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Number of items: 98.
Article
Ahmed, Nehaal;
Spears, Richard J;
Sheppard, Tom D;
Chudasama, Vijay;
(2022)
Functionalisation of ethereal-based saturated heterocycles with concomitant aerobic C–H activation and C–C bond formation.
Chemical Science
10.1039/d2sc01626e.
(In press).
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Ahmed, N;
Shamsabadi, A;
Chudasama, V;
(2019)
Formation of Synthetically Versatile 2-Aminobenzophenones from Readily Accessed Acyl Hydrazides.
ACS Omega
, 4
(27)
pp. 22602-22612.
10.1021/acsomega.9b03417.
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Akhbar, AR;
Chudasama, V;
Fitzmaurice, RJ;
Powell, L;
Caddick, S;
(2013)
Acyl hydrazides as acyl donors for the synthesis of diaryl and aryl alkyl ketones.
Chem Commun (Camb)
, 50
(6)
pp. 743-746.
10.1039/c3cc47967f.
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Aliev, AE;
Kulke, M;
Khaneja, HS;
Chudasama, V;
Sheppard, TD;
Lanigan, RM;
(2014)
Motional timescale predictions by molecular dynamics simulations: Case study using proline and hydroxyproline sidechain dynamics.
Proteins
, 82
(2)
pp. 195-215.
10.1002/prot.24350.
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Atkinson, BN;
Chudasama, V;
Browne, LE;
(2020)
Controlling Engineered P2X Receptors with Light.
Methods in Molecular Biology
, 2041
pp. 301-309.
10.1007/978-1-4939-9717-6_22.
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Ayrton, John-Paul;
Ho, Chapman;
Zhang, Haoran;
Chudasama, Vijay;
Frank, Stefanie;
Thomas, Michael R;
(2024)
Multivalent nanobody engineering for enhanced physisorption and functional display on gold nanoparticles.
Nanoscale
, 16
pp. 19881-19896.
10.1039/d4nr02762k.
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Bahou, Calise;
Chudasama, Vijay;
(2022)
The use of bromopyridazinedione derivatives in chemical biology.
Organic & Biomolecular Chemistry
10.1039/d2ob00310d.
(In press).
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Bahou, Calise;
Spears, Richard J;
Ramírez Rosales, Angela M;
Rochet, Léa NC;
Barber, Lydia J;
Stankevich, Ksenia S;
Miranda, Juliana F;
... Spicer, Christopher D; + view all
(2023)
Hydrogel Cross-Linking via Thiol-Reactive Pyridazinediones.
Biomacromolecules
10.1021/acs.biomac.3c00290.
(In press).
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Bahou, C;
Love, EA;
Leonard, S;
Spears, RJ;
Maruani, A;
Armour, K;
Baker, JR;
(2019)
Disulfide Modified IgG1: An Investigation of Biophysical Profile and Clinically Relevant Fc Interactions.
Bioconjugate Chemistry
, 30
(4)
pp. 1048-1054.
10.1021/acs.bioconjchem.9b00174.
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Bahou, C;
Richards, DA;
Maruani, A;
Love, EA;
Javaid, F;
Caddick, S;
Baker, JR;
(2018)
Highly homogeneous antibody modification through optimisation of the synthesis and conjugation of functionalised dibromopyridazinediones.
Organic & Biomolecular Chemistry
, 16
(8)
pp. 1359-1366.
10.1039/c7ob03138f.
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Bahou, C;
Spears, RJ;
Aliev, AE;
Maruani, A;
Fernandez, M;
Javaid, F;
Szijj, PA;
... Chudasama, V; + view all
(2019)
Use of pyridazinediones as extracellular cleavable linkers through reversible cysteine conjugation.
Chemical Communications
10.1039/c9cc08362f.
(In press).
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Bahou, C;
Szijj, PA;
Spears, RJ;
Wall, A;
Javaid, F;
Sattikar, A;
Love, EA;
... Chudasama, V; + view all
(2021)
A Plug-and-Play Platform for the Formation of Trifunctional Cysteine Bioconjugates that also Offers Control over Thiol Cleavability.
