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The molecular pathogenesis of morphoea: from genetics to future treatment targets

Saracino, AM; Denton, CP; Orteu, CH; (2017) The molecular pathogenesis of morphoea: from genetics to future treatment targets. British Journal of Dermatology , 177 (1) pp. 34-46. 10.1111/bjd.15001. Green open access

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Abstract

A number of immunoinflammatory and profibrotic mechanisms are recognised in the pathogenesis of broad sclerotic skin processes, and more specifically, morphoea. However, precise aetiopathogenesis is complex and remains unclear. Morphoea is clinically heterogeneous, with variable anatomical patterning, depth of tissue involvement, and sclerotic, inflammatory, atrophic and dyspigmented morphology. Underlying mechanisms determining these reproducible clinical subsets are poorly understood, but of great clinical and therapeutic relevance. Regional susceptibility mechanisms (such as environmental triggers, mosaicism and positional identity) together with distinct pathogenic determinants (including innate, adaptive and imbalanced pro and anti-fibrotic signaling pathways) are likely implicated. In the age of genetic profiling and personalised medicine, improved characterisation of the environmental, systemic, local, genetic and immunopathologic factors underpinning morphoea pathogenesis, may open the door to novel targeted therapeutic approaches. This article is protected by copyright. All rights reserved.

Type: Article
Title: The molecular pathogenesis of morphoea: from genetics to future treatment targets
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/bjd.15001
Publisher version: http://doi.org/10.1111/bjd.15001
Language: English
Additional information: © 2016 British Association of Dermatologists. This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
URI: https://discovery.ucl.ac.uk/id/eprint/1508701
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