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Article

Abignano, G; Blagojevic, J; Bissell, L-A; Dumitru, RB; Eng, S; Allanore, Y; Avouac, J; ... Del Galdo, F; + view all (2019) European multicentre study validates enhanced liver fibrosis test as biomarker of fibrosis in systemic sclerosis. Rheumatology , 58 (2) pp. 254-259. 10.1093/rheumatology/key271. Green open access
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Abraham, David J; Black, Carol M; Denton, Christopher P; Distler, Jörg HW; Domsic, Robyn; Feghali-Bostwick, Carol; Gourh, Pravitt; ... Krieg, Thomas; + view all (2025) An international perspective on the future of systemic sclerosis research. Nature Reviews Rheumatology , 21 (3) pp. 174-187. 10.1038/s41584-024-01217-2. Green open access
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Abu-Hanna, Jeries; Anastasakis, Evangelos; Patel, Jigisha A; Eddama, Mohammad Mahmoud Rajab; Denton, Christopher P; Taanman, Jan-Willem; Abraham, David; (2023) Prostacyclin mimetics inhibit DRP1-mediated pro-proliferative mitochondrial fragmentation in pulmonary arterial hypertension. Vascul Pharmacol , 151 , Article 107194. 10.1016/j.vph.2023.107194. Green open access
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Acosta-Herrera, M; Kerick, M; Lopéz-Isac, E; Assassi, S; Beretta, L; Simeón-Aznar, CP; Ortego-Centeno, N; ... Martin, J; + view all (2021) Comprehensive analysis of the major histocompatibility complex in systemic sclerosis identifies differential HLA associations by clinical and serological subtypes. Annals of the Rheumatic Diseases 10.1136/annrheumdis-2021-219884. (In press). Green open access
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Adler, S; Huscher, D; Siegert, E; Allanore, Y; Czirják, L; DelGaldo, F; Denton, CP; ... EUSTAR co-workers on behalf of the DeSScipher project research g; + view all (2018) Systemic sclerosis associated interstitial lung disease - individualized immunosuppressive therapy and course of lung function: results of the EUSTAR group. Arthritis Research & Therapy , 20 (1) , Article 17. 10.1186/s13075-018-1517-z. Green open access
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Ahmed, F; Maclean, RH; Nihtyanova, SI; Ong, VH; Murray, CD; Denton, CP; (2022) Autoantibody predictors of gastrointestinal symptoms in systemic sclerosis. Rheumatology , 61 (2) pp. 781-786. 10.1093/rheumatology/keab395. Green open access
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Ahmed Abdi, B; Lopez, H; Karrar, S; Renzoni, E; Wells, A; Tam, A; Etomi, O; ... Stratton, R; + view all (2017) Use of Patterned Collagen Coated Slides to Study Normal and Scleroderma Lung Fibroblast Migration. Scientific Reports , 7 , Article 2628. 10.1038/s41598-017-02621-3. Green open access
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Al Dulaijan, Basmah; Huang, Suiyuan; Lin, Celia JF; Denton, Christopher P; Khanna, Dinesh; (2025) Impact of Scleroderma‐Associated Autoantibodies on Clinical Outcome Assessments: Post Hoc Analysis From a Randomised, Double‐blind, Placebo‐controlled, Phase 3 Trial of Tocilizumab in Scleroderma. ACR Open Rheumatology , 7 (1) , Article e11782. 10.1002/acr2.11782. Green open access
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Al-Adwi, Yehya; Westra, Johanna; Van Goor, Harry; Burgess, Janette K; Denton, Christopher P; Mulder, Douwe J; (2022) Macrophages as determinants and regulators of fibrosis in systemic sclerosis. Rheumatology 10.1093/rheumatology/keac410. (In press). Green open access
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Allanore, Yannick; Khanna, Dinesh; Smith, Vanessa; Aringer, Martin; Hoffmann-Vold, Anna-Maria; Kuwana, Masataka; Merkel, Peter A; ... SENSCIS trial, investigators; + view all (2023) Effects of nintedanib in patients with limited cutaneous systemic sclerosis and interstitial lung disease. Rheumatology 10.1093/rheumatology/kead280. (In press). Green open access
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Allanore, Y; Denton, CP; Krieg, T; Cornelisse, P; Rosenberg, D; Schwierin, B; Matucci-Cerinic, M; (2016) Clinical characteristics and predictors of gangrene in patients with systemic sclerosis and digital ulcers in the Digital Ulcer Outcome Registry: a prospective, observational cohort. Annals of the Rheumatic Diseases , 75 (9) pp. 1736-1740. 10.1136/annrheumdis-2016-209481. Green open access
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Allanore, Y; Distler, O; Jagerschmidt, A; Illiano, S; Ledein, L; Boitier, E; Agueusop, I; ... Khanna, D; + view all (2018) Double-blind, Randomized, 8-week Placebo-controlled followed by a 16-week open label extension study, with the LPA1 receptor antagonist SAR100842 for Patients With Diffuse Cutaneous Systemic Sclerosis. Arthritis Rheumatology , 70 (10) pp. 1634-1643. 10.1002/art.40547. Green open access
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Allanore, Y; Distler, O; Matucci-Cerinic, M; Denton, CP; (2018) Review: Defining a Unified Vascular Phenotype in Systemic Sclerosis. Arthritis & Rheumatology , 70 (2) pp. 162-170. 10.1002/art.40377. Green open access
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Allanore, Y; Wung, P; Soubrane, C; Esperet, C; Marrache, F; Bejuit, R; Lahmar, A; ... Investigators; + view all (2020) A randomised, double-blind, placebo-controlled, 24- week, phase II, proof-of-concept study of romilkimab (SAR156597) in early diffuse cutaneous systemic sclerosis. Annals of the Rheumatic Diseases 10.1136/annrheumdis-2020-218447. (In press). Green open access
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Almadori, Aurora; Fung, Sze Ching; Denton, Christopher P; Butler, Peter EM; (2024) Fat Grafting and Adipose Stem Cells for Facial Systemic Sclerosis: A Systematic Review of the Literature. Aesthetic Surgery Journal , Article sjae200. 10.1093/asj/sjae200. (In press). Green open access
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Almadori, Aurora; Griffin, Michelle; Hyun, Jeon; Hansen, Esther; Denton, Christopher P; Butler, Peter EM; (2025) Long-term outcome of fat grafting to treat facial Systemic Sclerosis: a prospective cohort study. Plastic and Reconstructive Surgery , 156 (4) pp. 611-621. 10.1097/PRS.0000000000012111. Green open access
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Almadori, A; Griffin, M; Ryan, CM; Hunt, DF; Hansen, E; Kumar, R; Abraham, DJ; ... Butler, PEM; + view all (2019) Stem cell enriched lipotransfer reverses the effects of fibrosis in systemic sclerosis. PLoS One , 14 (7) , Article e0218068. 10.1371/journal.pone.0218068. Green open access
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Álvarez-Hernández, María Paula; Allanore, Yannick; Andrade, Ivo; Buch, Maya H; Coghlan, Gerry; Del Galdo, Francesco; Denton, Christopher P; ... Hughes, Michael; + view all (2024) Attitudes and barriers to pulmonary arterial hypertension screening in systemic sclerosis patients: A survey of UK-based rheumatologists. Journal of Scleroderma and Related Disorders 10.1177/23971983241235708. (In press). Green open access
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Alyousef, AA; Nihtyanova, S; Denton, C; Bosoni, P; Bellazzi, R; Tucker, A; (2018) Nearest Consensus Clustering Classification to Identify Subclasses and Predict Disease. Journal of Healthcare Informatics Research , 2 (4) pp. 402-422. 10.1007/s41666-018-0029-6. Green open access
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Amin, K; Sivakumar, B; Clarke, A; Puri, A; Denton, C; Butler, PE; (2013) Hand disease in scleroderma: a clinical correlate for chronic hand transplant rejection. SpringerPlus , 2 (1) , Article 577. 10.1186/2193-1801-2-577. Green open access
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Antoniou, KM; Margaritopoulos, GA; Goh, NS; Karagiannis, K; Desai, SR; Nicholson, AG; Siafakas, NM; ... Wells, AU; + view all (2016) Combined Pulmonary Fibrosis and Emphysema in Scleroderma-Related Lung Disease Has a Major Confounding Effect on Lung Physiology and Screening for Pulmonary Hypertension. Arthritis & Rheumatology , 68 (4) pp. 1004-1012. 10.1002/art.39528. Green open access
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Arbore, G; Ong, VH; Costantini, B; Denton, CP; Abraham, D; Placais, L; Blighe, K; ... Hourcade, DE; + view all (2020) Deep phenotyping detects a pathological CD4+ T-cell complosome signature in systemic sclerosis. Cellular & Molecular Immunology , 17 pp. 1010-1013. 10.1038/s41423-019-0360-8. Green open access
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Aringer, M; Denton, CP; (2018) Systemic sclerosis phase III clinical trials: Hope on the horizon? Journal of Scleroderma and Related Disorders , 3 (3) pp. 193-200. 10.1177/2397198318775353. Green open access
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Arnold, MB; Khanna, D; Denton, CP; van Laar, JM; Frech, TM; Anderson, ME; Baron, M; ... Pope, JE; + view all (2018) Patient acceptable symptom state in scleroderma: results from the tocilizumab compared with placebo trial in active diffuse cutaneous systemic sclerosis. Rheumatology , 57 (1) pp. 152-157. 10.1093/rheumatology/kex396. Green open access
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Assassi, Shervin; Denton, Christopher P; Zwick, Matthias; Schmid, Ramona; Ittrich, Carina; Litzenburger, Tobias; Visvanathan, Sudha; (2025) Peripheral blood gene expression profiling shows prognostic significance for the course of interstitial lung disease in systemic sclerosis. Arthritis & Rheumatology 10.1002/art.43262. (In press). Green open access
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Bageghni, SA; Hemmings, KE; Yuldasheva, NY; Maqbool, A; Gamboa-Esteves, FO; Humphreys, NE; Simonsen Jackson, M; ... Turner, NA; + view all (2019) Fibroblast-specific deletion of interleukin-1 receptor-1 reduces adverse cardiac remodeling following myocardial infarction. JCI Insight , 4 (17) , Article e125074. 10.1172/jci.insight.125074. Green open access
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Bageghni, SA; Hemmings, KE; Zava, N; Denton, CP; Porter, KE; Ainscough, JFX; Drinkhill, MJ; (2018) Cardiac fibroblast-specific p38α MAP kinase promotes cardiac hypertrophy via a putative paracrine interleukin-6 signaling mechanism. FASEB Journal , 32 (9) pp. 4941-4954. 10.1096/fj.201701455RR. Green open access
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Baron, M; Kahaleh, B; Bernstein, EJ; Chung, L; Clements, PJ; Denton, C; Domsic, RT; ... Vacca, A; + view all (2019) An interim report of the Scleroderma Clinical Trials Consortium working groups. Journal of Scleroderma and Related Disorders , 4 (1) pp. 17-27. 10.1177/2397198318783926. Green open access
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Becker, MO; Dobrota, R; Garaiman, A; Debelak, R; Fligelstone, K; Tyrrell Kennedy, A; Roennow, A; ... Distler, O; + view all (2021) Development and validation of a patient-reported outcome measure for systemic sclerosis: the EULAR Systemic Sclerosis Impact of Disease (ScleroID) questionnaire. Annals of the Rheumatic Diseases 10.1136/annrheumdis-2021-220702. (In press). Green open access
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Becker, M; Graf, N; Sauter, R; Allanore, Y; Curram, J; Denton, CP; Khanna, D; ... EUSTAR Collaborators (numerical order of centres); + view all (2019) Predictors of disease worsening defined by progression of organ damage in diffuse systemic sclerosis: a European Scleroderma Trials and Research (EUSTAR) analysis. Annals of the Rheumatic Diseases , 78 (9) pp. 1242-1248. 10.1136/annrheumdis-2019-215145. Green open access
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Beesley, Claire F; Goldman, Nina R; Taher, Taher E; Denton, Christopher P; Abraham, David J; Mageed, Rizgar A; Ong, Voon H; (2022) Dysregulated B cell function and disease pathogenesis in systemic sclerosis. Frontiers in Immunology , 13 , Article 999008. 10.3389/fimmu.2022.999008. Green open access
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Bellando-Randone, S; Wilhalme, H; Bruni, C; Czirjak, L; Distler, O; Allanore, Y; Cuomo, G; ... Cerinic, MM; + view all (2025) The effect of hydroxychloroquine on activities of daily living and hand function in systemic sclerosis: results from an analysis of the EUSTAR cohort. Arthritis Research & Therapy , 27 , Article 66. 10.1186/s13075-025-03476-0. Green open access
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Bernstein, Elana J; Denton, Christopher P; Huang, Suiyuan; Khanna, Dinesh; (2024) Baseline absolute monocyte count predicts lung function decline among patients with systemic sclerosis-associated interstitial lung disease: A post hoc analysis from the focuSSced trial. Seminars in Arthritis and Rheumatism , 65 , Article 152376. 10.1016/j.semarthrit.2024.152376. Green open access
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Betteridge, ZE; Woodhead, F; Lu, H; Shaddick, G; Bunn, CC; Denton, CP; Abraham, DJ; ... McHugh, NJ; + view all (2016) Anti-Eukaryotic Initiation Factor 2B Autoantibodies are Associated with Interstitial Lung Disease in Patients with Systemic Sclerosis. Arthritis & Rheumatology , 68 (11) pp. 2778-2783. 10.1002/art.39755. Green open access
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Bjørkekjær, Hilde Jenssen; Bruni, Cosimo; Broch, Kaspar; Brunborg, Cathrine; Carreira, Patricia E; Airò, Paolo; Simeón-Aznar, Carmen Pilar; ... EUSTAR, collaborators; + view all (2025) A comparative analysis of risk stratification tools in systemic sclerosis-associated pulmonary arterial hypertension: a EUSTAR analysis. Rheumatology 10.1093/rheumatology/keaf053. (In press). Green open access
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Blagojevic, J; Abignano, G; Avouac, J; Cometi, L; Frerix, M; Bellando-Randone, S; Guiducci, S; ... EUSTAR co-workers, .; + view all (2020) Use of vasoactive/vasodilating drugs for systemic sclerosis (SSc)-related digital ulcers (DUs) in expert tertiary centres: results from the analysis of the observational real-life DeSScipher study. Clinical Rheumatology , 39 pp. 27-36. 10.1007/s10067-019-04564-8. Green open access
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Blagojevic, J; Bellando-Randone, S; Abignano, G; Avouac, J; Cometi, L; Czirjak, L; Denton, CP; ... Matucci-Cerinic, M; + view all (2019) Classification, categorization and essential items for digital ulcer evaluation in systemic sclerosis: a DeSScipher/European Scleroderma Trials and Research group (EUSTAR) survey. Arthritis Research & Therapy , 21 (1) , Article 35. 10.1186/s13075-019-1822-1. Green open access
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Bossini-Castillo, L; Villanueva-Martin, G; Kerick, M; Acosta-Herrera, M; López-Isac, E; Simeón, CP; Ortego-Centeno, N; ... PRECISESADS collaborator group; + view all (2020) Genomic Risk Score impact on susceptibility to systemic sclerosis. Annals of the Rheumatic Diseases 10.1136/annrheumdis-2020-218558. (In press). Green open access
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Bouffette, Selena; Soret, Perrine; Cole, Alice; Nony, Emmanuel; Barbier Saint Hilaire, Pierre; Leclerc, Grégory; Alaoui, Lamine; ... Denton, Christopher P; + view all (2025) Multi-omic analysis identifies biological processes underlying progressive interstitial lung disease in systemic sclerosis. The FEBS Journal 10.1111/febs.70177. (In press). Green open access
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Brown, James T; Virsinskaite, Ruta; Kotecha, Tushar; Steeden, Jennifer A; Fontana, Marianna; Karia, Nina; Schreiber, Benjamin E; ... Knight, Daniel S; + view all (2024) Prognostic utility of exercise cardiovascular magnetic resonance in patients with systemic sclerosis-associated pulmonary arterial hypertension. European Heart Journal - Cardiovascular Imaging , Article jeae177. 10.1093/ehjci/jeae177. (In press). Green open access
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Brown, JT; Kotecha, T; Steeden, JA; Fontana, M; Denton, CP; Coghlan, JG; Knight, DS; (2021) Reduced exercise capacity in patients with systemic sclerosis is associated with lower peak tissue oxygen extraction: a cardiovascular magnetic resonance-augmented cardiopulmonary exercise study. Journal of Cardiovascular Magnetic Resonance , 23 (1) , Article 118. 10.1186/s12968-021-00817-1. Green open access
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Bruni, C; Buch, MH; Djokovic, A; De Luca, G; Dumitru, RB; Giollo, A; Galetti, I; ... Matucci-Cerinic, M; + view all (2023) Consensus on the assessment of systemic sclerosis–associated primary heart involvement: World Scleroderma Foundation/Heart Failure Association guidance on screening, diagnosis, and follow-up assessment. Journal of Scleroderma and Related Disorders 10.1177/23971983231163413. (In press). Green open access
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Bruni, C; Buch, MH; Furst, DE; De Luca, G; Djokovic, A; Dumitru, RB; Giollo, A; ... Matucci-Cerinic, M; + view all (2021) Primary systemic sclerosis heart involvement: A systematic literature review and preliminary data-driven, consensus-based WSF/HFA definition. Journal of Scleroderma and Related Disorders 10.1177/23971983211053246. (In press). Green open access
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Bruni, C; Lages, A; Patel, H; Nihtyanova, SI; Green, B; AbuHilal, M; Harvey, J; ... Denton, CP; + view all (2017) Resolution of paraneoplastic PM/Scl-positive systemic sclerosis after curative resection of a pancreatic tumour. Rheumatology , 56 (2) pp. 317-318. 10.1093/rheumatology/kew382. Green open access
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Bruni, C; Ngcozana, T; Braschi, F; Pucci, T; Piemonte, G; Benelli, L; Poli, M; ... Matucci-Cerinic, M; + view all (2019) Preliminary Validation of the Digital Ulcer Clinical Assessment Score in Systemic Sclerosis. The Journal of Rheumatology , 46 (6) pp. 603-608. 10.3899/jrheum.171486. Green open access
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Bütikofer, L; Varisco, PA; Distler, O; Kowal-Bielecka, O; Allanore, Y; Riemekasten, G; Villiger, PM; ... EUSTAR collaborators; + view all (2020) ACE inhibitors in SSc patients display a risk factor for scleroderma renal crisis-a EUSTAR analysis. Arthritis Research & Therapy , 22 (1) , Article 59. 10.1186/s13075-020-2141-2. Green open access
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Butler, EA; Baron, M; Fogo, AB; Frech, T; Ghossein, C; Hachulla, E; Hoa, S; ... Walker, UA; + view all (2019) Generation of a Core Set of Items to Develop Classification Criteria for Scleroderma Renal Crisis Using Consensus Methodology. Arthritis & Rheumatology , 71 (6) pp. 964-971. 10.1002/art.40809. Green open access
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Caetano, J; Nihtyanova, SI; Harvey, J; Denton, CP; Ong, VH; (2018) Distinctive clinical phenotype of anti-centromere antibody-positive diffuse systemic sclerosis. Rheumatology Advances in Practice , 2 (1) , Article rky002. 10.1093/rap/rky002. Green open access
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Campochiaro, Corrado; Suliman, Yossra A; Giuggioli, Dilia; Moinzadeh, Pia; Alunno, Alessia; Schoones, Jan W; Baron, Murray; ... Hughes, Michael; + view all (2025) Recommendations for the local management of digital ulcers in systemic sclerosis: A report from the World Scleroderma Foundation (WSF) ‘Ad hoc committee’. Journal of Scleroderma and Related Disorders 10.1177/23971983251339821. (In press). Green open access
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Campochiaro, Corrado; Suliman, Yossra A; Hughes, Michael; Schoones, Jan W; Giuggioli, Dilia; Moinzadeh, Pia; Baron, Murray; ... Alunno, Alessia; + view all (2023) Non-surgical local treatments of digital ulcers in systemic sclerosis: a systematic literature review. Seminars in Arthritis and Rheumatism , 63 , Article 152267. 10.1016/j.semarthrit.2023.152267. Green open access
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Campochiaro, C; Atay, S; Clark, KEN; Ong, V; Denton, CP; (2019) Autoimmunity and immunodeficiency at the crossroad: autoimmune disorders as the presenting feature of selective IgM deficiency. BMJ Case Reports , 12 (1) , Article e223180. 10.1136/bcr-2017-223180. Green open access
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Campochiaro, C; Host, LV; Ong, VH; Denton, CP; (2018) Development of systemic sclerosis in transgender females: a case series and review of the literature. Clinical and Experimental Rheumatology (In press).