Bioconjugate Chemistry
10.1021/acs.bioconjchem.1c00057.
(In press).
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Cal, PM;
Frade, RF;
Chudasama, V;
Cordeiro, C;
Caddick, S;
Gois, PM;
(2013)
Targeting cancer cells with folic acid-iminoboronate fluorescent conjugates.
Chem Commun (Camb)
, 50
(40)
pp. 5261-5263.
10.1039/c3cc47534d.
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Castañeda, L;
Maruani, A;
Schumacher, FF;
Miranda, E;
Chudasama, V;
Chester, KA;
Baker, JR;
... Caddick, S; + view all
(2013)
Acid-cleavable thiomaleamic acid linker for homogeneous antibody-drug conjugation.
Chemical Communications
, 49
pp. 8187-8189.
10.1039/c3cc45220d.
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Castaneda, L;
Wright, ZVF;
Marculescu, C;
Tran, TM;
Chudasama, V;
Maruani, A;
Hull, EA;
... Baker, JR; + view all
(2013)
A mild synthesis of N-functionalised bromomaleimides, thiomaleimides and bromopyridazinediones.
Tetrahedron Letters
, 54
(27)
3493 -3495.
10.1016/j.tetlet.2013.04.088.
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Cheng, MHY;
Maruani, A;
Savoie, H;
Chudasama, V;
Boyle, RW;
(2018)
Synthesis of a novel HER2 targeted aza-BODIPY-antibody conjugate: synthesis, photophysical characterisation and in vitro evaluation.
Organic & Biomolecular Chemistry
, 16
(7)
pp. 1144-1149.
10.1039/c7ob02957h.
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Chrzastek, Alina;
Thanasi, Ioanna A;
Irving, James A;
Chudasama, Vijay;
Baker, James R;
(2022)
Dual reactivity disulfide bridging reagents; enabling new approaches to antibody fragment bioconjugation.
Chemical Science
10.1039/d2sc04531a.
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Chudasama, V;
(2018)
Antibody - Drug conjugates (ADC) - Drug discovery today: Technologies.
[Editorial comment].
Drug Discovery Today - Technologies
, 30
pp. 1-2.
10.1016/j.ddtec.2018.11.003.
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Chudasama, V;
(2015)
Pentafluorophenyl vinyl sulfonate enables efficient, metal-free, radical-based alkene hydroacylation with an aldehyde as a limiting reagent.
RSC Advances
, 5
(55)
pp. 44423-44426.
10.1039/c5ra08353b.
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Chudasama, V;
Akhbar, AR;
Bahou, KA;
Fitzmaurice, RJ;
Caddick, S;
(2013)
Metal-free, hydroacylation of C[double bond, length as m-dash]C and N[double bond, length as m-dash]N bonds via aerobic C-H activation of aldehydes, and reaction of the products thereof.
Org Biomol Chem
, 11
(42)
pp. 7301-7317.
10.1039/c3ob41632a.
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Chudasama, V;
Bryden, F;
Savoie, H;
Maruani, A;
Cheng, M;
Beeby, A;
Rodrigues, J;
(2017)
Assembly of high-potency photosensitiser-antibody conjugates through application of dendron multiplier technology.
Bioconjugate Chemistry
, 29
(1)
pp. 176-181.
10.1021/acs.bioconjchem.7b00678.
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Chudasama, V;
Maruani, A;
Caddick, S;
(2016)
Recent advances in the construction of antibody–drug conjugates.
Nature Chemistry
, 8
pp. 114-119.
10.1038/nchem.2415.
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Chudasama, V;
Smith, MEB;
Schumacher, FF;
Papaioannou, D;
Waksman, G;
Baker, JR;
Caddick, S;
(2011)
Bromopyridazinedione-mediated protein and peptide bioconjugation.
Chemical Communications
, 47
(31)
8781 - 8783.
10.1039/c1cc12807h.
