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Biomarkers in sepsis.

Singer, M; (2013) Biomarkers in sepsis. Curr Opin Pulm Med , 19 (3) 305 - 309. 10.1097/MCP.0b013e32835f1b49. Green open access

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Abstract

Purpose of review: This review discusses the current developments in biomarkers for sepsis. Recent findings: With quantum leaps in technology, an array of biomarkers will become available within the next decade as point-of-care tools that will likely revolutionize the management of sepsis. These markers will facilitate early and accurate diagnosis, faster recognition of impending organ dysfunction, optimal selection and titration of appropriate therapies, and more reliable prognostication of risk and outcome. These diagnostics will also enable an improved characterization of the biological phenotype underlying sepsis and thus a better appreciation of the condition. Summary: The potential for novel biomarkers in sepsis will need to be properly realized with considerable funding, academic–industry collaborations, appropriate investigations and validation in heterogenous populations, but these developments do hold the capacity to transform patient care and outcomes.

Type: Article
Title: Biomarkers in sepsis.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1097/MCP.0b013e32835f1b49
Publisher version: http://dx.doi.org/10.1097/MCP.0b013e32835f1b49
Language: English
Additional information: Copyright: © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins. This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Biological Markers, Early Diagnosis, Humans, Multiple Organ Failure, Predictive Value of Tests, Prognosis, Risk, Sensitivity and Specificity, Sepsis
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Internal Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/1466629
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