Campochiaro, C; Lytton, S; Nihtyanova, S; Fuchs, D; Ong, VH; Denton, CP; (2019) Elevated kynurenine levels in diffuse cutaneous and anti-RNA polymerase III positive systemic sclerosis. Clinical Immunology , 199 pp. 18-24. 10.1016/j.clim.2018.12.009. Green open access
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Carrier, ME; Kwakkenbos, L; Boutron, I; Welling, J; Sauve, M; van den Ende, C; Schouffoer, AA; ... Manning, J; + view all (2018) Randomized feasibility trial of the Scleroderma patient-centered intervention network hand exercise program (SPIN-HAND): Study protocol. Journal of Scleroderma and Related Disorders , 3 (1) pp. 91-97. 10.5301/jsrd.5000263. Green open access
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Chaigne, B; Clary, G; Le Gall, M; Dumoitier, N; Fernandez, C; Lofek, S; Chafey, P; ... Mouthon, L; + view all (2018) Proteomic Analysis of Human Scleroderma Fibroblasts Response to Transforming Growth Factor-ß. Proteomics Clinical Applications , Article e1800069. 10.1002/prca.201800069. Green open access
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Chighizola, CB; Pregnolato, F; Meroni, PL; Denton, CP; Ong, VH; (2016) N-terminal pro Brain Natriuretic Peptide as predictor of outcome in scleroderma renal crisis. Clinical and Experimental Rheumatology , 34 (5) S122-S128. Green open access
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Chung, L; Denton, CP; Distler, O; Furst, DE; Khanna, D; Merkel, PA; (2012) Clinical trial design in scleroderma: where are we and where do we go next? Clinical and Experimental Rheumatology , 30 (2) (Suppl.71) 0097-0102. Green open access
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Chung, L; Spino, C; McLain, R; Johnson, SR; Denton, CP; Molitor, JA; Steen, VD; ... Khanna, D; + view all (2020) Safety and efficacy of abatacept in early diffuse cutaneous systemic sclerosis (ASSET): open-label extension of a phase 2, double-blind randomised trial. The Lancet Rheumatology , 2 (12) e743-e753. 10.1016/S2665-9913(20)30237-X. Green open access
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Clark, KEN; Csomor, E; Campochiaro, C; Galwey, N; Nevin, K; Morse, MA; Teo, YV; ... Denton, CP; + view all (2022) Integrated analysis of dermal blister fluid proteomics and genome-wide skin gene expression in systemic sclerosis: an observational study. The Lancet Rheumatology , 4 (7) e507-e516. 10.1016/S2665-9913(22)00094-7. Green open access
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Clark, Kristina Elizabeth Neergaard; Xu, Shiwen; Attah, Moustafa; Ong, Voon H; Buckley, Christopher Dominic; Denton, Christopher P; (2023) Single-cell analysis reveals key differences between early-stage and late-stage systemic sclerosis skin across autoantibody subgroups. Annals of the Rheumatic Diseases 10.1136/ard-2023-224184. (In press). Green open access
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Clark, Kristina EN; Campochiaro, Corrado; Host, Lauren V; Sari, Alper; Harvey, Jennifer; Denton, Christopher P; Ong, Voon H; (2022) Combinations of scleroderma hallmark autoantibodies associate with distinct clinical phenotypes. Scientific Reports , 12 , Article 11212. 10.1038/s41598-022-15062-4. Green open access
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Clark, Kristina EN; Denton, Christopher P; (2025) Old techniques still have relevance in personalised predictive medicine. Arthritis & Rheumatology 10.1002/art.43402. (In press).

Clark, Kristina EN; Gak, Nataliya; Orteu, Catherine H; Ong, Voon H; Derrett-Smith, Emma C; Denton, Christopher P; (2023) Skin biopsy analysis of concurrent keloidal morphoea and systemic sclerosis confirms overlapping pathogenic pathways. Clinical and Experimental Rheumatology , 41 (8) pp. 1644-1651. 10.55563/clinexprheumatol/dvxhgc. Green open access
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Clark, Kristina EN; Xu, Shiwen; Attar, Moustafa; Ong, Voon H; Buckley, Christopher D; Denton, Christopher P; (2025) Characterisation of a pathogenic non-migratory fibroblast population in systemic sclerosis skin. JCI Insight , Article e185618. 10.1172/jci.insight.185618. Green open access
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Clark, KE; Lopez, H; Abdi, BA; Guerra, SG; Shiwen, X; Khan, K; Etomi, O; ... Stratton, RJ; + view all (2015) Multiplex cytokine analysis of dermal interstitial blister fluid defines local disease mechanisms in systemic sclerosis. Arthritis Res Ther , 17 (1) , Article 73. 10.1186/s13075-015-0575-8. Green open access
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Clark, KEN; Campochiaro, C; Csomor, E; Taylor, A; Nevin, K; Galwey, N; Morse, MA; ... Denton, CP; + view all (2021) Molecular basis for clinical diversity between autoantibody subsets in diffuse cutaneous systemic sclerosis. Annals of the Rheumatic Diseases 10.1136/annrheumdis-2021-220402. (In press). Green open access
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Clark, KEN; Denton, CP; (2021) Unravelling extracellular matrix biomarkers in systemic sclerosis. The Lancet Rheumatology , 3 (3) e162-e163. 10.1016/S2665-9913(20)30412-4. Green open access
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Clark, KEN; Denton, CP; (2020) The patient knows best: a new self‐reported outcome measure for systemic sclerosis. British Journal of Dermatology , 183 (4) p. 610. 10.1111/bjd.19033. Green open access
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Coghlan, G; Wolf, M; Distler, O; Denton, CP; Doelberg, M; Harutyunova, S; Marra, AM; ... Grünig, E; + view all (2018) Incidence of pulmonary hypertension and determining factors in patients with systemic sclerosis. European Respiratory Journal , 51 (3) 10.1183/13993003.01197-2017. Green open access
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Coghlan, JG; Denton, CP; (2018) Aggressive combination therapy for treatment of systemic sclerosis-associated pulmonary hypertension. Journal of Scleroderma and Related Disorders , 3 (1) pp. 30-38. 10.1177/2397198318758422. Green open access
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Coghlan, JG; Denton, CP; Gruenig, E; Bonderman, D; Distler, O; Khanna, D; Mueller-Ladner, U; ... Seibold, JR; + view all (2014) Evidence-based detection of pulmonary arterial hypertension in systemic sclerosis: the DETECT study. Annals of the Rheumatic Diseases , 73 (7) pp. 1340-1349. 10.1136/annrheumdis-2013-203301. Green open access
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Colak, Seda Y; Di Donato, Stephano; Bixio, Riccardo; Bissell, Lesley-Anne; Barnes, Theresa; Nisar, Muhammed; Kakkar, Vishal; ... Del Galdo, Francesco; + view all (2025) Cross-validation and sensitivity to change of EULAR ScleroID as a measure of function and impact of disease in patients with systemic sclerosis. RMD Open: Rheumatic and Musculoskeletal Diseases , 11 (4) , Article e005999. 10.1136/rmdopen-2025-005999. Green open access
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Cole, Alice; Denton, Christopher P; (2022) Biomarkers in Systemic Sclerosis Associated Interstitial Lung Disease (SSc-ILD). Current Treatment Options in Rheumatology 10.1007/s40674-022-00196-3. (In press). Green open access
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Cole, Alice; Ong, Voon H; Denton, Christopher P; (2022) Renal Disease and Systemic Sclerosis: an Update on Scleroderma Renal Crisis. Clinical Reviews in Allergy and Immunology 10.1007/s12016-022-08945-x. (In press). Green open access
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Cole, Alice; Thomas, Rhys; Goldman, Nina; Howell, Kevin; Chakravarty, Kuntal; Denton, Christopher P; Ong, Voon H; (2022) Diffuse cutaneous systemic sclerosis following SARS-Co V-2 vaccination. Journal of Autoimmunity , 128 , Article 102812. 10.1016/j.jaut.2022.102812. Green open access
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Cutolo, M; Herrick, AL; Distler, O; Becker, MO; Beltran, E; Carpentier, P; Ferri, C; ... CAP Study Investigators; + view all (2016) Nailfold Videocapillaroscopic Features and Other Clinical Risk Factors for Digital Ulcers in Systemic Sclerosis: A Multicenter, Prospective Cohort Study. Arthritis and Rheumatology , 68 (10) pp. 2527-2539. 10.1002/art.39718. Green open access
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Davan-Wetton, Camilla Sa; Khodeneva, Natalya; Denton, Christopher P; Abraham, David J; Perretti, Mauro; Montero-Melendez, Trinidad; (2025) The senescence-like activity of BMS-470539 is associated with anti-fibrotic actions in models of dermal fibrosis. Arthritis Research & Therapy , 27 (1) , Article 187. 10.1186/s13075-025-03635-3. Green open access
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De Lorenzis, E; Kakkar, V; Di Donato, S; Wilson, M; Barnes, T; Denton, C; Derrett-Smith, E; ... Del Galdo, F; + view all (2024) Clinical trajectories of hand function impairment in systemic sclerosis: an unmet clinical need across disease subsets. RMD open , 10 (1) , Article e003216. 10.1136/rmdopen-2023-003216. Green open access
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Deibel, Elisabeth; Carreira, Patricia E; Vonk, Madelon; Del Papa, Nicoletta; Bečvář, Radim; Guillén-Del-Castillo, Alfredo; Campochiaro, Corrado; ... Hoffmann-Vold, Anna-Maria; + view all (2024) Does the Impact of COVID-19 on Patients With Systemic Sclerosis Change Over Time? Arthritis Care & Research , 76 (1) pp. 88-97. 10.1002/acr.25226. Green open access
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Del Galdo, Francesco; Lescoat, Alain; Conaghan, Philip G; Bertoldo, Eugenia; Čolić, Jelena; Santiago, Tânia; Suliman, Yossra A; ... Allanore, Yannick; + view all (2025) EULAR recommendations for the treatment of systemic sclerosis: 2023 update. Annals of the Rheumatic Diseases , 84 pp. 29-40. 10.1136/ard-2024-226430. Green open access
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Denton, Christopher P; (2025) Comment on: The 2024 British Society for Rheumatology guideline for management of systemic sclerosis. Reply. Rheumatology , 64 (5) pp. 3196-3197. 10.1093/rheumatology/keae659. Green open access
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Denton, Christopher P; De Lorenzis, Enrico; Roblin, Elen; Goldman, Nina; Alcacer-Pitarch, Begonya; Blamont, Emma; Buch, Maya; ... Ong, Voon; + view all (2023) Management of systemic sclerosis: British Society for Rheumatology guideline scope. Rheumatology Advances in Practice , 7 (1) , Article rkad022. 10.1093/rap/rkad022. Green open access
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Denton, Christopher P; De Lorenzis, Enrico; Roblin, Elen; Goldman, Nina; Alcacer-Pitarch, Begonya; Blamont, Emma; Buch, Maya H; ... Ong, Voon H; + view all (2024) The 2024 British Society for Rheumatology guideline for management of systemic sclerosis—executive summary. Rheumatology , Article keae390. 10.1093/rheumatology/keae390. Green open access
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Denton, Christopher P; De Lorenzis, Enrico; Roblin, Elen; Goldman, Nina; Alcacer-Pitarch, Begonya; Blamont, Emma; Buch, Maya H; ... Ong, Voon H; + view all (2024) The 2024 British Society for Rheumatology guideline for management of systemic sclerosis. Rheumatology , Article keae394. 10.1093/rheumatology/keae394. Green open access
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Denton, Christopher P; del Galdo, Francesco; Khanna, Dinesh; Vonk, Madelon C; Chung, Lorinda; Johnson, Sindhu R; Varga, John; ... Reid, Juliet; + view all (2023) Biological and clinical insights from a randomised phase II study of an anti-oncostatin M monoclonal antibody in systemic sclerosis. Rheumatology , 62 (1) pp. 234-242. 10.1093/rheumatology/keac300. Green open access
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Denton, Christopher P; Goh, Nicole S; Humphries, Stephen M; Maher, Toby M; Spiera, Robert; Devaraj, Anand; Ho, Lawrence; ... SENSCIS trial investigators, .; + view all (2022) Extent of fibrosis and lung function decline in patients with systemic sclerosis and interstitial lung disease: data from the SENSCIS trial. Rheumatology 10.1093/rheumatology/keac535. (In press). Green open access
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Denton, Christopher P; Kowal-Bielecka, Otylia; Proudman, Susanna M; Olesińska, Marzena; Worm, Margitta; Del Papa, Nicoletta; Matucci-Cerinic, Marco; ... Gasior, Maria J; + view all (2025) A Phase 2 randomised trial of safety and pharmacokinetics of IgPro20 and IgPro10 in patients with diffuse cutaneous systemic sclerosis. Rheumatology 10.1093/rheumatology/keaf066. (In press). Green open access
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Denton, Christopher P; Xu, Shiwen; Zhang, Fenge; Maclean, Rory H; Clark, Kristina EN; Borchert, Signe; Hussain, Rizwan I; ... Ong, Voon H; + view all (2023) Clinical and pathogenic significance of S100A4 overexpression in systemic sclerosis. Annals of the Rheumatic Diseases 10.1136/ard-2023-223862. (In press). Green open access
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Denton, CP; Khanna, D; (2021) Rational repurposing of tocilizumab for treatment of lung fibrosis in systemic sclerosis. Lancet Rheumatology , 3 (5) E321-E323. 10.1016/S2665-9913(21)00111-9. Green open access
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Denton, CP; Spierings, J; (2021) Combining datasets as well as therapies shows improved outcome in connective tissue disease associated pulmonary hypertension. Arthritis & Rheumatology , 73 (5) pp. 725-727. 10.1002/art.41670. Green open access
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Denton, CP; (2019) Challenges in systemic sclerosis trial design. Seminars in Arthritis and Rheumatism , 49 (3) S3-S7. 10.1016/j.semarthrit.2019.09.019. Green open access
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Denton, CP; (2016) Scleroderma Lung Study II—clarity or obfuscation? Lancet Respiratory Medicine , 4 (9) pp. 678-679. 10.1016/S2213-2600(16)30191-6. Green open access
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Denton, CP; (2016) Advances in pathogenesis and treatment of systemic sclerosis. Clinical Medicine , 16 (1) pp. 55-60. 10.7861/clinmedicine.16-1-55. Green open access
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Denton, CP; (2015) Advances in pathogenesis and treatment of systemic sclerosis. Clinical Medicine , 15 (6) s58-s63. 10.7861/clinmedicine.15-6-s58. Green open access
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Denton, CP; Campochiaro, C; Bruni, C; Distler, O; Iagnocco, A; Matucci Cerinic, M; (2020) COVID-19 and systemic sclerosis: Rising to the challenge of a pandemic. Journal of Scleroderma and Related Disorders 10.1177/2397198320963393. (In press). Green open access
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Denton, CP; Hachulla, É; Riemekasten, G; Schwarting, A; Frenoux, J-M; Frey, A; Le Brun, F-O; ... Raynaud Study Investigators; + view all (2017) Efficacy and Safety of Selexipag in Adults With Raynaud's Phenomenon Secondary to Systemic Sclerosis: A Randomized, Placebo-Controlled, Phase II Study. Arthritis & Rheumatology , 69 (12) pp. 2370-2379. 10.1002/art.40242. Green open access
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Denton, CP; Herrick, AL; (2018) Reply [Pauling, et al., Efficacy and Safety of Selexipag in Adults With Raynaud's Phenomenon Secondary to Systemic Sclerosis]. Arthritis & Rheumatology , 70 (6) p. 974. 10.1002/art.40480. Green open access
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Denton, CP; Hughes, M; Gak, N; Vila, J; Buch, MH; Chakravarty, K; Fligelstone, K; ... Ong, VH; + view all (2016) BSR and BHPR guideline for the treatment of systemic sclerosis. Rheumatology , 55 (10) pp. 1906-1910. 10.1093/rheumatology/kew224. Green open access
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Denton, CP; Khanna, D; (2017) Systemic sclerosis. The Lancet , 390 (10103) pp. 1685-1699. 10.1016/S0140-6736(17)30933-9. Green open access
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Denton, CP; Laird, B; Moros, L; Flores, JLL; (2020) Challenges in physician-patient communication for optimal management of systemic sclerosis-associated interstitial lung disease: a discourse analysis. Clinical Rheumatology 10.1007/s10067-020-05063-x. Green open access
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Denton, CP; Laird, B; Moros, L; Luna Flores, JL; (2020) Things left unsaid: important topics that are not discussed between patients with systemic sclerosis, their carers and their healthcare professionals-a discourse analysis. Clinical Rheumatology 10.1007/s10067-020-05371-2. (In press). Green open access
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Denton, CP; Murray, C; (2019) Cause or effect? Interpreting emerging evidence for dysbiosis in systemic sclerosis. Arthritis Research & Therapy , 21 , Article 81. 10.1186/s13075-019-1872-4. Green open access
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Denton, CP; Ong, VH; (2020) Challenges in evidence-based therapy for systemic sclerosis associated interstitial lung disease. The Lancet Respiratory Medicine , 8 (3) pp. 226-227. 10.1016/S2213-2600(20)30012-6. Green open access
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Denton, CP; Ong, VH; (2017) Interleukin-6 and related proteins as biomarkers in systemic sclerosis. [Review]. Journal of Scleroderma and Related Disorders , 2 (2) S13-S19. 10.5301/jsrd.5000266. Green open access
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Denton, CP; Ong, VH; Xu, S; Chen-Harris, H; Modrusan, Z; Lafyatis, R; Khanna, D; ... Sornasse, T; + view all (2018) Therapeutic interleukin-6 blockade reverses transforming growth factor-beta pathway activation in dermal fibroblasts: insights from the faSScinate clinical trial in systemic sclerosis. Annals of the Rheumatic Diseases , 77 (9) pp. 1362-1371. 10.1136/annrheumdis-2018-213031. Green open access
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Denton, CP; Wells, AU; Coghlan, JG; (2018) Major lung complications of systemic sclerosis (vol 14, pg 511, 2018). [Corrigendum]. Nature Reviews Rheumatology , 14 (11) p. 682. 10.1038/s41584-018-0108-3. Green open access
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Denton, CP; Wells, AU; Coghlan, JG; (2018) Major lung complications of systemic sclerosis. Nature Reviews Rheumatology , 14 pp. 511-527. 10.1038/s41584-018-0062-0. Green open access
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Denton, CP; Yee, P; Ong, VH; (2020) News and failures from recent treatment trials in systemic sclerosis. European Journal of Rheumatology 10.5152/eurjrheum.2020.19187. (In press). Green open access
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Derrett-Smith, E; Clark, KEN; Shiwen, X; Abraham, DJ; Hoyles, RK; Lacombe, O; Broqua, P; ... Denton, CP; + view all (2021) The pan-PPAR agonist lanifibranor reduces development of lung fibrosis and attenuates cardiorespiratory manifestations in a transgenic mouse model of systemic sclerosis. Arthritis Research and Therapy , 23 , Article 234. 10.1186/s13075-021-02592-x. Green open access
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Derrett-Smith, EC; Dooley, A; Gilbane, A; Trinder, S; Khan, K; Baliga, R; Holmes, A; ... Denton, CP; + view all (2013) Endothelial injury in a TGFβ dependent mouse model of scleroderma induces pulmonary arterial hypertension. Arthritis Rheum , 65 (11) pp. 2928-2939. 10.1002/art.38078. Green open access
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Derrett-Smith, EC; Martyanov, V; Chighizola, CB; Moinzadeh, P; Campochiaro, C; Khan, K; Wood, TA; ... Denton, CP; + view all (2017) Limited cutaneous systemic sclerosis skin demonstrates distinct molecular subsets separated by a cardiovascular development gene expression signature. Arthritis Research & Therapy , 19 , Article 156. 10.1186/s13075-017-1360-7. Green open access
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Dhaliwal, K; Griffin, M; Denton, CP; Butler, PEM; (2018) The novel use of botulinum toxin A for the treatment of Raynaud's phenomenon in the toes. BMJ Case Reports , 2018 , Article bcr-2017-219348. 10.1136/bcr-2017-219348. Green open access
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Dhaliwal, K; Griffin, MF; Salinas, S; Howell, K; Denton, CP; Butler, PEM; (2019) Optimisation of botulinum toxin type a treatment for the management of Raynaud's phenomenon using a dorsal approach: a prospective case series. Clinical Rheumatology , 38 pp. 3669-3676. 10.1007/s10067-019-04762-4. Green open access
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Di Donato, Stefano; Denton, Christopher P; Del Galdo, Francesco; (2025) Reply to: Circulating interferon alpha protein measured with digital ELISA as a biomarker for modified Rodnan skin score progression in limited systemic sclerosis: comment on the article from Di Donato et al. Arthritis & Rheumatology 10.1002/art.43223. (In press).

