UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

There is a need for new systemic sclerosis subset criteria. A content analytic approach

Johnson, SR; Soowamber, ML; Fransen, J; Khanna, D; Van den Hoogen, F; Baron, M; Matucci-Cerinic, M; ... Pope, JE; + view all (2018) There is a need for new systemic sclerosis subset criteria. A content analytic approach. Scandinavian Journal of Rheumatology , 47 (1) pp. 62-70. 10.1080/03009742.2017.1299793. Green open access

[thumbnail of Denton_There is a need for new systemic sclerosis subset criteria(redacted).pdf]
Preview
Text
Denton_There is a need for new systemic sclerosis subset criteria(redacted).pdf - Accepted Version

Download (558kB) | Preview

Abstract

Objectives: Systemic sclerosis (SSc) is heterogenous. The objectives of this study were to evaluate the purpose, strengths and limitations of existing SSc subset criteria, and identify ideas among experts about subsets. Methods: We conducted semi-structured interviews with randomly sampled international SSc experts. The interview transcripts underwent an iterative process with text deconstructed to single thought units until a saturated conceptual framework with coding was achieved and respondent occurrence tabulated. Serial cross-referential analyses of clusters were developed. Results: Thirty experts from 13 countries were included; 67% were male, 63% were from Europe and 37% from North America; median experience of 22.5 years, with a median of 55 new SSc patients annually. Three thematic clusters regarding subsetting were identified: research and communication; management; and prognosis (prediction of internal organ involvement, survival). The strength of the limited/diffuse system was its ease of use, however 10% stated this system had marginal value. Shortcomings of the diffuse/limited classification were the risk of misclassification, predictions/generalizations did not always hold true, and that the elbow or knee threshold was arbitrary. Eighty-seven percent use more than 2 subsets including: SSc sine scleroderma, overlap conditions, antibody-determined subsets, speed of progression, and age of onset (juvenile, elderly). Conclusions: We have synthesized an international view of the construct of SSc subsets in the modern era. We found a number of factors underlying the construct of SSc subsets. Considerations for the next phase include rate of change and hierarchal clustering (e.g. limited/diffuse, then by antibodies).

Type: Article
Title: There is a need for new systemic sclerosis subset criteria. A content analytic approach
Open access status: An open access version is available from UCL Discovery
DOI: 10.1080/03009742.2017.1299793
Publisher version: http://doi.org/10.1080/03009742.2017.1299793
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Systemic sclerosis, Scleroderma, Classification Criteria, Subsets, Content analysis
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
URI: https://discovery.ucl.ac.uk/id/eprint/1554830
Downloads since deposit
310Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item