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Whole blood gene expression profiling distinguishes systemic sclerosis-overlap syndromes from other subsets

Moinzadeh, P; Frommolt, P; Franitza, M; Toliat, MR; Becker, K; Nürnberg, P; Nihtyanova, SI; ... Krieg, T; + view all (2020) Whole blood gene expression profiling distinguishes systemic sclerosis-overlap syndromes from other subsets. Journal of the European Academy of Dermatology and Venereology , 34 (5) e236-e238. 10.1111/jdv.16198. Green open access

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Abstract

Among autoimmune rheumatic diseases, systemic sclerosis (SSc) is especially challenging due to its clinical diversity, reflected by the extent of skin and internal organ involvement 1 . Besides the two major subsets, limited and diffuse SSc (lcSSc, dcSSc), a substantial number of SSc cases exhibit overlap features of another rheumatic disease, summarized as SSc-overlap syndromes. A few of these are already well characterized by their specific clinical course and circulating antibodies (e.g., mixed connective tissue disease, polymyositis-scleroderma syndrome).

Type: Article
Title: Whole blood gene expression profiling distinguishes systemic sclerosis-overlap syndromes from other subsets
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/jdv.16198
Publisher version: https://doi.org/10.1111/jdv.16198
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: SSc, SSc-overlap, gene expression, systemic sclerosis
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
URI: https://discovery.ucl.ac.uk/id/eprint/10090432
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