Di Donato, Stefano; Denton, Christopher P; Del Galdo, Francesco; (2025) Reply to: Enhancing Predictive Biomarkers in Limited Cutaneous Systemic Sclerosis: The Role of Type I Interferon Score and Gender Considerations. Arthritis & Rheumatology 10.1002/art.43180. (In press).

Di Donato, Stefano; Ross, Rebecca; Karanth, Ranjitha; Kakkar, Vishal; De Lorenzis, Enrico; Bissell, Lesley-Anne; Clark, Kristina; ... Del Galdo, Francesco; + view all (2025) Serum Type I Interferon Score for Prediction of Clinically Meaningful Disease Progression in Limited Cutaneous Systemic Sclerosis. Arthritis & Rheumatology 10.1002/art.43120. (In press). Green open access
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Distler, JHW; Riemekasten, G; Denton, CP; (2023) The Exciting Future for Scleroderma: What Therapeutic Pathways Are on the Horizon? Rheumatic Disease Clinics of North America , 49 (2) pp. 445-462. 10.1016/j.rdc.2023.01.014. Green open access
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Distler, Jörg HW; Kuwana, Masataka; Assassi, Shervin; Denton, Christopher P; (2025) Emerging therapies for the treatment of systemic sclerosis. Nature Reviews Rheumatology , 21 pp. 612-625. 10.1038/s41584-025-01294-x.

Distler, O; Allanore, Y; Denton, CP; Kuwana, M; Matucci-Cerinic, M; Pope, JE; Atsumi, T; ... Khanna, D; + view all (2023) Riociguat in patients with early diffuse cutaneous systemic sclerosis (RISE-SSc): open-label, long-term extension of a phase 2b, randomised, placebo-controlled trial. The Lancet Rheumatology , 5 (11) e660-e669. 10.1016/S2665-9913(23)00238-2. Green open access
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Distler, Oliver; Bonderman, Diana; Coghlan, J Gerry; Denton, Christopher P; Grünig, Ekkehard; Khanna, Dinesh; McLaughlin, Vallerie V; ... Hachulla, Éric; + view all (2024) Performance of DETECT Pulmonary Arterial Hypertension Algorithm According to the Hemodynamic Definition of Pulmonary Arterial Hypertension in the 2022 European Society of Cardiology and the European Respiratory Society Guidelines. Arthritis & Rheumatology , 76 (5) pp. 777-782. 10.1002/art.42791. (In press). Green open access
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Distler, O; Allanore, Y; Denton, CP; Matucci-Cerinic, M; Pope, JE; Hinzmann, B; Davies, S; ... Khanna, D; + view all (2018) Factors influencing early referral, early diagnosis and management in patients with diffuse cutaneous systemic sclerosis. Rheumatology , 57 (5) pp. 813-817. 10.1093/rheumatology/kex504. Green open access
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Distler, O; Assassi, S; Cottin, V; Cutolo, M; Danoff, SK; Denton, CP; Distler, JHW; ... Maher, TM; + view all (2020) Predictors of progression in systemic sclerosis patients with interstitial lung disease. European Respiratory Journal , 55 (5) , Article 1902026. 10.1183/13993003.02026-2019. Green open access
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Distler, O; Pope, J; Denton, C; Allanore, Y; Matucci-Cerinic, M; de Oliveira Pena, J; Khanna, D; (2017) RISE-SSc: Riociguat in diffuse cutaneous systemic sclerosis. Respiratory Medicine , 122 (Sup 1) S14-S17. 10.1016/j.rmed.2016.09.011. Green open access
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Dobrota, R; Garaiman, A; Fligelstone, K; Tyrrell Kennedy, A; Roennow, A; Allanore, Y; Carreira, PE; ... Becker, MO; + view all (2024) Performance of the EULAR Systemic sclerosis Impact of Disease (ScleroID) questionnaire as a patient-reported outcome measure for patients with diffuse systemic sclerosis. RMD open , 10 (4) , Article e004653. 10.1136/rmdopen-2024-004653. Green open access
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Domsic, RT; Nihtyanova, SI; Wisniewski, SR; Fine, MJ; Lucas, M; Kwoh, CK; Denton, CP; (2017) Reply [for "Derivation and External Validation of a Prediction Rule for Five-Year Mortality in Patients with Early Diffuse Cutaneous Scleroderma"]. [Letter]. Arthritis & Rheumatology , 69 (1) p. 242. 10.1002/art.39853. Green open access
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Domsic, RT; Nihtyanova, SI; Wisniewski, SR; Fine, MJ; Lucas, M; Kwoh, CK; Denton, CP; (2016) Derivation and External Validation of a Prediction Rule for Five-Year Mortality in Patients With Early Diffuse Cutaneous Systemic Sclerosis. Arthritis & Rheumatology , 68 (4) pp. 993-1003. 10.1002/art.39490. Green open access
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Dougherty, DH; Kwakkenbos, L; Carrier, M-E; Salazar, G; Assassi, S; Baron, M; Bartlett, SJ; ... SPIN Investigators; + view all (2018) The Scleroderma Patient-Centered Intervention Network Cohort: baseline clinical features and comparison with other large scleroderma cohorts. Rheumatology , 57 (9) pp. 1623-1631. 10.1093/rheumatology/key139. Green open access
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Dritsoula, A; Papaioannou, I; Guerra, SG; Fonseca, C; Martin, J; Herrick, AL; Abraham, DJ; ... Ponticos, M; + view all (2018) The molecular basis for dysregulated activation of NKX2-5 in vascular remodelling of systemic sclerosis. Arthritis & Rheumatology , 70 (6) pp. 920-931. 10.1002/art.40419. Green open access
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Esposito, Anthony J; Selvan, Kavitha C; Richardson, Carrie; Khanna, Dinesh; Bemiss, Bradford C; Bernstein, Elana J; Chung, Jonathan H; ... Volkmann, Elizabeth R; + view all (2025) Systemic Sclerosis-Associated Interstitial Lung Disease: What We Know and How to Incorporate Guidelines into Clinical Practice. Chest 10.1016/j.chest.2025.11.047. (In press).

Evans, IC; Barnes, JL; Garner, IM; Pearce, DR; Maher, TM; Shi-Wen, X; Renzoni, EA; ... McAnulty, RJ; + view all (2016) Epigenetic Regulation of Cyclooxygenase-2 by methylation of c8orf4 in Pulmonary Fibrosis. Clinical Science , 130 (8) pp. 575-586. 10.1042/CS20150697. Green open access
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Fischer, A; Denton, CP; Matucci-Cerinic, M; Gillies, H; Blair, C; Tislow, J; Nathan, SD; (2016) Ambrisentan response in connective tissue disease-associated pulmonary arterial hypertension (CTD-PAH) - A subgroup analysis of the ARIES-E clinical trial. Respir Med , 117 pp. 254-263. 10.1016/j.rmed.2016.06.018. Green open access
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Flurey, Caroline A; Pauling, John D; Saketkoo, Lesley Ann; Denton, Christopher P; Galdas, Paul; Khanna, Dinesh; Williams, Adrian; (2022) "I turned in my man card": A qualitative study of the experiences, coping styles and support needs of men with systemic sclerosis. Rheumatology , Article keac585. 10.1093/rheumatology/keac585. (In press). Green open access
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Foeldvari, Ivan; Torok, Kathryn S; Anton, Jordi; Blakley, Michael; Constantin, Tamás; Curran, Megan; Cutolo, Maurizio; ... Furst, Daniel E; + view all (2023) Proposed Response Parameters for Twelve-Month Drug Trial in Juvenile Systemic Sclerosis: Results of the Hamburg International Consensus Meetings. Arthritis Care & Research , 75 (12) pp. 2453-2462. 10.1002/acr.25171. Green open access
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Foeldvari, Ivan; Torok, Kathryn S; Antón, Jordi; Blakley, Michael; Constantin, Tamás; Cutolo, Maurizio; Denton, Christopher P; ... Furst, Daniel F; + view all (2024) Best clinical practice in the treatment of juvenile systemic sclerosis: expert panel guidance - the result of the International Hamburg Consensus Meeting December 2022. Expert Review of Clinical Immunology , 20 (4) pp. 387-404. 10.1080/1744666X.2023.2298354. Green open access
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Foeldvari, Ivan; Torok, Kathryn S; Furtado E Silva, Juliana; Denton, Christopher P; Henes, Jörg; Horvei, Paulina; Franziska, Rosser; ... Smith, Vanessa; + view all (2025) Guidance for stem cell therapy for juvenile systemic sclerosis patients. Expert Review of Clinical Immunology , 21 (4) pp. 435-450. 10.1080/1744666X.2025.2474216.

