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Current and future outlook on disease modification and defining low disease activity in systemic sclerosis

Nagaraja, V; Cerinic, M-M; Furst, DE; Kuwana, M; Allanore, Y; Denton, CP; Raghu, G; ... Khanna, D; + view all (2020) Current and future outlook on disease modification and defining low disease activity in systemic sclerosis. Arthritis and Rheumatology , 72 (7) pp. 1049-1058. 10.1002/art.41246. Green open access

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Abstract

Systemic sclerosis (SS c) is an autoimmune rheumatic disease with heterogeneous clinical manifestations and a variable course in which the severity of the pathology dictates the disease prognosis and course. Among autoimmune rheumatic diseases, SS c has the highest mortality rate among all rheumatic diseases, though there are exciting new therapeutic targets that appear to halt the progression of SS c manifestations such as skin or lung fibrosis. In selected patients, high‐intensity regimens with autologous stem cell transplantation can favorably modify the course. In what was once thought to be an untreatable disease, targeted therapies have now changed the outlook of SS c to a treatable disorder. Herein, we discuss the targeted therapies modifying the outlook on selected organ involvement and creating opportunities for future treatment. We also present a framework for defining low disease activity in SS c.

Type: Article
Title: Current and future outlook on disease modification and defining low disease activity in systemic sclerosis
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/art.41246
Publisher version: https://doi.org/10.1002/art.41246
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
URI: https://discovery.ucl.ac.uk/id/eprint/10093205
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