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The role of endothelial cells in autoimmune rheumatic disease

Kanitkar, M; Denton, CP; (2024) The role of endothelial cells in autoimmune rheumatic disease. Current Opinion in Physiology , 37 , Article 100732. 10.1016/j.cophys.2023.100732. Green open access

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Abstract

Vasculopathy is a generic feature of autoimmune rheumatic disease and there is substantial evidence that endothelial cell dysfunction has a role in pathogenesis and clinical manifestations of this challenging group of diseases. Endothelial cells (EC) are a target for injury and through their essential functional role in vascular homoeostasis, this has significant impact. In addition, the emerging recognition that EC are important regulators of other cell types and can differentiate into other relevant cell types has direct relevance. These aspects are reviewed with a focus on recent published evidence regarding the importance of EC in development, progression and treatment of autoimmune rheumatic disease. The potential role of the adaptive and innate immune system in causing endothelial cell damage, including anti-endothelial cell autoantibodies, will be reviewed. Recent advances in understanding how EC may differentiate into mesenchymal lineages and the interplay between physiological roles in healing or tissue repair and dysfunctional responses in acquired connective tissue disease will be reviewed.

Type: Article
Title: The role of endothelial cells in autoimmune rheumatic disease
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.cophys.2023.100732
Publisher version: http://dx.doi.org/10.1016/j.cophys.2023.100732
Language: English
Additional information: Copyright © 2023 The Author(s). This is an open access article under the CC BY license (http:// creativecommons.org/licenses/by/4.0/).
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
URI: https://discovery.ucl.ac.uk/id/eprint/10186078
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