Fonseca, C; Lindahl, GE; Ponticos, M; Sestini, P; Renzoni, EA; Holmes, AM; Spagnolo, P; ... Abraham, DJ; + view all (2007) A polymorphism in the CTGF promoter region associated with systemic sclerosis. NEW ENGL J MED , 357 (12) 1210 - 1220. Green open access
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Franks, Jennifer M; Toledo, Diana M; Martyanov, Viktor; Wang, Yue; Huang, Suiyuan; Wood, Tammara A; Spino, Cathie; ... Whitfield, Michael L; + view all (2023) A Genomic Meta-Analysis of Clinical Variables and Their Association with Intrinsic Molecular Subsets in Systemic Sclerosis. Rheumatology , 62 (1) pp. 19-28. 10.1093/rheumatology/keac344. Green open access
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Galiè, N; Denton, CP; Dardi, F; Manes, A; Mazzanti, G; Li, B; Varanese, L; ... Palazzini, M; + view all (2017) Tadalafil in idiopathic or heritable pulmonary arterial hypertension (PAH) compared to PAH associated with connective tissue disease. International Journal of Cardiology , 235 pp. 67-72. 10.1016/j.ijcard.2017.02.094. Green open access
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Gholizadeh, S; Kwakkenbos, L; Carrier, ME; Mills, SD; Fox, RS; Jewett, LR; Gottesman, K; ... Persmann, J; + view all (2018) Validation of the social interaction anxiety scale in scleroderma: A scleroderma patientcentered intervention network cohort study. Journal of Scleroderma and Related Disorders , 3 (1) pp. 98-105. 10.5301/jsrd.5000264. Green open access
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Ghuman, Abeer; Khanna, Dinesh; Lin, Celia JF; Furst, Daniel E; Raghu, Ganesh; Martinez, Fernando J; Zucchetto, Mauro; ... Denton, Christopher P; + view all (2023) Prognostic and predictive markers of systemic sclerosis-interstitial lung disease in a clinical trial and long-term observational cohort. Rheumatology 10.1093/rheumatology/kead234. (In press). Green open access
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Giannakopoulos, I; Griffin, M; Denton, CP; Butler, PEM; (2020) Developing a quantitative tool to evaluate dermal fibrosis in systemic sclerosis patients: a case-control study. [Letter]. Clinical and Experimental Rheumatology , 38 (125) pp. 172-173. Green open access
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Gillespie, J; Ross, RL; Corinaldesi, C; Esteves, F; Derrett-Smith, E; McDermott, MF; Doody, GM; ... Del Galdo, F; + view all (2018) TGFβ activation primes canonical Wnt signaling through the downregulation of AXIN2. Arthritis & Rheumatology , 70 (6) pp. 932-942. 10.1002/art.40437. Green open access
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Goh, NS; Hoyles, RK; Denton, CP; Hansell, DM; Renzoni, EA; Maher, TM; Nicholson, AG; (2017) Short term pulmonary function trends are predictive of mortality in interstitial lung disease associated with systemic sclerosis. Arthritis & Rheumatology , 69 (8) pp. 1670-1678. 10.1002/art.40130. Green open access
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Goldman, Nina; Ong, Voon; Denton, Christopher; (2025) B cells and systemic sclerosis interstitial lung disease. Arthritis & Rheumatology , Article 43326. 10.1002/art.43326. (In press). Green open access
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Goldman, Nina; Ong, Voon H; Denton, Christopher P; (2024) Pathogenesis of interstitial lung disease in systemic sclerosis. heumatology and Immunology Research , 5 (3) pp. 141-151. 10.2478/rir-2024-0020. Green open access
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Goldman, Nina R; Nihtyanova, Svetlana I; Beesley, Claire F; Wells, Athol U; Denton, Christopher P; Renzoni, Elisabetta A; Mageed, Rizgar; (2025) Tocilizumab and rituximab for systemic sclerosis interstitial lung disease: a real-world cohort analysis. Rheumatology 10.1093/rheumatology/keaf006. (In press). Green open access
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González-Serna, D; Carmona, EG; Ortego-Centeno, N; Simeón, CP; Solans, R; Hernández-Rodríguez, J; Tolosa, C; ... Márquez, A; + view all (2018) A TNFSF13B functional variant is not involved in systemic sclerosis and giant cell arteritis susceptibility. PLOS ONE , 13 (12) , Article e0209343. 10.1371/journal.pone.0209343. Green open access
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Gordon, Jessica K; Showalter, Kimberly; Wu, Yin; Kwakkenbos, Linda; Carrier, Marie-Eve; Henry, Richard S; Østbø, Nora; ... SPIN COVID-19 Patient Advisory Team on behalf of the SPIN Invest; + view all (2022) Systemic sclerosis and COVID-19 vaccines: a SPIN Cohort study. The Lancet Rheumatology 10.1016/S2665-9913(21)00416-1. Green open access
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Gorlova, O; Martin, JE; Rueda, B; Koeleman, BP; Ying, J; Teruel, M; Diaz-Gallo, LM; ... Martin, J; + view all (2011) Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy. PLoS Genet , 7 (7) , Article e1002178. 10.1371/journal.pgen.1002178. Green open access
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Griffin, M; Ryan, CM; Pathan, O; Abraham, D; Denton, CP; Butler, PE; (2017) Characteristics of human adipose derived stem cells in scleroderma in comparison to sex and age matched normal controls: implications for regenerative medicine. Stem Cell Res Ther , 8 (1) , Article 23. 10.1186/s13287-016-0444-7. Green open access
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Griffin, MF; Jeon, FHK; Chew, BJW; Sherief, A; Denton, CP; Butler, PEM; (2020) Comparison of non-invasive methodologies to assess mouth opening following lipotransfer techniques to reverse oral fibrosis. [Letter]. Clinical and Experimental Rheumatology , 38 (125) p. 184. Green open access
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Griffiths-Jones, Deborah J; Garcia, Yvonne Sylvestre; Ryder, W David; Pauling, John D; Hall, Frances; Lanyon, Peter; Bhat, Smita; ... Herrick, Ariane L; + view all (2023) A Phase II randomised controlled trial of oral prednisolone in early diffuse cutaneous systemic sclerosis (PRedSS). Rheumatology 10.1093/rheumatology/kead012. (In press). Green open access
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Guillevin, L; Hunsche, E; Denton, CP; Krieg, T; Schwierin, B; Rosenberg, D; Matucci-Cerinic, M; ... Hamilton, A; + view all (2013) Functional impairment of systemic scleroderma patients with digital ulcerations: results from the DUO Registry. Clinical and Experimental Rheumatology , 31 (2 (S76)) S71-S80. Green open access
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Herrick, Ariane L; Assassi, Shervin; Denton, Christopher P; (2022) Skin involvement in early diffuse cutaneous systemic sclerosis: an unmet clinical need. Nature Reviews Rheumatology , 18 pp. 276-285. 10.1038/s41584-022-00765-9. Green open access
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Herrick, Ariane L; Denton, Christopher P; (2023) Enrichment strategies for clinical trials targeting skin fibrosis and interstitial lung disease in systemic sclerosis. Current Opinion in Rheumatology , 35 (6) pp. 349-355. 10.1097/BOR.0000000000000976. Green open access
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Herrick, AL; Griffiths-Jones, DJ; Ryder, WD; Mason, JC; Denton, CP; (2020) Clinical trial protocol: PRednisolone in early diffuse cutaneous Systemic Sclerosis (PRedSS). Journal of Scleroderma and Related Disorders 10.1177/2397198320957552. (In press). Green open access
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Herrick, AL; Pan, X; Peytrignet, S; Lunt, M; Hesselstrand, R; Mouthon, L; Silman, A; ... Denton, CP; + view all (2017) Treatment outcome in early diffuse cutaneous systemic sclerosis: the European Scleroderma Observational Study (ESOS). Annals of the Rheumatic Diseases , 76 (7) pp. 1207-1218. 10.1136/annrheumdis-2016-210503. Green open access
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Herrick, AL; Peytrignet, S; Lunt, M; Pan, X; Hesselstrand, R; Mouthon, L; Silman, AJ; ... Denton, CP; + view all (2018) Patterns and predictors of skin score change in early diffuse systemic sclerosis from the European Scleroderma Observational Study. Annals of the Rheumatic Diseases , 77 (4) pp. 563-570. 10.1136/annrheumdis-2017-211912. Green open access
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Highland, KB; Distler, O; Kuwana, M; Allanore, Y; Assassi, S; Azuma, A; Bourdin, A; ... Maher, TM; + view all (2021) Efficacy and safety of nintedanib in patients with systemic sclerosis-associated interstitial lung disease treated with mycophenolate: a subgroup analysis of the SENSCIS trial. Lancet. Respiratory medicine , 9 (1) pp. 96-106. 10.1016/S2213-2600(20)30330-1. Green open access
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Hoa, S; Stern, EP; Denton, CP; Hudson, M; Scleroderma Clinical Trials Consortium Scleroderma Renal Crisis; Investigators of the Scleroderma Clinical Trials Consortium Scle; (2017) Towards developing criteria for scleroderma renal crisis: A scoping review. Autoimmunity Reviews , 16 (4) pp. 407-415. 10.1016/j.autrev.2017.02.012. Green open access
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Hoffmann-Vold, AM; Distler, O; Bruni, C; Denton, CP; de Vries-Bouwstra, J; Matucci Cerinic, M; Vonk, MC; (2022) Systemic sclerosis in the time of COVID-19. The Lancet Rheumatology , 4 (8) e566-e575. 10.1016/S2665-9913(22)00130-8. Green open access
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Host, LV; Campochiaro, C; Afonso, A; Nihtyanova, SI; Denton, CP; Ong, VH; (2021) High proton pump inhibitor exposure increases risk of calcinosis in systemic sclerosis. Rheumatology , 60 (2) pp. 849-854. 10.1093/rheumatology/keaa332. Green open access
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Hsu, VM; Denton, CP; Domsic, RT; Furst, DE; Rischmueller, M; Stanislav, M; Steen, VD; ... Hough, DR; + view all (2018) Pomalidomide in Patients with Interstitial Lung Disease due to Systemic Sclerosis: A Phase II, Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group Study. The Journal of Rheumatology , 45 (3) pp. 405-410. 10.3899/jrheum.161040. Green open access
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Hughes, M; Allanore, Y; Baron, M; Del Galdo, F; Denton, CP; Frech, T; Furst, DE; ... Matucci-Cerinic, M; + view all (2022) Proton pump inhibitors in systemic sclerosis: a reappraisal to optimise treatment of gastro-oesophageal reflux disease. The Lancet Rheumatology , 4 (11) e795-e803. 10.1016/S2665-9913(22)00183-7. Green open access
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Hughes, M; Allanore, Y; Chung, L; Pauling, JD; Denton, CP; Matucci-Cerinic, M; (2021) Author Correction: Raynaud phenomenon and digital ulcers in systemic sclerosis. [Corrigendum]. Nature Reviews Rheumatology , 17 , Article 246. 10.1038/s41584-021-00591-5. Green open access
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Hughes, M; Denton, CP; (2022) The critical need for patient-reported outcome measures to assess the severity and impact of systemic sclerosis. British Journal of Dermatology , 186 (1) pp. 11-12. 10.1111/bjd.20777. Green open access
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Hughes, M; Denton, CP; Khanna, D; (2021) Rituximab for the treatment of systemic sclerosis-interstitial lung disease. Rheumatology , 60 (2) pp. 489-491. 10.1093/rheumatology/keaa675. Green open access
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Hughes, M; Kahaleh, B; Denton, CP; Mason, JC; Matucci-Cerinic, M; (2021) ANCA in systemic sclerosis, when vasculitis overlaps with vasculopathy: a devastating combination of pathologies. Rheumatology , 60 (12) pp. 5509-5516. 10.1093/rheumatology/keab278. Green open access
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Hughes, M; Alcacer-Pitarch, B; Allanore, Y; Baron, M; Boin, F; Bruni, C; Chung, L; ... Matucci-Cerinic, M; + view all (2020) Digital ulcers: should debridement be a standard of care in systemic sclerosis? The Lancet Rheumatology , 2 (5) e302-e307. 10.1016/S2665-9913(19)30164-X. Green open access
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Hughes, M; Allanore, Y; Chung, L; Pauling, JD; Denton, CP; Matucci-Cerinic, M; (2020) Raynaud phenomenon and digital ulcers in systemic sclerosis. Nature Reviews Rheumatology , 16 pp. 208-221. 10.1038/s41584-020-0386-4. Green open access
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Hughes, M; Allanore, Y; El Aoufy, K; Denton, CP; Khanna, D; Krieg, T; Matucci-Cerinic, M; (2021) A Practical Approach to the Management of Digital Ulcers in Patients With Systemic Sclerosis: A Narrative Review. JAMA Dermatology 10.1001/jamadermatol.2021.1463. (In press).

Hughes, M; Murray, A; Denton, CP; Herrick, AL; (2018) Should all digital ulcers be included in future clinical trials of systemic sclerosis-related digital vasculopathy? Medical Hypotheses , 116 pp. 101-104. 10.1016/j.mehy.2018.04.024. Green open access
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Hughes, M; Pauling, JD; Armstrong-James, L; Denton, CP; Galdas, P; Flurey, C; (2020) Gender-related differences in systemic sclerosis. Autoimmunity Reviews , 19 (4) , Article 102494. 10.1016/j.autrev.2020.102494. Green open access
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Hughes, M; Pauling, JD; Jones, J; Denton, CP; Domsic, RT; Frech, TM; Herrick, AL; ... Moore, A; + view all (2020) Patient experiences of digital ulcer development and evolution in systemic sclerosis. Rheumatology , 59 (8) pp. 2156-2158. 10.1093/rheumatology/keaa037. Green open access
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Hughes, M; Pauling, JD; Jones, J; Denton, CP; Domsic, RT; Frech, TM; Herrick, AL; ... Moore, A; + view all (2020) A Multi-Centre Qualitative Study Exploring the Patient Experience of Digital Ulcers in Systemic Sclerosis. Arthritis Care and Research , 72 (5) pp. 723-733. 10.1002/acr.24127. Green open access
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Hughes, M; Tracey, A; Bhushan, M; Chakravarty, K; Denton, CP; Dubey, S; Guiducci, S; ... Herrick, AL; + view all (2018) Reliability of digital ulcer definitions as proposed by the UK Scleroderma Study Group: A challenge for clinical trial design. Journal of Scleroderma and Related Disorders , 3 (2) pp. 170-174. 10.1177/2397198318764796. Green open access
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Humbert, M; Coghlan, JG; Ghofrani, HA; Grimminger, F; He, JG; Riemekasten, G; Vizza, CD; ... Denton, CP; + view all (2017) Riociguat for the treatment of pulmonary arterial hypertension associated with connective tissue disease: results from PATENT-1 and PATENT-2. Annals of Rheumatic Diseases , 76 (2) pp. 422-426. 10.1136/annrheumdis-2015-209087. Green open access
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Huscher, D; Pittrow, D; Distler, O; Denton, CP; Foeldvari, I; Humbert, M; Matucci-Cerinic, M; ... Furst, DE; + view all (2010) Interactions between rheumatologists and cardio-/pulmonologists in the assessment and use of outcome measures in pulmonary arterial hypertension related to systemic sclerosis. Clinical and Experimental Rheumatology , 28 (2) S47-S52. Green open access
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Hutchings, David C; Denton, Christopher P; Venetucci, Luigi; Trafford, Andrew W; (2025) Suppression of premature ventricular complexes with the PDE5 inhibitor sildenafil: First clinical experience. Experimental Physiology 10.1113/EP092932. (In press). Green open access
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Ikeda, T; Fragiadaki, M; Shi-Wen, X; Ponticos, M; Khan, K; Denton, C; Garcia, P; ... Abraham, D; + view all (2016) Data on CUX1 isoforms in idiopathic pulmonary fibrosis lung and systemic sclerosis skin tissue sections. Data in Brief , 8 pp. 1377-1380. 10.1016/j.dib.2016.08.014. Green open access
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Ikeda, T; Fragiadaki, M; Shi-wen, X; Ponticos, M; Khan, K; Denton, C; Garcia, P; ... Abraham, D; + view all (2016) Transforming growth factor-β-induced CUX1 isoforms are associated with fibrosis in systemic sclerosis lung fibroblasts. Biochemistry and Biophysics Reports , 7 pp. 246-252. 10.1016/j.bbrep.2016.06.022. Green open access
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Jaeger, VK; Distler, O; Maurer, B; Czirják, L; Lóránd, V; Valentini, G; Vettori, S; ... Walker, UA; + view all (2017) Functional disability and its predictors in systemic sclerosis: a study from the DeSScipher project within the EUSTAR group. Rheumatology , 57 (3) pp. 441-450. 10.1093/rheumatology/kex182. Green open access
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Jaeger, VK; Tikly, M; Xu, D; Siegert, E; Hachulla, E; Airò, P; Valentini, G; ... EUSTAR co-authors; + view all (2020) Racial differences in systemic sclerosis disease presentation: a European Scleroderma Trials and Research group study. Rheumatology , 59 (7) pp. 1684-1694. 10.1093/rheumatology/kez486. Green open access
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Jaeger, VK; Valentini, G; Hachulla, E; Cozzi, F; Distler, O; Airó, P; Czirják, L; ... EUSTAR co-authors; + view all (2018) Smoking in Systemic Sclerosis: a Longitudinal European Scleroderma Trials and Research Group Study. Arthritis & Rheumatology , 70 (11) pp. 1829-1834. 10.1002/art.40557. Green open access
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Jaeger, VK; Wirz, EG; Allanore, Y; Rossbach, P; Riemekasten, G; Hachulla, E; Distler, O; ... EUSTAR co-authors, ECA; + view all (2016) Incidences and Risk Factors of Organ Manifestations in the Early Course of Systemic Sclerosis: A Longitudinal EUSTAR Study. PLoS One , 11 (10) , Article e0163894. 10.1371/journal.pone.0163894. Green open access
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Jeon, FHK; Griffin, M; Denton, CP; Butler, PEM; (2020) Feasibility study of stem-cell enriched autologous lipotransfer to treat oro-facial fibrosis in systemic sclerosis (Sys-Stem): Protocol for open-label randomised controlled trial. International Journal of Surgery Protocols , 23 pp. 6-10. 10.1016/j.isjp.2020.07.002. Green open access
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Jerjen, Rebekka; Nikpour, Mandana; Krieg, Thomas; Denton, Christopher P; Saracino, Amanda M; (2022) Systemic sclerosis in adults. Part I: Clinical features and pathogenesis. Journal of The American Academy of Dermatology , 87 (5) pp. 937-954. 10.1016/j.jaad.2021.10.065. Green open access
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Jerjen, Rebekka; Nikpour, Mandana; Krieg, Thomas; Denton, Christopher P; Saracino, Amanda M; (2022) Systemic sclerosis in adults. Part II: Management and therapeutics. Journal of the American Academy of Dermatology , 87 (5) pp. 957-978. 10.1016/j.jaad.2021.10.066. Green open access
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Jewett, LR; Kwakkenbos, L; Carrier, M-E; Malcarne, VL; Bartlett, SJ; Furst, DE; Gottesman, K; ... Thombs, BD; + view all (2016) Examination of the association of sex and race/ethnicity with appearance concerns: a Scleroderma Patient-centered Intervention Network (SPIN) Cohort study. Clinical and Experimental Rheumatology , 34 (5) PI 0092-PF 0099. Green open access
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Johnson, SR; Soowamber, ML; Fransen, J; Khanna, D; Van den Hoogen, F; Baron, M; Matucci-Cerinic, M; ... Pope, JE; + view all (2018) There is a need for new systemic sclerosis subset criteria. A content analytic approach. Scandinavian Journal of Rheumatology , 47 (1) pp. 62-70. 10.1080/03009742.2017.1299793. Green open access
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Kakkar, Vishal; Assassi, Shervin; Allanore, Yannick; Kuwana, Masataka; Denton, Christopher P; Khanna, Dinesh; Del Galdo, Francesco; (2022) Type 1 interferon activation in systemic sclerosis: a biomarker, a target or the culprit. Current Opinion in Rheumatology , 34 (6) pp. 357-364. 10.1097/BOR.0000000000000907. (In press). Green open access
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Kanitkar, M; Denton, CP; (2024) The role of endothelial cells in autoimmune rheumatic disease. Current Opinion in Physiology , 37 , Article 100732. 10.1016/j.cophys.2023.100732. Green open access
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Kerick, Martin; Acosta-Herrera, Marialbert; Pilar Simeon-Aznar, Carmen; Luis Callejas, Jose; Assassi, Shervin; Proudman, Susanna M; Nikpour, Mandana; ... Martin, Javier; + view all (2022) Complement component C4 structural variation and quantitative traits contribute to sex-biased vulnerability in systemic sclerosis. npj Genomic Medicine , 7 , Article 57. 10.1038/s41525-022-00327-8. Green open access
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Khanna, D; Denton, CP; (2021) Integrating new therapies for systemic sclerosis-associated lung fibrosis in clinical practice. The Lancet Respiratory Medicine , 9 (6) pp. 560-562. 10.1016/S2213-2600(21)00163-6. Green open access
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Khanna, D; Lescoat, A; Roofeh, D; Bernstein, EJ; Kazerooni, EA; Roth, MD; Martinez, F; ... Denton, CP; + view all (2021) Systemic Sclerosis–Associated Interstitial Lung Disease: How to Incorporate Two Food and Drug Administration–Approved Therapies in Clinical Practice. Arthritis & rheumatology , 74 (1) pp. 13-27. 10.1002/art.41933. Green open access
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Khanna, D; Lin, CJF; Furst, DE; Wagner, B; Zucchetto, M; Raghu, G; Martinez, FJ; ... focuSSced investigators; + view all (2022) Long-Term Safety and Efficacy of Tocilizumab in Early Systemic Sclerosis-Interstitial Lung Disease: Open Label Extension of a Phase 3 Randomized Controlled Trial. American Journal of Respiratory and Critical Care Medicine , 205 (6) pp. 674-684. 10.1164/rccm.202103-0714OC. Green open access
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Khanna, D; Tashkin, DP; Denton, CP; Lubell, MW; Vazquez-Mateo, C; Wax, S; (2019) Ongoing clinical trials and treatment options for patients with systemic sclerosis-associated interstitial lung disease. Rheumatology , 58 (4) pp. 567-579. 10.1093/rheumatology/key151. Green open access
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Khanna, D; Tashkin, DP; Wells, AU; Seibold, JR; Wax, S; Vazquez-Mateo, C; Fleuranceau-Morel, P; ... Denton, CP; + view all (2021) STRATUS, a Phase II Study of Abituzumab in Patients with Systemic Sclerosis-associated Interstitial Lung Disease. The Journal of Rheumatology , 48 (8) pp. 1295-1298. 10.3899/jrheum.191365. Green open access
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Khanna, Dinesh; Denton, Christopher P; Assassi, Shervin; Kuwana, Masataka; Allanore, Yannick; Domsic, Robyn T; Kleoudis, Christi; ... Del Galdo, Francesco; + view all (2024) A randomised, parallel-group, double-blind, placebo-controlled phase 3 study to Determine the effectiveness of the type I interferon receptor antibody, Anifrolumab, In SYstemic sclerosis: DAISY study design and rationale. Clinical and Experimental Rheumatology , 42 (8) pp. 1635-1644. 10.55563/clinexprheumatol/s8qcyu. Green open access
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Khanna, Dinesh; Denton, Christopher P; Furst, Daniel E; Mayes, Maureen D; Matucci-Cerinic, Marco; Smith, Vanessa; de Vries, Dick; ... Ahmed, Sohail; + view all (2023) A 24-Week, Phase IIa, Randomized, Double-blind, Placebo-controlled Study of Ziritaxestat in Early Diffuse Cutaneous Systemic Sclerosis (NOVESA). Arthritis & Rheumatology , 75 (8) pp. 1434-1444. 10.1002/art.42477. Green open access
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Khanna, Dinesh; Kramer, Frank; Höfler, Josef; Ghadessi, Mercedeh; Sandner, Peter; Allanore, Yannick; Denton, Christopher P; ... Distler, Oliver; + view all (2024) Biomarker analysis from the phase 2b randomized placebo-controlled trial of riociguat in early diffuse cutaneous systemic sclerosis. Rheumatology , 63 (11) pp. 3124-3134. 10.1093/rheumatology/keae150. Green open access
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Khanna, Dinesh; Maher, Toby M; Volkmann, Elizabeth R; Allanore, Yannick; Smith, Vanessa; Assassi, Shervin; Kreuter, Michael; ... Denton, Christopher P; + view all (2023) Effect of nintedanib in patients with systemic sclerosis-associated interstitial lung disease and risk factors for rapid progression. RMD Open , 9 (1) , Article e002859. 10.1136/rmdopen-2022-002859. Green open access
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Khanna, D; Allanore, Y; Denton, CP; Kuwana, M; Matucci-Cerinic, M; Pope, JE; Atsumi, T; ... Distler, O; + view all (2020) Riociguat in patients with early diffuse cutaneous systemic sclerosis (RISE-SSc): randomised, double-blind, placebo-controlled multicentre trial. Annals of the Rheumatic Diseases , 79 (5) pp. 618-625. 10.1136/annrheumdis-2019-216823. Green open access
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Khanna, D; Berrocal, VJ; Giannini, EH; Seibold, JR; Merkel, PA; Mayes, MD; Baron, M; ... Furst, DE; + view all (2016) The American College of Rheumatology Provisional Composite Response Index for Clinical Trials in Early Diffuse Cutaneous Systemic Sclerosis. Arthritis Care & Research , 68 (2) pp. 167-178. 10.1002/acr.22804. Green open access
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Khanna, D; Berrocal, VJ; Giannini, EH; Seibold, JR; Merkel, PA; Mayes, MD; Baron, M; ... Furst, DE; + view all (2016) The American College of Rheumatology Provisional Composite Response Index for Clinical Trials in Early Diffuse Cutaneous Systemic Sclerosis. Arthritis & Rheumatology , 68 (2) pp. 299-311. 10.1002/art.39501. Green open access
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Khanna, D; Denton, CP; Jahreis, A; van Laar, JM; Frech, TM; Anderson, ME; Baron, M; ... Furst, DE; + view all (2016) Safety and efficacy of subcutaneous tocilizumab in adults with systemic sclerosis (faSScinate): a phase 2, randomised, controlled trial. Lancet , 387 (10038) pp. 2630-2640. 10.1016/S0140-6736(16)00232-4. Green open access
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Khanna, D; Denton, CP; Lin, CJ; van Laar, JM; Frech, TM; Anderson, ME; Baron, M; ... Furst, DE; + view all (2018) Safety and efficacy of subcutaneous tocilizumab in systemic sclerosis: results from the open-label period of a phase II randomised controlled trial (faSScinate). Annals of the Rheumatic Diseases , 77 pp. 212-220. 10.1136/annrheumdis-2017-211682. Green open access
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Khanna, D; Denton, CP; Merkel, PA; Krieg, T; Le Brun, F-O; Marr, A; Papadakis, K; ... Furst, DE; + view all (2016) Effect of Macitentan on the Development of New Ischemic Digital Ulcers in Patients With Systemic Sclerosis DUAL-1 and DUAL-2 Randomized Clinical Trials. JAMA: Journal Of The American Medical Association , 315 (18) pp. 1975-1988. 10.1001/jama.2016.5258.