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Creamer, Adam;
Fiego, Alessandra Lo;
Agliano, Alice;
Prados-Martin, Lino;
Høgset, Håkon;
Najer, Adrian;
Richards, Daniel A;
... Stevens, Molly M; + view all
(2023)
Modular Synthesis of Semiconducting Graft Co-polymers to Achieve "clickable" Fluorescent Nanoparticles with Long Circulation and Specific Cancer Targeting.
Advanced Materials
, Article e2300413. 10.1002/adma.202300413.
(In press).
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Dinesen, Anders;
Andersen, Veronica L;
Elkhashab, Marwa;
Pilati, Diego;
Bech, Pernille;
Fuchs, Elisabeth;
Samuelsen, Torbjørn R;
... Howard, Kenneth A; + view all
(2024)
An Albumin-Holliday Junction Biomolecular Modular Design for Programmable Multifunctionality and Prolonged Circulation.
Bioconjugate Chemistry
, 35
(2)
pp. 214-222.
10.1021/acs.bioconjchem.3c00491.
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Dinesen, Anders;
Winther, Alexander;
Wall, Archie;
Märcher, Anders;
Palmfeldt, Johan;
Chudasama, Vijay;
Wengel, Jesper;
... Howard, Kenneth A; + view all
(2022)
Albumin Biomolecular Drug Designs Stabilized through Improved Thiol Conjugation and a Modular Locked Nucleic Acid Functionalized Assembly.
Bioconjugate Chemistry
, 33
(2)
pp. 333-342.
10.1021/acs.bioconjchem.1c00561.
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Farleigh, M;
Pham, TT;
Yu, Z;
Kim, J;
Sunassee, K;
Firth, G;
Forte, N;
... Ma, MT; + view all
(2021)
New Bifunctional Chelators Incorporating Dibromomaleimide Groups for Radiolabeling of Antibodies with Positron Emission Tomography Imaging Radioisotopes.
Bioconjugate Chemistry
, 32
(7)
pp. 1214-1222.
10.1021/acs.bioconjchem.0c00710.
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Fernandez, M;
Javaid, F;
Chudasama, V;
(2018)
Advances in targeting the folate receptor in the treatment/imaging of cancers.
Chemical Science
, 9
(4)
pp. 790-810.
10.1039/c7sc04004k.
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Fernández, M;
Shamsabadi, A;
Chudasama, V;
(2020)
Fine-tuning thio-pyridazinediones as SMDC scaffolds (with intracellular thiol release via a novel self-immolative linker).
Chemical Communications
10.1039/c9cc08744c.
(In press).
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Forte, N;
Benni, I;
Karu, K;
Chudasama, V;
Baker, JR;
(2019)
Cysteine-to-lysine transfer antibody fragment conjugation.
Chemical Science
, 10
(47)
pp. 10919-10924.
10.1039/c9sc03825f.
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Forte, N;
Chudasama, V;
Baker, JR;
(2018)
Homogeneous antibody-drug conjugates via site-selective disulfide bridging.
Drug Discovery Today: Technologies
, 30
pp. 11-20.
10.1016/j.ddtec.2018.09.004.
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Forte, N;
Livanos, M;
Miranda, E;
Morais, M;
Yang, X;
Rajkumar, VS;
Chester, KA;
... Baker, JR; + view all
(2018)
Tuning the Hydrolytic Stability of Next Generation Maleimide Cross-Linkers Enables Access to Albumin-Antibody Fragment Conjugates and tri-scFvs.
Bioconjugate Chemistry
, 29
(2)
pp. 486-492.
10.1021/acs.bioconjchem.7b00795.
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Gaitzsch, J;
Chudasama, V;
Morecroft, E;
Messager, L;
Battaglia, G;
(2016)
Synthesis of an Amphiphilic Miktoarm Star Terpolymer for Self-Assembly into Patchy Polymersomes.
ACS Macro Letters
, 5
(3)
pp. 351-354.
10.1021/acsmacrolett.5b00913.
