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Emerging evidence-based therapies for systemic sclerosis

Raja, J; Denton, CP; (2016) Emerging evidence-based therapies for systemic sclerosis. Indian Journal of Rheumatology , 11 (3) pp. 153-163. 10.4103/0973-3698.187423. Green open access

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Abstract

Systemic sclerosis (SSc) (scleroderma) is an uncommon multisystem connective tissue disease with high unmet need and mortality. There has been an improvement in overall outcome and survival over the past three decades, but it still has the highest mortality among any of the autoimmune rheumatic diseases. Progress in its management has come through more organized assessment and treatment together with the emergence of therapies that can target specific complications of the disease such as renal crisis and pulmonary arterial hypertension. In addition, there is a growing understanding of pathogenesis that allows more targeted approaches to therapy to be explored in clinical trials. In this review, several aspects of SSc management including the more targeted therapies including strategies to block specific pathways or mediators have been discussed.

Type: Article
Title: Emerging evidence-based therapies for systemic sclerosis
Open access status: An open access version is available from UCL Discovery
DOI: 10.4103/0973-3698.187423
Publisher version: https://doi.org/10.4103/0973-3698.187423
Language: English
Additional information: Copyright © 2016 Indian Journal of Rheumatology | Published by Wolters Kluwer - Medknow. This is an open access article distributed under the terms of the Creative Commons Attribution‑NonCommercial‑ShareAlike 3.0 License (https://creativecommons.org/licenses/by-nc-sa/3.0/), which allows others to remix, tweak, and build upon the work non‑commercially, as long as the author is credited and the new creations are licensed under the identical terms.
Keywords: Immunosuppressants, scleroderma, systemic sclerosis, therapies, treatments
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
URI: https://discovery.ucl.ac.uk/id/eprint/10050656
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