Khanna, D; Furst, DE; Clements, PJ; Allanore, Y; Baron, M; Czirjak, L; Distler, O; ... Denton, CP; + view all (2017) Standardization of the modified Rodnan skin score for use in clinical trials of systemic sclerosis. Journal of Scleroderma and Related Disorders , 2 (1) pp. 11-18. 10.5301/jsrd.5000231. Green open access
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Khanna, D; Lin, CJF; Furst, DE; Goldin, J; Kim, G; Kuwana, M; Allanore, Y; ... focuSSced investigators; + view all (2020) Tocilizumab in systemic sclerosis: a randomised, double-blind, placebo-controlled, phase 3 trial. The Lancet Respiratory Medicine , 8 (10) pp. 963-974. 10.1016/S2213-2600(20)30318-0. Green open access
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Khanna, D; Spino, C; Johnson, S; Chung, L; Whitfield, M; Denton, CP; Berrocal, V; ... Furst, DE; + view all (2020) Abatacept in Early Diffuse Cutaneous Systemic Sclerosis - Results of a Phase 2 Investigator-Initiated, Multicenter, Double-Blind Randomized Placebo-Controlled Trial. Arthritis and Rheumatology , 72 (1) pp. 125-136. 10.1002/art.41055. Green open access
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Khanna, D; Tashkin, DP; Denton, CP; Renzoni, EA; Desai, SR; Varga, J; (2019) Aetiology, Risk Factors, and Biomarkers in Systemic Sclerosis with Interstitial Lung Disease. American Journal of Respiratory and Critical Care Medicine 10.1164/rccm.201903-0563CI. (In press). Green open access
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Knight, Daniel S; Karia, Nina; Cole, Alice R; Maclean, Rory H; Brown, James T; Masi, Ambra; Patel, Rishi K; ... Muthurangu, Vivek; + view all (2022) Distinct cardiovascular phenotypes are associated with prognosis in systemic sclerosis: a cardiovascular magnetic resonance study. European Heart Journal - Cardiovascular Imaging , Article jeac120. 10.1093/ehjci/jeac120. Green open access
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Knight, Daniel S; Virsinskaite, Ruta; Karia, Nina; Cole, Alice R; Maclean, Rory H; Brown, James T; Patel, Rishi K; ... Muthurangu, Vivek; + view all (2024) Native myocardial T1 and right ventricular size by CMR predict outcome in systemic sclerosis-associated pulmonary hypertension. Rheumatology , Article keae141. 10.1093/rheumatology/keae141. (In press). Green open access
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Knobler, R; Geroldinger-Simić, M; Kreuter, A; Hunzelmann, N; Moinzadeh, P; Rongioletti, F; Denton, CP; ... Krieg, T; + view all (2024) Consensus statement on the diagnosis and treatment of sclerosing diseases of the skin, Part 1: Localized scleroderma, systemic sclerosis and overlap syndromes. Journal of the European Academy of Dermatology and Venereology , 38 (7) pp. 1251-1280. 10.1111/jdv.19912. Green open access
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Knobler, Robert; Geroldinger-Simić, Marija; Kreuter, Alexander; Hunzelmann, Nicolas; Moinzadeh, Pia; Rongioletti, Franco; Denton, Christopher; ... Krieg, Thomas; + view all (2024) Consensus statement on the diagnosis and treatment of sclerosing diseases of the skin, Part 2: Scleromyxoedema and scleroedema. Journal of the European Academy of Dermatology and Venereology 10.1111/jdv.19937. (In press). Green open access
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Knobler, R; Moinzadeh, P; Hunzelmann, N; Kreuter, A; Cozzio, A; Mouthon, L; Cutolo, M; ... Krieg, T; + view all (2017) European dermatology forum S1-guideline on the diagnosis and treatment of sclerosing diseases of the skin, Part 2: Scleromyxedema, scleredema and nephrogenic systemic fibrosis. Journal of the European Academy of Dermatology and Venereology , 31 (10) pp. 1581-1594. 10.1111/jdv.14466. Green open access
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Knobler, R; Moinzadeh, P; Hunzelmann, N; Kreuter, A; Cozzio, A; Mouthon, L; Cutolo, M; ... Krieg, T; + view all (2017) European Dermatology Forum S1-guideline on the diagnosis and treatment of sclerosing diseases of the skin, Part 1: localized scleroderma, systemic sclerosis and overlap syndromes. Journal of the European Academy of Dermatology and Venereology , 31 (9) pp. 1401-1424. 10.1111/jdv.14458. Green open access
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Kovacs, Gabor; Bartolome, Sonja; Denton, Christopher P; Gatzoulis, Michael A; Gu, Sue; Khanna, Dinesh; Badesch, David; (2024) Definition, classification and diagnosis of pulmonary hypertension. European Respiratory Journal , 64 (3) 10.1183/13993003.01324-2024. Green open access
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Kowal-Bielecka, O; Fransen, J; Avouac, J; Becker, M; Kulak, A; Allanore, Y; Distler, O; ... EUSTAR Coauthors; + view all (2017) Update of EULAR recommendations for the treatment of systemic sclerosis. Annals of Rheumatic Diseases , 76 (8) pp. 1327-1339. 10.1136/annrheumdis-2016-209909. Green open access
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Kundu, D; Abraham, D; Black, CM; Denton, CP; Bruckdorfer, KR; (2014) Reduced levels of S-nitrosothiols in plasma of patients with systemic sclerosis and Raynaud's phenomenon. Vascul Pharmacol , 63 (3) 178 - 181. 10.1016/j.vph.2014.09.003. Green open access
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Kuster, S; Jordan, S; Elhai, M; Held, U; Steigmiller, K; Bruni, C; Cacciapaglia, F; ... Distler, O; + view all (2022) Effectiveness and safety of tocilizumab in patients with systemic sclerosis: a propensity score matched controlled observational study of the EUSTAR cohort. RMD open , 8 (2) , Article e002477. 10.1136/rmdopen-2022-002477. Green open access
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Kuwana, M; Allanore, Y; Denton, CP; Distler, JH; Steen, V; Khanna, D; Matucci-Cerinic, M; ... Distler, O; + view all (2022) Nintedanib in patients with systemic sclerosis-associated interstitial lung disease: subgroup analyses by autoantibody status and skin score. Arthritis & Rheumatology , 74 (3) pp. 518-526. 10.1002/art.41965. Green open access
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Kuwana, Masataka; Saito, Aiko; Farrington, Sue; Galetti, Ilaria; Denton, Christopher P; Khanna, Dinesh; (2025) Physician–patient communication in the treatment of systemic sclerosis–associated interstitial lung disease: A narrative review and recommendations. Journal of Scleroderma and Related Disorders 10.1177/23971983251324803. (In press). Green open access
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Kuwana, Masataka; Saito, Aiko; Farrington, Sue; Galetti, Ilaria; Denton, Christopher P; Khanna, Dinesh; (2025) How do doctors and patients communicate about the treatment of systemic sclerosis-associated interstitial lung disease? A plain language summary of publication. Therapeutic Advances in Respiratory Disease , 19 pp. 1-9. 10.1177/17534666251371814. Green open access
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Kwakkenbos, L; Carrier, ME; Welling, J; Levis, B; Levis, AW; Sauve, M; Turner, KA; ... Roux, S; + view all (2022) Randomized controlled trial of an internet-based self-guided hand exercise program to improve hand function in people with systemic sclerosis: the Scleroderma Patient-centered Intervention Network Hand Exercise Program (SPIN-HAND) trial. Trials , 23 , Article 994. 10.1186/s13063-022-06923-4. Green open access
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Lakin, Kimberly S; Wu, Yin; Gordon, Jessica K; Kwakkenbos, Linda; Carrier, Marie-Eve; Henry, Richard S; Denton, Christopher P; ... SPIN, Investigators; + view all (2024) COVID-19 vaccinations and infections among individuals with systemic sclerosis: A Scleroderma Patient-centered Intervention Network (SPIN) Cohort study. Semin Arthritis Rheum , 67 , Article 152453. 10.1016/j.semarthrit.2024.152453. Green open access
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Langridge, BJ; Jeon, FHK; Almadori, A; Griffin, MF; Denton, CP; Butler, PEM; (2021) Autologous lipotransfer can improve the outcomes of localised scleroderma. Clinical and Experimental Rheumatology , 39 (4) , Article S159. Green open access
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Langridge, BJ; Jeon, FHK; Almadori, A; Griffin, MF; Denton, CP; Butler, PEM; (2021) Autologous lipotransfer canimprove the outcomes of localised scleroderma. Clinical and Experimental Rheumatology , 39 (4) S159. Green open access
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Lazzaroni, M-G; Marasco, E; Campochiaro, C; DeVries-Bouwstra, J; Gonzalez-Perez, M-I; Rojas-Serrano, J; Hachulla, E; ... EUSTAR co-authors; + view all (2021) The clinical phenotype of Systemic Sclerosis patients with anti-PM/Scl antibodies: results from the EUSTAR cohort. Rheumatology , 60 (11) pp. 5028-5041. 10.1093/rheumatology/keab152. Green open access
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Lee, YC; Fox, RS; Kwakkenbos, L; Levis, B; Carrier, ME; Welling, J; Sauvé, M; ... Wilcox, P; + view all (2021) Pain levels and associated factors in the Scleroderma Patient-centered Intervention Network (SPIN) cohort: a multicentre cross-sectional study. The Lancet Rheumatology , 3 (12) e844-e854. 10.1016/S2665-9913(21)00318-0. Green open access
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Lepri, Gemma; Hughes, Michael; Allanore, Yannick; Denton, Christopher P; Furst, Daniel E; Wang, Yukai; Santiago, Tania; ... Matucci-Cerinic, Marco; + view all (2023) The role of skin ultrasound in systemic sclerosis: looking below the surface to understand disease evolution. The Lancet Rheumatology , 5 (7) e422-e425. 10.1016/S2665-9913(23)00100-5. Green open access
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Lescoat, Alain; Allanore, Yannick; Del Galdo, Francesco; Kuwana, Masataka; Bellando-Randone, Silvia; Denton, Christopher P; Khanna, Dinesh; (2025) From the grey area of pre-systemic sclerosis to very early disease and irreversible tissue damage: the challenge of defining at-risk patients for future preventive trials in systemic sclerosis. Annals of the Rheumatic Diseases 10.1016/j.ard.2025.11.021. (In press).

