Spierings, Julia;
Ong, Voon H;
Denton, Christopher P;
(2022)
Three Cases of Systemic Sclerosis Within One Family With Different Antibodies and Clinical Features.
The Journal of Rheumatology
, 49
(5)
pp. 544-546.
10.3899/jrheum.211139.
Preview |
Text
Family case report SSc-for UCL accepted.pdf - Accepted Version Download (157kB) | Preview |
Abstract
Systemic sclerosis (SSc) is a heterogeneous disorder in which both genetic and environmental factors play a role in the pathogenesis.1 Familial occurrence of SSc is uncommon and accounts for < 2% of cases.2 Familial cases tend to have similar autoantibodies and disease features.3 HLA studies suggest that major histocompatibility complex (MHC) genes exert their influence primarily on antinuclear antibody (ANA) expression in SSc.4 Also, skin biology differences to anti-RNA polymerase III (ARA) and antitopoisomerase antibodies (ATA) were studied, suggesting both shared and ANA-specific molecular drivers.5.
| Type: | Article |
|---|---|
| Title: | Three Cases of Systemic Sclerosis Within One Family With Different Antibodies and Clinical Features |
| Location: | Canada |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3899/jrheum.211139 |
| Publisher version: | https://doi.org/10.3899/jrheum.211139 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10144296 |
Archive Staff Only
 |
View Item |
