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A multicentre study of validity and reliability of responses to hand cold challenge as measured by laser speckle contrast imaging and thermography: outcome measures for systemic sclerosis-related Raynaud's phenomenon

Wilkinson, JD; Leggett, SA; Marjanovic, EJ; Moore, TL; Allen, J; Anderson, ME; Britton, J; ... Murray, AK; + view all (2018) A multicentre study of validity and reliability of responses to hand cold challenge as measured by laser speckle contrast imaging and thermography: outcome measures for systemic sclerosis-related Raynaud's phenomenon. Arthritis Rheumatology , 70 (6) pp. 903-911. 10.1002/art.40457. Green open access

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Abstract

BACKGROUND: Objective and reliable outcome measures to facilitate clinical trials of novel treatments for systemic sclerosis (SSc)-related Raynaud's phenomenon (RP) are badly needed. Laser speckle contrast imaging (LSCI) and thermography are non-invasive measures of perfusion that show excellent potential. The purpose of this multi-centre study was to determine the reliability and validity of a hand cold challenge protocol using LSCI, standard thermography and low-cost mobile phone-based thermography. METHODS: Patients with RP secondary to SSc were recruited from 6 UK tertiary-SSc centres and underwent cold challenge on 2 consecutive days. Changes in cutaneous perfusion/temperature at each visit were imaged simultaneously using LSCI, standard and mobile phone thermography. Measurements included area under reperfusion/rewarming curve (AUC) and maximum perfusion/rewarming (MAX). Test-retest reliability was assessed using intraclass correlation coefficients (ICC). Estimated latent correlations assessed convergent validity of LSCI and thermography. RESULTS: 159 patients were recruited (84% female, 77% limited cutaneous, median age 63.3 years). LSCI and standard thermography both had substantial reliability, ICCs (95%CI) for AUC were 0.67(0.54-0.76) and 0.68(0.58-0.80) respectively, and for MAX were 0.64(0.52-0.75) and 0.72(0.64-0.81) respectively. Very high latent correlations (95% CI) were present for AUCs of LSCI and thermography [0.94(0.87-1.00)], and for AUCs of standard and mobile phone thermography [0.98(0.94-1.00)]. CONCLUSION: This is the first multi-centre study examining reliability and validity of cold challenge using LSCI and thermography in patients with SSc-related RP. LSCI and thermography demonstrated good potential as outcome measures. LSCI, standard and mobile phone thermography had very high convergent validity.

Type: Article
Title: A multicentre study of validity and reliability of responses to hand cold challenge as measured by laser speckle contrast imaging and thermography: outcome measures for systemic sclerosis-related Raynaud's phenomenon
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/art.40457
Publisher version: http://doi.org/10.1002/art.40457
Language: English
Additional information: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
URI: https://discovery.ucl.ac.uk/id/eprint/10044119
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