UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Systemic sclerosis phase III clinical trials: Hope on the horizon?

Aringer, M; Denton, CP; (2018) Systemic sclerosis phase III clinical trials: Hope on the horizon? Journal of Scleroderma and Related Disorders , 3 (3) pp. 193-200. 10.1177/2397198318775353. Green open access

[thumbnail of Systemic sclerosis phase III clinical trials-accepted ms UCL.pdf]
Preview
Text
Systemic sclerosis phase III clinical trials-accepted ms UCL.pdf - Accepted Version

Download (548kB) | Preview

Abstract

While significant progress has been made in treating systemic sclerosis, many patients still have an outcome that is far from satisfactory. For the first time in history, several drugs are now in phase III randomized controlled trials. Approaches tested include the anti-B cell antibody rituximab, the anti-interleukin-6 receptor antibody tocilizumab, the antifibrotic drugs nintedanib and pirfenidone, and the cannabinoid receptor mimetic lenabasum. That all these drugs are in advanced clinical trials despite the relatively low incidence of the disease therefore is good news. Not only is there realistic hope that at least some of the approaches will work, this also indicates growing industry interest, for most of the trials are company-sponsored. This review attempts to delineate the ongoing trials and to summarize the underlying evidence of these candidate systemic sclerosis drugs.

Type: Article
Title: Systemic sclerosis phase III clinical trials: Hope on the horizon?
Open access status: An open access version is available from UCL Discovery
DOI: 10.1177/2397198318775353
Publisher version: https://doi.org/10.1177%2F2397198318775353
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Scleroderma, therapy, inflammatory, fibrotic, B cells, cytokines
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
URI: https://discovery.ucl.ac.uk/id/eprint/10062755
Downloads since deposit
456Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item