Lescoat, Alain; Bellando-Randone, Silvia; Campochiaro, Corrado; Del Galdo, Francesco; Denton, Christopher P; Farrington, Sue; Galetti, Ilaria; ... Matucci-Cerinic, Marco; + view all (2023) Beyond very early systemic sclerosis: deciphering pre‑scleroderma and its trajectories to open new avenues for preventive medicine. The Lancet Rheumatology , 5 (11) E683-E694. 10.1016/S2665-9913(23)00212-6. Green open access
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Lescoat, A; Murphy, SL; Roofeh, D; Pauling, JD; Hughes, M; Sandler, R; Zimmermann, F; ... Khanna, D; + view all (2021) Considerations for a combined index for limited cutaneous systemic sclerosis to support drug development and improve outcomes. Journal of Scleroderma and Related Disorders , 6 (1) pp. 66-76. 10.1177/2397198320961967. Green open access
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Liakouli, V; Elies Comez, J; El-Sherbiny, YM; Scarcia, M; Grant, G; Abignano, G; Derrett-Smith, EC; ... Del Galdo, F; + view all (2017) Scleroderma fibroblasts suppress angiogenesis via TGF-β/caveolin-1 dependent secretion of pigment epithelium-derived factor. Annals of the Rheumatic Diseases 10.1136/annrheumdis-2017-212120. (In press). Green open access
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Lilburn, David ML; Garthwaite, Helen S; Ganeshan, Balaji; Win, Thida; Screaton, Nicholas J; Hoy, Luke R; Walls, Darren; ... Porter, Joanna C; + view all (2025) [18F]FDG PET/CT Predicts Patient Survival in Patients with Systemic Sclerosis-Associated Interstitial Lung Disease. Journal of Nuclear Medicine , Article jnumed.125.269497. 10.2967/jnumed.125.269497. Green open access
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Lilleker, JB; Vencovsky, J; Wang, G; Wedderburn, LR; Diederichsen, LP; Schmidt, J; Oakley, P; ... all EuroMyositis contributors; + view all (2018) The EuroMyositis registry: an international collaborative tool to facilitate myositis research. Annals of the Rheumatic Diseases , 77 (1) pp. 30-39. 10.1136/annrheumdis-2017-211868. Green open access
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López-Isac, E; Acosta-Herrera, M; Kerick, M; Assassi, S; Satpathy, AT; Granja, J; Mumbach, MR; ... Martin, J; + view all (2019) GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways. Nature Communications , 10 , Article 4955. 10.1038/s41467-019-12760-y. Green open access
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López-Isac, E; Bossini-Castillo, L; Palma, AB; Assassi, S; Simeón, CP; Ortego-Centeno, N; Vicente, E; ... Martín, J; + view all (2017) Analysis of ATP8B4 F436L missense variant in a large Systemic sclerosis cohort. Arthritis & Rheumatology , 69 (6) pp. 1337-1338. 10.1002/art.40058. Green open access
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López-Isac, E; Martín, JE; Assassi, S; Simeón, CP; Carreira, P; Ortego-Centeno, N; Freire, M; ... Martín, J; + view all (2016) Cross-disease Meta-analysis of Genome-wide Association Studies for Systemic Sclerosis and Rheumatoid Arthritis Reveals IRF4 as a New Common Susceptibility Locus. Arthritis & Rheumatology , 68 (9) pp. 2338-2344. 10.1002/art.39730. Green open access
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Lynch, BM; Stern, EP; Ong, V; Harber, M; Burns, A; Denton, CP; (2016) UK Scleroderma Study Group (UKSSG) guidelines on the diagnosis and management of scleroderma renal crisis. Clinical and Experimental Rheumatology , 34 (5) , Article Sup 100. Green open access
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Maclean, Rory H; Ahmed, Fiza; Ong, Voon H; Murray, Charles D; Denton, Christopher P; (2023) Phenome-Wide Association Study of Drugs and Co-morbidities Associated with Gastrointestinal Dysfunction in Systemic Sclerosis. The Journal of Rheumatology , 50 (2) , Article 220990. 10.3899/jrheum.220990. Green open access
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Maher, Toby M; Tudor, Veronica A; Saunders, Peter; Gibbons, Michael A; Fletcher, Sophie V; Denton, Christopher P; Hoyles, Rachel K; ... RECITAL Investigators; + view all (2023) Rituximab versus intravenous cyclophosphamide in patients with connective tissue disease-associated interstitial lung disease in the UK (RECITAL): a double-blind, double-dummy, randomised, controlled, phase 2b trial. The Lancet Respiratory Medicine , 11 (1) pp. 45-54. 10.1016/S2213-2600(22)00359-9. Green open access
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Maher, Toby M; Tudor, Veronica A; Saunders, Peter; Zanghelini, Fernando; Grossi Sampedro, Carlota; Xydopoulos, Georgios; Gibbons, Michael; ... Molyneaux, Philip L; + view all (2024) Rituximab compared to intravenous cyclophosphamide in adults with connective tissue disease-associated interstitial lung disease: the RECITAL RCT. Efficacy and Mechanism Evaluation , 11 (4) pp. 1-68. 10.3310/lywq8541. Green open access
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Maltez, Nancy; Ross, Laura; Baron, Murray; Alunno, Alessia; Campochiaro, Corrado; Suliman, Yossra A; Schoones, Jan W; ... Hughes, Michael; + view all (2025) Treatment recommendations for the systemic pharmacological treatment of systemic sclerosis digital ulcers: Results from the World Scleroderma Foundation Ad Hoc Committee. Journal of Scleroderma and Related Disorders 10.1177/23971983251340559. (In press). Green open access
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Margaritopoulos, GA; Antoniou, KM; Denton, CP; Wells, AU; (2017) Combined Pulmonary Fibrosis and Emphysema in Scleroderma-Related Lung Disease: Reply to Saketkoo et al. Arthritis & Rheumatology , 69 (1) pp. 240-241. 10.1002/art.39930. Green open access
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Martínez-López, Javier; Rangel-Peláez, Carlos; Rodriguez-Martin, Inmaculada; Guillen-Del-Castillo, Alfredo; Simeón-Aznar, Carmen P; Callejas, José L; International SSc Group; PRECISESADs Clinical Consortium; ... Kerick, Martin; + view all (2025) Distinct effects of complement C4A and C4B copy number in Systemic Sclerosis serological and clinical subtypes. Arthritis & Rheumatology 10.1002/art.43433. (In press). Green open access
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Matucci-Cerinic, M; Bruni, C; Allanore, Y; Clementi, M; Dagna, L; Damjanov, NS; de Paulis, A; ... Taliani, G; + view all (2020) Systemic sclerosis and the COVID-19 pandemic: World Scleroderma Foundation preliminary advice for patient management. Annals of the Rheumatic Diseases 10.1136/annrheumdis-2020-217407. (In press). Green open access
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Matucci-Cerinic, M; Krieg, T; Guillevin, L; Schwierin, B; Rosenberg, D; Cornelisse, P; Denton, CP; (2015) Elucidating the burden of recurrent and chronic digital ulcers in systemic sclerosis: long-term results from the DUO Registry. Annals of the Rheumatic Diseases , 75 pp. 1770-1776. 10.1136/annrheumdis-2015-208121. Green open access
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Mehta, P; Bunker, CB; Ciurtin, C; Porter, JC; Chambers, RC; Papdopoulou, C; Garthwaite, H; ... Denton, CP; + view all (2021) Chilblain-like acral lesions in long COVID-19: management and implications for understanding microangiopathy. The Lancet Infectious Diseases , 21 (7) p. 912. 10.1016/s1473-3099(21)00133-x. Green open access
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Mehta, Puja; Hoyles, Rachel K; Gunawardena, Harsha; Gooptu, Bibek; Choudhary, Nazia; Heightmann, Melissa J; Garthwaite, Helen; ... Denton, Christopher P; + view all (2022) Rheumatologists have an important role in the management of interstitial lung disease (ILD): a cross-speciality, multi-centre, U.K. perspective. Rheumatology 10.1093/rheumatology/keac061. Green open access
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Mihai, C; Antic, M; Dobrota, R; Bonderman, D; Chadha-Boreham, H; Coghlan, JG; Denton, CP; ... Distler, O; + view all (2018) Factors associated with disease progression in early-diagnosed pulmonary arterial hypertension associated with systemic sclerosis: longitudinal data from the DETECT cohort. Annals of the Rheumatic Diseases , 77 (1) pp. 128-132. 10.1136/annrheumdis-2017-211480. Green open access
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Mills, SD; Kwakkenbos, L; Carrier, ME; Gholizadeh, S; Fox, RS; Jewett, LR; Gottesman, K; ... Launay, D; + view all (2018) Validation of the Social Appearance Anxiety Scale in Patients With Systemic Sclerosis: A Scleroderma Patient-Centered Intervention Network Cohort Study. Arthritis Care and Research , 70 (10) pp. 1557-1562. 10.1002/acr.23514. Green open access
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Moezinia, CJ; Ji-Xu, A; Azari, A; Horlick, S; Denton, C; Stratton, R; (2020) Iloprost for COVID-19-related vasculopathy. The Lancet Rheumatology , 2 (10) e582-e583. 10.1016/S2665-9913(20)30232-0. Green open access
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Moinzadeh, P; Fonseca, C; Hellmich, M; Shah, AA; Chighizola, C; Denton, CP; Ong, VH; (2014) Association of anti-RNA polymerase III autoantibodies and cancer in scleroderma. Arthritis Res Ther , 16 (1) R53 - ?. 10.1186/ar4486. Green open access
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Moinzadeh, P; Frommolt, P; Franitza, M; Toliat, MR; Becker, K; Nürnberg, P; Nihtyanova, SI; ... Krieg, T; + view all (2020) Whole blood gene expression profiling distinguishes systemic sclerosis-overlap syndromes from other subsets. Journal of the European Academy of Dermatology and Venereology , 34 (5) e236-e238. 10.1111/jdv.16198. Green open access
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Moreno-Moral, A; Bagnati, M; Koturan, S; Ko, J-H; Fonseca, C; Harmston, N; Game, L; ... Petretto, E; + view all (2018) Changes in macrophage transcriptome associate with systemic sclerosis and mediate GSDMA contribution to disease risk. Annals of the Rheumatic Diseases , 77 (4) pp. 596-601. 10.1136/annrheumdis-2017-212454. Green open access
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Mura, S; Fin, A; Parodi, PC; Denton, CP; Howell, KJ; Rampino Cordaro, E; (2018) Autologous fat transfer in the successful treatment of upper limb linear morphoea. [Letter]. Clinical and Experimental Rheumatology (In press).

Nagaraja, V; Cerinic, M-M; Furst, DE; Kuwana, M; Allanore, Y; Denton, CP; Raghu, G; ... Khanna, D; + view all (2020) Current and future outlook on disease modification and defining low disease activity in systemic sclerosis. Arthritis and Rheumatology , 72 (7) pp. 1049-1058. 10.1002/art.41246. Green open access
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Nagel, C; Marra, AM; Benjamin, N; Blank, N; Cittadini, A; Coghlan, G; Distler, O; ... Grünig, E; + view all (2019) Reduced Right Ventricular Output Reserve in Patients With Systemic Sclerosis and Mildly Elevated Pulmonary Artery Pressure. Arthritis & Rheumatology , 71 (5) pp. 805-816. 10.1002/art.40814. Green open access
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Nevskaya, T; Pope, JE; Turk, MA; Shu, J; Marquardt, A; van den Hoogen, F; Khanna, D; ... Johnson, SR; + view all (2021) Systematic analysis of the literature in search of defining systemic sclerosis subsets. The Journal of Rheumatology , 48 (11) pp. 1698-1717. 10.3899/jrheum.201594. (In press). Green open access
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Ngcozana, T; Ong, VH; Denton, CP; (2020) Improving access to digital ulcer care through nurse-led clinic: a service evaluation. Musculoskeletal Care , 18 (1) pp. 92-97. 10.1002/msc.1433. Green open access
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Nihtyanova, Svetlana I; Schreiber, Benjamin E; Ong, Voon H; Wells, Athol U; Coghlan, John G; Denton, Christopher P; (2022) Dynamic prediction of pulmonary hypertension in systemic sclerosis using landmark analysis. Arthritis and Rheumatology 10.1002/art.42349. (In press). Green open access
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Nihtyanova, SI; Denton, CP; (2020) Pathogenesis of systemic sclerosis associated interstitial lung disease. Journal of Scleroderma and Related Disorders , 5 (S2) pp. 6-16. 10.1177/2397198320903867. Green open access
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Nihtyanova, SI; Denton, CP; (2017) Scleroderma Lung Involvement, Autoantibodies, and Outcome Prediction: The Confounding Effect of Time. [Editorial comment]. The Journal of Rheumatology , 44 (4) pp. 404-406. 10.3899/jrheum.170055. Green open access
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Nihtyanova, SI; Sari, A; Harvey, JC; Leslie, A; Derrett-Smith, EC; Fonseca, C; Ong, VH; (2020) Using autoantibodies and cutaneous subset to develop outcome-based disease classification in systemic sclerosis. Arthritis & Rheumatology , 72 (3) pp. 465-476. 10.1002/art.41153. Green open access
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Nikitorowicz-Buniak, J; Denton, CP; Abraham, D; Stratton, R; (2015) Partially Evoked Epithelial-Mesenchymal Transition (EMT) Is Associated with Increased TGFβ Signaling within Lesional Scleroderma Skin. PLoS One , 10 (7) , Article e0134092. 10.1371/journal.pone.0134092. Green open access
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Oláh, C; Schwartz, N; Denton, C; Kardos, Z; Putterman, C; Szekanecz, Z; (2020) Cognitive dysfunction in autoimmune rheumatic diseases. Arthritis Research & Therapy , 22 , Article 78. 10.1186/s13075-020-02180-5. Green open access
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Ong, VH; Denton, CP; (2022) When the game changes: efficacy of rituximab in systemic sclerosis. The Lancet Rheumatology , 4 (8) e527-e529. 10.1016/S2665-9913(22)00161-8. Green open access
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Orlandi, M; Landini, N; Sambataro, G; Nardi, C; Tofani, L; Bruni, C; Bellando-Randone, S; ... Matucci-Cerinic, M; + view all (2022) The role of chest CT in deciphering interstitial lung involvement: systemic sclerosis versus COVID-19. Rheumatology , 61 (4) pp. 1600-1609. 10.1093/rheumatology/keab615. Green open access
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Orteu, CH; Ong, VH; Denton, CP; (2020) Scleroderma mimics – Clinical features and management. Best Practice & Research Clinical Rheumatology , 34 (1) , Article 101489. 10.1016/j.berh.2020.101489. Green open access
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Pain, Clare E; Lythgoe, Hanna; Willis, Emily; Sampath, Sunil; Deepak, Samundeeswari; Torok, Kathryn S; Duong, Phuoc H; ... Denton, Christopher P; + view all (2025) Evaluating the relevance of the 2024 BSR systemic sclerosis guideline to juvenile systemic sclerosis. Rheumatology 10.1093/rheumatology/keaf249. (In press).

Pakozdi, A; Wilson, H; Black, CM; Denton, CP; (2009) Does long term therapy with lansoprazole slow progression of oesophageal involvement in systemic sclerosis? Clinical and Experimental Rheumatology , 27 (3) , Article Suppl.54. Green open access
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Pan, Z; Marra, AM; Benjamin, N; Eichstaedt, CA; Blank, N; Bossone, E; Cittadini, A; ... Grünig, E; + view all (2019) Early treatment with ambrisentan of mildly elevated mean pulmonary arterial pressure associated with systemic sclerosis: a randomized, controlled, double-blind, parallel group study (EDITA study). Arthritis Research and Therapy , 21 , Article 217. 10.1186/s13075-019-1981-0. Green open access
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Papaioannou, Ioannis; Dritsoula, Athina; Baliga, Reshma S; Trinder, Sarah L; Cook, Emma; Xu, Shiwen; Hobbs, Adrian; ... Ponticos, Markella; + view all (2024) NKX2-5 regulates vessel remodeling in scleroderma-associated pulmonary arterial hypertension. JCI Insight , 9 (10) , Article e164191. 10.1172/jci.insight.164191. Green open access
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Papaioannou, I; Xu, S; Denton, CP; Abraham, D; Ponticos, M; (2018) STAT3 controls COL1A2 enhancer activation cooperatively with JunB, regulates type I collagen synthesis post-transcriptionally and is essential for lung myofibroblast differentiation. Molecular Biology of the Cell , 29 (2) pp. 84-95. 10.1091/mbc.E17-06-0342. Green open access
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Parker, LK; Ponte, C; Howell, KJ; Ong, VH; Denton, CP; Schreiber, BE; (2017) Clinical features and management of erythromelalgia: long term follow-up of 46 cases. Clinical and Experimental Rheumatology , 35 (1) pp. 80-84. Green open access
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Parkes, J; Rothwell, S; Day, P; McHugh, NJ; Betteridge, Z; Cooper, R; Ollier, WE; ... Lamb, J; + view all (2016) Systematic Protein-Protein Interaction and Pathway Analyses in the Idiopathic Inflammatory Myopathies. Arthritis Research & Therapy , 18 , Article 156. 10.1186/s13075-016-1061-7. Green open access
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Parkes, JE; Rothwell, S; Oldroyd, A; Chinoy, H; Lamb, JA; Lundberg, IE; Miller, FW; ... Betteridge, ZE; + view all (2018) Genetic background may contribute to the latitude-dependent prevalence of dermatomyositis and anti-TIF1-γ autoantibodies in adult patients with myositis. Arthritis Research and Therapy , 20 , Article 117. 10.1186/s13075-018-1617-9. Green open access
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Pauling, John D; Allanore, Yannick; Buch, Maya H; Cutolo, Maurizio; Del Galdo, Francesco; Denton, Christopher P; Di Donato, Stefano; ... Hughes, Michael; + view all (2025) Exploiting a unified vascular framework to predict organ-specific complications and accomplish disease modification in systemic sclerosis. The Lancet Rheumatology 10.1016/S2665-9913(25)00251-6. (In press).

