermacher, P; Rehberg, S; Trimmel, H; Joannidis, M; Heinz, G; Cerny, V; Dostál, P; Siebers, C; Guarracino, F; Pratesi, F; Biancofiore, G; Girardis, M; Kadlecova, P; Bouvet, O; Zörer, M; Grohmann-Izay, B; Krejcy, K; Klade, C; Krumpl, G; - view fewer (2018) Landiolol in patients with septic shock resident in an intensive care unit (LANDI-SEP): study protocol for a randomized controlled trial. Trials , 19 (637) 10.1186/s13063-018-3024-6.

van Valburg, MK; Arbous, MS; Georgieva, M; Brealey, DA; Singer, M; Geerts, BF; (2018) Clinical Predictors of Survival and Functional Outcome of Stroke Patients Admitted to Critical Care. Critical Care Medicine , 46 (7) pp. 1085-1092. 10.1097/CCM.0000000000003127.

Verhoef, TI; Morris, S; Mathur, A; Singer, M; (2015) Potential economic consequences of a cardioprotective agent for patients with myocardial infarction: modelling study. BMJ Open , 5 (11) , Article e008164. 10.1136/bmjopen-2015-008164.

Villa, A; Xue, H; Scully, M; David, S; Bercades, G; Brealey, D; Singer, M; ... Arulkumaran, N; + view all Villa, A; Xue, H; Scully, M; David, S; Bercades, G; Brealey, D; Singer, M; Snow, TAC; Arulkumaran, N; - view fewer (2025) Plasma from patients with sepsis induces release of neutrophil extracellular traps from healthy volunteer neutrophils ex vivo. British Journal of Anaesthesia , 135 (4) pp. 1116-1118. 10.1016/j.bja.2025.06.046.

Vincent, Jean-Louis; Singer, Mervyn; Einav, Sharon; Moreno, Rui; Wendon, Julia; Teboul, Jean-Louis; Bakker, Jan; ... De Backer, Daniel; + view all Vincent, Jean-Louis; Singer, Mervyn; Einav, Sharon; Moreno, Rui; Wendon, Julia; Teboul, Jean-Louis; Bakker, Jan; Hernandez, Glenn; Annane, Djillali; De Man, Angélique ME; Monnet, Xavier; Ranieri, V Marco; Hamzaoui, Olfa; Takala, Jukka; Juffermans, Nicole; Chiche, Jean-Daniel; Myatra, Sheila N; De Backer, Daniel; - view fewer (2021) Equilibrating SSC guidelines with individualized care. Critical Care , 25 , Article 397. 10.1186/s13054-021-03813-0.

Welte, T; Dellinger, RP; Ebelt, H; Ferrer, M; Opal, SM; Singer, M; Vincent, J-L; ... Torres, A; + view all Welte, T; Dellinger, RP; Ebelt, H; Ferrer, M; Opal, SM; Singer, M; Vincent, J-L; Werdan, K; Martin-Loeches, I; Almirall, J; Artigas, A; Ignacio Ayestaran, J; Nuding, S; Ferrer, R; Sirgo Rodriguez, G; Shankar-Hari, M; Alvarez-Lerma, F; Riessen, R; Sirvent, J-M; Kluge, S; Zacharowski, K; Bonastre Mora, J; Lapp, H; Woebker, G; Achtzehn, U; Brealey, D; Kempa, A; Sanchez Garcia, M; Brederlau, J; Kochanek, M; Reschreiter, HP; Wise, MP; Belohradsky, BH; Bobenhausen, I; Dalken, B; Dubovy, P; Langohr, P; Mayer, M; Schuettrumpf, J; Wartenberg-Demand, A; Wippermann, U; Wolf, D; Torres, A; - view fewer (2018) Efficacy and safety of trimodulin, a novel polyclonal antibody preparation, in patients with severe community-acquired pneumonia: a randomized, placebo-controlled, double-blind, multicenter, phase II trial (CIGMA study). Intensive Care Medicine , 44 (4) pp. 438-448. 10.1007/s00134-018-5143-7.

