Ackland, GL;
Kazymov, V;
Marina, N;
Singer, M;
Gourine, AV;
(2013)
Peripheral neural detection of danger-associated and pathogen-associated molecular patterns.
Crit Care Med
, 41
(6)
e85 - e92.
10.1097/CCM.0b013e31827c0b05.
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Abstract
Bidirectional links between the nervous and immune systems modulate inflammation. The cellular mechanisms underlying the detection of danger-associated molecular patterns and pathogen-associated molecular patterns by the nervous system are not well understood. We hypothesized that the carotid body, a tissue of neural crest origin, detect pathogen associated molecular patterns and danger associated molecular patterns via an inflammasome-dependent mechanism similar to that described in immune cells.
| Type: |
Article
|
| Title: |
Peripheral neural detection of danger-associated and pathogen-associated molecular patterns. |
| Location: |
United States |
| Open access status: |
An open access version is available from UCL Discovery |
| DOI: |
10.1097/CCM.0b013e31827c0b05 |
| Publisher version: |
http://dx.doi.org/10.1097/CCM.0b013e31827c0b05 |
| Language: |
English |
| Additional information: |
© 2013 by the Society of Critical Care Medicine and Lippincott Williams & Wilkins. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
PMCID: PMC4154842 |
| Keywords: |
Animals, Calcium, Carotid Body, Carotid Sinus, Disease Models, Animal, Humans, Inflammation Mediators, Lipopolysaccharides, Mice, Mice, Inbred C57BL, Neutrophils, Random Allocation, Rats, Rats, Sprague-Dawley, Toll-Like Receptors, Zymosan |
| UCL classification: |
UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Department of Education
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Experimental and Translational Medicine |
| URI: |
https://discovery.ucl.ac.uk/id/eprint/1389784 |
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