UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Sidestream Dark Field (SDF) imaging of oral microcirculation in the assessment of systemic sclerosis

Sha, M; Griffin, M; Denton, CP; Butler, PE; (2019) Sidestream Dark Field (SDF) imaging of oral microcirculation in the assessment of systemic sclerosis. [Letter]. Microvascular Research , 126 , Article 103890. 10.1016/j.mvr.2019.103890. Green open access

[thumbnail of Oral microcirculation SSc-2019-UCL reprint Letter to the Editor.pdf]
Preview
Text
Oral microcirculation SSc-2019-UCL reprint Letter to the Editor.pdf - Accepted Version

Download (247kB) | Preview

Abstract

Introduction Systemic sclerosis (SSc) is a systemic disease characterised by abnormalities in small blood vessels, skin and organ fibrosis. It is assessed using generalised skin thickening scores, autoantibodies and nailfold capillaroscopy. Sidestream Dark Field imaging (SDF) is a non-invasive imaging tool that assesses microcirculation. This study aims to investigate the potential of using SDF as a diagnostic tool in SSc. Method Oral microcirculation of 20 patients with SSc was compared to 20 age and gender matched controls using SDF imaging. Sublingual, buccal and incisor regions of the mouth were examined. All volunteers were female averaging 48.0 (24–64) years old. Vasculature was assessed by calculating the De Backer score and Functional Capillary Density (FCD) on an imaging software. Results At all regions of the mouth, SSc patients had a significantly lower De Backer score compared to controls (SSc 3.484 ± 0.1361/mm vs Control 5.184 ± 0.1896/mm, unpaired t-test p < 0.0001). The SSc patients showed significantly lower FCDs compared to controls at all areas as well (SSc 19.65 ± 0.9445% vs Control 29.45 ± 1.681%, unpaired t-test, p < 0.0001). The incisor regions had significantly higher De Backer and FCD scores than buccal and sublingual regions in both control and SSc patients (one way anova, p < 0.05). De Backer/FCD scores showed significant correlation against Rodnan Skin Scores in patients with SSc (Pearson correlation, p < 0.05). Conclusions SSc patients showed decreased oral vasculature compared to controls. SDF imaging has shown the ability to be a useful diagnostic tool in the assessment of SSc.

Type: Article
Title: Sidestream Dark Field (SDF) imaging of oral microcirculation in the assessment of systemic sclerosis
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.mvr.2019.103890
Publisher version: https://doi.org/10.1016/j.mvr.2019.103890
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Sidestream Dark Field imaging, Microcirculation, Vasospasm, Scleroderma, Fibrosis, Oral mucosa
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
URI: https://discovery.ucl.ac.uk/id/eprint/10077954
Downloads since deposit
91Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item