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Galan, SRG;
Wickens, JR;
Dadova, J;
Ng, W-L;
Zhang, X;
Simion, RA;
Quinlan, R;
... Davis, BG; + view all
(2018)
Post-translational site-selective protein backbone alpha-deuteration.
Nature Chemical Biology
, 14
(10)
pp. 955-963.
10.1038/s41589-018-0128-y.
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Greene, MK;
Chen, T;
Robinson, E;
Straubinger, NL;
Minx, C;
Chan, DKW;
Wang, J;
... Scott, CJ; + view all
(2020)
Controlled coupling of an ultrapotent auristatin warhead to cetuximab yields a next-generation antibody-drug conjugate for EGFR-targeted therapy of KRAS mutant pancreatic cancer.
British Journal of Cancer
, 123
pp. 1502-1512.
10.1038/s41416-020-01046-6.
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Greene, MK;
Nogueira, JCF;
Tracey, SR;
Richards, DA;
McDaid, WJ;
Burrows, JF;
Campbell, K;
... Scott, CJ; + view all
(2020)
Refined construction of antibody-targeted nanoparticles leads to superior antigen binding and enhanced delivery of an entrapped payload to pancreatic cancer cells.
Nanoscale
10.1039/d0nr02387f.
(In press).
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Greene, MK;
Richards, DA;
Nogueira, JCF;
Campbell, K;
Smyth, P;
Fernández, M;
Scott, CJ;
(2018)
Forming next-generation antibody–nanoparticle conjugates through the oriented installation of non-engineered antibody fragments.
Chemical Science
, 9
(1)
pp. 79-87.
10.1039/C7SC02747H.
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Javaid, F;
Pilotti, C;
Camilli, C;
Kallenberg, D;
Bahou, C;
Blackburn, J;
R. Baker, J;
... Chudasama, V; + view all
(2021)
Leucine-rich alpha-2-glycoprotein 1 (LRG1) as a novel ADC target.
RSC Chemical Biology
, 2
(4)
pp. 1206-1220.
10.1039/d1cb00104c.
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Knight, E;
Robinson, E;
Smoktunowicz, N;
Chambers, RC;
Aliev, AE;
Inglis, GG;
Chudasama, V;
(2016)
Synthesis of novel and potent vorapaxar analogues.
Organic & Biomolecular Chemistry
, 14
(12)
pp. 3264-3274.
10.1039/c5ob02541a.
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Lee, MTW;
Maruani, A;
Baker, JR;
Caddick, S;
Chudasama, V;
(2015)
Next-generation disulfide stapling: reduction and functional re-bridging all in one.
Chemical Science
(1)
pp. 799-802.
10.1039/c5sc02666k.
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Lee, MTW;
Maruani, A;
Richards, DA;
Baker, JR;
Caddick, S;
Chudasama, V;
(2017)
Enabling the controlled assembly of antibody conjugates with a loading of two modules without antibody engineering.
Chemical Science
, 8
(3)
pp. 2056-2060.
10.1039/c6sc03655d.
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Loynachan, CN;
Thomas, MR;
Gray, ER;
Richards, DA;
Kim, J;
Miller, BS;
Brookes, JC;
... Stevens, MM; + view all
(2018)
Platinum Nanocatalyst Amplification: Redefining the Gold Standard for Lateral Flow Immunoassays with Ultrabroad Dynamic Range.
ACS Nano
, 12
(1)
pp. 279-288.
10.1021/acsnano.7b06229.
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Malde, Roshni;
Parkes, Michael A;
Staniforth, Michael;
Woolley, Jack M;
Stavros, Vasilios G;
Chudasama, Vijay;
Fielding, Helen H;
(2022)
Intramolecular thiomaleimide [2+2] photocycloadditions: stereoselective control for disulfide stapling and observation of excited state intermediates by transient absorption spectroscopy.
Chemical Science
10.1039/d1sc06804k.
(In press).
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Malde, Roshni;
Richards, Daniel A;
Salerno, Luigia;
Zhao, Yanbo;
Karu, Kersti;
Chudasama, Vijay;
Baker, James R;
(2023)
A Light‐Induced Decarboxylative‐Elimination of Substituted Maleimides as a Strategy Towards Triggered Photorelease.
