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The intensive care medicine research agenda on septic shock

Perner, A; Gordon, AC; Angus, DC; Lamontagne, F; Machado, F; Russell, JA; Timsit, J-F; ... Singer, M; + view all (2017) The intensive care medicine research agenda on septic shock. Intensive Care Medicine , 43 (9) pp. 1294-1305. 10.1007/s00134-017-4821-1. Green open access

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Abstract

Septic shock remains a global health challenge with millions of cases every year, high rates of mortality and morbidity, impaired quality of life among survivors and relatives, and high resource use both in developed and developing nations. Care and outcomes are improving through organisational initiatives and updated clinical practice guidelines based on clinical research mainly carried out by large collaborative networks. This progress is likely to continue through the collaborative work of the established and merging trials groups in many parts of the world and through refined trial methodology and translational work. In this review, international experts summarize the current position of clinical research in septic shock and propose a research agenda to advance this field.

Type: Article
Title: The intensive care medicine research agenda on septic shock
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s00134-017-4821-1
Publisher version: http://dx.doi.org/10.1007/s00134-017-4821-1
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: ICU, Randomized trials, Sepsis, Septic shock, RANDOMIZED CLINICAL-TRIAL, CRITICALLY-ILL PATIENTS, INTERNATIONAL CONSENSUS DEFINITIONS, GOAL-DIRECTED RESUSCITATION, HIGHER HEMOGLOBIN THRESHOLD, ACUTE KIDNEY INJURY, LONG-TERM OUTCOMES, SEVERE SEPSIS, HYDROXYETHYL STARCH, BETA(2)-ADRENERGIC RECEPTOR
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Experimental and Translational Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/10043204
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