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The role of hormones in sepsis: an integrated overview with a focus on mitochondrial and immune cell dysfunction

Melis, Miranda J; Miller, Muska; Peters, Vera BM; Singer, Mervyn; (2023) The role of hormones in sepsis: an integrated overview with a focus on mitochondrial and immune cell dysfunction. Clinical Science , 137 (9) pp. 707-725. 10.1042/cs20220709. Green open access

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Abstract

Sepsis is a dysregulated host response to infection that results in life-threatening organ dysfunction. Virtually every body system can be affected by this syndrome to greater or lesser extents. Gene transcription and downstream pathways are either up- or downregulated, albeit with considerable fluctuation over the course of the patient’s illness. This multi-system complexity contributes to a pathophysiology that remains to be fully elucidated. Consequentially, little progress has been made to date in developing new outcome-improving therapeutics. Endocrine alterations are well characterised in sepsis with variations in circulating blood levels and/or receptor resistance. However, little attention has been paid to an integrated view of how these hormonal changes impact upon the development of organ dysfunction and recovery. Here, we present a narrative review describing the impact of the altered endocrine system on mitochondrial dysfunction and immune suppression, two interlinked and key aspects of sepsis pathophysiology.

Type: Article
Title: The role of hormones in sepsis: an integrated overview with a focus on mitochondrial and immune cell dysfunction
Open access status: An open access version is available from UCL Discovery
DOI: 10.1042/cs20220709
Publisher version: https://doi.org/10.1042/CS20220709
Language: English
Additional information: ©2023 The Author(s). This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY)
Keywords: hormones, immune response, mitochondria, organ dysfunction, sepsis, stress response
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Experimental and Translational Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/10170000
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