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Editorial: Bench to Bedside—and Back Again: Finding the Goldilocks Zone Within the Scleroderma Universe

Pope, JE; Lee, JJ; Denton, CP; (2018) Editorial: Bench to Bedside—and Back Again: Finding the Goldilocks Zone Within the Scleroderma Universe. [Editorial comment]. Arthritis & Rheumatology , 70 (2) pp. 155-156. 10.1002/art.40373. Green open access

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Abstract

Systemic sclerosis (SSc) is a complex inflammatory connective tissue disease characterized by skin thickening, organ fibrosis and vasculopathy [1, 2]. The underlying disease mechanisms and pathophysiology are not fully understood. However, it appears to be, at least in part, driven by autoimmunity and inflammation associated with microvascular dysfunction ultimately resulting in excess extracellular matrix deposition in target organs [2-4]. Clinical heterogeneity coupled with our lack of understanding of the disease pathogenesis means that current treatment strategies are mostly organ based therapies using anti-rheumatic drugs that were originally approved for other indications [5]. Of course, this clinical diversity not only provides challenges to discovery of disease mechanisms, it also complicates often underpowered clinical trials that aim to find the right drugs for the right patient at the right time. This article is protected by copyright. All rights reserved.

Type: Article
Title: Editorial: Bench to Bedside—and Back Again: Finding the Goldilocks Zone Within the Scleroderma Universe
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/art.40373
Publisher version: https://doi.org/10.1002/art.40373
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Systemic sclerosis, biomarkers, clinical trial, early phase trial design, editorial, randomized trial
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
URI: https://discovery.ucl.ac.uk/id/eprint/10037967
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