European Journal of Organic Chemistry
, Article e202201372. 10.1002/ejoc.202201372.
(In press).
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Maneiro, MA;
Forte, N;
Shchepinova, MM;
Kounde, CS;
Chudasama, V;
Baker, JR;
Tate, EW;
(2020)
Antibody-PROTAC Conjugates Enable HER2-Dependent Targeted Protein Degradation of BRD4.
ACS Chemical Biology
10.1021/acschembio.0c00285.
(In press).
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Maruani, A;
Alom, S;
Canavelli, P;
Lee, MT;
Morgan, RE;
Chudasama, V;
Caddick, S;
(2015)
A mild TCEP-based para-azidobenzyl cleavage strategy to transform reversible cysteine thiol labelling reagents into irreversible conjugates.
Chemical Communications
, 51
(25)
pp. 5279-5282.
10.1039/c4cc08515a.
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Maruani, A;
Lee, MTW;
Watkins, G;
Akhbar, AR;
Baggs, H;
Shamsabadi, A;
Richards, DA;
(2016)
A facile, one-pot procedure for the conversion of aromatic aldehydes to esters, as well as thioesters and amides, via acyl hydrazide intermediates.
RSC Advances
, 6
(4)
pp. 3372-3376.
10.1039/C5RA26842G.
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Maruani, A;
Richards, DA;
Chudasama, V;
(2016)
Dual modification of biomolecules.
Organic & Biomolecular Chemistry
, 14
(26)
pp. 6165-6178.
10.1039/c6ob01010e.
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Maruani, A;
Savoie, H;
Bryden, F;
Caddick, S;
Boyle, R;
Chudasama, V;
(2015)
Site-selective multi-porphyrin attachment enables the formation of a next-generation antibody-based photodynamic therapeutic.
Chemical Communications
, 51
(83)
pp. 15304-15307.
10.1039/c5cc06985h.
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Maruani, A;
Smith, ME;
Miranda, E;
Chester, KA;
Chudasama, V;
Caddick, S;
(2015)
A plug-and-play approach to antibody-based therapeutics via a chemoselective dual click strategy.
Nat Commun
, 6
, Article 6645. 10.1038/ncomms7645.
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Maruani, A;
Szijj, P;
Bahou, C;
Nogueira, J;
Caddick, S;
Baker, JR;
Chudasama, V;
(2020)
A Plug-and-Play Approach for the De Novo Generation of Dually Functionalized Bispecifics.
Bioconjugate Chemistry
, 31
(3)
pp. 520-529.
10.1021/acs.bioconjchem.0c00002.
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Moody, P;
Chudasama, V;
Nathani, RI;
Maruani, A;
Martin, S;
Smith, ME;
Caddick, S;
(2014)
A rapid, site-selective and efficient route to the dual modification of DARPins.
Chem Commun (Camb)
, 50
(38)
pp. 4898-4900.
10.1039/c4cc00053f.
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Moody, P;
Smith, ME;
Ryan, CP;
Chudasama, V;
Baker, JR;
Molloy, J;
Caddick, S;
(2012)
Bromomaleimide-linked bioconjugates are cleavable in mammalian cells.
Chembiochem : A European Journal of Chemical Biology
, 13
(1)
39 - 41.
10.1002/cbic.201100603.
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Morais, M;
Forte, N;
Chudasama, V;
Baker, JR;
(2019)
Application of Next-Generation Maleimides (NGMs) to Site-Selective Antibody Conjugation.
Methods in Molecular Biology
, 2033
pp. 15-24.
10.1007/978-1-4939-9654-4_2.
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Morais, M;
Nunes, JPM;
Karu, K;
Forte, N;
Benni, I;
Smith, MEB;
Caddick, S;
... Baker, JR; + view all
(2017)
Optimisation of the dibromomaleimide (DBM) platform for native antibody conjugation by accelerated post-conjugation hydrolysis.
