UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

A novel synthetic chemistry approach to linkage-specific ubiquitin conjugation.

Morgan, RE; Chudasama, V; Moody, P; Smith, ME; Caddick, S; (2015) A novel synthetic chemistry approach to linkage-specific ubiquitin conjugation. Org Biomol Chem , 13 (14) 4165 - 4168. 10.1039/c5ob00130g. Green open access

[thumbnail of c5ob00130g.pdf] PDF
c5ob00130g.pdf

Download (873kB)

Abstract

Ubiquitination is of great importance as the post-translational modification of proteins with ubiquitin, or ubiquitin chains, facilitates a number of vital cellular processes. Herein we present a facile method of preparing various ubiquitin conjugates under mild conditions using michael acceptors based on dibromo-maleimides and dibromo-pyridazinediones.

Type: Article
Title: A novel synthetic chemistry approach to linkage-specific ubiquitin conjugation.
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1039/c5ob00130g
Publisher version: http://dx.doi.org/10.1039/c5ob00130g
Language: English
Additional information: Copyright © Royal Society of Chemistry 2015. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry
URI: https://discovery.ucl.ac.uk/id/eprint/1462917
Downloads since deposit
178Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item