Whitehouse, Tony; Hossain, Anower; Perkins, Gavin D; Gordon, Anthony C; Bion, Julian; Young, Duncan; Mcauley, Danny; ... Lall, Ranjit; + view all Whitehouse, Tony; Hossain, Anower; Perkins, Gavin D; Gordon, Anthony C; Bion, Julian; Young, Duncan; Mcauley, Danny; Singer, Mervyn; Lord, Janet; Gates, Simon; Veenith, Tonny; Maccallum, Niall S; Yeung, Joyce; Innes, Richard; Welters, Ingeborg; Boota, Nafisa; Skilton, Emma; Ghuman, Belinder; Hill, Maddy; Regan, Scott E; Mistry, Dipesh; Lall, Ranjit; - view fewer (2023) Landiolol and Organ Failure in Patients With Septic Shock The STRESS-L Randomized Clinical Trial. JAMA: Journal of the American Medical Association , 330 (17) pp. 1641-1652. 10.1001/jama.2023.20134.

Wilson, JK; Zhao, Y; Singer, M; Spencer, J; Shankar-Hari, M; (2018) Lymphocyte subset expression and serum concentrations of PD-1/PD-L1 in sepsis - pilot study. Critical Care , 22 , Article 95. 10.1186/s13054-018-2020-2.

Xerri, Alexandre; Gallardo, Frédéric; Kober, Frank; Mathieu, Calypso; Fourny, Natacha; Thi, Thom Tran; Mege, Jean-Louis; ... Leone, Marc; + view all Xerri, Alexandre; Gallardo, Frédéric; Kober, Frank; Mathieu, Calypso; Fourny, Natacha; Thi, Thom Tran; Mege, Jean-Louis; Singer, Mervyn; Lalevée, Nathalie; Bernard, Monique; Leone, Marc; - view fewer (2022) Female hormones prevent sepsis-induced cardiac dysfunction: an experimental randomized study. Scientific Reports , 12 , Article 4939. 10.1038/s41598-022-08889-4.

Yang, P; Kuc, RE; Brame, AL; Dyson, A; Singer, M; Glen, RC; Cheriyan, J; ... Maguire, JJ; + view all Yang, P; Kuc, RE; Brame, AL; Dyson, A; Singer, M; Glen, RC; Cheriyan, J; Wilkinson, IB; Davenport, AP; Maguire, JJ; - view fewer (2017) [Pyr(1)]Apelin-13((1-12)) Is a Biologically Active ACE2 Metabolite of the Endogenous Cardiovascular Peptide [Pyr(1)]Apelin-13. FRONTIERS IN NEUROSCIENCE , 11 (ARTN 92) 10.3389/fnins.2017.00092.

Zimmermann, Tobias; Brealey, David; Singer, Mervyn; (2024) Diagnosing sepsis: where we’re at and where we’re going. Intensive Care Medicine , 50 pp. 957-959. 10.1007/s00134-024-07428-1.

Zolfaghari, PS; Packer, S; Singer, M; Nair, SP; Bennett, J; Street, C; Wilson, M; (2009) In vivo killing of Staphylococcus aureus using a light-activated antimicrobial agent. BMC MICROBIOL , 9 , Article 27. 10.1186/1471-2180-9-27.

Thesis

Fullerton, JN; (2016) The Role of Prostaglandin E2 in Critical Illness-Induced Immune Dysfunction. Doctoral thesis , UCL (University College London).

Dataset

Dyson, AP; Dal-Pizzol, F; Sabbatini, G; Lach, AB; Galfo, F; Dos Santos Cardoso, J; Pescador Mendonça, B; ... Singer, M; + view all Dyson, AP; Dal-Pizzol, F; Sabbatini, G; Lach, AB; Galfo, F; Dos Santos Cardoso, J; Pescador Mendonça, B; Hargreaves, I; Bollen Pinto, B; Bromage, DI; Martin, JF; Moore, KP; Feelisch, M; Singer, M; - view fewer (2017) INORGANIC THIOMETALLATES AS A NEW CLASS OF SULFIDE-DONORS: CHEMISTRY, PHARMACOLOGY AND IMPACT ON ISCHEMIA/REPERFUSION INJURY. [Dataset]. Bloomsbury Institute of Intensive Care Medicine, Division of Medicine: London, UK.

This list was generated on Sun Feb 1 01:47:25 2026 GMT.