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The novel use of botulinum toxin A for the treatment of Raynaud's phenomenon in the toes

Dhaliwal, K; Griffin, M; Denton, CP; Butler, PEM; (2018) The novel use of botulinum toxin A for the treatment of Raynaud's phenomenon in the toes. BMJ Case Reports , 2018 , Article bcr-2017-219348. 10.1136/bcr-2017-219348. Green open access

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Abstract

Raynaud's phenomenon is a vasospastic disorder of the digital vessels triggered by exposure to cold or stress. It is most commonly observed in the hands, but also frequently affects the toes. We present three cases of patients with severe Raynaud's phenomenon in the toes, secondary to scleroderma. The diagnosis of Raynaud's syndrome and scleroderma was established according to the 2010 American College of Rheumatology and European League Against Rheumatism criteria. Patients were treated with 10 units of botulinum toxin injected into each foot. Two millilitres was injected into the base of each toe in both the left and right feet. Six weeks postinjection into the toes, patients reported an improvement of cold intolerance, colour change and frequency and severity of Raynaud's attacks. The effects were reported to last up to 5 months. To our knowledge, these are the first reported cases of the treatment of Raynaud's phenomenon in the toes with botulinum toxin A.

Type: Article
Title: The novel use of botulinum toxin A for the treatment of Raynaud's phenomenon in the toes
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1136/bcr-2017-219348
Publisher version: http://doi.org/10.1136/bcr-2017-219348
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Plastic and reconstructive surgery, rheumatology
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
URI: https://discovery.ucl.ac.uk/id/eprint/10046350
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