Pauling, John D; Yu, Lan; Frech, Tracy M; Herrick, Ariane L; Hummers, Laura K; Shah, Ami A; Denton, Christopher P; ... Domsic, Robyn T; + view all (2024) Construct validity and reliability of the Assessment of Systemic Sclerosis-Associated Raynaud’s Phenomenon (ASRAP) questionnaire. Rheumatology , 63 (5) pp. 1281-1290. 10.1093/rheumatology/kead371. Green open access
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Peytrignet, S; Denton, CP; Lunt, M; Hesselstrand, R; Mouthon, L; Silman, A; Pan, X; ... Herrick, AL; + view all (2017) Disability, fatigue, pain and their associates in early diffuse cutaneous systemic sclerosis: the European Scleroderma Observational Study. Rheumatology , Article kex410. 10.1093/rheumatology/kex410. (In press). Green open access
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Ponticos, M; Papaioannou, I; Xu, S; Holmes, AM; Khan, K; Denton, CP; Bou-Gharios, G; (2015) Failed degradation of JunB contributes to overproduction of type I collagen and development of dermal fibrosis in patients with systemic sclerosis. Arthritis Rheumatol , 67 (1) 243 - 253. 10.1002/art.38897. Green open access
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Pope, Janet E; Denton, Christopher P; Johnson, Sindhu R; Fernandez-Codina, Andreu; Hudson, Marie; Nevskaya, Tatiana; (2023) State-of-the-art evidence in the treatment of systemic sclerosis. Nature Reviews Rheumatology , 19 pp. 212-226. 10.1038/s41584-023-00909-5. Green open access
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Pope, JE; Lee, JJ; Denton, CP; (2018) Editorial: Bench to Bedside—and Back Again: Finding the Goldilocks Zone Within the Scleroderma Universe. [Editorial comment]. Arthritis & Rheumatology , 70 (2) pp. 155-156. 10.1002/art.40373. Green open access
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Quillinan, N; Clark, KE; Youl, B; Vernes, J; McIntosh, D; Haq, S; Denton, CP; (2017) Multiplex serum protein analysis reveals potential mechanisms and markers of response to hyperimmune caprine serum in systemic sclerosis. Arthritis Research & Therapy , 19 , Article 45. 10.1186/s13075-017-1252-x. Green open access
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Raja, J; Denton, CP; (2016) Emerging evidence-based therapies for systemic sclerosis. Indian Journal of Rheumatology , 11 (3) pp. 153-163. 10.4103/0973-3698.187423. Green open access
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Raja, J; Nihtyanova, SI; Murray, CD; Denton, CP; Ong, VH; (2016) Sustained benefit from intravenous immunoglobulin therapy for gastrointestinal involvement in systemic sclerosis. Rheumatology , 55 (1) pp. 115-119. 10.1093/rheumatology/kev318. Green open access
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Ramyead, S; Denton, CP; Orteu, CH; Swale, V; Mayor-Jerez, J; Gardette, E; (2023) A purple plaque in a patient with systemic sclerosis. Journal of Scleroderma and Related Disorders , 8 (2) NP1-NP3. 10.1177/23971983231152342. Green open access
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Roblin, Elen; Clark, Kristina EN; Beesley, Claire; Ong, Voon H; Denton, Christopher P; (2024) Testing a candidate composite serum protein marker of skin severity in systemic sclerosis. Rheumatology Advances in Practice , 8 (2) , Article rkae039. 10.1093/rap/rkae039. Green open access
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Rodolfi, S; Denton, CP; Ong, VH; (2025) Systemic sclerosis-associated severe gastric antral vascular ectasia treated with tocilizumab:A case report and review of the literature. Journal of Scleroderma and Related Disorders 10.1177/23971983241309570. (In press). Green open access
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Rodolfi, Stefano; Clark, Kristina; Abdi, Bahja Ahmed; Roblin, Elen; Kanitkar, Medha; Ong, Voon H; Voskuyl, Alexandre E; ... Spierings, Julia; + view all (2025) A composite biomarker score to predict modified Rodnan skin score in systemic sclerosis: insight from autologous stem cell transplantation international scleroderma trial. Arthritis Research & Therapy 10.1186/s13075-025-03704-7. (In press). Green open access
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Rodolfi, Stefano; Ng, Cheryl Chun Man; Ruiz Bejerano, Ana Maria; Kanitkar, Medha; Ong, Voon H; Denton, Christopher P; (2025) Impact of immunosuppression on development and outcome of systemic sclerosis-associated pulmonary arterial hypertension. Clinical and Experimental Rheumatology , 43 (8) pp. 1492-1498. 10.55563/clinexprheumatol/x0keg5. Green open access
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Rodolfi, Stefano; Ong, Voon H; Denton, Christopher P; (2024) Recent developments in connective tissue disease associated pulmonary arterial hypertension. International Journal of Cardiology Congenital Heart Disease , Article 100513. 10.1016/j.ijcchd.2024.100513. (In press). Green open access
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Roofeh, D; Lin, CJF; Goldin, J; Kim, GH; Furst, DE; Denton, CP; Huang, S; ... focuSSced investigators; + view all (2021) Tocilizumab Prevents Progression of Early Systemic Sclerosis Associated Interstitial Lung Disease. Arthritis & Rheumatology , 73 (7) pp. 1301-1310. 10.1002/art.41668. Green open access
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Roofeh, David; Brown, Kevin K; Kazerooni, Ella A; Tashkin, Donald; Assassi, Shervin; Martinez, Fernando; Wells, Athol U; ... Khanna, Dinesh; + view all (2023) Systemic Sclerosis Associated Interstitial Lung Disease: A Conceptual Framework for Subclinical, Clinical, and Progressive Disease. Rheumatology , 62 (5) pp. 1877-1886. 10.1093/rheumatology/keac557. Green open access
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Roofeh, D; Distler, O; Allanore, Y; Denton, CP; Khanna, D; (2020) Treatment of systemic sclerosis associated ILD: Lessons from clinical trials. Journal of Scleroderma and Related Disorders , 5 (2 Suppl) pp. 61-71. 10.1177/2397198320903208. Green open access
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Rosa-Baez, Carlos; Rangel-Pelaez, Carlos; Rodriguez-Martin, Inmaculada; Kerick, Martin; Guillen-Del-Castillo, Alfredo; Simeon-Aznar, Carmen P; Callejas, José Luis; ... Australian Scleroderma Interest Group (ASIG); + view all (2025) Assessing the MUC5B promoter variant in a large cohort of systemic sclerosis-associated interstitial lung disease. RMD Open , 11 (3) , Article e005754. 10.1136/rmdopen-2025-005754. Green open access
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Ross, Laura; Maltez, Nancy; Hughes, Michael; Schoones, Jan W; Baron, Murray; Chung, Lorinda; Giuggioli, Dilia; ... Alunno, Alessia; + view all (2023) Systemic pharmacological treatment of digital ulcers in systemic sclerosis: a systematic literature review. Rheumatology , 62 (12) pp. 3785-3800. 10.1093/rheumatology/kead289. Green open access
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Ross, Rebecca L; Caballero-Ruiz, Begoña; Clarke, Emily L; Kakkar, Vishal; Wasson, Christopher W; Mulipa, Panji; De Lorenzis, Enrico; ... Del Galdo, Francesco; + view all (2024) Biological hallmarks of systemic sclerosis are present in the skin and serum of patients with Very Early Diagnosis of SSc (VEDOSS). Rheumatology 10.1093/rheumatology/keae698. (In press). Green open access
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Roth, Eliane; Bruni, Cosimo; Petelytska, Liubov; Becker, Mike Oliver; Dobrota, Rucsandra; Jordan, Suzana; Mihai, Carina; ... EUSTAR collaborators; + view all (2025) Gastroesophageal reflux disease is associated with a more severe interstitial lung disease in systemic sclerosis in the EUSTAR cohort. Rheumatology 10.1093/rheumatology/keaf016. (In press). Green open access
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Rothwell, S; Cooper, RG; Lundberg, IE; Gregersen, PK; Hanna, MG; Machado, PM; Herbert, MK; ... Chinoy, H; + view all (2017) Immune-Array Analysis in Sporadic Inclusion Body Myositis Reveals HLA-DRB1 Amino Acid Heterogeneity Across the Myositis Spectrum. Arthritis & Rheumatology , 69 (5) pp. 1090-1099. 10.1002/art.40045. Green open access
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Ryerson, CJ; Denton, CP; (2017) The Fine Line Between Success and Failure in Scleroderma Lung Fibrosis Trials. American Journal of Respiratory and Critical Care Medicine , 197 (5) pp. 553-554. 10.1164/rccm.201711-2268ED. Green open access
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S. Rapoport, C; Choi, AK; Kwakkenbos, L; Carrier, ME; Henry, RS; Mouthon, L; Roesch, SC; ... Marie, I; + view all (2023) Evaluation of Measurement Properties and Differential Item Functioning in the English and French Versions of the University of California, Los Angeles, Loneliness Scale-6: A Scleroderma Patient-Centered Intervention Network (SPIN) Study. Arthritis Care and Research 10.1002/acr.25115. (In press). Green open access
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Sabanovic, Hana; Pauling, John D; Baron, Murray; Clemens, Laurence; Del Galdo, Francesco; Denton, Christopher P; Distler, Oliver; ... Ross, Laura; + view all (2025) 'Am I doing this right?' Physician perceptions of the global assessment in clinical trials of systemic sclerosis. Rheumatology , Article keaf377. 10.1093/rheumatology/keaf377. (In press). Green open access
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Saracino, Amanda M; Kelberman, Daniel; Otto, Georg W; Gagunashvili, Andrey; Abraham, David J; Denton, Christopher P; (2023) Unravelling morphoea aetiopathogenesis by next-generation sequencing of paired skin biopsies. Archives of Dermatological Research 10.1007/s00403-023-02541-5. (In press). Green open access
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Saracino, AM; Denton, CP; Orteu, CH; (2017) The molecular pathogenesis of morphoea: from genetics to future treatment targets. British Journal of Dermatology , 177 (1) pp. 34-46. 10.1111/bjd.15001. Green open access
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Saracino, AM; George, C; Nihtyanova, SI; Denton, CP; (2020) Comparing paediatric- and adult-onset linear morphoea in a large tertiary-referral scleroderma centre. Journal of Scleroderma and Related Disorders 10.1177/2397198320925684. (In press). Green open access
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Saunders, P; Tsipouri, V; Keir, GJ; Ashby, D; Flather, MD; Parfrey, H; Babalis, D; ... Maher, TM; + view all (2017) Rituximab versus cyclophosphamide for the treatment of connective tissue disease-associated interstitial lung disease (RECITAL): study protocol for a randomised controlled trial. Trials , 18 , Article 275. 10.1186/s13063-017-2016-2. Green open access
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Schwaiger, JP; Knight, DS; Kaier, T; Gallimore, A; Denton, CP; Schreiber, BE; Handler, C; (2017) Two-dimensional knowledge-based volumetric reconstruction of the right ventricle documents short-term improvement in pulmonary hypertension. Echocardiography , 34 (6) pp. 817-824. 10.1111/echo.13541. Green open access
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Schwaiger, JP; Loder, CD; Dobarro, D; Kaier, T; Reddecliffe, S; Schreiber, BE; Handler, C; ... Coghlan, JG; + view all (2017) Optical coherence tomography evaluation of pulmonary arterial vasculopathy in Systemic Sclerosis. Scientific Reports , 7 , Article 43304. 10.1038/srep43304. Green open access
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Seibold, JR; Wigley, FM; Schiopu, E; Denton, CP; Silver, RM; Steen, VD; Domsic, R; ... Rollins, K; + view all (2017) Digital ulcers in SSc treated with oral treprostinil: A randomized, double-blind, placebo-controlled study with open-label follow-up. Journal of Scleroderma and Related Disorders , 2 (1) pp. 42-49. 10.5301/jsrd.5000232. Green open access
file