Organic and Biomolecular Chemistry
, 15
(14)
pp. 2859-2860.
10.1039/c7ob00220c.
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Morgan, RE;
Chudasama, V;
Moody, P;
Smith, ME;
Caddick, S;
(2015)
A novel synthetic chemistry approach to linkage-specific ubiquitin conjugation.
Org Biomol Chem
, 13
(14)
4165 - 4168.
10.1039/c5ob00130g.
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Nathani, RI;
Chudasama, V;
Ryan, CP;
Moody, PR;
Morgan, RE;
Fitzmaurice, RJ;
Smith, ME;
... Caddick, S; + view all
(2013)
Reversible protein affinity-labelling using bromomaleimide-based reagents.
Organic & Biomolecular Chemistry
, 11
(15)
2408 -2411.
10.1039/c3ob40239h.
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Nathani, RI;
Moody, P;
Chudasama, V;
Smith, MEB;
Fitzmaurice, RJ;
Caddick, S;
(2013)
A novel approach to the site-selective dual labelling of a protein via chemoselective cysteine modification.
Chemical Science
, 4
(9)
pp. 3455-3458.
10.1039/C3SC51333E.
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Nogueira, JCF;
Greene, MK;
Richards, DA;
Furby, AO;
Steven, J;
Porter, A;
Barelle, C;
... Chudasama, V; + view all
(2019)
Oriented attachment of VNAR proteins, via site-selective modification, on PLGA-PEG nanoparticles enhances nanoconjugate performance.
Chemical Communications
, 55
(53)
pp. 7671-7674.
10.1039/c9cc02655j.
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Nogueira, JCF;
Paliashvili, K;
Bradford, A;
Di Maggio, F;
Richards, DA;
Day, RM;
Chudasama, V;
(2020)
Functionalised thermally induced phase separation (TIPS) microparticles enabled for “click” chemistry.
Organic & Biomolecular Chemistry
10.1039/d0ob00106f.
(In press).
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Nunes, JP;
Morais, M;
Vassileva, V;
Robinson, E;
Rajkumar, VS;
Smith, ME;
Pedley, RB;
... Chudasama, V; + view all
(2015)
Functional native disulfide bridging enables delivery of a potent, stable and targeted antibody-drug conjugate (ADC).
Chemical Communications
, 51
(53)
pp. 10624-10627.
10.1039/c5cc03557k.
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Nunes, JPM;
Vassileva, V;
Robinson, E;
Morais, M;
Smith, MEB;
Pedley, RB;
Caddick, S;
... Chudasama, V; + view all
(2017)
Use of a next generation maleimide in combination with THIOMAB (TM) antibody technology delivers a highly stable, potent and near homogeneous THIOMAB (TM) antibody-drug conjugate (TDC).
RSC ADVANCES
, 7
(40)
pp. 24828-24832.
10.1039/c7ra04606e.
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Patel, Mikesh;
Forte, Nafsika;
Bishop, Charlie R;
Porter, Michael J;
Dagwell, Matthew;
Karu, Kersti;
Chudasama, Vijay;
(2023)
The Nitrile Bis-Thiol Bioconjugation Reaction.
Journal of the American Chemical Society
10.1021/jacs.3c08762.
(In press).
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Petri, L;
Szijj, PA;
Kelemen, Á;
Imre, T;
Gömöry, Á;
Lee, MTW;
Hegedűs, K;
... Keserű, GM; + view all
(2020)
Cysteine specific bioconjugation with benzyl isothiocyanates.
RSC Advances
, 10
(25)
pp. 14928-14936.
10.1039/d0ra02934c.
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Pye, H;
Butt, MA;
Reinert, HW;
Maruani, A;
Nunes, JP;
Marklew, JS;
Qurashi, M;
... Lovat, LB; + view all
(2016)
A HER2 selective theranostic agent for surgical resection guidance and photodynamic therapy.
Photochemical & Photobiological Sciences
, 15
(10)
pp. 1227-1238.
10.1039/c6pp00139d.
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Richards, DA;
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