UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Interaction between the promoter MUC5B polymorphism and mucin expression: is there a difference according to ILD subtype?

Stock, CJ; Conti, C; Montero-Fernandez, Á; Caramori, G; Molyneaux, PL; George, PM; Kokosi, M; ... Renzoni, EA; + view all (2020) Interaction between the promoter MUC5B polymorphism and mucin expression: is there a difference according to ILD subtype? Thorax 10.1136/thoraxjnl-2020-214579. (In press). Green open access

[thumbnail of UCL upload file MUC5B polymorphism and mucin expression-CS accepted Thorax 2020.pdf]
Preview
Text
UCL upload file MUC5B polymorphism and mucin expression-CS accepted Thorax 2020.pdf - Accepted Version

Download (743kB) | Preview

Abstract

The MUC5B promoter variant rs35705950 is associated with idiopathic pulmonary fibrosis (IPF). MUC5B glycoprotein is overexpressed in IPF lungs. We examined immunohistochemical expression of MUC5B in different interstitial lung disease patterns according to rs35705950 T-allele carriage. We observed increased expression of MUC5B in T-allele carriers in both distal airways and honeycomb cysts in patients with IPF (n=23), but no difference in MUC5B expression according to T-carrier status in the distal airways of patients with idiopathic non-specific interstitial pneumonitis (n=17), in scleroderma-associated non-specific interstitial pneumonitis (n=15) or in control lungs (n=20), suggesting that tissue overexpression in MUC5B rs35705950 T-carriers is specific to IPF.

Type: Article
Title: Interaction between the promoter MUC5B polymorphism and mucin expression: is there a difference according to ILD subtype?
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1136/thoraxjnl-2020-214579
Publisher version: https://doi.org/10.1136/thoraxjnl-2020-214579
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
URI: https://discovery.ucl.ac.uk/id/eprint/10102985
Downloads since deposit
208Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item