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Liver dysfunction and phosphatidylinositol-3-kinase signalling in early sepsis: experimental studies in rodent models of peritonitis.

Recknagel, P; Gonnert, FA; Westermann, M; Lambeck, S; Lupp, A; Rudiger, A; Dyson, A; ... Bauer, M; + view all (2012) Liver dysfunction and phosphatidylinositol-3-kinase signalling in early sepsis: experimental studies in rodent models of peritonitis. PLoS Med , 9 (11) , Article e1001338. 10.1371/journal.pmed.1001338. Green open access

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Abstract

Hepatic dysfunction and jaundice are traditionally viewed as late features of sepsis and portend poor outcomes. We hypothesized that changes in liver function occur early in the onset of sepsis, yet pass undetected by standard laboratory tests.

Type: Article
Title: Liver dysfunction and phosphatidylinositol-3-kinase signalling in early sepsis: experimental studies in rodent models of peritonitis.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pmed.1001338
Publisher version: http://dx.doi.org/10.1371/journal.pmed.1001338
Language: English
Additional information: © 2012 Recknagel et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Funding: This study was supported by the German Federal Ministry of Education and Research within the “Center for Sepsis Control and Care” (grant 01 EO 1002, Project D1.2; to MB). This work was further supported by grants P18613 and P19118 of the Austrian Science Foundation (to MT). Some of the studies were performed at UCLH/UCL, which receives a proportion of its funding from the UK Department of Health's NIHR Biomedical Research Centre's funding scheme. MS, AD, and JEC received funding from the UK Medical Research Council. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Competing interests: The authors declare that a patent has been filed regarding the use of bile acids for the diagnosis of sepsis (MB). MS is a member of the Editorial Board of PLOS Medicine. The authors declare that no other competing interests exist.
Keywords: Animals, Bile Acids and Salts, Biological Markers, Blotting, Western, Cholestasis, Coinfection, Feces, Gene Expression Regulation, Genome-Wide Association Study, Humans, Liver, Liver Diseases, Liver Function Tests, Male, Mice, Mice, Inbred C57BL, Microscopy, Electron, Scanning, Peritonitis, Phosphatidylinositol 3-Kinase, Rats, Rats, Wistar, Sepsis, Signal Transduction, Spectrum Analysis, Raman, Xenobiotics
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Experimental and Translational Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/1372793
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