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Reduced levels of S-nitrosothiols in plasma of patients with systemic sclerosis and Raynaud's phenomenon.

Kundu, D; Abraham, D; Black, CM; Denton, CP; Bruckdorfer, KR; (2014) Reduced levels of S-nitrosothiols in plasma of patients with systemic sclerosis and Raynaud's phenomenon. Vascul Pharmacol , 63 (3) 178 - 181. 10.1016/j.vph.2014.09.003. Green open access

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Abstract

S-Nitrosothiols (RSNOs) are bioactive forms of nitric oxide which are involved in cell signalling and redox regulation of vascular function. Circulating S-nitrosothiols are predominantly in the form of S-nitrosoalbumin. In this study plasma concentrations of S-nitrosothiols were measured in patients with systemic sclerosis (SSc) where NO metabolism is known to be abnormal.

Type: Article
Title: Reduced levels of S-nitrosothiols in plasma of patients with systemic sclerosis and Raynaud's phenomenon.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.vph.2014.09.003
Publisher version: http://dx.doi.org/10.1016/j.vph.2014.09.003
Language: English
Additional information: © 2014 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: Acetic acid (PubChem: ClD:176), Copper sulphate (PubChem: ClD 24462), Dithiothreitol (PubChem: ClD 19001), Ethylenediaminetetracetic acid (Pub Chem ClD 6049), N-ethylmaleimide (PubChem ClD:4362), Nitric oxide (PubChem: ClD: 145068), Potassium iodide (PubChem ClD: 4875), S-nitrosothiols, Skin score, Sulfanilamide (PubChem: ClD 5333), Systemic sclerosis
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
URI: https://discovery.ucl.ac.uk/id/eprint/1458818
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