Sha, M; Griffin, M; Denton, CP; Butler, PE; (2019) Sidestream Dark Field (SDF) imaging of oral microcirculation in the assessment of systemic sclerosis. [Letter]. Microvascular Research , 126 , Article 103890. 10.1016/j.mvr.2019.103890. Green open access
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Shah, Shivani; Denton, Christopher P; (2022) Scleroderma autoantibodies in guiding monitoring and treatment decisions. Current Opinion in Rheumatology , 34 (6) pp. 302-310. 10.1097/BOR.0000000000000904. Green open access
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Shi-wen, X; Liu, SX; Eastwood, M; Sonnylal, S; Denton, CP; Abraham, DJ; Leask, A; (2009) Rac Inhibition Reverses the Phenotype of Fibrotic Fibroblasts. PLOS ONE , 4 (10) , Article e7438. 10.1371/journal.pone.0007438. Green open access
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Shiwen, X; Stratton, R; Nikitorowicz-Buniak, J; Ahmed-Abdi, B; Ponticos, M; Denton, C; Abraham, D; ... Smith, BD; + view all (2015) A Role of Myocardin Related Transcription Factor-A (MRTF-A) in Scleroderma Related Fibrosis. PLoS One , 10 (5) , Article e0126015. 10.1371/journal.pone.0126015. Green open access
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Simonneau, G; Montani, D; Celermajer, DS; Denton, CP; Gatzoulis, MA; Krowka, M; Williams, PG; (2018) Haemodynamic definitions and updated clinical classification of pulmonary hypertension. European Respiratory Journal 10.1183/13993003.01913-2018. Green open access
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Smith, Vanessa; Denton, Christopher P; Herrick, Ariane L; Ittrich, Carina; Alves, Margarida; Cutolo, Maurizio; (2025) Nailfold capillaroscopy in patients with systemic sclerosis-associated interstitial lung disease: a substudy of the SENSCIS trial. RMD Open: Rheumatic and Musculoskeletal Diseases , 11 (4) , Article e005704. 10.1136/rmdopen-2025-005704. Green open access
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Smith, V; Herrick, AL; Ingegnoli, F; Damjanov, N; Angelis; Denton, CP; Distler, O; ... EULAR Study Group on Microcirculation in Rheumatic Diseases and; + view all (2020) Standardisation of nailfold capillaroscopy for the assessment of patients with Raynaud's phenomenon and systemic sclerosis. Autoimmunity Reviews , Article 102458. 10.1016/j.autrev.2020.102458. (In press). Green open access
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Smith, V; Vanhaecke, A; Herrick, AL; Distler, O; Guerra, MG; Denton, CP; Deschepper, E; ... EULAR Study Group on Microcirculation in Rheumatic Diseases; + view all (2019) Fast track algorithm: How to differentiate a "scleroderma pattern" from a "non-scleroderma pattern". Autoimmunity Reviews , Article 102394. 10.1016/j.autrev.2019.102394. (In press). Green open access
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Sobanski, V; Giovannelli, J; Allanore, Y; Riemekasten, G; Airo, P; Vettori, S; Cozzi, F; ... Poindron, V; + view all (2019) Phenotypes Determined by Cluster Analysis and Their Survival in the Prospective European Scleroderma Trials and Research Cohort of Patients With Systemic Sclerosis. Arthritis & Rheumatology , 71 (9) pp. 1553-1570. 10.1002/art.40906. Green open access
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Sobanski, V; Giovannelli, J; Lynch, BM; Schreiber, BE; Nihtyanova, SI; Harvey, J; Handler, CE; ... Coghlan, JG; + view all (2016) Characteristics and Survival of Anti-U1 RNP Antibody-Positive Patients With Connective Tissue Disease-Associated Pulmonary Arterial Hypertension. Arthritis & Rheumatology , 68 (2) pp. 484-493. 10.1002/art.39432. Green open access
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Spiera, Robert; Kuwana, Masataka; Khanna, Dinesh; Hummers, Laura; Frech, Tracy M; Stevens, Wendy; Matucci-Cerinic, Marco; ... RESOLVE-1 Study Group; + view all (2023) Efficacy and Safety of Lenabasum, a Cannabinoid Type 2 Receptor Agonist, in a Phase 3 Randomized Trial in Diffuse Cutaneous Systemic Sclerosis. Arthritis & Rheumatology 10.1002/art.42510. (In press). Green open access
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Spiera, R; Khanna, D; Kuwana, M; Furst, DE; Frech, TM; Hummers, L; Stevens, W; ... Denton, CP; + view all (2021) A randomised, double-blind, placebo-controlled phase 3 study of lenabasum in diffuse cutaneous systemic sclerosis: RESOLVE-1 design and rationale. Clinical and Experimental Rheumatology , 39 (4) S124-S133. Green open access
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Spierings, J; Bandini, G; Allanore, Y; Papa, ND; Denton, CP; Distler, O; Furst, DE; ... Hughes, M; + view all (2025) Management of disease progression after autologous hematopoietic stem cell transplantation in systemic sclerosis: Results from an international questionnaire-based study. Seminars in Arthritis and Rheumatism , 71 , Article 152638. 10.1016/j.semarthrit.2025.152638. Green open access
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Spierings, J; Nihtyanova, SI; Derrett-Smith, E; Clark, KEN; van Laar, JM; Ong, V; Denton, CP; (2022) Outcomes linked to eligibility for stem cell transplantation trials in diffuse cutaneous systemic sclerosis. Rheumatology , 61 (5) pp. 1948-1956. 10.1093/rheumatology/keab604. Green open access
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Spierings, Julia; Ong, Voon H; Denton, Christopher P; (2022) Three Cases of Systemic Sclerosis Within One Family With Different Antibodies and Clinical Features. The Journal of Rheumatology , 49 (5) pp. 544-546. 10.3899/jrheum.211139. Green open access
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Spierings, Julia; Welsing, Paco MJ; Colak, Seda; Quah, Helen; Del Galdo, Francesco; Herrick, Ariane L; Hughes, Michael; ... Denton, Christopher P; + view all (2025) Self-reported skin severity and quality of life in systemic sclerosis: multicentre validation of PASTUL. Rheumatology , 64 (5) pp. 2802-2809. 10.1093/rheumatology/keae561. Green open access
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Spierings, J; Ong, V; Denton, CP; (2021) PASTUL questionnaire: a tool for self-assessment of scleroderma skin during the COVID-19 pandemic. Annals of the Rheumatic Diseases 10.1136/annrheumdis-2020-219775. (In press). Green open access
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Stern, Edward P; Host, Lauren V; Wanjiku, Ivy; Escott, K Jane; Gilmour, Peter S; Ochiel, Rachel; Unwin, Robert; ... Denton, Christopher P; + view all (2022) Zibotentan in systemic sclerosis-associated chronic kidney disease: a phase II randomised placebo-controlled trial. Arthritis Research and Therapy , 24 , Article 130. 10.1186/s13075-022-02818-6. Green open access
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Stern, EP; Guerra, SG; Chinque, H; Acquaah, V; González-Serna, D; Ponticos, M; Martin, J; ... Denton, CP; + view all (2020) Analysis of anti-RNA polymerase III antibody positive systemic sclerosis suggests altered GPATCH2L and CTNND2 expression in scleroderma renal crisis. The Journal of Rheumatology , 47 (3) , Article 190945. 10.3899/jrheum.190945. Green open access
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Stern, EP; Unwin, R; Burns, A; Ong, VH; Denton, CP; (2021) Exploring molecular pathology of chronic kidney disease in systemic sclerosis by analysis of urinary and serum proteins. Rheumatology Advances in Practice , 5 (1) , Article rkaa083. 10.1093/rap/rkaa083. Green open access
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Stock, Carmel JW; Nan, Yang; Fang, Yingying; Kokosi, Maria; Kouranos, Vasilios; George, Peter M; Chua, Felix; ... Renzoni, Elisabetta A; + view all (2024) Deep-learning CT imaging algorithm to detect usual interstitial pneumonia pattern in patients with systemic sclerosis-associated interstitial lung disease: association with disease progression and survival. Rheumatology 10.1093/rheumatology/keae571. (In press). Green open access
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Stock, CJW; Hoyles, RK; Daccord, C; Kokosi, M; Visca, D; De Lauretis, A; Alfieri, V; ... Renzoni, EA; + view all (2021) Serum markers of pulmonary epithelial damage in systemic sclerosis-associated interstitial lung disease and disease progression. Respirology , 26 (5) pp. 461-468. 10.1111/resp.13988. Green open access
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Stock, CJ; Conti, C; Montero-Fernandez, Á; Caramori, G; Molyneaux, PL; George, PM; Kokosi, M; ... Renzoni, EA; + view all (2020) Interaction between the promoter MUC5B polymorphism and mucin expression: is there a difference according to ILD subtype? Thorax 10.1136/thoraxjnl-2020-214579. (In press). Green open access
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Stock, CJW; De Lauretis, A; Visca, D; Daccord, C; Kokosi, M; Kouranos, V; Margaritopoulos, G; ... Renzoni, EA; + view all (2020) Defining genetic risk factors for scleroderma-associated interstitial lung disease. Clinical Rheumatology 10.1007/s10067-019-04922-6. (In press). Green open access
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Stratton, R; Taki, Z; Denton, C; Ahmed Abdi, B; (2020) Pathogenic Activation of Mesenchymal Stem Cells is induced by the Disease Microenvironment in Systemic Sclerosis. Arthritis and Rheumatology , 72 (8) pp. 1361-1374. 10.1002/art.41267. Green open access
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Suleman, Y; Clark, KEN; Cole, AR; Ong, VH; Denton, CP; (2021) Real-world experience of Tocilizumab in systemic sclerosis: potential benefit on lung function for anti-topoisomerase (ATA) positive patients. Rheumatology , 60 (8) pp. 3945-3946. 10.1093/rheumatology/keab273. Green open access
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Suliman, Yossra A; Campochiaro, Corrado; Hughes, Michael; Schoones, Jan W; Giuggioli, Dilia; Moinzadeh, Pia; Baron, Murray; ... Alunno, Alessia; + view all (2023) Surgical management of digital ulcers in systemic sclerosis: A systematic literature review. Seminars in Arthritis and Rheumatism , 63 , Article 152266. 10.1016/j.semarthrit.2023.152266. Green open access
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Suliman, YA; Bruni, C; Johnson, SR; Praino, E; Alemam, M; Borazan, N; Cometi, L; ... Furst, DE; + view all (2017) Defining Skin Ulcers in Systemic Sclerosis: Systematic Literature Review and Proposed World Scleroderma Foundation (WSF) Definition. Journal of Scleroderma and Related Disorders , 2 (2) pp. 115-120. 10.5301/jsrd.5000236. Green open access
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Taher, TE; Ong, VH; Bystrom, J; Hillion, S; Simon, Q; Denton, CP; Pers, JO; ... Mageed, RA; + view all (2018) Association of Defective Regulation of Autoreactive Interleukin‐6–Producing Transitional B Lymphocytes With Disease in Patients With Systemic Sclerosis. Arthritis and Rheumatology , 70 (3) pp. 450-461. 10.1002/art.40390. Green open access
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Tam, Angela YY; Khan, Korsa; Xu, Shiwen; Bergin, Marianne; Huang, Linghong; Arroyo Colon, Erik; Cheng, Danyi; ... Abraham, David J; + view all (2025) Critical role for Transglutaminase 2 in scleroderma skin fibrosis and in the development of dermal sclerosis in a mouse model of scleroderma. Arthritis & Rheumatology 10.1002/art.43104. (In press). Green open access
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Tam, AYY; Horwell, AL; Trinder, SL; Khan, K; Xu, S; Ong, V; Denton, CP; ... Abraham, DJ; + view all (2021) Selective deletion of Connective Tissue Growth Factor attenuates experimentally -induced pulmonary fibrosis and pulmonary arterial hypertension. The International Journal of Biochemistry & Cell Biology , Article 105961. 10.1016/j.biocel.2021.105961. (In press). Green open access
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Taroni, JN; Greene, CS; Martyanov, V; Wood, TA; Christmann, RB; Farber, HW; Lafyatis, RA; ... Whitfield, ML; + view all (2017) A novel multi-network approach reveals tissue-specific cellular modulators of fibrosis in systemic sclerosis. Genome Medicine , 9 (1) , Article 27. 10.1186/s13073-017-0417-1. Green open access
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Teles, Carolina; Liyanage, Chiranthi Kongala; Chow, Geoffrey; Denton, Christopher P; Ong, Voon; (2023) Relapsing polychondritis in systemic sclerosis: A rare vasculitic mimic. Journal of Scleroderma and Related Disorders 10.1177/23971983221141599. (In press). Green open access
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Tornling, Göran; Batta, Rohit; Salvail, Dan; Raud, Johan; Denton, Christopher P; (2023) Effects of the Oral Angiotensin II Type 2 Receptor Agonist C21 in Sugen-Hypoxia Induced Pulmonary Hypertension in Rats. International Journal of Molecular Sciences , 24 (8) , Article 7478. 10.3390/ijms24087478. Green open access
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Tornling, Göran; Edenius, Charlotte; Pauling, John D; Denton, Christopher P; Olsson, Anna; Kowalski, Jan; Murray, Andrea; ... Herrick, Ariane L; + view all (2024) A phase 2 trial investigating the efficacy and safety of the mPGES-1 inhibitor vipoglanstat in systemic sclerosis-related Raynaud's. Rheumatology , Article keae049. 10.1093/rheumatology/keae049. (In press). Green open access
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Valentini, G; Huscher, D; Riccardi, A; Fasano, S; Irace, R; Messiniti, V; Matucci-Cerinic, M; ... Müeller-Ladner, U; + view all (2019) Vasodilators and low-dose acetylsalicylic acid are associated with a lower incidence of distinct primary myocardial disease manifestations in systemic sclerosis: results of the DeSScipher inception cohort study. Annals of the Rheumatic Diseases , 78 (11) pp. 1576-1582. 10.1136/annrheumdis-2019-215486. Green open access
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Valentini, G; Ludici, M; Walker, UA; Jaeger, VK; Baron, M; Carreira, P; Czirják, L; ... Allanore, Y; + view all (2017) The European Scleroderma Trials and Research group (EUSTAR) task force for the development of revised activity criteria for systemic sclerosis: derivation and validation of a preliminarily revised EUSTAR activity index. Annals of the Rheumatic Diseases , 76 (1) pp. 270-276. 10.1136/annrheumdis-2016-209768. Green open access
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Vanhaecke, Amber; Cutolo, Maurizio; Distler, Oliver; Riccieri, Valeria; Allanore, Yannick; Denton, Christopher P; Hachulla, Eric; ... EULAR Study Group on Microcirculation in Rheumatic Diseases., .; + view all (2022) Nailfold capillaroscopy in SSc: innocent bystander or promising biomarker for novel severe organ involvement/progression? Rheumatology , 61 (11) pp. 4384-4396. 10.1093/rheumatology/keac079. Green open access
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Villanueva-Martin, Gonzalo; Acosta-Herrera, Marialbert; Kerick, Martin; López-Isac, Elena; Simeón, Carmen P; Callejas, José L; Assassi, Shervin; ... Bossini-Castillo, Lara; + view all (2022) The Effect of Body Fat Distribution on Systemic Sclerosis. Journal of Clinical Medicine , 11 (20) , Article 6014. 10.3390/jcm11206014. Green open access
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Volkmann, Elizabeth R; Assassi, Shervin; Denton, Christopher P; Simonovska, Rozeta; Sambevski, Steven; Alves, Margarida; Bernstein, Elana J; (2025) Open Access Outcomes in Systemic Sclerosis-Associated Interstitial Lung Disease Based on Serological Profiles: Focus on Anti-Centromere and Anti-RNA Polymerase III Antibodies. Journal of Rheumatology 10.3899/jrheum.2024-1063. (In press).

Volkmann, Elizabeth R; Denton, Christopher P; Kolb, Martin; Wijsenbeek-Lourens, Marlies S; Emson, Claire; Hudson, Krischan; Amatucci, Anthony J; ... Khanna, Dinesh; + view all (2024) Lysophosphatidic acid receptor 1 inhibition: a potential treatment target for pulmonary fibrosis. European Respiratory Review , 33 (172) , Article 240015. 10.1183/16000617.0015-2024. Green open access
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Volkmann, Elizabeth R; Kreuter, Michael; Hoffmann-Vold, Anna M; Wijsenbeek, Marlies; Smith, Vanessa; Khanna, Dinesh; Denton, Christopher P; ... SENSCIS trial investigators; + view all (2022) Dyspnoea and cough in patients with systemic sclerosis-associated interstitial lung disease in the SENSCIS trial. Rheumatology , Article keac091. 10.1093/rheumatology/keac091. (In press). Green open access
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Vreeburg, Yumiko L; Knight, Daniel S; Coghlan, John G; Ong, Voon H; Denton, Christopher P; (2023) Recurrent episodes of Takotsubo cardiomyopathy in systemic sclerosis. Journal of Scleroderma and Related Disorders 10.1177/23971983231188824. (In press). Green open access
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Wasson, Christopher W; Dibb, Sophie L; Caballero-Ruiz, Begoña; Bamigbola, Ifeoluwa E; Di Donato, Stefano; Madourie-Clavane, Eva M; Wells, Rebecca; ... Del Galdo, Francesco; + view all (2025) Transforming growth factor beta (TGF-β) induces type 1 interferon signalling in systemic sclerosis keratinocytes through the chloride intracellular channel 4 (CLIC4). Arthritis Res Ther , 27 , Article 173. 10.1186/s13075-025-03632-6. Green open access
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Wasson, CW; Caballero-Ruiz, B; Gillespie, J; Derrett-Smith, E; Mankouri, J; Denton, CP; Canettieri, G; ... Del Galdo, F; + view all (2022) Induction of Pro-Fibrotic CLIC4 in Dermal Fibroblasts by TGF-β/Wnt3a Is Mediated by GLI2 Upregulation. Cells , 11 (3) , Article 530. 10.3390/cells11030530. Green open access
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Weibel, L; Theiler, M; Howell, KJ; Denton, CP; Waelchli, R; Atherton, D; Woo, P; (2020) Prospective evaluation of treatment response and disease reversibility of paediatric localized scleroderma (morphoea) to steroids and methotrexate using multi-modal imaging. Journal of the European Academy of Dermatology and Venereology , 34 (7) pp. 1609-1616. 10.1111/jdv.16308. Green open access
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Wells, A; Denton, CP; (2019) Pulmonary Complications of Connective Tissue Disease. Seminars in Respiratory and Critical Care Medicine , 40 (2) pp. 145-146. 10.1055/s-0039-1688716. Green open access
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Wells, A; Devaraj, A; Renzoni, EA; Denton, CP; (2019) Multidisciplinary Evaluation in Patients with Lung Disease Associated with Connective Tissue Disease. Seminars in Respiratory and Critical Care Medicine , 40 (2) pp. 184-193. 10.1055/s-0039-1684020. Green open access
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Werner, Franziska; Prentki Santos, Estefania; Michel, Konstanze; Schrader, Hanna; Völker, Katharina; Potapenko, Tamara; Krebes, Lisa; ... Kuhn, Michaela; + view all (2023) Ablation of C-type natriuretic peptide/cGMP signaling in fibroblasts exacerbates adverse cardiac remodeling in mice. JCI Insight 10.1172/jci.insight.160416. (In press). Green open access
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White, Barbara; Furst, Daniel E; Frech, Tracy M; Kuwana, Masataka; Hummers, Laura; Stevens, Wendy; Kafaja, Suzanne; ... RESOLVE‐1 investigators; + view all (2025) Comparative Efficacy of Immunosuppressive Therapies in the Treatment of Diffuse Cutaneous Systemic Sclerosis. ACR Open Rheumatology , 7 (3) , Article e70004. 10.1002/acr2.70004. Green open access
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Wijsenbeek, M; Kreuter, M; Olson, A; Fischer, A; Bendstrup, E; Wells, CD; Denton, CP; ... Cottin, V; + view all (2019) Progressive Fibrosing Interstitial Lung Diseases: Current Practice in Diagnosis and Management. Current Medical Research and Opinion , 35 (11) pp. 2015-2024. 10.1080/03007995.2019.1647040. Green open access
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Wilkinson, JD; Leggett, SA; Marjanovic, EJ; Moore, TL; Allen, J; Anderson, ME; Britton, J; ... Murray, AK; + view all (2018) A multicentre study of validity and reliability of responses to hand cold challenge as measured by laser speckle contrast imaging and thermography: outcome measures for systemic sclerosis-related Raynaud's phenomenon. Arthritis Rheumatology , 70 (6) pp. 903-911. 10.1002/art.40457. Green open access
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Wojeck, RK; Knisely, MR; Bailey, DE; Somers, TJ; Kwakkenbos, L; Carrier, ME; Nielson, WR; ... Varga, J; + view all (2023) Patterns of patient-reported symptoms and association with sociodemographic and systemic sclerosis disease characteristics: a scleroderma Patient-centered Intervention Network (SPIN) Cohort cross-sectional study. eClinicalMedicine , 62 , Article 102104. 10.1016/j.eclinm.2023.102104. Green open access
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Wollin, L; Distler, JHW; Denton, CP; Gahlemann, M; (2019) Rationale for the evaluation of nintedanib as a treatment for systemic sclerosis–associated interstitial lung disease. Journal of Scleroderma and Related Disorders 10.1177/2397198319841842. (In press). Green open access
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Wu, W; Jordan, S; Graf, N; Pena, J; Curram, J; Allanore, Y; Matucci-Cerinic, M; ... Distler, O; + view all (2019) Progression of Skin Fibrosis Is Associated with Decline in Lung Function in Patients with Diffuse Cutaneous Systemic Sclerosis: A European Scleroderma Trials and Research (EUSTAR) Analysis. Annals of the Rheumatic Diseases 10.1136/annrheumdis-2018-213455. Green open access
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Xanthouli, Panagiota; Uesbeck, Paul; Lorenz, Hanns-Martin; Blank, Norbert; Eichstaedt, Christina A; Harutyunova, Satenik; Egenlauf, Benjamin; ... Benjamin, Nicola; + view all (2024) Effect of ambrisentan in patients with systemic sclerosis and mild pulmonary arterial hypertension: long-term follow-up data from EDITA study. Arthritis Research & Therapy , 26 (1) , Article 136. 10.1186/s13075-024-03363-0. Green open access
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Xu, SW; Chen, YL; Denton, CP; Eastwood, M; Renzoni, EA; Bou-Gharios, G; Pearson, JD; ... Abraham, DJ; + view all (2004) Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts. MOL BIOL CELL , 15 (6) 2707 - 2719. 10.1091/mbc.E03-12-0902. Green open access
file

Yaseen, B; Lopez, H; Taki, Z; Zafar, S; Rosario, H; Abdi, BA; Vigneswaran, S; ... Stratton, R; + view all (2020) Interleukin-31 promotes pathogenic mechanisms underlying skin and lung fibrosis in scleroderma. Rheumatology , 59 (9) pp. 2625-2636. 10.1093/rheumatology/keaa195. Green open access
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Yu, Lan; Domsic, Robyn T; Saketkoo, Lesley-Ann; Withey, Jane; Frech, Tracy M; Herrick, Ariane L; Hummers, Laura K; ... Pauling, John D; + view all (2023) The Assessment of Systemic sclerosis-associated RAynaud's Phenomenon (ASRAP) questionnaire: Item Bank and Short Form Development. Arthritis Care & Research , 75 (8) pp. 1725-1734. 10.1002/acr.25038. Green open access
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Proceedings paper

Alyousef, AA; Nihtyanova, S; Denton, CP; Bosoni, P; Bellazzi, R; Tucker, A; (2019) Latent class multi-label classification to identify subclasses of disease for improved prediction. In: Proceedings of the 2019 IEEE 32nd International Symposium on Computer-Based Medical Systems (CBMS). (pp. pp. 535-538). IEEE Green open access
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Thesis

Quillinan, NP; (2016) Treatment of Diffuse Cutaneous Systemic Sclerosis with Hyperimmune Caprine Serum. Doctoral thesis , UCL (University College London). Green open access
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Saracino, Amanda; (2020) The molecular aetiopathogenesis of adult morphoea. Doctoral thesis (Ph.D), UCL (University College London). Green open access
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This list was generated on Sun Jan 11 07:32:58 2026 GMT.